scholarly journals Vitamins D and B12, Altered Synaptic Plasticity and Extracellular Matrix

2021 ◽  
Author(s):  
Marcela Bermudez Echeverry ◽  
Silvia Honda Takada ◽  
Bruna Petrucelli Arruda ◽  
Debora Sterzeck Cardoso ◽  
Pamela Pinheiro Martins ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Extracellular Matrix ◽  
Brain Plasticity ◽  
Autism Spectrum ◽  
Matrix Metalloproteases ◽  
Gabaergic Inhibition ◽  
Dynamic Interactions ◽  
B12 Deficiency ◽  
Neuropsychiatric Conditions

Brain plasticity is regulated through dynamic interactions between perineuronal nets, matrix metalloproteases (MMPs) and the extracellular matrix (ECM). Several studies have identified a crucial role for vitamins D and B12 in brain development and a deficiency in these vitamins may contribute to the emergence of cognitive deficits, as well as the onset of both autism spectrum disorder and schizophrenia. However, the mechanisms underlying the interplay between ECM, MMPs, vitamins and these neuropsychiatric conditions are poorly understood. In this chapter, we seek to understand how the risk of neurodegeneration in vulnerable individuals and the aetiology of specific neuropsychiatric disorders are affected by vitamin D and B12 deficiency, in conjunction with low levels of the antioxidant glutathione, impaired GABAergic inhibition, and alterations in the permanent ECM.

scholarly journals Vitamin D Supplementation is Beneficial for Children with Autism Spectrum Disorder: A Meta-analysis

2020 ◽  
Vol 18 (2) ◽  
pp. 203-213
Author(s):  
Liyao Song ◽  
Xiaomei Luo ◽  
Qing Jiang ◽  
Zhi Chen ◽  
Lifang Zhou ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Meta Analysis ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Vitamin D Supplementation ◽  
Spectrum Disorder

scholarly journals Vitamin D and Autism Spectrum Disorder: A Literature Review

Nutrients ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 236 ◽  
Author(s):  
Hajar Mazahery ◽  
Carlos Camargo ◽  
Cathryn Conlon ◽  
Kathryn Beck ◽  
Marlena Kruger ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Literature Review ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Rickets treatment improves more than bone health in toddler with autism spectrum disorder: A brief report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1987002 ◽  
Author(s):  
Leah D Stalnaker ◽  
Priya Prasher ◽  
Susan Flesher
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Case Report ◽  
Effective Treatment ◽  
Vitamin D Deficiency ◽  
Developmental Delay ◽  
Bone Health ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder

Children with autism spectrum disorder have been found to have lower levels of vitamin D than their peers. Our case report supports the hypothesis that vitamin D may be an effective treatment for developmental delay in autism. In addition, we review the literature surrounding vitamin D deficiency as a potential cause of autism spectrum disorder and the role that vitamin D may play in treatment.

Neonatal Vitamin D Status in Relation to Autism Spectrum Disorder and Developmental Delay in the Charge Case-Control Study

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Rebecca J. Schmidt ◽  
Qiaojuan Niu ◽  
Darryl Eyles ◽  
Robin Hansen ◽  
Ana-Maria Iosif
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Developmental Delay ◽  
Case Control Study ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Vitamin D Status ◽  
Control Study

Bench to bedside review: Possible role of vitamin D in autism spectrum disorder

2018 ◽  
Vol 260 ◽  
pp. 360-365 ◽  
Author(s):  
Feiyong Jia ◽  
Ling Shan ◽  
Bing Wang ◽  
Honghua Li ◽  
Chunyue Miao ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Hypovitaminosis D as a risk factor for severe autism spectrum disorder

2021 ◽  
Vol 61 (2) ◽  
pp. 82-8
Author(s):  
Diyah Rakanita Undang ◽  
Mei Neni Sitaresmi ◽  
Roni Naning
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Risk Factor ◽  
General Hospital ◽  
Parental Education ◽  
Hypovitaminosis D ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Children With Asd ◽  
Vitamin D Levels

Background Vitamin D is an important risk factor for autism spectrum disorder (ASD). However, research on hypovitaminosis D as a risk factor for severe ASD  has been limited. To our knowledge, no such studies have been done in Indonesia. Objective To evaluate hypovitaminosis D as a risk factor for severe ASD. Methods This cross-sectional study included children aged 2-18 years who fulfilled the ASD DSM-5 diagnostic criteria. Subjects were consecutively sampled from April - June 2019 at the Child Growth and Polyclinic, Dr. Sardjito General Hospital, Yogyakarta. Assessment of ASD severity was carried out using the Childhood Autism Rating Scale Second Edition (CARS-2) questionnaire. Serum 25(OH)D examination was done in the Clinical Laboratory, Dr. Sardjito General Hospital.  Results Of 36 children with ASD, 36.1% had hypovitaminosis D (<30 ng/mL) and 69.4% had severe ASD, based on the CARS-2 questionnaire (≥37-60). Bivariate analysis revealed that children with hypovitaminosis D had more severe CARS-2 values ​​(92.3%) compared to those with normal vitamin D levels (56.5%) (PR 1.633; 95%CI 1.10 to 2.42; P=0.031). Multivariate analysis with logistic regression revealed that hypovitaminosis D increased the risk of severe ASD (PR 1.65; 95%CI 1.06 to 2.56; P=0.037). However, other variables such as gender, parental education, attention deficit and hyperactivity disorder (ADHD), epilepsy, sleep disorders, pharmacotherapy and non-pharmacotherapy had no significant relationships with severe ASD. Conclusion Children with ASD and hypovitaminosis D have a 1.65 times higher risk of severe ASD compared to children with ASD and sufficient vitamin D levels. We recommend that children with ASD undergo serum 25(OH)D monitoring.

scholarly journals Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case–control study

2019 ◽  
Vol 12 (6) ◽  
pp. 976-988 ◽  
Author(s):  
Rebecca J. Schmidt ◽  
Qiaojuan Niu ◽  
Darryl W. Eyles ◽  
Robin L. Hansen ◽  
Ana‐Maria Iosif
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Developmental Delay ◽  
Case Control Study ◽  
Autism Spectrum ◽  
Case Control ◽  
Spectrum Disorder ◽  
Vitamin D Status ◽  
Control Study

Vitamin D Deficiency and Autism Spectrum Disorder

2020 ◽  
Vol 26 (21) ◽  
pp. 2460-2474
Author(s):  
Martina Siracusano ◽  
Assia Riccioni ◽  
Roberta Abate ◽  
Arianna Benvenuto ◽  
Paolo Curatolo ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Autism Spectrum ◽  
Vitamin D Supplementation ◽  
Spectrum Disorder ◽  
Potential Efficacy ◽  
The Central Nervous System ◽  
Core Symptoms

: Vitamin D is a neurosteroid hormone crucially involved in neurodevelopment. Neural cell proliferation, neurotransmission, oxidative stress and immune function represent the main mechanisms mediated by vitamin D in the Central Nervous System. Therefore, its deficiency during pregnancy and early childhood may significantly impact on a developing brain, leading to possible adverse neuropsychological outcomes including Autism Spectrum Disorder (ASD). Significant vitamin D deficiency is described within children affected by ASD and in pregnant mothers whose offspring will later develop ASD, suggesting a possible role of the hormone as a contributing risk factor in the etiopathogenesis of ASD. We reviewed the actual literature on the potential contributing role of prenatal and early postnatal vitamin D deficiency in ASD etiopathogenesis, at both genetic and environmental levels, and the possible effect of vitamin D supplementation in autistic children. Conflicting but promising results emerged on the topic. : Further Randomized Controlled Trials studies carried out during pregnancy and early infancy are necessary for better understanding the possible contribution of vitamin D deficiency in the etiopathogenesis of autism and the potential efficacy of the hormone supplementation in the improvement of ASD core symptoms.

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