scholarly journals Study on the Effect of Socio-Demographic Factors on Different Congenital Disorders

2021 ◽  
Author(s):  
Poulami Majumder ◽  
Subrata Kumar Dey
Keyword(s):  
Down Syndrome ◽  
Turner Syndrome ◽  
Cleft Lip ◽  
Ambiguous Genitalia ◽  
Sociodemographic Factors ◽  
Congenital Disorders ◽  
Cleft Lip Palate ◽  
And Gender ◽  
Analysis System ◽  
Socio Demographic Factors

Congenital disorders define the disease that occurs since the birth of a baby. Down syndrome, Turner syndrome, cleft lip, and congenital heart disease are the most common congenital disorders worldwide. A retrospective study was carried out, examining the effect of sociodemographic factors on congenital anomalies in the state of West Bengal, India, over a period of 6 years. A total of 595 cases with congenital disorders including Down syndrome, Turner syndrome, and other abnormalities (cleft lip/palate, syndactyly, ambiguous genitalia) were statistically analyzed along with the sociodemographic characteristics through Statistical Analysis System (SAS) 9.3.2. Down syndrome is seemed to be associated with age, ethnicity, parental addiction, especially smoking, while Turner syndrome is associated with ethnicity and gender. Other congenital disorders such as ambiguous genitalia are found to be associated with maternal addiction.

scholarly journals Persuasive Da’wah Agenda based on Sociodemographic Factors: A Study in Cimahi

2019 ◽  
Vol 35 (1) ◽  
pp. 19-27
Author(s):  
Bambang Saiful Ma'arif ◽  
Umar Yusuf ◽  
Suliadi Suliadi ◽  
Parihat Parihat
Keyword(s):  
Random Sampling ◽  
Demographic Factors ◽  
Sampling Technique ◽  
Sociodemographic Factors ◽  
Primary Research ◽  
Important Data ◽  
Sociodemographic Factor ◽  
Religious Theme ◽  
And Gender ◽  
Socio Demographic Factors

This paper is a result of primary research titled “Mapping the Profile of Persuasive Da’wah Agenda in Cimahi City.” Cimahi is well known as the industrial centre of ‘creative animation’. The method of research is quantitative by conducting surveys through questionnaires to 399 respondents in Cimahi using multistage random sampling technique. This paper presents important data on the socio-demographic factors of the citizens which can be basic in planning the effective da’wah activities. The sociodemographic factor aforementioned are age, education, and gender of respondents. Those factors must be accurately identified in order to plan the persuasive da’wah. The views of the citizens toward da’wah activity can be parameters toward persuasive da’wah, including what religious theme they preferred to, their preference on the actual da’wah themes, their liking on entrepreneurial da’wah, etc. Citizens give responses to da’wah agenda of both bil-lisan (da’wah through speech) and bil-hal (da’wah through one’s character). The more accepted a da’wah, it means the more persuasive the da’wah is. When citizens do not like the da’wah, it can be said an unpersuasive one. Da’wah persuasion is closely related to its acceptability by the citizens.

Cleft Lip/Palate in Tanzanian Children and Its Relationship with Socio-Demographic Factors and Oral-Health Status

2014 ◽  
Vol 24 (9) ◽  
pp. 698-699
Author(s):  
Matilda Mtaya Mlangwa ◽  
Emeria Mugonzibwa ◽  
Ditte Lundvig ◽  
Frank Wagener ◽  
Hans Von Den Hoff ◽  
...  
Keyword(s):  
Health Status ◽  
Oral Health ◽  
Cleft Lip ◽  
Demographic Factors ◽  
Oral Health Status ◽  
Cleft Lip Palate ◽  
Socio Demographic Factors

scholarly journals Advantages of using toothpaste containing propolis and plant oils for gingivitis prevention and oral cavity hygiene in cleft lip/palate patients

2021 ◽  
Vol 142 ◽  
pp. 111992
Author(s):  
Agnieszka Machorowska-Pieniążek ◽  
Tadeusz Morawiec ◽  
Marcin Olek ◽  
Anna Mertas ◽  
David Aebisher ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Cleft Lip ◽  
Plant Oils ◽  
Cleft Lip Palate

scholarly journals Isoform-Specific Roles of Mutant p63 in Human Diseases

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 536
Author(s):  
Christian Osterburg ◽  
Susanne Osterburg ◽  
Huiqing Zhou ◽  
Caterina Missero ◽  
Volker Dötsch
Keyword(s):  
Cleft Lip ◽  
Ectodermal Dysplasia ◽  
Skin Development ◽  
Disease Mechanisms ◽  
Skin Fragility ◽  
Cleft Lip Palate ◽  
Life Threatening ◽  
Functional Consequences ◽  
Development And Differentiation

The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the DNA binding domain cause Ectrodactyly, Ectodermal Dysplasia, characterized by limb deformation, cleft lip/palate, and ectodermal dysplasia while mutations in in the C-terminal domain of the α-isoform cause Ankyloblepharon-Ectodermal defects-Cleft lip/palate (AEC) syndrome, a life-threatening disorder characterized by skin fragility, severe, long-lasting skin erosions, and cleft lip/palate. The molecular disease mechanisms of these syndromes have recently become elucidated and have enhanced our understanding of the role of p63 in epidermal development. Here we review the molecular cause and functional consequences of these p63-mutations for skin development and discuss the consequences of p63 mutations for female fertility.

Perceptual Speech Outcomes After Early Primary Palatal Repair in Ugandan Patients With Cleft Palate

2020 ◽  
pp. 105566562098024
Author(s):  
Kim Bettens ◽  
Laura Bruneel ◽  
Cassandra Alighieri ◽  
Daniel Sseremba ◽  
Duncan Musasizib ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Speech Therapy ◽  
Cleft Lip And Palate ◽  
Control Group ◽  
English Speaking ◽  
And Gender ◽  
Early Primary ◽  
Velopharyngeal Function ◽  
Normal Speech

Objective: To provide speech outcomes of English-speaking Ugandan patients with a cleft palate with or without cleft lip (CP±L). Design: Prospective case–control study. Setting: Referral hospital for patients with cleft lip and palate in Uganda. Participants: Twenty-four English-speaking Ugandan children with a CP±L (15 boys, 9 girls, mean 8.4 years) who received palatal closure prior to 6 months of age and an age- and gender-matched control group of Ugandan children without cleft palate. Interventions: Comparison of speech outcomes of the patient and control group. Main Outcome Measures: Perceptual speech outcomes including articulation, resonance, speech understandability and acceptability, and velopharyngeal composite score (VPC-sum). Information regarding speech therapy, fistula rate, and secondary surgery. Results: Normal speech understandability was observed in 42% of the patients, and 38% were judged with normal speech acceptability. Only 16% showed compensatory articulation. Acceptable resonance was found in 71%, and 75% of the patients were judged perceptually to present with competent velopharyngeal function based on the VPC-sum. Additional speech intervention was recommended in 25% of the patients. Statistically significant differences for all these variables were still observed with the control children ( P < .05). Conclusions: Overall, acceptable speech outcomes were found after early primary palatal closure. Comparable or even better results were found in comparison with international benchmarks, especially regarding the presence of compensatory articulation. Whether this approach is transferable to Western countries is the subject for further research.

scholarly journals Alveolar cleft and maximum cleft width as predictors for difficult laryngoscopy and intubation in patients with unilateral complete cleft lip and palate

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Gamal A. Abdelhameed ◽  
Wael A. Ghanem ◽  
Simon H. Armanios ◽  
Tamer Nabil Abdelrahman
Keyword(s):  
Body Weight ◽  
Odds Ratio ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Difficult Laryngoscopy ◽  
Secondary Outcome ◽  
Pediatric Airway ◽  
Alveolar Cleft ◽  
Cleft Lip Palate ◽  
Width Measurements

Abstract Background Cleft lip and palate is one of the commonest congenital anomalies, which have an impact on feeding, speech, and dental development away from the significant psychosocial sequel. Early surgical repair aims to restore appearance and function, and the modern techniques can leave many defects undetectable. Therefore, the anesthetic challenge facing the pediatric airway with such abnormalities is still of a great impact. The aim of our study among 189 patients enrolled is to correlate alveolar gap and maximum cleft width measurements as predictors of difficult laryngoscopy and intubation in infants with unilateral complete cleft lip/palate aging from 1 to 6 months. As a secondary outcome, their weight is to be correlated too as another parameter. Results The alveolar gap and maximum cleft width are both of equal high predictive power (p value ≤ 0.001) with 100% sensitivity for both and specificity of 76.10% and 82.39% respectively, with a cut off value of ≤ 10 mm and 11 mm for these dimensions respectively, and odds ratio of incidence of difficult intubation is 4.18 and 5.68 respectively, while body weight ≤ 5.75 kg has an odds ratio of 2.32. Conclusion Alveolar cleft and maximum cleft width can be used as predictors for anticipation of difficult laryngoscopy and intubation infant patients with unilateral complete cleft lip and palate, while body weight ≤ 5.75 kg increases the risk more than twice.

A novel H208DTP63mutation in a familial case of ectrodactyly–ectodermal dysplasia–cleft lip/palate syndrome without clefting

2009 ◽  
Vol 34 (8) ◽  
pp. e726-e728 ◽  
Author(s):  
L. Sorasio ◽  
E. Biamino ◽  
E. Garelli ◽  
G. B. Ferrero ◽  
M. C. Silengo
Keyword(s):  
Cleft Lip ◽  
Familial Case ◽  
Cleft Lip Palate
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