scholarly journals New Insights into the Pathogenesis of Ovarian Cancer: Oxidative Stress

2018 ◽  
Author(s):  
Ghassan M. Saed ◽  
Robert T. Morris ◽  
Nicole M. Fletcher
Keyword(s):  
Oxidative Stress ◽  
Ovarian Cancer

scholarly journals COVID-19 and cytokine storm syndrome: can what we know about interleukin-6 in ovarian cancer be applied?

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Antonio Macciò ◽  
Sara Oppi ◽  
Clelia Madeddu
Keyword(s):  
Oxidative Stress ◽  
Ovarian Cancer ◽  
Effective Treatment ◽  
Interleukin 6 ◽  
Advanced Ovarian Cancer ◽  
T Cell Response ◽  
Disease Spread ◽  
Cell Mediated Immunity ◽  
Cytokine Storm ◽  
Coagulation Disorders

AbstractImproving early diagnosis along with timely and effective treatment of COVID-19 are urgently needed. However, at present, the mechanisms underlying disease spread and development, defined prognosis, and immune status of patients with COVID-19 remain to be determined. Patients with severe disease state exhibit a hyperinflammatory response associated with cytokine storm syndrome, hypercoagulability, and depressed cell-mediated immunity. These clinical manifestations, sharing similar pathogenesis, have been well-studied in patients with advanced ovarian cancer. The present review suggests treatment approaches for COVID-19 based on strategies used against ovarian cancer, which shares similar immunopathology and associated coagulation disorders.The chronicization of the hyperinflammatory cytokine storm in patients with severe COVID-19 highlights a defective resistance phase that leads to aspecific chronic inflammation, associated with oxidative stress, which impairs specific T-cell response, induces tissue and endothelial damage, and thrombosis associated with systemic effects that lead to severe multi-organ failure and death. These events are similar to those observed in advanced ovarian cancer which share similar pathogenesis mediated primarily by Interleukin-6, which is, as well demonstrated in ovarian cancer, the key cytokine driving the immunopathology, related systemic symptoms, and patient prognosis.Consistent with findings in other disease models with similar immunopathology, such as advanced ovarian cancer, treatment of severe COVID-19 infection should target inflammation, oxidative stress, coagulation disorders, and immunodepression to improve patient outcome. Correctly identifying disease stages, based on available laboratory data, and developing a specific protocol for each phase is essential for effective treatment.

scholarly journals The Role of Oxidative Stress in the Development of Cisplatin Resistance in Epithelial Ovarian Cancer

2013 ◽  
Vol 21 (4) ◽  
pp. 503-508 ◽  
Author(s):  
Jimmy Belotte ◽  
Nicole M. Fletcher ◽  
Awoniyi O. Awonuga ◽  
Mitchell Alexis ◽  
Husam M. Abu-Soud ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cisplatin Resistance

SILAC-based quantitative proteomics identified lysosome as a fast response target to PDT agent Gd-N induced oxidative stress in human ovarian cancer IGROV1 cells

2015 ◽  
Vol 11 (11) ◽  
pp. 3059-3067 ◽  
Author(s):  
Dandan Qi ◽  
Qianqian Wang ◽  
Hongguang Li ◽  
Tao Zhang ◽  
Rongfeng Lan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ovarian Cancer ◽  
Quantitative Proteomics ◽  
Fast Response ◽  
Human Ovarian Cancer ◽  
Proteomic Identification ◽  
Response Target

A PDT agent Gd-N was successfully applied in SILAC based quantitative proteomic identification of fast response targets to oxidative stress.

Mitochondria-related oxidative stress contributes to ovarian cancer-promoting activity of mesothelial cells subjected to malignant ascites

2018 ◽  
Vol 98 ◽  
pp. 82-88 ◽  
Author(s):  
Martyna Pakuła ◽  
Justyna Mikuła-Pietrasik ◽  
Łukasz Stryczyński ◽  
Paweł Uruski ◽  
Sebastian Szubert ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ovarian Cancer ◽  
Malignant Ascites ◽  
Mesothelial Cells

scholarly journals Oxidative stress-induced DNA damage and homocysteine accumulation may beinvolved in ovarian cancer progression in both young and old patients

2016 ◽  
Vol 46 ◽  
pp. 583-589 ◽  
Author(s):  
Shazia Anwer BUKHARI ◽  
Kashaf ZAFAR ◽  
Muhammad Ibrahim RAJOKA ◽  
Zubair IBRAHIM ◽  
Sadia JAVED ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ovarian Cancer ◽  
Dna Damage ◽  
Cancer Progression ◽  
Old Patients

Dichloroacetate Induces Apoptosis of Epithelial Ovarian Cancer Cells Through a Mechanism Involving Modulation of Oxidative Stress

2011 ◽  
Vol 18 (12) ◽  
pp. 1253-1261 ◽  
Author(s):  
Ghassan M. Saed ◽  
Nicole M. Fletcher ◽  
Zhong L. Jiang ◽  
Husam M. Abu-Soud ◽  
Michael P. Diamond
Keyword(s):  
Oxidative Stress ◽  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Cancer Cells ◽  
Ovarian Cancer Cells
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