scholarly journals Innovative Blood Tests for Hepatocellular Carcinoma: Liquid Biopsy and Evaluation of Systemic Inflammatory Reaction

2018 ◽  
Author(s):  
Ilze Strumfa ◽  
Dzeina Mezale ◽  
Boriss Strumfs ◽  
Andrejs Vanags ◽  
Arturs Kalva ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Inflammatory Reaction ◽  
Liquid Biopsy ◽  
Blood Tests ◽  
Systemic Inflammatory Reaction

scholarly journals Systemic Inflammatory Reaction to Intravitreal Bevacizumab: A Case Report

2021 ◽  
Author(s):  
Samuel Burridge ◽  
Richard Stratton ◽  
Riaz Asaria
Keyword(s):  
Adverse Effects ◽  
Inflammatory Reaction ◽  
Intravitreal Bevacizumab ◽  
Case Presentation ◽  
Blood Tests ◽  
Bevacizumab Treatment ◽  
Systemic Inflammatory Reaction ◽  
Life Threatening ◽  
History Of ◽  
Systemic Side Effects

Abstract IntroductionTo present a case of systemic inflammatory reaction, with associated pleural and pericardial effusions, following intravitreal bevacizumab for retinal macroaneurysm. Case presentationA 73 year old female was commenced on monthly intravitreal bevacizumab injections for right eye macroaneurysm and associated macular oedema. Eight days following her third injection, the patient was admitted to hospital with a history of fever, rigors, arthralgia and vomiting. Admission blood tests demonstrated mild thrombocytopaenia and raised inflammatory markers. A CT chest revealed small pericardial and pleural effusions. The patient improved without treatment and was later discharged from hospital. As intravitreal bevacizumab treatment continued, the patient developed two further episodes of fever and vomiting, with both episodes occurring approximately nine days following each injection. The patient then underwent outpatient medical review by infectious disease and rheumatology specialists, at which time the recurrent episodes of systemic inflammation were diagnosed as secondary to intravitreal bevacizumab.ConclusionsThough rare, patients can develop serious and potentially life-threatening systemic adverse effects from intravitreal anti-VEGF treatment. Ophthalmologists should always enquire about systemic side effects; in this way, adverse effects may be recognised sooner and a change or cessation of therapy considered.

scholarly journals Liquid Biopsy in Hepatocellular Carcinoma: Where Are We Now?

Cancers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2274
Author(s):  
Filippo Pelizzaro ◽  
Romilda Cardin ◽  
Barbara Penzo ◽  
Elisa Pinto ◽  
Alessandro Vitale ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liquid Biopsy ◽  
Predictive Biomarkers ◽  
Invasive Procedure ◽  
Therapeutic Monitoring ◽  
Comprehensive Overview ◽  
Improve Patient Survival ◽  
Prognostic Tests ◽  
Prognostic Stratification ◽  
New Biomarkers

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related death worldwide. Diagnostic, prognostic, and predictive biomarkers are urgently needed in order to improve patient survival. Indeed, the most widely used biomarkers, such as alpha-fetoprotein (AFP), have limited accuracy as both diagnostic and prognostic tests. Liver biopsy provides an insight on the biology of the tumor, but it is an invasive procedure, not routinely used, and not representative of the whole neoplasia due to the demonstrated intra-tumoral heterogeneity. In recent years, liquid biopsy, defined as the molecular analysis of cancer by-products, released by the tumor in the bloodstream, emerged as an appealing source of new biomarkers. Several studies focused on evaluating extracellular vesicles, circulating tumor cells, cell-free DNA and non-coding RNA as novel reliable biomarkers. In this review, we aimed to provide a comprehensive overview on the most relevant available evidence on novel circulating biomarkers for early diagnosis, prognostic stratification, and therapeutic monitoring. Liquid biopsy seems to be a very promising instrument and, in the near future, some of these new non-invasive tools will probably change the clinical management of HCC patients.

scholarly journals SUBMICROSCOPIC CHANGES OF BRITTLE CELLS IN THE FORMATION OF SYNDROME OF SYSTEMIC INFLAMMATORY REACTION

2017 ◽  
Vol 16 (4) ◽  
pp. 9-12
Author(s):  
V. V. Boiko ◽  
P. N. Zamiatyn ◽  
Yu. N. Solovei ◽  
A. Y. Trubchanyn ◽  
V. P. Nevzorov ◽  
...  
Keyword(s):  
Inflammatory Reaction ◽  
Systemic Inflammatory Reaction

scholarly journals The value of liquid biopsy in the diagnosis and staging of hepatocellular carcinoma: a systematic review

2021 ◽  
Vol 0 ◽  
pp. 0-0
Author(s):  
Poh Tan ◽  
Lisa Grundy ◽  
Peter Makary ◽  
Khem Hua Eng ◽  
George Ramsay ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Systematic Review ◽  
Liquid Biopsy

scholarly journals DISTURBANCE OF AN APOPTOSIS OF NEUTROPHILS AT A SEPSIS

2018 ◽  
Vol 8 (2) ◽  
pp. 119-126 ◽  
Author(s):  
X.-F. Shen ◽  
W.-X. Guan ◽  
J.-F. Du ◽  
L. V. Puzyryova
Keyword(s):  
Inflammatory Reaction ◽  
Infectious Agent ◽  
Natural Conditions ◽  
Systemic Inflammatory Reaction ◽  
Programmed Death ◽  
Peking University ◽  
Cellular Apoptosis ◽  
A Cell ◽  
And Migration ◽  
A Current

The sepsis represents life-endangering disturbances of functions of the internals caused by a dizregulyation of a macroorganism to the  infectious agent and is difficult interaction of pro-inflammatory and  antiinflammatory processes that not seldom defines the fate of  patients. The predetermining factor of a sepsis is the originator. The  immunosupression caused by the originator promotes generalization  of an infection, and the intensive bacteriemia caused by generalization leads to the accruing endotoxinemia that aggravates  immunosupression even more and leads finally to systemic inflammatory reaction — the main and most dangerous implication  of a sepsis. The syndrome of systemic inflammation with  uncontrollable emission of cytokines is the cornerstone of a sepsis.  The pathophysiology of a sepsis begins with impassioned inflammatory reaction which can last several days, and then passes  into more lingering immunosupressivny period where the outcome  depends on the immune system of the patient. Cellular apoptosis is  one of leaders in sepsis immunosupression development. In article  mechanisms of disturbance of an apoptosis of neutrophils are  described that, undoubtedly, affects weighting of a current of a  sepsis and as a result, a failure. Migration of neutrophils under  natural conditions includes four various phases which during a sepsis  are broken. The mechanisms worsening migration of  neutrophils, contributing to the development of a sepsis were  investigated in numerous scientific works. Authors of Peking  University offered schemes of a way of disturbance of an apoptosis  of neutrophils and migration of neutrophils at a sepsis. Despite the  extensive accumulated experience on studying of a pathogenesis of  septic states, there are no effective and specific remedies of fight  from a sepsis now. Perhaps, by prevention of disturbance of the  programmed death of a cell the cytokines developed anti-apoptotic,  caspase inhibitors will be. 

scholarly journals External validation of an algorithm combining multi‐analyte blood tests (FibroTest‐LCR1‐LCR2) to identify subjects at risk of hepatocellular carcinoma in patients with chronic liver disease

GastroHep ◽  
2019 ◽  
Vol 1 (3) ◽  
pp. 146-153
Author(s):  
Valentina Peta ◽  
Marianne Ziol ◽  
Françoise Imbert‐Bismut ◽  
Angela Sutton ◽  
Denis Monneret ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
At Risk ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
External Validation ◽  
Chronic Liver ◽  
Blood Tests

scholarly journals Exosomal MicroRNAs as Liquid Biopsy Biomarkers in Hepatocellular Carcinoma

2020 ◽  
Vol Volume 13 ◽  
pp. 2021-2030 ◽  
Author(s):  
Shuo Wang ◽  
Yongxiang Yang ◽  
Lili Sun ◽  
Guoliang Qiao ◽  
Yunlong Song ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liquid Biopsy
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