scholarly journals Platelet-Rich Plasma for Injured Peripheral Nerves: Biological Repair Process and Clinical Application Guidelines

2019 ◽  
Author(s):  
Mikel Sánchez ◽  
Ane Garate ◽  
Ane Miren Bilbao ◽  
Jaime Oraa ◽  
Fernando Yangüela ◽  
...  
Keyword(s):  
Clinical Application ◽  
Peripheral Nerves ◽  
Platelet Rich Plasma ◽  
Repair Process ◽  
Biological Repair

scholarly journals Effectiveness of Biologic Factors in Shoulder Disorders

2017 ◽  
Vol 11 (1) ◽  
pp. 163-182 ◽  
Author(s):  
Dimitrios Giotis ◽  
Ashkan Aryaei ◽  
Theofanis Vasilakakos ◽  
Nikolaos K. Paschos
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Clinical Studies ◽  
Platelet Rich Plasma ◽  
Repair Process ◽  
Poor Quality ◽  
Loss Of Function ◽  
Shoulder Disorders ◽  
Biologic Factors

Background:Shoulder pathology can cause significant pain, discomfort, and loss of function that all interfere with activities of daily living and may lead to poor quality of life. Primary osteoarthritis and rotator cuff diseases with its sequalae are the main culprits. Management of shoulder disorders using biological factors gained an increasing interest over the last years. This interest reveals the need of effective treatments for shoulder degenerative disorders, and highlights the importance of a comprehensive and detailed understanding of the rapidly increasing knowledge in the field.Methods:This study will describe most of the available biology-based strategies that have been recently developed, focusing on their effectiveness in animal and clinical studies.Results:Data fromin vitrowork will also be briefly presented; in order to further elucidate newly acquired knowledge regarding mechanisms of tissue degeneration and repair that would probably drive translational work in the next decade. The role of platelet rich-plasma, growth factors, stem cells and other alternative treatments will be described in an evidence-based approach, in an attempt to provide guidelines for their clinical application. Finally, certain challenges that biologic treatments face today will be described as an initiative for future strategies.Conclusion:The application of different growth factors and mesenchymal stem cells appears as promising approaches for enhancing biologic repair. However, data from clinical studies are still limited, and future studies need to improve understanding of the repair process in cellular and molecular level and evaluate the effectiveness of biologic factors in the management of shoulder disorders.

Platelet-Rich Plasma Powder: A New Preparation Method for the Standardization of Growth Factor Concentrations

2016 ◽  
Vol 45 (4) ◽  
pp. 954-960 ◽  
Author(s):  
Matthias Kieb ◽  
Frank Sander ◽  
Cornelia Prinz ◽  
Stefanie Adam ◽  
Anett Mau-Möller ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Clinical Application ◽  
Whole Blood ◽  
Sports Medicine ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Transforming Growth Factor Β1 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Tgf Β1

Background: Platelet-rich plasma (PRP) is widely used in sports medicine. Available PRP preparations differ in white blood cell, platelet, and growth factor concentrations, making standardized research and clinical application challenging. Purpose: To characterize a newly standardized procedure for pooled PRP that provides defined growth factor concentrations. Study Design: Controlled laboratory study. Methods: A standardized growth factor preparation (lyophilized PRP powder) was prepared using 12 pooled platelet concentrates (PCs) derived from different donors via apheresis. Blood samples and commercially available PRP (SmartPrep-2) served as controls (n = 5). Baseline blood counts were analyzed. Additionally, single PCs (n = 5) were produced by standard platelet apheresis. The concentrations of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), platelet-derived growth factor AB (PDGF-AB), transforming growth factor β1 (TGF-β1), insulin-like growth factor 1 (IGF-1), interleukin (IL)–1α, IL-1β, and IL-1 receptor agonist (IL-1RA) were analyzed by enzyme-linked immunosorbent assay, and statistical analyses were performed using descriptive statistics, mean differences, 95% CIs, and P values (analysis of variance). Results: All growth factor preparation methods showed elevated concentrations of the growth factors VEGF, bFGF, PDGF-AB, and TGF-β1 compared with those of whole blood. Large interindividual differences were found in VEGF and bFGF concentrations. Respective values (mean ± SD in pg/mL) for whole blood, SmartPrep-2, PC, and PRP powder were as follows: VEGF (574 ± 147, 528 ± 233, 1087 ± 535, and 1722), bFGF (198 ± 164, 410 ± 259, 151 ± 99, and 542), PDGF-AB (2394 ± 451, 17,846 ± 3087, 18,461 ± 4455, and 23,023), and TGF-β1 (14,356 ± 4527, 77,533 ± 13,918, 68,582 ± 7388, and 87,495). IGF-1 was found in SmartPrep-2 (1539 ± 348 pg/mL). For PC (2266 ± 485 pg/mL), IGF-1 was measured at the same levels of whole blood (2317 ± 711 pg/mL) but was not detectable in PRP powder. IL-1α was detectable in whole blood (111 ± 35 pg/mL) and SmartPrep-2 (119 ± 44 pg/mL). Conclusion: Problems with PRP such as absent standardization, lack of consistency among studies, and black box dosage could be solved by using characterized PRP powder made by pooling and lyophilizing multiple PCs. The new PRP powder opens up new possibilities for PRP research as well as for the treatment of patients. Clinical Relevance: The preparation of pooled PRP by means of lyophilization may allow physicians to apply a defined amount of growth factors by using a defined amount of PRP powder. Moreover, PRP powder as a dry substance with no need for centrifugation could become ubiquitously available, thus saving time and staff resources in clinical practice. However, before transferring the results of this basic science study to clinical application, regulatory issues have to be cleared.

The Effects of Platelet-Rich Plasma on Cartilage: Basic Science and Clinical Application

2011 ◽  
Vol 19 (3) ◽  
pp. 154-159 ◽  
Author(s):  
Lisa A. Fortier ◽  
Catherine H. Hackett ◽  
Brian J. Cole
Keyword(s):  
Clinical Application ◽  
Basic Science ◽  
Platelet Rich Plasma

The Effects of Platelet-Rich Plasma on Muscle: Basic Science and Clinical Application

2011 ◽  
Vol 19 (3) ◽  
pp. 149-153 ◽  
Author(s):  
Hector A. Mejia ◽  
James P. Bradley
Keyword(s):  
Clinical Application ◽  
Basic Science ◽  
Platelet Rich Plasma

scholarly journals A narrative review of the research progress and clinical application of platelet-rich plasma

2021 ◽  
Vol 10 (3) ◽  
pp. 29-29
Author(s):  
Yiqiu Cao ◽  
Xiaoxuan Zhu ◽  
Ruixin Zhou ◽  
Yayi He ◽  
Zhourui Wu ◽  
...  
Keyword(s):  
Clinical Application ◽  
Platelet Rich Plasma ◽  
Narrative Review ◽  
Research Progress

scholarly journals The Clinical Application Of Platelet Concentrates: A Systematic Meta-analysis

2015 ◽  
Vol 5 (1) ◽  
pp. 21-26
Author(s):  
Sneha Ketan Gada
Keyword(s):  
Clinical Application ◽  
Oral Surgery ◽  
Therapeutic Potential ◽  
Platelet Rich Plasma ◽  
Meta Analysis ◽  
Pediatric Dentistry ◽  
Platelet Concentrates ◽  
Bone Contact ◽  
Platelet Rich Fibrin ◽  
Regenerative Dentistry

ABSTRACT Background Autologous plasma rich in platelets is derived blood product whose uses in dentistry dates back to the 1990s and it has been gaining popularity ever since. Aim A systematic review of the available literature to determine the efficacy, safety and success of platelet concentrates in physiological systems as well as describing its vigilant use. Study design and methods A Medline search with keywords ‘platelet rich plasma dental’ further filtered using Boolean opera- tors (AND, OR, NOT) and combination of specific keywords as follows: ‘platelet rich fibrin’, ‘platelet rich plasma regenerative’, ‘platelet rich plasma periodontal’, ‘platelet rich plasma extraction’ with a custom range of 10 years was performed, which yielded 88 results out of which 32 were selected based on the inclusion criteria. Results Significantly, successful outcomes have been wit- nessed in the field of osteoregeneration though it has been evidenced that adequate platelet rich plasma (PrP) additives are essential to bear a therapeutic potential. Favoring blood cell adhesion on the root surface optimizing periodontal healing, PrP has also shown positive effect on gingival repair; though controversial facts have also been reported. In the scope of implant dentistry, PrP has also reported greater implant-bone contact when used in both gel or liquid form. Emerging as a possible pulp capping agent along with properties of decreased chances root growth, PrP has successfully completed apexo- genesis in cases of pulpotomy.   Research has shown that although clinical results from the comparison of PrP alone vs PrP and resorbable membrane or various graft materials has shown a varied results, additional research in the field is needed. Conclusion Platelet rich plasma has shown promising results in the field of regenerative dentistry, with high success rate in implantology, periodontology and oral surgery. Because of conflicting success rates reported in literature further research is warrented. Clinical implication Platelet rich fibrin has displayed various features of rapid clinical healing, excellent bone density, less surgical time, less resorption during healing and decreased postoperative pain, as compared to guided bone regeneration procedures. Platelet rich plasma has also shown a myriad of applications ranging from hard tissue regeneration to soft tissue management, stretching across to the field of pediatric dentistry and endodontics. How to cite this article Gada SK, Gupta P. the Clinical Application of Platelet Concentrates: A Systematic Meta- analysis. Int J Prosthodont restor Dent 2015;5(1):21-26.

COULD PLATELET RICH PLASMA BE SOAKED TO A POLYMERIC HYDROGEL WHICH COULD BE USED AT BIOLOGICAL REPAIR OF CARTILAGE

2015 ◽  
pp. 40-40 ◽  
Author(s):  
Mehmet İŞYAR ◽  
Yazar Adı Yazar Soyadı ◽  
İbrahim YILMAZ ◽  
Olcay GÜLER ◽  
Mahir MAHİROĞULLARI
Keyword(s):  
Platelet Rich Plasma ◽  
Polymeric Hydrogel ◽  
Biological Repair

scholarly journals Basic science and clinical application of platelet-rich plasma for cartilage defects and osteoarthritis: a review

2013 ◽  
Vol 21 (11) ◽  
pp. 1627-1637 ◽  
Author(s):  
Y. Zhu ◽  
M. Yuan ◽  
H.Y. Meng ◽  
A.Y. Wang ◽  
Q.Y. Guo ◽  
...  
Keyword(s):  
Clinical Application ◽  
Basic Science ◽  
Platelet Rich Plasma ◽  
Cartilage Defects
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