scholarly journals Medicinal Plants of the Peruvian Amazon: Bioactive Phytochemicals, Mechanisms of Action, and Biosynthetic Pathways

2019 ◽  
Author(s):  
Juan Carlos Castro ◽  
Joseph Dylan Maddox ◽  
Marianela Cobos ◽  
Jae Diana Paredes ◽  
Anthony Jhoao Fasabi ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Mechanisms Of Action ◽  
Biosynthetic Pathways ◽  
Peruvian Amazon ◽  
Bioactive Phytochemicals

scholarly journals A phytochemical-based medication search for the SARS-CoV-2 infection by molecular docking models towards spike glycoproteins and main proteases

RSC Advances ◽  
2021 ◽  
Vol 11 (20) ◽  
pp. 12003-12014
Author(s):  
Anju Choorakottayil Pushkaran ◽  
Prajeesh Nath EN ◽  
Anu R. Melge ◽  
Rammanohar Puthiyedath ◽  
C. Gopi Mohan
Keyword(s):  
Molecular Docking ◽  
Medicinal Plants ◽  
Viral Infection ◽  
Bioactive Phytochemicals

Identifying best bioactive phytochemicals from different medicinal plants using molecular docking techniques demonstrates a potential pre-clinical compound discovery against SARS-CoV-2 viral infection.

scholarly journals Medicinal plants possess sedative and anxiolytic effect with emphasis on their mechanisms of action

2021 ◽  
Vol 17 (3) ◽  
pp. 061-077
Author(s):  
Ali Esmail Al-Snafi
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Anxiolytic Effect ◽  
Mechanisms Of Action ◽  
Aminobutyric Acid ◽  
Na Channels ◽  
Medical Problems ◽  
Current Review ◽  
Acid Type ◽  
Web Science

Insomnia and anxiety are worldwide medical problems. Plant extracts possessed sedative and anxiolytic effect via different mechanisms included interactions with Na+ channels, γ-aminobutyric acid type A receptors, N-methyl-D-aspartate receptors and chatecholamines. In the current review, Web Science, PubMed, Scopus and Science Direct, were searched to investigate the plants with sedative and anxiolytic effects

scholarly journals Advances in Phenazines over the Past Decade: Review of Their Pharmacological Activities, Mechanisms of Action, Biosynthetic Pathways and Synthetic Strategies

Marine Drugs ◽  
2021 ◽  
Vol 19 (11) ◽  
pp. 610
Author(s):  
Junjie Yan ◽  
Weiwei Liu ◽  
Jiatong Cai ◽  
Yiming Wang ◽  
Dahong Li ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Pharmacological Activity ◽  
Biological Activities ◽  
Natural Compounds ◽  
Mechanisms Of Action ◽  
Biosynthetic Pathways ◽  
Pharmacological Activities ◽  
Chemical Structures ◽  
The Past ◽  
Synthetic Derivatives

Phenazines are a large group of nitrogen-containing heterocycles, providing diverse chemical structures and various biological activities. Natural phenazines are mainly isolated from marine and terrestrial microorganisms. So far, more than 100 different natural compounds and over 6000 synthetic derivatives have been found and investigated. Many phenazines show great pharmacological activity in various fields, such as antimicrobial, antiparasitic, neuroprotective, insecticidal, anti-inflammatory and anticancer activity. Researchers continued to investigate these compounds and hope to develop them as medicines. Cimmino et al. published a significant review about anticancer activity of phenazines, containing articles from 2000 to 2011. Here, we mainly summarize articles from 2012 to 2021. According to sources of compounds, phenazines were categorized into natural phenazines and synthetic phenazine derivatives in this review. Their pharmacological activities, mechanisms of action, biosynthetic pathways and synthetic strategies were summarized. These may provide guidance for the investigation on phenazines in the future.

Herbal Medicines and Nutraceuticals for Diabetic Vascular Complications: Mechanisms of Action and Bioactive Phytochemicals

2010 ◽  
Vol 16 (34) ◽  
pp. 3776-3807 ◽  
Author(s):  
Eshaifol A. Omara ◽  
Antony Kam ◽  
Ali Alqahtania ◽  
Kong M. Li ◽  
Valentina Razmovski-Naumovski ◽  
...  
Keyword(s):  
Herbal Medicines ◽  
Vascular Complications ◽  
Mechanisms Of Action ◽  
Diabetic Vascular Complications ◽  
Bioactive Phytochemicals

scholarly journals Phytotherapy in the Management of Diabetes: A Review

2017 ◽  
Author(s):  
Paolo Governa ◽  
Giulia Baini ◽  
Vittoria Borgonetti ◽  
Giulia Cettolin ◽  
Daniela Giachetti ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Clinical Investigation ◽  
Clinical Effectiveness ◽  
Mechanisms Of Action ◽  
Evidence Based ◽  
Medicinal Products ◽  
Key Points ◽  
Treatment Of Diabetes ◽  
Alpha Glucosidase

Phytotherapy has long been a source of medicinal products and many attempts to use herbal medicine for the treatment of diabetes has been done over the years. Several medicinal plants and their preparations demonstrated to act in key points of glucidic metabolism. The most common mechanisms of action found include the inhibition of α-glucosidase and of AGE formation, the increase of GLUT-4 and PPARs expression and the antioxidant activity.Despite the large amount of literature available, the actual clinical effectiveness of medicinal plants in controlling diabetes related symptoms is still controversial and there is a crucial need for stronger evidence-based data. In this review, an overview of the medicinal plants, which use in the management of diabetes is supported by authoritative monograph, is provided. References to some species which are currently under growing clinical investigation are also reported.

scholarly journals Phytotherapy in the Management of Diabetes: A Review

2017 ◽  
Author(s):  
Paolo Governa ◽  
Giulia Baini ◽  
Vittoria Borgonetti ◽  
Giulia Cettolin ◽  
Daniela Giachetti ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Clinical Investigation ◽  
Clinical Effectiveness ◽  
Mechanisms Of Action ◽  
Evidence Based ◽  
Medicinal Products ◽  
Key Points ◽  
Treatment Of Diabetes ◽  
Alpha Glucosidase

Phytotherapy has long been a source of medicinal products and many attempts to use herbal medicine for the treatment of diabetes has been done over the years. Several medicinal plants and their preparations demonstrated to act in key points of glucidic metabolism. The most common mechanisms of action found include the inhibition of α-glucosidase and of AGE formation, the increase of GLUT-4 and PPARs expression and the antioxidant activity. Despite the large amount of literature available, the actual clinical effectiveness of medicinal plants in controlling diabetes related symptoms is still controversial and there is a crucial need for stronger evidence-based data. In this review, an overview of the medicinal plants, which use in the management of diabetes is supported by authoritative monograph, is provided. References to some species which are currently under growing clinical investigation are also reported.

scholarly journals Traditional knowledge for the improvement of their health, with medicinal species in the indigenous communities of the Shawi ethnic group, in Peruvian Amazon

2020 ◽  
Vol 3 (3) ◽  
pp. 45-52
Author(s):  
Elsa L Rengifo ◽  
◽  
Lizardo Fachin ◽  
Angel M Rodriguez del Castillo ◽  
Jose L Palacios ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Ethnic Group ◽  
Traditional Knowledge ◽  
Buenos Aires ◽  
Indigenous Communities ◽  
Peruvian Amazon ◽  
Santa Cruz ◽  
Medicinal Species ◽  
Common Diseases

Shawi ethnic group located in the Peruvian Amazon know and apply medicinal plants to their health. The study was carried out in communities of Buenos Aires, Nuevo Cachiyacu and Santa Cruz in the Balsapuerto district, Alto Amazonas province, Loreto region; in workshops, visits to their farms and local forests. 27% were women and 73% male, ages in the range of 19 to 70 years old. The objective was to document the knowledge of uses of medicinal plants, with open interviews. Analyzed data included species common names, type of most common diseases, how they cure them and methods of plant preparation. Information of 24 species which they consider the most used was collected. Those corresponded to 17 botanical families and they use them for treatment of 22 diseases. The largest number in treatments were diarrhea, stomach colic and external wounds with five species, and the rest of diseases with three, two to one species. The leaves are the most used in infusions.

scholarly journals Nature as a Treasure Trove for Anti-COVID-19: Luteolin and Naringenin from Indonesian Traditional Herbal Medicine Reveal Potential SARS-CoV-2 Mpro Inhibitors Insight from in Silico Studies

2020 ◽  
Author(s):  
Wahyu Prasetyo ◽  
Triana Kusumaningsih ◽  
Maulidan Firdaus
Keyword(s):  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Medicinal Plants ◽  
Small Molecule ◽  
In Silico ◽  
Dft Studies ◽  
Traditional Herbal Medicine ◽  
In Silico Studies ◽  
Bioactive Phytochemicals

<div>Since the worldwide is currently facing the COVID-19 pandemic, there are no drugs or vaccines have been approved</div><div>for the treatment of SARS-CoV-2 infection. Therefore, there is an urgent need for in-depth research on emerging</div><div>human infectious coronaviruses. As part of our endeavour in combating this COVID-19 pandemic, in this paper, we</div><div>report on the discovery of an active antiviral small-molecule from Indonesian traditional herbal medicine used in Jamu</div><div>to inhibit 3CLpro of SARS-CoV-2 using in-silico approaches. As one of the mega biodiversity countries, Indonesia has</div><div>more than 1,180 species that can be prospected for medicine plants. Jamu, the Indonesian traditional herbal medicine,</div><div>is supposed to have similar potentials as those of traditional Chinese medicine (TCM). However, due to the lack of</div><div>scientific proof, Jamu is not recognised in the Guideline of COVID-19 Patients, particularly in Indonesia. Thus, in</div><div>this study, we performed virtual docking screening along with pharmacokinetic and DFT studies of selected 49</div><div>bioactive phytochemicals from several medicinal plants used in Jamu against the 3CLpro enzyme of SARS-CoV-2.</div><div>From the result, it was noted that from a set of 49 phytochemicals of medicinal plants used in Jamu, 2 phytochemicals,</div><div>i.e., Luteolin and Naringenin were identified as potential druggable inhibitors candidates of 3CLpro of SARS CoV-2.</div>

Botanical Sources for Alzheimer’s: A Review on Reports From Traditional Persian Medicine

2017 ◽  
Vol 32 (7) ◽  
pp. 429-437 ◽  
Author(s):  
Ayda Hosseinkhani ◽  
Ali Sahragard ◽  
Aida Namdari ◽  
Mohammad M. Zarshenas
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Medicinal Plants ◽  
Herbal Medicines ◽  
Mechanisms Of Action ◽  
Cholinesterase Inhibition ◽  
Clinical Validation ◽  
Persian Medicine ◽  
Traditional Persian Medicine ◽  
Butyryl Cholinesterase

Herbal medicines for the treatment of Alzheimer’s disease (AD) have attracted considerable attention nowadays. Alzheimer’s disease is described in traditional Persian medicine (TPM) by the term Nesyān. In this study, 5 main medicinal medieval Persian manuscripts were reviewed to filter plants reported for the treatment of Nesyān. Databases were searched for related possible mechanisms of action of these medicinal plants. Each herb was searched for along with these keywords: “acetyl and butyryl cholinesterase inhibition,” “antioxidant,” “anti-inflammatory,” and “anti-amyloidogenic.” In Total, 44 herbs were used for the treatment of Nesyān; 40 of those were authenticated. Also, 30 plants had at least one of the mechanisms of action that were searched for or related pharmacological functions known for the treatment of AD. In this work, we introduce promising candidates in TPM that could undergo further investigation for identification of their active compounds and clinical validation in the treatment of AD.

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