scholarly journals Phytotherapy in the Management of Diabetes: A Review

2017 ◽  
Author(s):  
Paolo Governa ◽  
Giulia Baini ◽  
Vittoria Borgonetti ◽  
Giulia Cettolin ◽  
Daniela Giachetti ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Clinical Investigation ◽  
Clinical Effectiveness ◽  
Mechanisms Of Action ◽  
Evidence Based ◽  
Medicinal Products ◽  
Key Points ◽  
Treatment Of Diabetes ◽  
Alpha Glucosidase

Phytotherapy has long been a source of medicinal products and many attempts to use herbal medicine for the treatment of diabetes has been done over the years. Several medicinal plants and their preparations demonstrated to act in key points of glucidic metabolism. The most common mechanisms of action found include the inhibition of α-glucosidase and of AGE formation, the increase of GLUT-4 and PPARs expression and the antioxidant activity. Despite the large amount of literature available, the actual clinical effectiveness of medicinal plants in controlling diabetes related symptoms is still controversial and there is a crucial need for stronger evidence-based data. In this review, an overview of the medicinal plants, which use in the management of diabetes is supported by authoritative monograph, is provided. References to some species which are currently under growing clinical investigation are also reported.

scholarly journals Phytotherapy in the Management of Diabetes: A Review

2017 ◽  
Author(s):  
Paolo Governa ◽  
Giulia Baini ◽  
Vittoria Borgonetti ◽  
Giulia Cettolin ◽  
Daniela Giachetti ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Medicinal Plants ◽  
Clinical Investigation ◽  
Clinical Effectiveness ◽  
Mechanisms Of Action ◽  
Evidence Based ◽  
Medicinal Products ◽  
Key Points ◽  
Treatment Of Diabetes ◽  
Alpha Glucosidase

Phytotherapy has long been a source of medicinal products and many attempts to use herbal medicine for the treatment of diabetes has been done over the years. Several medicinal plants and their preparations demonstrated to act in key points of glucidic metabolism. The most common mechanisms of action found include the inhibition of α-glucosidase and of AGE formation, the increase of GLUT-4 and PPARs expression and the antioxidant activity.Despite the large amount of literature available, the actual clinical effectiveness of medicinal plants in controlling diabetes related symptoms is still controversial and there is a crucial need for stronger evidence-based data. In this review, an overview of the medicinal plants, which use in the management of diabetes is supported by authoritative monograph, is provided. References to some species which are currently under growing clinical investigation are also reported.

scholarly journals Earthworms Dilong: Ancient, Inexpensive, Noncontroversial Models May Help Clarify Approaches to Integrated Medicine Emphasizing Neuroimmune Systems

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Edwin L. Cooper ◽  
Mariappan Balamurugan ◽  
Chih-Yang Huang ◽  
Clara R. Tsao ◽  
Jesus Heredia ◽  
...  
Keyword(s):  
Soil Conservation ◽  
Innate Immune System ◽  
Mechanisms Of Action ◽  
Innate Immune ◽  
Evidence Based ◽  
Ecological Role ◽  
Medicinal Products ◽  
Integrated Medicine ◽  
Ethical Concerns ◽  
Extensive Analysis

Earthworms have provided ancient cultures with food and sources of medicinal cures. Ayurveda, traditional Chinese medicine (TCM), and practices in Japan, Vietnam, and Korea have focused first on earthworms as sources of food. Gradually fostering an approach to potential beneficial healing properties, there are renewed efforts through bioprospecting and evidence-based research to understand by means of rigorous investigations the mechanisms of action whether earthworms are used as food and/or as sources of potential medicinal products. Focusing on earthworms grew by serendipity from an extensive analysis of the earthworm’s innate immune system. Their immune systems are replete with leukocytes and humoral products that exert credible health benefits. Their emerging functions with respect to evolution of innate immunity have long been superseded by their well-known ecological role in soil conservation. Earthworms as inexpensive, noncontroversial animal models (without ethical concerns) are not vectors of disease do not harbor parasites that threaten humans nor are they annoying pests. By recognizing their numerous ecological, environmental, and biomedical roles, substantiated by inexpensive and more comprehensive investigations, we will become more aware of their undiscovered beneficial properties.

scholarly journals ANTIDIABETIC EFFECTS OF MEDICINAL PLANTS

2021 ◽  
Vol 9 (1) ◽  
pp. 1-17
Author(s):  
A. O. Ojetunde
Keyword(s):  
Medicinal Plants ◽  
Mechanisms Of Action ◽  
Glucose Lowering ◽  
Chemical Substances ◽  
Results Of Treatment ◽  
Chronic Disorder ◽  
Bioactive Ingredients ◽  
Treatment Of Diabetes ◽  
Medical Plants ◽  
Antidiabetic Effects

Diabetes is a chronic disorder that is characterized by an increase in blood glucose (hyperglycemia) with alteration of protein, carbohydrates, and fat metabolism. Consequently, it can lead to renal failure, atherosclerosis, nerve damage, blindness, and coronary heart disease. It is also known as the 5th leading cause of death. Although, there are numerous types of glucose-lowering drugs that exhibit anti-diabetic effects but results of treatment in patients are still not so perfect. Therefore, many treatments that include the use of medicinal plants are suggested and encouraged. Medical plants are believed to contain chemical substances with potential curative effects and can often have anti-diabetic effects. This study introduced about 23 effective medicinal plants reported by various experimental researchers with the curative potential to treat diabetes. Although, most of the research used animal models, there is a clear indication that medicinal plants with anti-diabetic potentials are being investigated by several researchers. However, there is a need for further research to be conducted with isolated bioactive ingredients present in these plants in order to have potential ingredients that could be used as a pharmacological agent in the treatment of diabetes mellitus with fewer adverse effects. Again, the mechanisms of action of these medicinal plants in ameliorating diabetes need to be investigated.

Phytochemical screening and evaluation of antioxidant activity of the stem bark of Anacardium occidentale L. and Vitellaria paradoxa C.F. Gaertn, two medicinal plants from Poro region (Northern of Côte d'Ivoire)

2021 ◽  
Vol 1 (2) ◽  
pp. 022-028
Author(s):  
Gboko Abiba Ouattara ◽  
Tiekpa Wawa Justine ◽  
Kamagaté Tidiane ◽  
Boni Ahoussi Pascal ◽  
Kabran Aka Faustin ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Stem Bark ◽  
Anacardium Occidentale ◽  
Phytochemical Screening ◽  
Vitellaria Paradoxa ◽  
Dpph Method ◽  
Treatment Of Diabetes ◽  
Major Chemical ◽  
Chemical Groups

Anacardium occidentale and Vitellaria paradoxa are two medicinal plants traditionally used by Ivorian, particularly in the treatment of diabetes, arterial hypertension and diarrhea. The objective of this work was to evaluate the phytochemical constituents and the antioxidant activity of the stem barks of A. occidentale L. and V. paradoxa. The stem bark of both plants was used for the aqueous extraction. Major chemical groups were identified using the tube staining method followed by confirmation by thin layer chromatography (TLC). The antioxidant activity of the extracts was evaluated by DPPH method. The results of phytochemical screening of plant extracts revealed the presence of polyphenols, anthraquinones, tannins, sterols, terpenes and saponins. In addition, the evaluation of the antioxidant activity by spectrophotometry using the DPPH method showed that all extracts had significant and different antioxydant activity compared to the reference molecule (Vitamin C, IC50 = 0.80 ± 0.70 µg/mL) with respective IC50 of 0.42 ± 0.32 µg/mL for V. paradoxa and 0.87 ± 0.77 µg/mL for A. occidentale. V. paradoxa therefore has the best antioxydant activity. These results could explain the therapeutic virtues of A. occidentale and V. paradoxa in the treatment of various pathologies.

scholarly journals Semaglutide (Rybelsus)

2021 ◽  
Vol 1 (9) ◽  
Author(s):  
Reimbursement Team
Keyword(s):  
Cost Effectiveness ◽  
Glycemic Control ◽  
Oral Administration ◽  
Drug Class ◽  
Clinical Effectiveness ◽  
Medicinal Products ◽  
Diet And Exercise ◽  
Clinician Perspectives ◽  
Treatment Of Diabetes

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class. The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada's federal, provincial, and territorial governments, with the exception of Quebec. This review assesses semaglutide (Rybelsus), 3 mg, 7 mg, and 14 mg tablets, for oral administration Indication: Semaglutide is indicated as an adjunct to diet and exercise to improve glycemic control in adults with T2DM: as monotherapy when metformin is considered inappropriate due to intolerance or contraindications; in combination with other medicinal products for the treatment of diabetes.

scholarly journals Phytochemical Study and Antioxidant Activity of Annona muricata (Annonaceae) and Corchorus olitorius (Tiliaceae) Two Medicinal Plants from the Ivorian Pharmacopoeia Used in the Treatment of Diabetes

2021 ◽  
Vol 9 (1) ◽  
pp. 31-42
Author(s):  
Abba P. Obouayeba Obou C. Okou ◽  
Bognan J.A.A. Ackah Bi Tra L. Tra ◽  
Tanoh H. Kouakou Allico J.Djaman ◽  
Jean D. N guessan
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants ◽  
Gallic Acid ◽  
Aqueous Extract ◽  
Corchorus Olitorius ◽  
Annona Muricata ◽  
Phytochemical Screening ◽  
Phytochemical Study ◽  
Ic50 Value ◽  
Treatment Of Diabetes

Annona muricata and Corchorus olitorius are two medicinal plants whose leaves are widely used in Ivory Coast both in nutrition and for the treatment of various pathologies because of their phytochemical compositions. The objective of this study was to determine the phytochemicals and to assess the antioxidant property of the leaves of these two plants. The phytochemical study was carried out using tests for the identification and quantification of phytoconstituents. As for the study of antioxidant activity, it was carried out by measuring the anti-free radical activity either by ABTS or by DPPH. Qualitative phytochemical screening revealed the presence of flavonoids, polyphenols, saponins, sterols, catechetical tannins and terpenes. The quantitative phytochemical screening of the extracts showed that the content of flavonoids (329.10 ± 2.51 mg Eq quercetin/Kg) and that of polyphenols (82.09 ± 0.13 mg Eq gallic acid/g) of Annona muricata are higher than the content of flavonoids (178.45 ± 1.09 mg Eq quercetin/Kg) and that of polyphenols (67.98 ± 5.22 mg Eq gallic acid/g) of Corchorus olitorius. The results of the antioxidant activity by measurement of the ABTS radical shows that the aqueous extract of Annona muricata exhibits the best activity with an IC50 value of 1.79 ± 0.15 μM, while the aqueous extract of Corchorus olitorius records an IC50 value of 2.64 ± 0.05 μM. Similar results are observed with the measurement of DPPH. The various metabolites demonstrated have various therapeutic properties which may be involved in the treatment of diabetes. This would confirm the therapeutic use reported by the populations. However, the evaluation of the antimalarial, antibacterial and anti-inflammatory activities as well as the toxicity test of the aqueous extract of these plants would be necessary.

Antioxidant activity some endemic Iranian medicinal plants (Apiaceae)

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
M Setayesh ◽  
A Siahpoosh ◽  
A Ghasemi Pirbalouti ◽  
R Abdizadeh
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Plants

Antioxidant Activity, Inhibition α-Glucosidase of Ethanol Extract of Strychnos nitida G. Don and Identification of Active Compounds

2019 ◽  
Vol 5 (3) ◽  
pp. 11-20
Author(s):  
Stefani Dhale Rale ◽  
Hasim Hasim ◽  
Syamsul Falah
Keyword(s):  
Antioxidant Activity ◽  
Ethyl Acetate ◽  
Ethanol Extract ◽  
Ethyl Acetate Fraction ◽  
Inhibition Activity ◽  
Active Compounds ◽  
Activity Inhibition ◽  
Activity Test ◽  
Ic50 Value ◽  
Treatment Of Diabetes

This study aims to find the treatment of diabetes using natural materials by exploring plants in the province of East Nusa Tenggara. his research was conducted out by extracting the Strychnos nitida G.Don stem using a method of maceration by ethanol 70%. Ethanol extract was then fractionated using n-hexane and ethyl acetate. Simplicia from maceration and fractionation results were then tested for antioxidant activity, α-glucosidase inhibition activity and identification of active compounds. The results showed that ethyl acetate fraction had the lowest IC50 value of 86.83 μg / ml. Results of the α-glucosidase activity test showed that ethyl acetate fraction and n-heksan fraction at 900 ppm had the highest percentage of inhibition of 34.23% and 33.89%. Identification using LCMS/MS method showed that ethyl acetate fraction consist of Benzenemethamine, N, N-dioctyl- as an antioxidantcompound and compound 24-methyl-5-cholestone-hexol as an antidiabetic compound. From the results of this study, we concluded that the extract of kayu ular Strychnos nitida G.Don stem has inhibition activity toward α-glucosidase enzyme.

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