scholarly journals Medicinal plants possess sedative and anxiolytic effect with emphasis on their mechanisms of action

2021 ◽  
Vol 17 (3) ◽  
pp. 061-077
Author(s):  
Ali Esmail Al-Snafi
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Anxiolytic Effect ◽  
Mechanisms Of Action ◽  
Aminobutyric Acid ◽  
Na Channels ◽  
Medical Problems ◽  
Current Review ◽  
Acid Type ◽  
Web Science

Insomnia and anxiety are worldwide medical problems. Plant extracts possessed sedative and anxiolytic effect via different mechanisms included interactions with Na+ channels, γ-aminobutyric acid type A receptors, N-methyl-D-aspartate receptors and chatecholamines. In the current review, Web Science, PubMed, Scopus and Science Direct, were searched to investigate the plants with sedative and anxiolytic effects

scholarly journals A complementary and alternative natural antidepressant therapy with emphasis on their mechanisms of action

2021 ◽  
Vol 2 (1) ◽  
pp. 007-021
Author(s):  
Ali Esmail Al-Snafi
Keyword(s):  
Medicinal Plants ◽  
Antidepressant Activity ◽  
Mechanisms Of Action ◽  
D2 Receptors ◽  
D1 And D2 Receptors ◽  
Normal Limits ◽  
Current Review ◽  
Stress Mediators ◽  
Α2 Receptors ◽  
Pituitary Adrenal Axis

Medicinal plants can exert antidepressant activity by many mechanisms included neutralization of various stress mediators (regulate the activity of the hypothalamic- pituitary- adrenal axis and reduce CRF, and ACTH and corticosterone) [5], interaction with serotonergic systems (5-HT3, 5HT2A, 5-HT1A), noradrenergic (α1 and α2 receptors) and dopaminergic (D1 and D2) receptors [6],restoring monoamine transmitters and their receptors to normal limits in certain regions of the cortex, in addition to reducing of oxidative stress and amelioration of inflammatory mediators. The current review discussed the antidepressant activity of medicinal plants, with emphasis on their mechanisms of action.

scholarly journals Towards Advances in Medicinal Plant Antimicrobial Activity: A Review Study on Challenges and Future Perspectives

2021 ◽  
Vol 9 (10) ◽  
pp. 2041
Author(s):  
Natalia Vaou ◽  
Elisavet Stavropoulou ◽  
Chrysa Voidarou ◽  
Christina Tsigalou ◽  
Eugenia Bezirtzoglou
Keyword(s):  
Antimicrobial Activity ◽  
Medicinal Plants ◽  
Medicinal Plant ◽  
Plant Extracts ◽  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Mechanisms Of Action ◽  
Future Perspectives ◽  
Pharmacodynamic Profile ◽  
Medicinal Plant Extracts

The increasing incidence of drug- resistant pathogens raises an urgent need to identify and isolate new bioactive compounds from medicinal plants using standardized modern analytical procedures. Medicinal plant-derived compounds could provide novel straightforward approaches against pathogenic bacteria. This review explores the antimicrobial activity of plant-derived components, their possible mechanisms of action, as well as their chemical potential. The focus is put on the current challenges and future perspectives surrounding medicinal plants antimicrobial activity. There are some inherent challenges regarding medicinal plant extracts and their antimicrobial efficacy. Appropriate and optimized extraction methodology plant species dependent leads to upgraded and selective extracted compounds. Antimicrobial susceptibility tests for the determination of the antimicrobial activity of plant extracts may show variations in obtained results. Moreover, there are several difficulties and problems that need to be overcome for the development of new antimicrobials from plant extracts, while efforts have been made to enhance the antimicrobial activity of chemical compounds. Research on the mechanisms of action, interplay with other substances, and the pharmacokinetic and/or pharmacodynamic profile of the medicinal plant extracts should be given high priority to characterize them as potential antimicrobial agents.

Natural products from the traditional Moroccan pharmacopoeia: A potential lead for the prevention and treatment of COVID-19

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1278-1285
Author(s):  
Mohamed Yafout ◽  
Amine Ousaid ◽  
Ibrahim Sbai El Otmani ◽  
Youssef Khayati ◽  
Amal Ait Haj Said
Keyword(s):  
Medicinal Plants ◽  
Plant Extracts ◽  
Molecular Mechanisms ◽  
Scientific Literature ◽  
Treatment Protocol ◽  
World Health ◽  
The World ◽  
Health Organization ◽  
Promising Source

The new SARS-CoV-2 belonging to the coronaviruses family has caused a pandemic affecting millions of people around the world. This pandemic has been declared by the World Health Organization as an international public health emergency. Although several clinical trials involving a large number of drugs are currently underway, no treatment protocol for COVID-19 has been officially approved so far. Here we demonstrate through a search in the scientific literature that the traditional Moroccan pharmacopoeia, which includes more than 500 medicinal plants, is a fascinating and promising source for the research of natural molecules active against SARS-CoV-2. Multiple in-silico and in-vitro studies showed that some of the medicinal plants used by Moroccans for centuries possess inhibitory activity against SARS-CoV or SARS-CoV-2. These inhibitory activities are achieved through the different molecular mechanisms of virus penetration and replication, or indirectly through stimulation of immunity. Thus, the potential of plants, plant extracts and molecules derived from plants that are traditionally used in Morocco and have activity against SARS-CoV-2, could be explored in the search for a preventive or curative treatment against COVID-19. Furthermore, safe plants or plant extracts that are proven to stimulate immunity could be officially recommended by governments as nutritional supplements.

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