scholarly journals Analgesic and Anti-Inflammatory Effect of Ghanaian Medicinal Plants

2020 ◽  
Author(s):  
Evelyn Asante-Kwatia ◽  
Abraham Yeboah Mensah ◽  
Michael Frimpong Baidoo
Keyword(s):  
Medicinal Plants ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Review of Experimental Pharmacological Studies of Plants Used for Asthma Management in Africa

2020 ◽  
Vol 4 (2) ◽  
pp. 1-11
Author(s):  
Amenan Geneviève N’guessan-Irié ◽  
Keyword(s):  
Medicinal Plants ◽  
Animal Experiments ◽  
Asthma Management ◽  
Plantes Médicinales ◽  
Review Of The Literature ◽  
Spasmolytic Activity ◽  
Study Protocols ◽  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Objectives: The aim was to contribute to the promotion of medicinal plants used in Africa for management of asthma by analyzing their experimental pharmacological evaluation data. Methods: We carried out a systematic review of the literature based on the following research equations in English and in French: « médecine traditionnelle africaine » ET « asthma » ; « African traditional medicine » AND « asthma » or « Medicine African traditional » AND « asthma » ; « plantes médicinales » ET « asthma » ET « antispasmodique » ; «medicinal plants » AND « asthma » AND « anti-spasmodic » ; « plantes médicinales » ET « asthma » ET « anti-inflammatoire » ; «medicinal plants » AND « asthma » AND « anti-inflammatory ». Results: The study revealed 184 medicinal plants used in Africa for the treatment of asthma, 34 of which showed pharmacological properties in favor of their use. In animal experiments, 18 of these plants exerted a spasmolytic effect, 22 an anti-inflammatory effect and 6 both effects. The spasmolytic activity study protocols were based primarily on inhibition of smooth airway muscle contraction, including trachea, induced by various spasmogenic agents. As for of the methods used to study anti-inflammatory activity, the majority of them consisted of tests for carrageenan-induced edema or for formalin-induced leg irritation. Conclusion: Our results justify the need for standardization of experimental study protocols for the recovery of medicinal plants.

Anti-inflammatory effect of Mongolia and Vietnamese medicinal plants against LPS-induced NO release in the RAW 264.7 cell

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
QH Juan ◽  
T Batmunkh ◽  
DT Nga ◽  
S Eun-Mi ◽  
YH Joo ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
No Release ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Asnakech Alemu ◽  
Wondmagegn Tamiru ◽  
Teshome Nedi ◽  
Workineh Shibeshi
Keyword(s):  
Acetic Acid ◽  
Medicinal Plants ◽  
Analgesic Effect ◽  
Rodent Models ◽  
Paw Edema ◽  
Traditional Remedies ◽  
Latency Response ◽  
Anti Inflammatory ◽  
Dose Levels ◽  
Inflammatory Effect

Background. Pain and inflammation are the major health problems commonly treated with traditional remedies mainly using medicinal plants. Leonotis ocymifolia is one of such medicinal plants used in folkloric medicine of Ethiopia. However, the plant has not been scientifically evaluated. The aim of this study was to evaluate analgesic and anti-inflammatory effects of the 80% methanol leaves extract of Leonotis ocymifolia using rodent models. Method. The central and peripheral analgesic effect of the extract at 100, 200, and 400 mg/kg dose levels was evaluated using hot plate and acetic acid induced writhing rodent models, whereas carrageenan induced paw edema and cotton pellet granuloma methods were used to screen anti-inflammatory effect of the extract at the same dose levels. Acute toxicity test was also done. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test and p<0.05 was considered significant. Results. The extract did not produce mortality up to 2000 mg/kg. All tested doses of the extract showed significant analgesic effect with maximum latency response of 62.8% and inhibition of acetic acid induced writhing. Maximum anti-inflammatory effect was recorded at 6 h after induction, with 75.88% reduction in carrageenan induced paw edema. Moreover, all tested doses of extract significantly inhibited the formation of inflammatory exudates and granuloma formation (p<0.001). Conclusion. The study indicated that the extract was safe in mice and it has both analgesic and anti-inflammatory effect in rodent models.

scholarly journals Evaluation of anti-inflammatory effect of traditional medicinal plants, Gynura segetum

2014 ◽  
Vol 4 (1) ◽  
pp. 4.1-4.4 ◽  
Author(s):  
Lay-Jing Seow ◽  
Hooi-Kheng Beh ◽  
Amirin Sadikun ◽  
Mohd Zaini Asmawi
Keyword(s):  
Medicinal Plants ◽  
Traditional Medicinal Plants ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals The Anti-inflammatory Effect of Honeysuckle Flowers (Lonicera japonica Thunb., Caprifoliaceae) in Combination with Oroxylum Indicum (Oroxylum indicum Vent. Bignoniaceae)

2020 ◽  
Vol 36 (2) ◽  
Author(s):  
Le Thi Hong Diem ◽  
Phan Thi Van Anh ◽  
Nguyen Thi Thanh Loan ◽  
Do Hong Ngoc
Keyword(s):  
Medicinal Plants ◽  
Inflammatory Responses ◽  
Publishing House ◽  
Microglial Cells ◽  
Lonicera Japonica ◽  
Root Bark ◽  
Oroxylum Indicum ◽  
Anti Inflammatory ◽  
Medical Publishing ◽  
Inflammatory Effect

  This study investigates the anti-inflammatory effect of the honeysuckle flower in combination with Oroxylum indicum in search of a new kind of anti-inflammatory therapy drugs with stronger anti-inflammatory effects and without unwanted adverse reactions. The study results show that a honeysuckle flower dose of 0.72 g/kg/day, Oroxylum indicum dose of 1.2 g/kg/day together with honeysuckle flower combined with Oroxylum indicum with 1:1 ratio had an acute anti-inflammatory effect on the white rat on a mouse Leg Edema Model with carrageenin and the model causing mouse peritonitis. The results also show that a honeysuckle flower dose of 1.44 g/kg/day, Oroxylum indicum the dose of 2.4 g/kg/day together with honeysuckle flower combined with Oroxylum indicum with 1:1 ratio had a chronic anti-inflammation effect on the white mouse on the model causing chronic inflammation of the granuloma. These results open up a subsequent research direction on the possibility of combining various anti-inflammatory medicinal herbs to obtain better anti-inflammatory efficacy and contribute to the promoting of the effect of the available domestic medicinal resources. Keywords Honeysuckle flowers, Oroxylum indicum, anti-inflammatory effect References [1] Vu Trieu An, Immunology, Hanoi Medical Publishing House, 2001, pp. 250 - 252.[2] Nguyen Ngoc Lanh, Pathophysiology, Medical Publishing House, 2012, pp. 209 - 229.[3] Le Dinh Roanh, Nguyen Dinh Mao, Inflammatory and infectious pathology, Medical Publishing House,1997, pp. 1 - 132.[4] Vo Van Chi, Dictionary of Vietnamese medicinal plants, Medicine Publishing House,1997, pp. 633-634.[5] Paulina Melega, Lonicera japonica Flower, Veterinarian Reviewed on June 20 (2012).[6] Jin Tae, Seung-Woo Han, et al., Anti-inflammatory effect of Lonicera japonica in proteinase-activated receptor 2-mediated paw edema, Clinica Chimica Acta, Apr; 330(1-2) (2003) 165 - 171.[7] Wie Jong Kwar, Chang Kyun Han, et al., Loniceroside C, an Anti-inflammatory Saponin from Lonicera japonica, Chem. Pharm. Bull (Tokyo) Mar; 51(3) (2003) 333-335.[8] JH. Lee, WS. Ko, YH. Kim, et al., Anti-inflammatory effect of the aqueous extract from Lonicera japonica flower is related to inhibition of NF-KappaB activation through reducing I-kappaBalpha degradation in rat liver, Int J Mol Med, Jan; 7(1) (2001) 79 - 83.[9] Min Ho Han, Won Sup Lee, Arulkumar Nagappan, et al., Flavonoid Isolated from Flowers of Lonicera japonica Thunb. Inhibit Inflammatory Responses in BV2 Microglial Cells by Suppressing TNF-α and IL-β Through PI3K/Akt/NF-Kb Signaling Pathways, Phytotherapy Research, 30(11) (2016) 1824 - 1832. [10] Seung-Hwan Kwon, Shi-Xun Ma, Sa-lk Hong, et al., Lonicera japonica Thunb. Extract Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses by Suppressing NF-κB Signaling in BV-2 Microglial Cells, J Med Food, Jul 1. 18(7) (2015) 762-775.[11] Do Tat Loi, Vietnamese medicinal plants and herbs, Thoi Dai Publishing House, (2011), 75 - 77, 726 - 728.[12] Mamatha Karnati, Rodda H Chandra, Ciddi Veeresham, et al., Anti-arthritic activity of root bark of Oroxylum indicum (L.) vent against adjuvant-induced arthritis, Pharmacognosy Research, Apr-Jun 5(2) (2013) 121-128.[13] Vietnam Pharmacopoeia Council, Vietnam Pharmacopoeia IV, Medical Publishing House, 2009, pp. 806- 856.[14] C.A. Winter, E.A Risley and G.W Nuss, Carrageenin induced edema in hind paw of the rat as an assay for anti-inflammatory drugs, Proc. Soe. Exp. Bio. Med, No 111 (1962) 544 - 547.[15] Julon, J.C.Guyonnet, et al., Etude des propriétés pharmacologiques d’un nowel anti-inflammatoire, J.Pharmacol (Paris), 3(2) (1971) 259 - 286.  

Reduction of paw edema and liver oxidative stress in carrageenan-induced acute inflammation by Lobaria pulmonaria and Parmelia caperata, lichen species, in mice

2019 ◽  
pp. 1-9
Author(s):  
Samira Salem ◽  
Essaid Leghouchi ◽  
Rachid Soulimani ◽  
Jaouad Bouayed
Keyword(s):  
Time Course ◽  
Acute Inflammation ◽  
Lichen Species ◽  
Paw Edema ◽  
Sod Activity ◽  
Edema Formation ◽  
Lobaria Pulmonaria ◽  
Anti Inflammatory ◽  
Endogenous Antioxidant ◽  
Inflammatory Effect

Abstract. Paw edema volume reduction is a useful marker in determining the anti-inflammatory effect of drugs and plant extracts in carrageenan-induced acute inflammation. In this study, the anti-inflammatory effect of Lobaria pulmonaria (LP) and Parmelia caperata (PC), two lichen species, was examined in carrageenan-induced mouse paw edema test. Compared to the controls in carrageenan-induced inflammation (n = 5/group), our results showed that pretreatment by single oral doses with PC extract (50–500 mg/kg) gives better results than LP extract (50–500 mg/kg) in terms of anti-edematous activity, as after 4 h of carrageenan subplantar injection, paw edema formation was inhibited at 82–99% by PC while at 35–49% by LP. The higher anti-inflammatory effect of PC, at all doses, was also observed on the time-course of carrageenan-induced paw edema, displaying profile closely similar to that obtained with diclofenac (25 mg/kg), an anti-inflammatory drug reference (all p < 0.001). Both LP and PC, at all doses, significantly ameliorated liver catalase (CAT) activity (all p < 0.05). However, superoxide dismutase (SOD) activity, glutathione peroxidase (GPx) activity and glutathione (GSH) levels were found increased in liver of PC- compared to LP-carrageenan-injected mice. Our findings demonstrated on one hand higher preventive effects of PC compared to LP in a mouse carrageenan-induced inflammatory model and suggested, on the other hand, that anti-inflammatory effects elicited by the two lichens were closely associated with the amelioration in the endogenous antioxidant status of liver.

Anti-inflammatory effect of Curcuma longa (turmeric) rhizome when administered topically in gel form

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
AH Mollik ◽  
W Mozammel Haq ◽  
S Chandra Bachar ◽  
R Jahan ◽  
M Rahmatullah
Keyword(s):  
Curcuma Longa ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory effect of Mitragyna speciosa crude methanol extract on the guinea pig ileum

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
WM Shaik Mossadeq ◽  
K Syamimi ◽  
MP Azyyati ◽  
ZA Zakaria ◽  
AK Arifah ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Methanol Extract ◽  
Guinea Pig Ileum ◽  
Mitragyna Speciosa ◽  
Anti Inflammatory ◽  
Crude Methanol Extract ◽  
Inflammatory Effect
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