scholarly journals Phytochemical screening, butyrylcholinesterase inhibitory activity and anti-inflammatory effect of some Tunisian medicinal plants

2018 ◽  
Vol 114 ◽  
pp. 84-88 ◽  
Author(s):  
H. Edziri ◽  
B. Marzouk ◽  
H. Mabrouk ◽  
M. Garreb ◽  
W. Douki ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Inhibitory Activity ◽  
Phytochemical Screening ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals PHYTOCHEMICAL SCREENING AND ANTI-INFLAMMATORY EFFECT TEST OF ETHANOL EXTRACT OF TURMERIC RHIZOME (Curcuma domestica Val.)TOWARD MALE WHITE MOUSE (Rattus norvegicus)

2017 ◽  
Vol 1 (2) ◽  
Author(s):  
Rulia Meilina
Keyword(s):  
Ethanol Extract ◽  
White Mouse ◽  
Phytochemical Screening ◽  
Suspension Control ◽  
Anti Inflammatory ◽  
Ethanol Extracts ◽  
Group B ◽  
Group D ◽  
Better Than ◽  
Inflammatory Effect

Anti-inflammatory effect of ethanol rhizome of turmeric was conducted toward white mouse which is induced the carrageenan solution (lambda carrageenan) 1 %, research was conducted by dividing the animals into 5 groups.Group A was given CMC 0,5%, group B was given Indometacin with dose 100 mg/kgBB, group C was given  ethanol rhizome extract of turmeric with dose 400 mg/kgBB, group D was given ethanol rhizome extract of turmeric with dose 500 mg/kgBB, group E was given ethanol rhizome extract of turmeric with dose 600 mg/kgBB. Result of phytochemical screening toward powder and ethanol extract of rhizome of turmeric shows that chemical compounds which are involved are alkaloids, flavonoids, and aetheric oil. In the other hand, result of phytochemical screening toward ethanol extract of turmeric’s rhizome are alkaloids,flavonoids,anthraquinones, glycosides. Result of anti-inflammatory test shows that there is the real difference among groups of mouse which were given CMC suspension (control), suspension of ethanol extracts of turmeric’s rhizome with dose 400 mg/kg BB, 500 mg/kg BB, 600 mg/kg BB (material test) and suspension of indomethacin with dose 100 mg/kg BB (positive comparison). Suspension of ethanol extract of turmeric’s rhizome with dose 600 mg/kg BB shows that anti-inflammatory capability is better than dose 400 mg/kg BB and 500 mg/kg BB, and suspension of ethanol extract of turmeric’s rhizome dose 600 mg/kg BB shows the anti-inflammatory effect which is not really different with suspension of indomethacin with dose 100 mg/kg BB, it is showed by  ANOVA statistic analysis among those comparisons toward indomethacin suspension as positive comparison.Keywords:Anti-inflammatory, Indomethacin, Turmeric Rhizome

scholarly journals Review of Experimental Pharmacological Studies of Plants Used for Asthma Management in Africa

2020 ◽  
Vol 4 (2) ◽  
pp. 1-11
Author(s):  
Amenan Geneviève N’guessan-Irié ◽  
Keyword(s):  
Medicinal Plants ◽  
Animal Experiments ◽  
Asthma Management ◽  
Plantes Médicinales ◽  
Review Of The Literature ◽  
Spasmolytic Activity ◽  
Study Protocols ◽  
Pharmacological Studies ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Objectives: The aim was to contribute to the promotion of medicinal plants used in Africa for management of asthma by analyzing their experimental pharmacological evaluation data. Methods: We carried out a systematic review of the literature based on the following research equations in English and in French: « médecine traditionnelle africaine » ET « asthma » ; « African traditional medicine » AND « asthma » or « Medicine African traditional » AND « asthma » ; « plantes médicinales » ET « asthma » ET « antispasmodique » ; «medicinal plants » AND « asthma » AND « anti-spasmodic » ; « plantes médicinales » ET « asthma » ET « anti-inflammatoire » ; «medicinal plants » AND « asthma » AND « anti-inflammatory ». Results: The study revealed 184 medicinal plants used in Africa for the treatment of asthma, 34 of which showed pharmacological properties in favor of their use. In animal experiments, 18 of these plants exerted a spasmolytic effect, 22 an anti-inflammatory effect and 6 both effects. The spasmolytic activity study protocols were based primarily on inhibition of smooth airway muscle contraction, including trachea, induced by various spasmogenic agents. As for of the methods used to study anti-inflammatory activity, the majority of them consisted of tests for carrageenan-induced edema or for formalin-induced leg irritation. Conclusion: Our results justify the need for standardization of experimental study protocols for the recovery of medicinal plants.

scholarly journals Phytochemical screening and arginase inhibitory activity of extracts from several Tunisian medicinal plants

2019 ◽  
Vol 120 ◽  
pp. 313-318 ◽  
Author(s):  
R. Attia ◽  
C. Messaoud ◽  
K. Arraki ◽  
A. Zedet ◽  
C. Demougeot ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Inhibitory Activity ◽  
Phytochemical Screening

scholarly journals Phytochemical Screening and Anti-Inflammatory Effect of Marrubium vulgare L. Methanol Extract on Carrageenan-Induced Paw Inflammation in Rats

2017 ◽  
Vol 23 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Fatemeh Fathiazad ◽  
Maryam Rameshrad ◽  
Samira Asghari ◽  
Sanaz Hamedeyazdan ◽  
Alireza Garjani ◽  
...  
Keyword(s):  
Methanol Extract ◽  
Phytochemical Screening ◽  
Marrubium Vulgare ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Inhibitory effects of hydroethanolic extracts from three Cameroonian medicinal plants on proteins inflammation and growth of multi-resistant strains of Mycobacterium tuberculosis

2021 ◽  
Vol 11 (4-S) ◽  
pp. 15-21
Author(s):  
Esther Del florence Ndedi Moni ◽  
Patrick Hervé Diboue Betote ◽  
Christelle Wayoue Kom ◽  
Chimène Félicite Mekoulou Benga ◽  
Armelle Deutou Tchamgoue ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Medicinal Plants ◽  
Inhibitory Action ◽  
Ethanol Extract ◽  
Inflammatory Activity ◽  
Phytochemical Screening ◽  
Resistant Strains ◽  
Anti Inflammatory ◽  
Ethanol Extracts

The present work aimed to determine the phytochemical components and evaluate the in vitro anti-inflammatory and anti-mycobacterial effects of hydroethanolic extracts of Allium sativum L bulbs, Drypetes gossweileri S. MOORE stem-barks and Pentadiplandra brazzeana Baill roots against several resistant strains of Mycobacterium tuberculosis. The phytochemical screenings of extracts were carried out according the colorimetric and precipitation tests to reveal the presence of phytochemical compounds. The anti-inflammatory effects of extracts were evaluated using in vitro Bovine Serum Albumin denaturation and proteinase inhibitory action assays. The inhibitory parameters of hydro-ethanol extracts were evaluated by the microdilution method agaisnt Mycobacterium tuberculosis. The phytochemical screening of hydro-ethanol extracts revealed the presence of phenols, polyphenols, flavonoids, alkaloids, cathechic tannins, triterpens, steroids, anthocyanins and leucoanthocyanins. The anti-inflammatory activity of hydro-ethanol extracts of D. gossweileri, P. brazzeana and A. sativum have shown the inhibitory concentrations 50 (IC50) values ranging from 356.70, 183.30 and 226.30 mg/mL for BSA denaturation and 31.92, 33.62 and 56.93 mg/mL for proteinase inhibitory action respectively. The hydroethanolic extracts of D. gossweileri, P. brazzeana and A. sativum exhibited moderate and weak anti-mycobacterial activities with the minimum inhibitory concentrations (MICs) ranging from 312.5 to 2500 μg/mL. A. sativum hydro-ethanol extract has shown the highest anti-mycobacterial activity with MIC of 312.5 μg/mL against isoniazid resistant of M. tuberculosis and extremely resistant drug strain of M. tuberculosis. These results suggest that hydro-ethanol extracts of A. sativum, D. gossweileri and P. brazzeana are efficient against tuberculosis caused by multi-resistant Mycobacterium tuberculosis strains and are able to resorb the inflammation induced during infection. Keywords: Anti-inflammatory activity, Anti-mycobacterial effect, Hydroethanolic extracts, Medicinal plants, Phytochemical screening.

Anti-inflammatory effect of Mongolia and Vietnamese medicinal plants against LPS-induced NO release in the RAW 264.7 cell

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
QH Juan ◽  
T Batmunkh ◽  
DT Nga ◽  
S Eun-Mi ◽  
YH Joo ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
No Release ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Effects of nanosuspension and inclusion complex techniques on the in vitro protease inhibitory activity of naproxen

2014 ◽  
Vol 50 (1) ◽  
pp. 165-171 ◽  
Author(s):  
Senthil Rajan Dharmalingam ◽  
Kumarappan Chidambaram ◽  
Srinivasan Ramamurthy ◽  
Shamala Nadaraju
Keyword(s):  
Inclusion Complex ◽  
Inhibitory Activity ◽  
Lower Percentage ◽  
Physiochemical Properties ◽  
Trypsin Inhibitory Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Antitryptic Activity ◽  
Inflammatory Effect

This study investigated the effects of nanosuspension and inclusion complex techniques on in vitro trypsin inhibitory activity of naproxen—a member of the propionic acid derivatives, which are a group of antipyretic, analgesic, and non-steroidal anti-inflammatory drugs. Nanosuspension and inclusion complex techniques were used to increase the solubility and anti-inflammatory efficacy of naproxen. The evaporative precipitation into aqueous solution (EPAS) technique and the kneading methods were used to prepare the nanosuspension and inclusion complex of naproxen, respectively. We also used an in vitro protease inhibitory assay to investigate the anti-inflammatory effect of modified naproxen formulations. Physiochemical properties of modified naproxen formulations were analyzed using UV, IR spectra, and solubility studies. Beta-cyclodextrin inclusion complex of naproxen was found to have a lower percentage of antitryptic activity than a pure nanosuspension of naproxen did. In conclusion, nanosuspension of naproxen has a greater anti-inflammatory effect than the other two tested formulations. This is because the nanosuspension formulation reduces the particle size of naproxen. Based on these results, the antitryptic activity of naproxen nanosuspension was noteworthy; therefore, this formulation can be used for the management of inflammatory disorders.

scholarly journals The anti-arthritic and anti-inflammatory activities of aqueous extract powder bark of Anthocleista schweinfurthii Gilg (Loganiaceae)

2018 ◽  
Vol 8 (6-s) ◽  
pp. 174-181
Author(s):  
Valdi Steve Djova ◽  
Ascension Maximilienne Nyegue ◽  
François-Xavier Etoa
Keyword(s):  
Aqueous Extract ◽  
Selective Inhibition ◽  
Positive Control ◽  
Inflammatory Activity ◽  
Moderate Activity ◽  
Phytochemical Screening ◽  
Ic50 Value ◽  
Anti Inflammatory ◽  
Inflammatory Effect

  Aqueous extract bark of Anthocleista schweinfurthii (ASE) was investigated for anti-arthritic, anti-inflammatory activities and phytochemicals screening. Phytochemical screening was carried out according, to LC-MS procedures, the anti-inflammatory effect of ASE was evaluated in vitro inhibition of 15-lipoxygenase (15-LOX) enzyme and  proteinase inhibiting action assays. The anti-arthritic activity was performed according to the Bovine Serum Albumin (BSA) test. The chemical composition of ASE showed that it was mainly composed of isocyanate, biphenyltriol, methoxyflavanone, soscoparin and glucopyroside. In the anti-inflammatory assays, ASE showed selective inhibition of 15-lipooxygenase with IC50 value of and moderate activity against the inhibition of proteinase action with IC50 value of L. Both the methods  showed that the ASE posses good anti-inflammatory activity. ASE had strong in vitro anti-arthritic activity with IC50 of , the positive control Diclofenac had IC50 value of  The result of this study justified the use of this plant in traditional Cameroonian medicine in the treatment of inflammation. ASE may offer a new source of potential therapeutic agents for the effective treatment of arthritis and inflammation.    Keywords: Anthocleista schweinfurthii, phytochemical screening, anti-arthritic activity, anti-inflammatory activity,     

scholarly journals Antidiabetic Activity of Extract Combination of Orthosiphon aristatus and Oryza sativa L. var glutinosa

2021 ◽  
Vol 4 (3) ◽  
pp. 202-209
Author(s):  
Eris Septiana ◽  
Nurul Maulida Rizka ◽  
Yadi Yadi ◽  
Partomuan Simanjuntak
Keyword(s):  
Biological Activity ◽  
Oryza Sativa ◽  
Medicinal Plants ◽  
Inhibitory Activity ◽  
Oryza Sativa L ◽  
Ethanol Extract ◽  
Antidiabetic Activity ◽  
Phytochemical Screening ◽  
Ic50 Value

Traditionally and scientifically, research has shown that Orthosiphon aristatus and Oryza sativa L. var. glutinosa have antidiabetic activity. The combination of two medicinal plants can increase their biological activity. This study aimed to determine the antidiabetic activity of O. aristatus and O. sativa L. var. glutinosa on single and combined extracts. Phytochemical screening of the single extract was done qualitatively. The α-glucosidase inhibitory method was used as an antidiabetic activity. The results showed that every extract contained alkaloids, steroids/triterpenoids, flavonoids, tannins, quinones, and coumarins. A single extract of O. sativa L. var glutinosa, O. aristatus, and their combinations (1:1, 1:2, and 2:1) had an α-glucosidase enzyme inhibitory activity with an IC50 value of 67.82, 80.93, 73.81, 88.72, and 61.51 µg/ml, respectively. The combination shows that the ratio of 1:1 was nearly additive, 1:2 was slight to moderate antagonism, and 2:1 was moderate to slight synergism. The combination of 96% ethanol extract of O. sativa L. var. glutinosa and O. aristatus in a ratio of 2:1 was the most effective in increasing its inhibitory activity.

scholarly journals Analgesic and Anti-Inflammatory Effects of 80% Methanol Extract of Leonotis ocymifolia (Burm.f.) Iwarsson Leaves in Rodent Models

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Asnakech Alemu ◽  
Wondmagegn Tamiru ◽  
Teshome Nedi ◽  
Workineh Shibeshi
Keyword(s):  
Acetic Acid ◽  
Medicinal Plants ◽  
Analgesic Effect ◽  
Rodent Models ◽  
Paw Edema ◽  
Traditional Remedies ◽  
Latency Response ◽  
Anti Inflammatory ◽  
Dose Levels ◽  
Inflammatory Effect

Background. Pain and inflammation are the major health problems commonly treated with traditional remedies mainly using medicinal plants. Leonotis ocymifolia is one of such medicinal plants used in folkloric medicine of Ethiopia. However, the plant has not been scientifically evaluated. The aim of this study was to evaluate analgesic and anti-inflammatory effects of the 80% methanol leaves extract of Leonotis ocymifolia using rodent models. Method. The central and peripheral analgesic effect of the extract at 100, 200, and 400 mg/kg dose levels was evaluated using hot plate and acetic acid induced writhing rodent models, whereas carrageenan induced paw edema and cotton pellet granuloma methods were used to screen anti-inflammatory effect of the extract at the same dose levels. Acute toxicity test was also done. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test and p<0.05 was considered significant. Results. The extract did not produce mortality up to 2000 mg/kg. All tested doses of the extract showed significant analgesic effect with maximum latency response of 62.8% and inhibition of acetic acid induced writhing. Maximum anti-inflammatory effect was recorded at 6 h after induction, with 75.88% reduction in carrageenan induced paw edema. Moreover, all tested doses of extract significantly inhibited the formation of inflammatory exudates and granuloma formation (p<0.001). Conclusion. The study indicated that the extract was safe in mice and it has both analgesic and anti-inflammatory effect in rodent models.

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