scholarly journals Failure of Tooth Development: Prevalence, Genetic Causes and Clinical Features

2021 ◽  
Author(s):  
Emilia Severin ◽  
George Gabriel Moldoveanu ◽  
Andreea Moldoveanu
Keyword(s):  
Tooth Development ◽  
Gene Mutations ◽  
Dental Arch ◽  
Tooth Agenesis ◽  
Missing Teeth ◽  
Related Quality ◽  
Wide Variability ◽  
Health Related ◽  
Clinical Consequences ◽  
Tooth Number

In dental practice may be encountered a wide variability in the clinical dental phenotype of tooth number. Failure of tooth development at the bud stage causes tooth agenesis and reduction in tooth number in the dental arch which involves various complications. Tooth agenesis is one of the most common developmental anomalies of human permanent dentition and tends to run in families, may aggregate within families, suggesting a genetic cause. Tooth agenesis can occur in association with a variety of craniofacial syndromes, but it is also found as an isolated trait (familial or sporadic). Other tooth anomalies, such as tooth shape and size, delayed eruption of teeth, malposition, short roots or taurodontism, have been noted in association with non-syndromic tooth agenesis as well. Both the deciduous and permanent dentitions may be affected by missing teeth. Variations in the number of missing teeth can be determined by a mutation in one gene, by mutations in multiple genes, induced by local or systemically acting environmental factor, caused by a combination of gene mutations and environmental factors acting together, or by damage to chromosomes. As the number of missing teeth increases, so does the severity of clinical consequences and the impact on oral health–related quality of life.

scholarly journals Anti–USAG-1 therapy for tooth regeneration through enhanced BMP signaling

2021 ◽  
Vol 7 (7) ◽  
pp. eabf1798
Author(s):  
A. Murashima-Suginami ◽  
H. Kiso ◽  
Y. Tokita ◽  
E. Mihara ◽  
Y. Nambu ◽  
...  
Keyword(s):  
Tooth Development ◽  
Bmp Signaling ◽  
Tooth Agenesis ◽  
Tooth Regeneration ◽  
Missing Teeth ◽  
Morphogenetic Protein ◽  
Genetic Abnormalities ◽  
Direct Binding ◽  
Tooth Germs ◽  
Lipoprotein Receptor Related Protein

Uterine sensitization–associated gene-1 (USAG-1) deficiency leads to enhanced bone morphogenetic protein (BMP) signaling, leading to supernumerary teeth formation. Furthermore, antibodies interfering with binding of USAG-1 to BMP, but not lipoprotein receptor–related protein 5/6 (LRP5/6), accelerate tooth development. Since USAG-1 inhibits Wnt and BMP signals, the essential factors for tooth development, via direct binding to BMP and Wnt coreceptor LRP5/6, we hypothesized that USAG-1 plays key regulatory roles in suppressing tooth development. However, the involvement of USAG-1 in various types of congenital tooth agenesis remains unknown. Here, we show that blocking USAG-1 function through USAG-1 knockout or anti–USAG-1 antibody administration relieves congenital tooth agenesis caused by various genetic abnormalities in mice. Our results demonstrate that USAG-1 controls the number of teeth by inhibiting development of potential tooth germs in wild-type or mutant mice missing teeth. Anti–USAG-1 antibody administration is, therefore, a promising approach for tooth regeneration therapy.

scholarly journals Comparison of Oral Health Related Quality of Life (OHRQoL) in Hypodontia Patients and Patients with Acquired Missing Teeth

2017 ◽  
Vol 6 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Shanti Chhetri ◽  
Muhammad Waseem Ullah Khan ◽  
Nazia Yazdanie
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Trauma Patients ◽  
Health Related Quality ◽  
Missing Teeth ◽  
Cross Sectional ◽  
Related Quality ◽  
Health Related ◽  
The Impact

Background: Hypodontia is the developmental absence of one or more teeth from the dentition whereas acquired missing teeth are those lost due to carries, periodontal problem or dental trauma. Patients with congenitally missing teeth suffer aesthetic, functional and psychological morbidity to various degree through childhood, adolescence and adulthood. Greater understanding of the impact of hypodontia on patient’s quality of life is very important. Oral health related quality of life (OHRQoL) is considered as an outcome measure to evaluate the consequences of edentulism and the available treatment options.Material and Methods: A cross-sectional comparative survey was carried out in the department of Prosthodontics, de’Montmorency College of Dentistry/Punjab Dental Hospital Lahore from 02/03/2010 to 01/09/2010. Total 80 partially dentate patients were studied which included 40 hypodontia patients and 40 patients with acquired missing teeth. All patients were given OHIP-14 questionnaire and responses were recorded on 5-point Likert scale. The mean scores of the two groups were calculated and compared using chi square test.Results: The total OHIP scores in hypodontia patients was more compared to that in patients with acquired missing teeth and difference was significant in the patient group with 4-5 missing teeth.Conclusion: As the missing teeth number increased, it was found that the OHRQoL in hypodontia patients was more impaired compared to the OHRQoL in patients with acquired missing teeth. Journal of Nobel Medical CollegeVolume 6, Number 1, Issue 10 (January-June, 2017), Page: 77-82

scholarly journals The Biology Underlying Abnormalities of Tooth Number in Humans

2017 ◽  
Vol 96 (11) ◽  
pp. 1248-1256 ◽  
Author(s):  
E. Juuri ◽  
A. Balic
Keyword(s):  
Animal Models ◽  
Signaling Pathways ◽  
Tooth Development ◽  
Current Knowledge ◽  
Tooth Agenesis ◽  
Cellular Mechanisms ◽  
Tooth Shape ◽  
Tooth Abnormalities ◽  
Tooth Number ◽  
The Common

In past decades, morphologic, molecular, and cellular mechanisms that govern tooth development have been extensively studied. These studies demonstrated that the same signaling pathways regulate development of the primary and successional teeth. Mutations of these pathways lead to abnormalities in tooth development and number, including aberrant tooth shape, tooth agenesis, and formation of extra teeth. Here, we summarize the current knowledge on the development of the primary and successional teeth in animal models and describe some of the common tooth abnormalities in humans.

The randomized shortened dental arch study: oral health-related quality of life

2013 ◽  
Vol 18 (2) ◽  
pp. 525-533 ◽  
Author(s):  
S. Wolfart ◽  
F. Müller ◽  
J. Gerß ◽  
G. Heyedcke ◽  
B. Marré ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Dental Arch ◽  
Health Related Quality ◽  
Shortened Dental Arch ◽  
Related Quality ◽  
Health Related

scholarly journals Patients’ Experiences of Living with Atrial Fibrillation: A Mixed Methods Study

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Marie Stridsman ◽  
Anna Strömberg ◽  
Jeroen Hendriks ◽  
Ulla Walfridsson
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Mixed Methods ◽  
Perceived Control ◽  
Healthcare Providers ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Clinical Consequences

Introduction. Awareness of epidemiological and clinical consequences of atrial fibrillation (AF) has increased, as have disease-related costs. Less attention has been paid to patient-related issues, such as understanding how symptoms, different therapies, and lifestyle adjustments affect daily life. We aimed to describe patients’ experiences of living with AF. Methods. The study design used a parallel convergent mixed methods approach. Patients with AF were included in the SMURF study and referred for catheter ablation. Patients completed questionnaires on symptoms, health-related quality of life, depression, anxiety, and perceived control and were interviewed. The datasets were analysed separately using inductive content analysis and descriptive statistics. Data were merged to obtain a final interpretation. Results. Nineteen patients were interviewed and 18 completed questionnaires. Twelve of the patients were male, mean age 60 years (45–75 years). Inductive qualitative analysis revealed three categories: (i) symptoms and concerns limiting life, (ii) dimensions of worries, and (iii) strategies for management. The most common symptoms were tiredness, weakness/fatigue, and breathlessness during activities, and the most pronounced negative impacts on health-related quality of life (HRQOL) were physically related, shown in the ASTA questionnaire. The most negative SF-36 scores were found in role limitations due to physical health problems and vitality. HADS revealed five patients with some degree of anxiety and four with some degree of depression. Patients had lower scores on perceived control than perceived helplessness in CAS. Patients’ perceived control was higher than their families’, and families experienced more helplessness. Conclusions. The mixed methods design deepens our understanding of challenges faced by patients. Patients experienced a limited ability to perform activities of daily living due to AF which created different kinds of worries that encouraged the use of various strategies to manage their lives. Healthcare providers need to be aware that relationships between patients and their relatives can change, and therefore they need to be supported and integrated into the care system.

Sign in / Sign up

Export Citation Format

Share Document