A case of ovarian serous adenocarcinoma with tubal intraepithelial carcinoma

Here we present postoperative pathology of an 82-year-old woman who presented with massive ascites, and an implant-like adenocarcinoma on her intrapelvic peritoneum, which revealed a minimal (<5mm) serous adenocarcinoma on her left ovary and an intraepithelial carcinoma on inner surface of her right Fallopian tube. The left ovarian serous adenocarcinoma may have originated as an intraepithelial carcinoma on contralateral Fallopian tube.

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THE ASSOCIATION OF THE APOLIPOPROTEIN E4 ALLELE (RS 429358) WITH OVARIAN SEROUS ADENOCARCINOMA

Problems in oncology ◽

10.37469/0507-3758-2017-63-4-627-631 ◽

2017 ◽

Vol 63 (4) ◽

pp. 627-631

Author(s):

Tatyana Ivanova ◽

Nataliya Sychenkova ◽

Vera Khorokhorina ◽

Nikolay Ryabchenko ◽

Sergey Ivanov ◽

...

Keyword(s):

Older Women ◽

Odds Ratio ◽

Area Under Curve ◽

Reproductive Age ◽

Prognostic Indicators ◽

Separate Analysis ◽

Women Of Reproductive Age ◽

Serous Adenocarcinoma ◽

Ovarian Serous Adenocarcinoma ◽

E4 Allele

The distribution of APOE 4 allele (rs 429358, C) was analyzed in healthy women (N=454) and patients with ovarian serous adenocarcinoma (N=114) in order to identify genetic predisposition to the disease. We determined the prognostic indicators of the E4 allele as a marker: odds ratio (OR) and AUC (Area Under Curve) - an area under the ROC curve. It was shown that APOE 4 allele was significantly associated with ovarian serous adenocarcinoma (p = 0,003; 0R=1,94; AUC=0,55). The Е4 genotypes frequency was significantly increased among patients (p = 0.02; 0R=1,8). Separate analysis of the two age subgroups (over 46 years and younger) found that the chance of developing ovarian serous adenocarcinoma was significantly increased for older women (p = 0,006; OR = 2,24, AUC = 0,76). Possible associations of APOE 4 with the ovarian serous adenocarcinoma in women of reproductive age deserve further studying.

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Ovarian carcinoma in a 14-year-old with classical salt-wasting congenital adrenal hyperplasia and bilateral adrenalectomy

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2014-0299 ◽

2015 ◽

Vol 28 (5-6) ◽

Cited By ~ 1

Author(s):

Christian Pina ◽

Ahmed Khattab ◽

Philip Katzman ◽

Lauren Bruckner ◽

Jeffrey Andolina ◽

...

Keyword(s):

Congenital Adrenal Hyperplasia ◽

Ovarian Carcinoma ◽

Left Ovary ◽

Bilateral Adrenalectomy ◽

Ca 125 ◽

Adrenal Hyperplasia ◽

Serous Adenocarcinoma ◽

Adrenal Tissue ◽

Ovarian Serous Adenocarcinoma ◽

21 Hydroxylase Deficiency

AbstractA 14-year-old female with classical congenital adrenal hyperplasia because of 21-hydroxylase deficiency underwent bilateral adrenalectomy at 6 years of age as a result of poor hormonal control. Because the patient was adrenalectomized, extra adrenal androgen production was suspected. Imaging studies including pelvic ultrasound and pelvic magnetic resonance imaging (MRI) were obtained to evaluate for adrenal rest tumors of the ovaries. Abdominal MRI was obtained to evaluate for residual adrenal tissue. A cystic lesion arising from her right ovary suspicious for ovarian neoplasm was noted on pelvic MRI. Right salpingo-oophorectomy was performed and histopathological examination revealed ovarian serous adenocarcinoma, low-grade, and well-differentiated. Tumor marker CA-125 was elevated and additional ovarian cancer staging workup confirmed stage IIIC due to one lymph node positive for carcinoma. The patient then developed a large left ovarian cyst, which led to a complete total abdominal hysterectomy and removal of the left ovary and fallopian tube. Pathology confirmed ovarian serous adenocarcinoma with microscopic focus of carcinoma in the left ovary. After numerous complications, the patient responded well to chemotherapy, CA-125 levels fell and no evidence of carcinoma was observed on subsequent imaging. To our knowledge, this is the first reported case of an ovarian serous adenocarcinoma in a patient with CAH. Although rare, we propose that the ovaries were the origin of androgen production and not residual adrenal tissue. The relationship between CAH and ovarian carcinomas has yet to be established, but further evaluation is needed given the poor survival rate of high-grade serous ovarian carcinoma.

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