Psychometric Evaluation of the Persian Version of Illustrated Memory Impairment Screen (PIMIS) Test in Elderly Patients with Alzheimer’s Disease in Iran

AbstractIron homeostasis disturbance has been implicated in Alzheimer’s disease (AD), and excess iron exacerbates oxidative damage and cognitive defects. Ferroptosis is a nonapoptotic form of cell death dependent upon intracellular iron. However, the involvement of ferroptosis in the pathogenesis of AD remains elusive. Here, we report that ferroportin1 (Fpn), the only identified mammalian nonheme iron exporter, was downregulated in the brains of APPswe/PS1dE9 mice as an Alzheimer’s mouse model and Alzheimer’s patients. Genetic deletion of Fpn in principal neurons of the neocortex and hippocampus by breeding Fpnfl/fl mice with NEX-Cre mice led to AD-like hippocampal atrophy and memory deficits. Interestingly, the canonical morphological and molecular characteristics of ferroptosis were observed in both Fpnfl/fl/NEXcre and AD mice. Gene set enrichment analysis (GSEA) of ferroptosis-related RNA-seq data showed that the differentially expressed genes were highly enriched in gene sets associated with AD. Furthermore, administration of specific inhibitors of ferroptosis effectively reduced the neuronal death and memory impairments induced by Aβ aggregation in vitro and in vivo. In addition, restoring Fpn ameliorated ferroptosis and memory impairment in APPswe/PS1dE9 mice. Our study demonstrates the critical role of Fpn and ferroptosis in the progression of AD, thus provides promising therapeutic approaches for this disease.

Download Full-text

Development and psychometric evaluation of the Social Connectedness Index in nursing home residents with Alzheimer's disease and dementia using the Minimum Data Set 3.0

International Journal of Geriatric Psychiatry ◽

10.1002/gps.5516 ◽

2021 ◽

Author(s):

Carol A. Bova ◽

Bill M. Jesdale ◽

Attah Mbrah ◽

Lynn Botelho ◽

Kate L. Lapane

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Nursing Home ◽

Social Connectedness ◽

Nursing Home Residents ◽

Psychometric Evaluation ◽

Minimum Data Set ◽

Data Set ◽

Minimum Data ◽

The Social

Download Full-text

The Semantic Memory Impairment of Alzheimer's Disease: Category-Specific?

Cortex ◽

10.1016/s0010-9452(96)80023-2 ◽

1996 ◽

Vol 32 (1) ◽

pp. 143-153 ◽

Cited By ~ 49

Author(s):

Lynette J. Tippett ◽

Murray Grossman ◽

Martha J. Farah

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Semantic Memory ◽

Memory Impairment ◽

Disease Category

Download Full-text

P4-093: Semantic memory impairment in Alzheimer's disease and frontotemporal dementia is associated with semantic network degradation

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.2114 ◽

2011 ◽

Vol 7 ◽

pp. S734-S734

Author(s):

Kimiko Domoto-Reilly ◽

Daisy Sapolsky ◽

Michael Brickhouse ◽

Mark Hollenbeck ◽

Brad Dickerson

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Frontotemporal Dementia ◽

Semantic Memory ◽

Memory Impairment ◽

Semantic Network

Download Full-text

Theracurmin supplementation may be a therapeutic option for older patients with alzheimer’s disease: a 6-month retrospective follow-up study

Current Alzheimer Research ◽

10.2174/1567205019666211221125255 ◽

2021 ◽

Vol 19 ◽

Author(s):

Fatma Sena Dost ◽

Derya Kaya ◽

Mehmet Selman Ontan ◽

Neziha Erken ◽

Esra Ateş Bulut ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Elderly Patients ◽

Therapeutic Option ◽

Disease Course ◽

Clock Drawing Test ◽

Global Challenge ◽

Follow Up Study ◽

Therapeutic Opportunity

Background: Alzheimer’s Disease (AD) is still a great global challenge and agents with various mechanisms represent a promising therapeutic opportunity. Theracurmin, a very highly absorbable curcumin formulation, was shown to improve memory and attention in non-demented people. Objective: To investigate the effect of Theracurmin on disease course in elderly patients with mild cognitive impairment (MCI) and AD. Methods: This follow-up study was performed retrospectively on 93 patients with MCI or AD. All patients underwent comprehensive geriatric assessment, including Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MOCA), clock-drawing test, activities of daily living (ADL), at baseline and end of the 6th-month. 19 patients with AD and 17 with MCI were treated with Theracurmin 180 mg/day per oral. Results: MMSE, MOCA and instrumental ADL scores decreased in AD patients that were not treated with Theracurmin (p<0.001, p=0.011, and p=0.004, respectively), whereas these scores remained stable in those treated with Theracurmin. This stabilization in the instrumental ADL was also observed in MCI patients treated with Theracurmin. During the follow-up, three of MCI patients who did not receive Theracurmin progressed to AD, whereas only one patient progressed in those who received it. Conclusion: Theracurmin seems to be a therapeutic option for elderly patients with AD and MCI via providing stabilization of the disease course by preventing progressive loss in cognitive functions and ADLs.

Download Full-text

Effects of Gossypium herbaceam Extract Administration on the Learning and Memory Function in the Naturally Aged Rats: Neuronal Niche Improvement1

Journal of Alzheimer s Disease ◽

10.3233/jad-2012-112153 ◽

2012 ◽

Vol 31 (1) ◽

pp. 101-111 ◽

Cited By ~ 4

Author(s):

Yanyong Liu ◽

Haji Akber Aisa ◽

Chao Ji ◽

Nan Yang ◽

Haibo Zhu ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Learning And Memory ◽

Memory Impairment ◽

Neuroprotective Effect ◽

Memory Function ◽

Aged Rats

Aging-associated cognitive impairment is an important health care issue since individuals with mild cognitive impairment are more likely to develop Alzheimer’s disease. In the present study, the protective effect of Gossypium herbaceam extracts (GHE) on learning and memory impairment associated with aging were examined in vivo using Morris water maze and step through task. Furthermore, the antioxidant activity and neuroprotective effect of GHE was investigated with methods of histochemistry and biochemistry. These data showed that oral administration with GHE at the doses of 35, 70, and 140 mg/kg exerted an improved effect on the learning and memory impairment in aged rats. Subsequently, GHE afforded a beneficial action on eradication of free radicals without influence on the activity of glutathione peroxidase and superoxide dismutase. GHE treatment enhanced the expression levels of nerve growth factor. Meanwhile, proliferation of neural progenitor cells was elevated in hippocampus after treatment with GHE. Taken together, neurogenic niche improvement could be involved in the mechanism underlying neuroprotection of GHE against aging-associated cognitive impairment. These findings suggested that GHE might be a potential agent as cognitive-enhancing drugs that delay or halt mild cognitive impairment progression to Alzheimer’s disease or treatment of aging-associated cognitive impairment.

Download Full-text