scholarly journals Analysis of Association Between the Effects of Methylphenidate and DRD4 Gene Polymorphisms in Patients with Attention Deficit Hyperactivity Disorder

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Shahrokh Amiri ◽  
Sara Farhang ◽  
Mahmoud Shekari Khaniani ◽  
Sima Mansouri Derakhshan ◽  
Aziz Zadfattah ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Drug Treatment ◽  
Attention Deficit ◽  
Repeated Measure ◽  
Drd4 Gene ◽  
Salting Out ◽  
Laboratory Findings ◽  
Hyperactivity Disorder ◽  
Measure Analysis ◽  
Repeated Measure Analysis

Background: Drug treatment is one of the most important treatments for attention deficit hyperactivity disorder (ADHD). The DRD4 gene is a transporter and receptor coding gene of dopamine and is one of the most important genes under investigation in the disorder and etiology of ADHD. In this study, the association between rs3758653 C/T and VNTR exon 3 repetition polymorphisms of the DRD4 gene and the effects of methylphenidate were investigated in patients with ADHD disorder consuming methylphenidate. Methods: The descriptive-analytical study was performed on 122 patients (5 - 18 years old) with ADHD who were treated with methylphenidate. DNA was extracted using salting out method. Subsequently, the rs3758653 polymorphism in the 5'UTR region of DRD4 gene was genotyped by PCR-RFLP method, and the VNTR fragment in exon III of DRD4 gene was investigated by electrophoresis gel on acrylamide gel method. After eight weeks from the start of drug treatment with methylphenidate, the intensity of symptoms was evaluated using the Conners scale. Finally, all data from questionnaires and information that were resulted from laboratory findings were analyzed using ANOVA and repeated measure analysis. Results: Of the 122 patients under study, 15 patients (12.3%) were responded to the drug treatment, and 107 patients (87.7%) were not responded. The significant differences were not revealed in genotype, and allele frequencies of between rs3758653 (C/T) and exon III 3'VNTR repeats polymorphisms of the DRD4 gene and responder and non-responder of ADHD groups to the drug treatment. Conclusions: The results showed that the reduction of ADHD symptoms with drug treatment is not related to DRD4 sub-types in patients with ADHD.

scholarly journals DRD4 Gene Polymorphisms as a Risk Factor for Children with Attention Deficit Hyperactivity Disorder in Iranian Population

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Seyed Mahmoud Tabatabaei ◽  
Shahrokh Amiri ◽  
Sara Faghfouri ◽  
Seyed Gholamreza Noorazar ◽  
Shahin AbdollahiFakhim ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Tandem Repeats ◽  
Receptor Gene ◽  
Variable Number ◽  
Healthy Children ◽  
Drd4 Gene ◽  
Hyperactivity Disorder ◽  
Significant Difference ◽  
Northwest Of Iran

Background and Objective. Dopamine dysfunction is known to be associated with attention deficit hyperactivity disorder (ADHD). Dopamine D4 receptor gene (DRD4) is one of the important genes in this pathway. This study intended to investigate the variable number of tandem repeats (VNTR) in exon 3 of the DRD4 gene in Iranian children and adolescents. Materials and Methods. In this study, 130 children with ADHD, aged 6–14 years, and 130 healthy children, within the same age range, were enrolled. All children were selected from northwest of Iran which have Caucasian ethnic background and are of a Turkic ethnic group. VNTR polymorphisms of the DRD4 gene were evaluated by PCR using exon 3-specific primers followed by agarose gel electrophoresis. Findings. The Hardy-Weinberg principle and Chi-square test showed a significant difference in 4-repetition (4R) alleles between the ADHD (76.2%) and control (53.8%) groups (p=0.004; X2=17.39; df=5). The least percentage of repetition alleles in both groups was 2R. Conclusion. There is a significant correlation between the 4R alleles of DRD4 and ADHD in the northwest of Iran.

scholarly journals Drug treatment for attention-deficit/hyperactivity disorder and suicidal behaviour: register based study

BMJ ◽  
2014 ◽  
Vol 348 (jun18 18) ◽  
pp. g3769-g3769 ◽  
Author(s):  
Q. Chen ◽  
A. Sjolander ◽  
B. Runeson ◽  
B. M. D'Onofrio ◽  
P. Lichtenstein ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Drug Treatment ◽  
Attention Deficit ◽  
Suicidal Behaviour ◽  
Hyperactivity Disorder

scholarly journals Dopamine receptor DRD4 gene and stressful life events in persistent attention deficit hyperactivity disorder

2015 ◽  
Vol 168 (6) ◽  
pp. 480-491 ◽  
Author(s):  
Cristina Sánchez-Mora ◽  
Vanesa Richarte ◽  
Iris Garcia-Martínez ◽  
Mireia Pagerols ◽  
Montse Corrales ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Dopamine Receptor ◽  
Life Events ◽  
Attention Deficit ◽  
Stressful Life Events ◽  
Stressful Life ◽  
Drd4 Gene ◽  
Hyperactivity Disorder

Mortality Associated with Attention-Deficit Hyperactivity Disorder (ADHD) Drug Treatment

Drug Safety ◽  
2009 ◽  
Vol 32 (11) ◽  
pp. 1089-1096 ◽  
Author(s):  
Suzanne McCarthy ◽  
Noel Cranswick ◽  
Laura Potts ◽  
Eric Taylor ◽  
Ian C.K. Wong
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Drug Treatment ◽  
Attention Deficit ◽  
Hyperactivity Disorder

scholarly journals Determining the association between polymorphisms of the DAT1 and DRD4 genes with attention deficit hyperactivity disorder in children from Java Island

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Cempaka Thursina ◽  
Dian Kesumapramudya Nurputra ◽  
Indra Sari Kusuma Harahap ◽  
Nur Imma Fatimah Harahap ◽  
Nihayatus Sa’adah ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Attention Deficit ◽  
Genotype Distribution ◽  
Drd4 Gene ◽  
Normal Children ◽  
Repeat Allele ◽  
Hyperactivity Disorder ◽  
Vntr Polymorphism ◽  
Dat1 Gene ◽  
Significant Difference

Attention deficit hyperactivity disorder (ADHD) is one of the most common neurobehavioural in the children. Genetic factor is known one of the factors which contributed in ADHD development. VNTR polymorphism in 3’UTR exon 15 of DAT1 gene and exon 3 of DRD4 gene are reported to be associated in ADHD. In this study we examine the association of ADHD with VNTR polymorphism of DAT1 and DRD4 gene in Indonesian children. Sixty-five ADHD children and 70 normal children (6- 13 years of age), were included in the study, we matched by age and gender. ADHD was diagnosed by DSM-IV. We performed a casecontrol study to found the association between ADHD and VNTR polymorphism of DAT1 and DRD4 genes. The 10-repeat allele of DAT1 and 2-repeat allele of DRD4 were higher in Indonesian children. Although the frequency of these allele was higher, but it was similar both in ADHD and control groups. Neither DAT1 nor DRD4 gene showed showed significant difference in genotype distribution and frequency allele between both groups (p > 0.05). No association between ADHD and VNTR polymorphism of DAT1 and DRD4 genes found in Indonesian children. This data suggest that DAT1 and DRD4 do not contribute to etiology of ADHD in Indonesian children. Further studies are needed to clarify association between VNTR polymorphism of DAT1 and DRD4 genetic with ADHD of Indonesian children in larger sample size and family based study.

scholarly journals Family-based association study of DRD4 gene in methylphenidate-responded Attention Deficit/Hyperactivity Disorder

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173748 ◽  
Author(s):  
Patrick Wing-leung Leung ◽  
Janice Ka Yan Chan ◽  
Lu Hua Chen ◽  
Chi Chiu Lee ◽  
Se Fong Hung ◽  
...  
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Association Study ◽  
Attention Deficit ◽  
Drd4 Gene ◽  
Hyperactivity Disorder ◽  
Family Based
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