repeated measure analysis
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2021 ◽  
Vol 12 ◽  
Author(s):  
P. S. Swathi ◽  
Raghavendra Bhat ◽  
Apar Avinash Saoji

Background and Objective: Attention and memory are essential aspects of cognitive health. Yogasanas, pranayama, and meditation have shown to improve cognitive functions. There has been no assessment of Trataka (yogic visual concentration) on working or on spatial memory. The present study was planned to assess the immediate effects of Trataka and of eye exercise sessions on the Corsi-block tapping task (CBTT).Methods: A total of 41 healthy volunteers of both genders with age 23.21 ± 2.81 years were recruited. All participants underwent baseline assessment, followed by 2 weeks of training in Trataka (including eye exercise). Each training session lasted for 20 min/day for 6 days a week. After completion of the training period, a 1-week washout period was given. Each participant then was assessed in two sessions in Trataka and in eye exercise on two separate days, maintaining the same time of the day. Repeated measure analysis of variance with Holm’s adjustment was performed to check the difference between the sessions.Results: Significant within-subjects effects were observed for forward Corsi span andforward total score (p < 0.001), and also for backward Corsi span (p < 0.05) and backward total score (p < 0.05). Post hoc analyses revealed Trataka session to be better than eye exercises and baseline. The eye exercise session did not show any significant changes in the CBTT.Conclusion: The result suggests that Trataka session improves working memory, spatial memory, and spatial attention.


2021 ◽  
Vol 15 ◽  
Author(s):  
Xinjun Suo ◽  
Lining Guo ◽  
Dianxun Fu ◽  
Hao Ding ◽  
Yihong Li ◽  
...  

Currently, comparative studies evaluating the quantification accuracy of pyramidal tracts (PT) and PT branches that were tracked based on four mainstream diffusion models are deficient. The present study aims to evaluate four mainstream models using the high-quality Human Connectome Project (HCP) dataset. Diffusion tensor imaging (DTI), diffusion spectral imaging (DSI), generalized Q-space sampling imaging (GQI), and Q-ball imaging (QBI) were used to construct the PT and PT branches in 50 healthy volunteers from the HCP. False and true PT fibers were identified based on anatomic information. One-way repeated measure analysis of variance and post hoc paired-sample t-test were performed to identify the best PT and PT branch quantification model. The number, percentage, and density of true fibers of PT obtained based on GQI and QBI were significantly larger than those based on DTI and DSI (all p < 0.0005, Bonferroni corrected), whereas false fibers yielded the opposite results (all p < 0.0005, Bonferroni corrected). More trunk branches (PTtrunk) were present in the four diffusion models compared with the upper limb (PTUlimb), lower limb (PTLlimb), and cranial (PTcranial) branches. In addition, significantly more true fibers were obtained in PTtrunk, PTUlimb, and PTLlimb based on the GQI and QBI compared with DTI and DSI (all p < 0.0005, Bonferroni corrected). Finally, GQI-based group probabilistic maps showed that the four PT branches exhibited relatively unique spatial distributions. Therefore, the GQI and QBI represent better diffusion models for the PT and PT branches. The group probabilistic maps of PT branches have been shared with the public to facilitate more precise studies on the plasticity of and the damage to the motor pathway.


2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Shahrokh Amiri ◽  
Sara Farhang ◽  
Mahmoud Shekari Khaniani ◽  
Sima Mansouri Derakhshan ◽  
Aziz Zadfattah ◽  
...  

Background: Drug treatment is one of the most important treatments for attention deficit hyperactivity disorder (ADHD). The DRD4 gene is a transporter and receptor coding gene of dopamine and is one of the most important genes under investigation in the disorder and etiology of ADHD. In this study, the association between rs3758653 C/T and VNTR exon 3 repetition polymorphisms of the DRD4 gene and the effects of methylphenidate were investigated in patients with ADHD disorder consuming methylphenidate. Methods: The descriptive-analytical study was performed on 122 patients (5 - 18 years old) with ADHD who were treated with methylphenidate. DNA was extracted using salting out method. Subsequently, the rs3758653 polymorphism in the 5'UTR region of DRD4 gene was genotyped by PCR-RFLP method, and the VNTR fragment in exon III of DRD4 gene was investigated by electrophoresis gel on acrylamide gel method. After eight weeks from the start of drug treatment with methylphenidate, the intensity of symptoms was evaluated using the Conners scale. Finally, all data from questionnaires and information that were resulted from laboratory findings were analyzed using ANOVA and repeated measure analysis. Results: Of the 122 patients under study, 15 patients (12.3%) were responded to the drug treatment, and 107 patients (87.7%) were not responded. The significant differences were not revealed in genotype, and allele frequencies of between rs3758653 (C/T) and exon III 3'VNTR repeats polymorphisms of the DRD4 gene and responder and non-responder of ADHD groups to the drug treatment. Conclusions: The results showed that the reduction of ADHD symptoms with drug treatment is not related to DRD4 sub-types in patients with ADHD.


2021 ◽  
Vol 45 (6) ◽  
pp. 1079-1090
Author(s):  
Young Sam Oh ◽  
Na Kyoung Song

Objectives: This research examines social distancing changes over time, and by region of the United States after the COVID-19 pandemic began. Methods: We utilized information on social distancing from the Google Community Mobility Reports. We performed one-way repeated-measure analysis of variance (RM-ANOVA) to examine the overall changes in the 6 types of social distancing from baseline to the 12-week follow-up (March 1 to May 24, 2020). We applied a 2-way RM-ANOVA to evaluate the effects of time and 4 regions on social distancing. Results: According to one-way RM-ANOVA results, social distancing tended to increase until Time 3 (March 30 to April 12) and 4 (April 13 to April 26), before decreasing again, regardless of the area. The 2-way RM-ANOVA results revealed that the social distancing variations in the 6 area types over time were statistically significant in each region, along with the interaction of regions and time. Compared to other regions, social distancing was the highest in the Northeast area, except in park areas. Conclusions: We found that social distancing can be influenced not only by contagion changes, but also by regional differences. Understanding the features of social distancing can play a significant role in helping society build a promising COVID-19 prevention model.


Author(s):  
Tingji Chen ◽  
Yanting Sun ◽  
Chengzhi Feng ◽  
Wenfeng Feng

Abstract. Emotional signals from the face and body are normally perceived as an integrated whole in everyday life. Previous studies have revealed an incongruent effect which refers to distinctive behavioral and neural responses to emotionally congruent versus incongruent face-body compounds. However, it remains unknown which kind of the face-body compounds caused the incongruence effect. In the present study, we added neutral face and neutral body stimuli to form new face-body compounds. Forty subjects with normal or corrected-to-normal vision participated in this experiment. By comparing the face-body compounds with emotional conflict and face-body compounds with neutral stimuli, we could investigate the source of the incongruent effect. For both behavioral and event-related potential (ERP) data, a 2 (bodily expression: happiness, fear) × 2 (congruence: congruent, incongruent) repeated-measure analysis of variance (ANOVA) was performed to re-investigate the incongruent effect and a 3 (facial expression: fearful, happy, neutral) × 3 (bodily expression: fearful, happy, neutral) repeated-measure ANOVA was performed to clarify the source of the incongruent effect. As expected, both behavioral and ERP results have successfully repeated the incongruent effect. Specifically, the behavioral data showed that emotionally congruent versus incongruent face-body compounds were recognized more accurately ( p < .05). The ERP component of N2 was modulated by the emotional congruency between the facial and bodily expression showing that the emotionally incongruent compounds elicited greater N2 amplitudes than emotionally congruent compounds ( p < .05). No incongruent effect was found for P1 or P3 component ( p = .079, p = .99, respectively). Furthermore, by comparing the emotionally incongruent pairs with the neutral baseline, the present study suggests that the source of the incongruent effect might be from the happy face-fearful body compounds. We speculate that the emotion expressed by the fearful body was much more intensive than the emotion expressed by the happy body and thus caused a stronger interference in judging the facial expressions.


Author(s):  
Omid Hamidi ◽  
Seyed Reza Borzu ◽  
Saman Maroufizadeh ◽  
Payam Amini

Introduction: One of the complications of hemodialysis treatment is hypotension, which can increase morbidity and mortality and compromise dialysis efficacy. Dialysate temperature is an important factor that contributes to hemodynamic stability during hemodialysis. This study investigated the effect of dialysate temperature on the patients' blood pressure and pulse rate. Model-based approaches were used to produce more reliable results compared with traditional methods. Methods: A total of 30 patients were studied during 9 dialysis sessions. Dialysate temperatures were 37° C, 36° C and 35° C. A joint longitudinal model was used to analyze both responses of blood pressure and pulse rate, simultaneously. Results: The results showed that low-dialysate temperature was not significantly associated with higher systolic blood pressure (p>0.05) or a higher pulse rate (p>0.05) either during or after dialysis. Pulse rate and blood pressure were higher for women during dialysate (p<0.001). However, increasing age was associated with higher blood pressure and a lower pulse rate (p<0.001). Conclusion: Using several separate, repeated measure analysis of variances may produce misleading results, when there is more than one response variable measured over time, Multivariate statistical methods (including joint longitudinal models), should be used.  


Author(s):  
Samer Mheissen ◽  
Haris Khan ◽  
Mohammed Almuzian ◽  
Emad Eddin Alzoubi ◽  
Nikolaos Pandis

Summary Background In orthodontic trials, longitudinal designs with multiple outcome measurements over time are common. The aim of this epidemiological study was to examine whether optimal statistical analysis approaches have been used in longitudinal orthodontic trials. Methods Pubmed was searched in August 2021 for longitudinal orthodontic trials with at least three time points of outcome assessment published in the 2017–20 period. Study selection and data extraction were done independently and in duplicate. The analysis approaches undertaken were tabulated and associations between study characteristics and the use of optimal analysis or not were assessed using Fisher’s exact test and logistic regression. Results One hundred forty-seven out of 563 unique records were deemed eligible for inclusion. Only 26.50% of these trials used an optimal statistical analysis for longitudinal data where the data structure is accounted for. None of the study characteristics except the statistical significance of the results were associated with the appropriateness of the statistical analysis. The odds of significant results in studies with suboptimal analyses were higher than that in studies with optimal longitudinal analyses (odds ratio: 3.48, 95% confidence interval: 1.62, 7.46, P = 0.001). For the studies with optimal analysis, the most frequent test was repeated-measure analysis of variance (RM-ANOVA). The reporting of the statistical analysis section was suboptimal in the majority of the trials. Conclusion Most longitudinal orthodontic trials are not analysed using optimal statistical approaches. Inferences and interpretation of their results are likely to be compromised.


2021 ◽  
Vol 9 (2) ◽  
pp. 290-298
Author(s):  
Rian Tri Prayogo ◽  
Sendy Mohamad Anugrah ◽  
Ardhika Falaahudin ◽  
Dody Tri Iwandana ◽  
Rifqi Festiawan

Pembatasan kegiatan masyarakat akibat penyebaran virus covid-19 telah mengubah olahraga di Indonesia sehingga memaksa para atlet untuk melakukan latihan mandiri di tempat tinggalnya masing-masing dengan program latihan yang dibuat oleh para pelatihnya. Tujuan penelitian ini adalah membandingkan kapasitas aerobik, aspek kelincahan, dan daya tahan otot lokal atlet pencak silat sebelum dan sesudah masa latihan mandiri. Metode penelitian yang digunakan adalah deskritptif dengan melibatkan 12 atlet pencak silat putra kategori tanding Kabupaten Karawang. Hasil penelitian menunjukan bahwa terjadi penurunan signifikan pada kapasitas aerobik (p= 0.025) dan performa kelincahan (0.042) namun pada daya tahan otot lokal tidak terdapat perbedaan. Kesimpulan penelitian ini adalah terjadi penurunan pada kapasitas aerobik dan aspek kelincahan pada atlet pencak silat Kabupaten Karawang setelah masa latihan di tempat tinggalnya masing-masing akibat dari pemberlakukan pembatasan kegiatan masyarakat (PPKM), namun pada komponen daya tahan otot-otot lokal tidak terdapat perubahan.The sports activity of badminton and responses to changes in blood uric acid at productive age AbstractThis study aims to determine whether there was a response to changes in uric acid levels due to the physical activity of badminton. The design of this study is a quasi-experimental. The sample used in this study was eight respondents with certain criteria. Treat physical activity twice on different days with 4 measurements of uric acid levels. The method of this study is repeated measure analysis. When subjects are measured repeatedly, requiring fewer subjects per experiment, then repeated measures analysis can be used. The results showed that the treatment of badminton had a significant effect on changes in uric acid levels with a probability value of 0,038. These results were obtained by using the Greenhouse-Geisser test where the assumptions of normality and homogeneity were satisfied. From the marginal test results using pairwise comparisons, there was a significant difference in the average uric acid levels at 15 minutes after exercise and 9 hours the following day, where there was a decrease of 1.169 mg/dl. Badminton can reduce uric acid levels, which is indicated by a decrease of 0.15 mg/dl at 09.00 the next day compared to before exercise. Marginally, this decrease is not statistically significant, but regular badminton can be an option for physical activity for those who want to reduce uric acid levels.


2021 ◽  
Vol 9 (2) ◽  
pp. 279-289
Author(s):  
Angkit Kinasih ◽  
Ronaldo Lomi Djara ◽  
Ferry Fredy Karwur

Penelitian ini bertujuan untuk mengetahui ada tidaknya respon perubahan pada kadar asam urat akibat aktivitas olahraga bulu tangkis.  Desain penelitian ini adalah quasi eksperimen. Sampel yang digunakan sebanyak delapan responden dengan kriteria tertentu. Perlakukan aktivitas fisik dilakukan dua kali pada hari yang berbeda dengan 4 kali pengukuran kadar asam urat. Metode penelitian yang digunakan adalah repeated measure analysis. Ketika subyek diukur berulang kali dengan jumlah yang sedikit per percobaan maka repeated measures analysis dapat digunakan. Hasil penelitian menunjukkan bahwa perlakukan olahraga bulu tangkis memberikan respon perubahan yang signifikan terhadap perubahan kadar asam urat dengan nilai probabilitas sebesar 0,038. Hasil ini diperoleh dengan menggunakan uji Greenhouse-Geisser dimana asumsi normalitas dan homogenitas telah terpenuhi. Pada hasil uji marginal menggunakan pairwise comparisons, terdapat perbedaan yang signifikan pada rata-rata kadar asam urat 15 menit setelah olahraga dan jam 09.00 hari berikutnya, dimana terjadi penurunan sebesar 1,169 mg/dl. Olahraga bulu tangkis dapat menurunkan kadar asam urat yang ditandai dengan adanya penurunan sebesar 0,15 mg/dl pada jam 09.00 hari berikutnya dibandingkan dengan sebelum olahraga. Secara marginal, penurunan ini tidak signifikan secara statistik, namun olahraga bulu tangkis yang rutin dapat menjadi salah satu pilihan aktifitas fisik bagi yang ingin menurunkan kadar asam urat.The sports activity of badminton and responses to changes in blood uric acid at productive ageAbstractThis study aims to determine whether there was a response to changes in uric acid levels due to the physical activity of badminton. The design of this study is a quasi-experimental. The sample used in this study was eight respondents with certain criteria. Treat physical activity twice on different days with 4 measurements of uric acid levels. The method of this study is repeated measure analysis. When subjects are measured repeatedly, requiring fewer subjects per experiment, then repeated measures analysis can be used. The results showed that the treatment of badminton had a significant effect on changes in uric acid levels with a probability value of 0,038. These results were obtained by using the Greenhouse-Geisser test where the assumptions of normality and homogeneity were satisfied. From the marginal test results using pairwise comparisons, there was a significant difference in the average uric acid levels at 15 minutes after exercise and 9 hours the following day, where there was a decrease of 1.169 mg/dl. Badminton can reduce uric acid levels, which is indicated by a decrease of 0.15 mg/dl at 09.00 the next day compared to before exercise. Marginally, this decrease is not statistically significant, but regular badminton can be an option for physical activity for those who want to reduce uric acid levels.


Author(s):  
Sujeet Kumar Sinha ◽  
Alfarghal Mohamad ◽  
Suman Penwal

Abstract Purpose The aim of the present study was to assess the vestibuloocular reflex (VOR) gain function and VOR gain asymmetry during the various phases of the menstrual cycle in young healthy female participants. The study also aimed to characterize the presence or absence of corrective saccades during the various phases of the menstrual cycle. Method Twenty-nine young healthy females participated in the study. The video head impulse test (vHIT) was performed in lateral, left anterior right posterior, and right anterior left posterior plane during the various phases of the menstrual cycle to see the changes in VOR gain function and VOR gain asymmetry ratio changes. Results A repeated measure analysis of variance test did not show any significant main effect for the VOR gain function and VOR gain asymmetry ratio in various phases of the menstrual cycle in all the participants. The result suggested no changes in VOR gain function and VOR asymmetry ratio in healthy females during the menstrual cycle. Also, there was an absence of saccades in the entire participants group during the various phases of the menstrual cycle. Conclusions As the VOR gain function does not change during the various phases of the menstrual cycle in young healthy females, there is no need to consider the various phases of the menstrual cycle while testing any female participant during the vHIT test.


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