Effect of Aspirin Dose on Preeclampsia Prevention and Fetal-maternal Complications: A Randomized Clinical Trial

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Maryam Chamani ◽  
Saeid Shahrabi ◽  
Ali Malmir ◽  
Fereshteh Hassanzadeh
Keyword(s):  
Clinical Trial ◽  
Intrauterine Growth Restriction ◽  
Developmental Disorders ◽  
Treatment Process ◽  
Fetal Death ◽  
The Other ◽  
Intrauterine Fetal Death ◽  
P Value ◽  
Maternal Complications ◽  
Intrauterine Growth

Background: Preeclampsia (PE) is a disease characterized by abnormalities in the placenta and endothelial cells. The pathogenesis is not fully understood; however, aspirin prescription can be effective to treat the disease and prevent fetal developmental disorders. Methods: This study was performed as a clinical trial in Shahid Akbrabadi Hospital in Tehran city. Eighty patients participated in two groups (n = 40). The first group of patients received the dose of 80 mg, and the second group received the dose of 160 mg aspirin. Then, the fetal-maternal and treatment process complications were examined in the patients. Results: The results showed that the incidence of fetal-maternal complications, including intrauterine growth restriction (IUGR) and intrauterine fetal death (IUFD) was lower in patients treated with 160 mg aspirin than in the other group, but this difference was not statistically significant (P-value > 0.05). Aspirin complications such as bleeding were more in the second group than in the first one (P-value < 0.05). Conclusions: Although the increasing dose of aspirin reduces fetal-maternal complications in PE patients, the problems such as aspirin-induced bleeding should be considered.

scholarly journals Maternal and perinatal outcomes of hyperthyroidsm in pregnancy at Dr. Cipto Mangunkusumo Hospital, Jakarta, period of January 2015 - December 2016

2021 ◽  
Vol 29 (1) ◽  
pp. 36
Author(s):  
Fita Maulina ◽  
M Adya F F Dilmy ◽  
Ali Sungkar
Keyword(s):  
Pregnant Women ◽  
Preterm Delivery ◽  
Intrauterine Growth Restriction ◽  
Fetal Death ◽  
Perinatal Outcomes ◽  
Growth Restriction ◽  
Intrauterine Fetal Death ◽  
Adequate Treatment ◽  
Intrauterine Growth ◽  
In Pregnancy

Objectives: To report maternal and perinatal outcomes of hyperthyroidsm in pregnancy.Case Report: There were 3622 cases of delivering pregnant women during the period of the study. From this number, the prevalence of pregnant women with hyperthyroid was 0.2 %. We reported 9 cases of hyperthyroid in pregnancy. The number of pregnancy complication and outcome on pregnant women with hyperthyroidism were preterm labor (44%) and preeclampsia (22%), both were found in group of mother who did taking antihyperthyroid therapy. In those who did not take antihyperthyroid therapy 11% had spontaneous abortion and 11% had preterm delivery. Fetal complications were intrauterine growth restriction (11%) and intrauterine fetal death (23%), both of these complication were on the group who did not take antihyperthyroid. On the contrary, 44% babies were born with normal birthweight in group who took antihyperthyroid.Conclusion: There were differences noted between the group that took adequate treatment and the group that did not take antihyperthyroid. The incidence of intrauterine growth restriction and intrauterine fetal death were high in group that did not took antihyperthyroid therapy but the incidence of preterm delivery as the maternal complication was high in group that did take the antihyperthyroid therapy.  

Antiphosphatidylserine/prothrombin Antibodies in Antiphospholipid Syndrome with Intrauterine Growth Restriction and Preeclampsia

2018 ◽  
Vol 45 (9) ◽  
pp. 1263-1272 ◽  
Author(s):  
Valentina Canti ◽  
Stefania Del Rosso ◽  
Marta Tonello ◽  
Roberta Lucianò ◽  
Ariela Hoxha ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Lupus Erythematosus ◽  
Pregnancy Complications ◽  
Intrauterine Growth Restriction ◽  
Late Pregnancy ◽  
Additional Treatment ◽  
Growth Restriction ◽  
Intrauterine Fetal Death ◽  
Thrombotic Risk ◽  
Intrauterine Growth

Objective.Antibodies that recognize the phosphatidylserine/prothrombin complex (antiphosphatidylserine/prothrombin antibodies; aPS/PT) might reveal enhanced thrombotic risk in patients with systemic lupus erythematosus. Little is known about their association with pregnancy complications in the antiphospholipid syndrome (APS).Methods.We enrolled 55 patients with APS who were seeking pregnancy in 2 Italian hospitals. Antiphospholipid antibodies (aPL), including anticardiolipin antibodies, anti-β2-glycoprotein I antibodies, lupus-like anticoagulant, and aPS/PT antibodies were assessed, and the patients were prospectively followed for 24 months.Results.There were 65% (36/55) of the APS patients who had aPS/PT antibodies. Forty-seven pregnancies were followed, including 33 of aPS/PT+ patients. Forty-one of the 47 patients (87%) who initiated a pregnancy eventually gave birth to a child. The pregnancy duration and the mean newborn weight at delivery were significantly lower in aPS/PT+ than in aPS/PT− patients (33.1 ± 4.7 vs 36.2 ± 3.4 wks of gestation, respectively, and 2058 ± 964 g vs 2784 ± 746 g, respectively, p < 0.05). Late pregnancy complications, including intrauterine fetal death, preterm delivery, preeclampsia, and intrauterine growth restriction (IUGR), were more frequent in aPS/PT+ patients, independent of the therapy. Titers of aPS/PT IgG were significantly inversely correlated with the neonatal weight at delivery. Vascular injury, as reflected by thrombosis, fibrinoid necrosis, ischemic and hemorrhagic areas, and presence of chorangiomas characterized the IUGR placentas in the presence of aPS/PT.Conclusion.The aPS/PT antibodies might represent markers of aPL-related pregnancy complications, IUGR/preeclampsia in particular, and could help identify beforehand patients who may require additional treatment.

scholarly journals Physical activity during pregnancy and fetal outcomes: a case-control study

2010 ◽  
Vol 44 (1) ◽  
pp. 90-101 ◽  
Author(s):  
Monica Yuri Takito ◽  
Maria Helena D'Aquino Benício
Keyword(s):  
Physical Activity ◽  
Birth Weight ◽  
Preterm Birth ◽  
Low Birth Weight ◽  
Intrauterine Growth Restriction ◽  
Case Control Study ◽  
Growth Restriction ◽  
P Value ◽  
Intrauterine Growth ◽  
Control Study

OBJECTIVE: To investigate the relationship between physical activity during the second trimester pregnancy and low birth weight, preterm birth, and intrauterine growth restriction. METHODS: Case-control study including 273 low birth weight newborns and 546 controls carried out in the city of São Paulo, Southeastern Brazil, in 2005. Low birth weight cases were grouped into two subsamples: preterm birth (n=117) and intrauterine growth restriction (n=134), with their related controls. Information was collected by means of interviews with mothers shortly after birth and transcription of medical records. Data were analyzed using conditional multiple and hierarchical logistic regression. RESULTS: Light physical activity for over 7 hours per day was shown to be protective against low birth weight (adjusted OR=0.61; 95% CI 0.39-0.94) with a dose-response relationship (p-value for trend=0.026). A similar trend was found for intrauterine growth restriction (adjusted OR=0.51; 95% CI 0.26-0.97). Homemaking activities were associated as a protective factor for both low birth weight and preterm birth (p-value for trend=0.013 and 0.035, respectively). Leisure-time walking was found to be protective against preterm birth. CONCLUSIONS: Mild physical activity during the second trimester of pregnancy such as walking has an independent protective effect on low birth weight, preterm birth, and intrauterine growth restriction.

scholarly journals UTERINE ARTERY DOPPLER INDICES AS PREDICTIVE MEASURES FOR THE PRE-ECLAMPSIA AND INTRAUTERINE GROWTH RESTRICTION

2020 ◽  
Vol 2020 (1) ◽  
Author(s):  
MN Rashid ◽  
M Kari ◽  
R Rashid ◽  
MA Rana ◽  
A Amjad ◽  
...  
Keyword(s):  
Intrauterine Growth Restriction ◽  
Uterine Artery ◽  
Growth Restriction ◽  
Cross Sectional Survey ◽  
Maternal Complications ◽  
Cross Sectional ◽  
Uterine Artery Doppler ◽  
Intrauterine Growth ◽  
Pregnant Females ◽  
Doppler Indices

Preeclampsia and Intrauterine growth restriction (IUGR) remains as the important causes for the neonatal and maternal complications leading to even death in some cases. Uterine artery Doppler USG can be done transvaginally or trans abdominal and performed in the 1st or 2nd trimester of the pregnancy to detect these complications Doppler waveform suggested the high vascular resistance to blood flow. In our present study, we conclude uterine artery Doppler indices as prognostic procedure for the preeclampsia and intrauterine growth restriction. A cross-sectional survey design with convenient sampling technique was used. Mixture of standardized and self-modified structured questionnaire was undertaken to determine the indices of pre eclampsia and IUGR by uterine artery. The data was collected from Bahria International Hospital, Lahore during the period of 9 months. This study was included 162 pregnant females with identification of the main uterine artery on a longitudinal scan lateral to the uterus.  Initial diastolic notch of right and left side of the uterine artery waveforms was recorded. At every antenatal checkup, urine was tested for protein and blood pressure readings were taken to identify preeclampsia. Further analysis was done dividing patients as normotensive and those patients developing hypertension after 30 weeks of gestation. After delivery neonates observed for IUGR by head circumference and body weight. The study was concluded that from the total sample size of 162 pregnant females who undergoes uterine artery Doppler, 34% females shows diastolic notch and almost all of these later diagnosed with preeclampsia and 19.8% deliver babies with IUGR. So, based on the study, we have concluded that uterine artery Doppler is helpful to provide diagnosis of preeclampsia and IUGR in early pregnancy.

scholarly journals Comparison between use of combination of mifepristone and misoprostol versus misoprostol alone in the management of intrauterine fetal death

2018 ◽  
Vol 7 (7) ◽  
pp. 2778
Author(s):  
Sreeveena Talasani ◽  
Pran Hitha Venkamolla ◽  
Kalpana Betha
Keyword(s):  
Side Effects ◽  
Fetal Death ◽  
Intrauterine Fetal Death ◽  
P Value ◽  
Ultrasound Scan ◽  
Efficacy And Safety ◽  
Medical Sciences ◽  
The Mean ◽  
Group 2 ◽  
Group 1

Background: Intrauterine fetal death (IUFD) is estimated to occur in 1% of all pregnancies. The advent of prostaglandins has revolutionized the management of IUFD. There are limited studies using a combined regimen of mifepristone and misoprost for induction of labor in IUFD. Hence this study was undertaken to assess the efficacy and safety of combined regimen with misoprostol alone, in the management of IUFD.Methods: This hospital based prospective study included 60 pregnant women with IUFD admitted at Mediciti Institute of Medical Sciences, during the period January 2015 to July 2016. An ultrasound scan was performed to confirm IUFD and localize the placenta. Women were divided alternatively into 2 groups with 30 in each group (group 1- women received 200 mg mifepristone orally followed by misoprostol after 24 hours & in group 2, 100 µg misoprostol  every 6 hourly for a maximum of 4 doses between gestational age  24-26 weeks, 25-50 µg 4 hourly for a maximum of 6 doses beyond 26 weeks).Results: The mean induction to delivery interval was 10 hours in group 1 and 16.3 hours in group 2 (p value 0.007). Mean dose of misoprostol required in group 1 was 1.87 and 2.67 in group 2 (p value 0.008). With respect to side effects, the two groups did not differ significantly.Conclusions: The combined regimen was more effective than misoprostol for the induction of labour in IUFD, in terms of higher rate of successful delivery and shorter induction to delivery interval. 

Alpha hemoglobin stabilizing protein (AHSP) in hemolysis elevated liver enzyme and low platelet (HELLP) syndrome, intrauterine growth restriction (IUGR) and fetal death

2005 ◽  
Vol preprint (2007) ◽  
pp. 1
Author(s):  
Monica Emanuelli ◽  
Davide Sartini ◽  
Valentina Rossi ◽  
Alessandra Corradetti ◽  
Beatrice Landi ◽  
...  
Keyword(s):  
Liver Enzyme ◽  
Intrauterine Growth Restriction ◽  
Hellp Syndrome ◽  
Fetal Death ◽  
Elevated Liver Enzyme ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals Effect of Low Dose Aspirin in Low Risk Pregnant Ladies with Abnormal Uterine Artery Doppler Results, and the Evaluation of Maternal and Fetal outcomes: A Randomized Clinical Trial

2018 ◽  
pp. 85-89
Author(s):  
Parzhin Jalal Ali ◽  
Chro Najmaddin Fattah
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Uterine Artery ◽  
Low Dose ◽  
Low Risk ◽  
The Other ◽  
P Value ◽  
Uterine Artery Doppler ◽  
Dose Aspirin ◽  
Low Dose Aspirin

This study aimed to identify the effect of low dose aspirin administration in low risk pregnant ladies who have abnormal uterine artery Doppler results. Patients and Methods: A randomized clinical trial was performed on 50 pregnant ladies (≥16 weeks of gestation) in Sulaymaniyah Maternity Teaching Hospital during January 2017 to January 2018. The participants were randomly enrolled into two groups; the participants in the first group were given 100 mg of aspirin tablet each but the other group was given nothing. Results: Preeclampsia was significantly (P-value of <0.001) less in the aspirin group as compared to the other group (16% and 40% respectively). The pulsatility index (PI) was not significantly different in both the groups (P-value = 0.69), but resistance index (RI) was significantly lower in the aspirin group (P-value of <0.001). Conclusion: Doppler study of the uterine artery at 16 weeks or higher in low risk pregnant women appears to be useful as a screening test and low dose of aspirin therapy at early stage of pregnancy will decrease the incidence of preeclampsia.  

scholarly journals Trapped Placenta and Conceptus in Uterine Sacculation: Two Rare Case Reports

2013 ◽  
Vol 5 (2) ◽  
pp. 89-90
Author(s):  
MS Kokila ◽  
Akhilesh Dutta Dwivedi ◽  
H Indira ◽  
L Dwarakinath
Keyword(s):  
Intrauterine Growth Restriction ◽  
Rare Case ◽  
Fetal Death ◽  
Case Reports ◽  
Intrauterine Fetal Death ◽  
Fetal Demise ◽  
Retained Placenta ◽  
Emergency Situations ◽  
Uterine Curettage ◽  
Failed Induction

ABSTRACT Uterine sacculation is a very rare pregnancy complication having an incidence of about one in 3000 pregnancies. It is more commonly associated with retroverted uterus. Isolated sacculation either congenital or acquired is very rare. Without timely intervention, this can cause miscarriage, intrauterine fetal death, preterm delivery, uterine rupture, adherent/retained placenta and postpartum hemorrhage. Retained placenta is a common complication of congenital sacculation. Acquired sacculation occurs secondary to uterine surgeries, like uterine curettage, hysterotomy, cesarean section or following misoprost use. A rare case of retained placenta in the congenital uterine sacculation, first diagnosed during laparotomy done for failed manual removal of placenta, which was removed by hysterotomy. Another case with failed induction of abortion for intrauterine fetal demise and threatened rupture of acquired sacculation are reported. Awareness and early diagnosis of uterine sacculation allows clinicians to be prepared for emergency situations and better manage complications, to limit fetomaternal morbidity and mortality. Abbreviations IUGR: Intrauterine growth restriction; IUFD: Intrauterine fetal death. How to cite this article Kokila MS, Indira H, Dwivedi AD, Dwarakinath L. J South Asian Feder Obst Gynae 2013;5(2): 89-90.

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