Comparison of Virulence Factors of Different Candida Species Isolated from the Oral Cavity of Cancer Patients and Normal Individuals

Background Operating room slowdowns occur at specific intervals in the year as a cost-saving measure. We aim to investigate the impact of these slowdowns on the care of oral cavity cancer patients at a Canadian tertiary care centre.Methods A total of 585 oral cavity cancer patients seen between 1999 and 2015 at the London Health Science Centre (lhsc) Head and Neck Multidisciplinary Clinic were included in this study. Operating room hours and patient load from 2006 to 2014 were calculated. Our primary endpoint was the wait time from consultation to definitive surgery. Exposure variables were defined according to wait time intervals occurring during time periods with reduced operating room hours.Results Overall case volume rose significantly from 2006 to 2014 (p < 0.001), while operating room hours remained stable (p = 0.555). Patient wait times for surgery increased from 16.3 days prior to 2003 to 25.5 days in 2015 (p = 0.008). Significant variability in operating room hours was observed by month, with lowest reported for July and August (p = 0.002). The greater the exposure to these months, the more likely patients were to wait longer than 28 days for surgery (odds ratio per day [or]: 1.07, 95% confidence interval [ci]: 1.05 to 1.10, p < 0.001). Individuals seen in consultation preceding a month with below average operating room hours had a higher risk of disease recurrence and/or death (hazard ratio [hr]: 1.59, 95% ci: 1.10 to 2.30, p = 0.014).Conclusions Scheduled reductions in available operating room hours contribute to prolonged wait times and higher disease recurrence. Further work is needed to identify strategies maximizing efficient use of health care resources without negatively affecting patient outcomes.

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Candida spp. occurrence in oral cavities of breastfeeding infants and in their mothers' mouths and breasts

Pesquisa Odontológica Brasileira ◽

10.1590/s1517-74912003000200010 ◽

2003 ◽

Vol 17 (2) ◽

pp. 151-155 ◽

Cited By ~ 13

Author(s):

Maria Stella Amorim da Costa Zöllner ◽

Antonio Olavo Cardoso Jorge

Keyword(s):

Oral Cavity ◽

Candida Species ◽

Statistical Difference ◽

Control Group ◽

Biochemical Tests ◽

Candida Spp ◽

Lactating Women ◽

Sabouraud Agar ◽

Breastfed Infants ◽

Yeast Strains

This study aimed to determine the occurrence of Candida spp. in the oral cavity of predominantly breastfed infants and in their mothers' mouths and breasts, as well as in the oral cavity of bottlefed infants and in non-lactating women. One hundred and sixty nine women and eighty-five milk-fed infants took part in this study and were divided into four groups: 1) infants predominantly on breastfeeding (n = 55) and their mothers (n = 55); 2) infants on bottlefeeding (n = 30); 3) non-lactating women on whom oral collections were performed (n = 80) and, 4) non-lactating women on whom breast collections were performed (n = 34). Oral and mammary swabs were cultured on Sabouraud agar dextrose with chloramphenicol. The Candida yeast strains found were isolated and identified through morphological and biochemical tests. Candida species were much less frequent in infants who were predominantly breastfed than in those who were bottlefed. Yeasts were much more frequent on the breasts of lactating women, with statistical difference in relation to the control group.

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UP-2.025: Virulence Factors and Susceptibility Patterns of Candida Species Isolated from Patients with Obstructive Uropathy and Bladder Carcinoma

Urology ◽

10.1016/j.urology.2009.07.244 ◽

2009 ◽

Vol 74 (4) ◽

pp. S240

Author(s):

T. El-Leithy ◽

N. Fam ◽

M. El-Saeed

Keyword(s):

Virulence Factors ◽

Bladder Carcinoma ◽

Candida Species ◽

Obstructive Uropathy ◽

Susceptibility Patterns

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Impact of microsatellite alteration in surgical margins on local recurrence in oral cavity cancer patients

European Archives of Oto-Rhino-Laryngology ◽

10.1007/s00405-016-4215-y ◽

2016 ◽

Vol 274 (1) ◽

pp. 431-439 ◽

Cited By ~ 3

Author(s):

Jin-Ching Lin ◽

Chen-Chi Wang ◽

Rong-San Jiang ◽

Wen-Yi Wang ◽

Shih-An Liu

Keyword(s):

Local Recurrence ◽

Oral Cavity ◽

Cancer Patients ◽

Oral Cavity Cancer ◽

Surgical Margins

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Molecular characterization of Candida dubliniensis and Candida albicans in the oral cavity of drug abusers using duplex polymerase chain reaction

Current Medical Mycology ◽

10.18502/cmm.4.1.29 ◽

2018 ◽

Vol 4 (1) ◽

Cited By ~ 1

Author(s):

Parastoo Hassani Abharian ◽

Parvin Dehghan ◽

Peyman Hassani Abharian ◽

Sepideh Tolouei

Keyword(s):

Polymerase Chain Reaction ◽

Candida Albicans ◽

Oral Cavity ◽

Candida Species ◽

Species Complex ◽

Candida Dubliniensis ◽

Drug Abusers ◽

Chain Reaction ◽

Polymerase Chain ◽

Duplex Polymerase Chain Reaction

Background and Purpose: Candida dubliniensis is closely related to the most pathogenic and prevalent yeast, namely C. albicans. Candida species can opportunistically overgrow in vulnerable individuals and cause a variety of diseases. The current study aimed to identify and isolate C. dubliniensis species present in the Candida albicans species complex identified in the oral cavity of drug abusers. Materials and Methods: This study was conducted on 53 strains of C. albicans species complex, isolated from the oral mucosa of drug abusers in Isfahan, Iran. DNA extraction was accomplished through boiling procedure. Duplex polymerase chain reaction (PCR) was performed to amplify ITS1-5.8S-ITS2 region using four specific primers. Fungal species were identified based on the difference in the size of the bands created in the Agarose gel. Results: Out of the 53 isolates under study, 30 (56.6%) and 14 (26.4%) samples were identified as C. albicans and C. dubliniensis, respectively. In the remaining 9 samples (17%), both types of Candida species were confirmed. Conclusion: The findings of the present study revealed the presence of a noticeable amount of C. dubliniensis in the oral cavity of drug abusers. Therefore, the probable presence of this fungus should be considered during the examination of oral infection among this group. To date, no research has directly investigated this issue in Iran.

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