Malignant Adenomyoepithelioma of the Breast With Malignant Proliferation of Epithelial and Myoepithelial Elements

2000 ◽  
Vol 124 (4) ◽  
pp. 632-636 ◽  
Author(s):  
Atif A. Ahmed ◽  
Debra S. Heller
Keyword(s):  
Light Microscopy ◽  
Distant Metastasis ◽  
Mitotic Rate ◽  
Myoepithelial Cells ◽  
Current Case ◽  
Cytologic Atypia ◽  
Rare Neoplasm ◽  
Local Invasion ◽  
Rare Lesion

Abstract Malignant adenomyoepithelioma of the breast is a rare lesion characterized by malignant proliferation of epithelial and myoepithelial cells that show characteristic histologic and immunohistochemical features. Eleven cases have been reported, 4 of which showed evidence of distant metastasis. The authors report a case of malignant adenomyoepithelioma in the axillary tail of a 71-year-old woman, one of the oldest patients described so far, and review the literature. Malignancy in the current case was evidenced by the presence of local invasion, high mitotic rate, and severe cytologic atypia. The tumor was associated with adenosis and lobular adenomyoepithelial hyperplasia. Malignant adenomyoepithelioma is a rare neoplasm, diagnosable by light microscopy and immunohistochemistry. To date, it has only been reported in women, who ranged in age from 26 to 76 years. Metastases have only been documented in tumors 2.0 cm in diameter or larger.

scholarly journals Soft tissue myoepithelial carcinoma

2006 ◽  
Vol 63 (6) ◽  
pp. 611-614 ◽  
Author(s):  
Zorica Stojsic ◽  
Dimitrije Brasanac ◽  
Dragoljub Bacetic ◽  
Radmila Jankovic ◽  
Neda Drndarevic
Keyword(s):  
Soft Tissue ◽  
Cell Types ◽  
Giant Cells ◽  
Myoepithelial Cells ◽  
High Grade ◽  
Myoepithelial Carcinoma ◽  
Cytologic Atypia ◽  
S 100 ◽  
Myxoid Matrix ◽  
Subcutaneous Adipose

Background. Myoepitheliomas are tumors composed predominantly or exclusively of myoepithelial cells, usually arising in salivary glands. Cutaneous/soft tissue localization is very rare, especially for the malignant myoepitheliomas. Case report. We presented a case of myoepithelial carcinoma involving subcutaneous adipose tissue of the left forearm in a woman aged 62 years. The tumor was composed of epithelioid and hyaline cell types, arranged in diffuse sheets, nests and loose clusters within hyalinized and myxoid matrix. The neoplasm displayed high-grade cytologic atypia with some cells having pleomorphic, hyperchromatic nuclei, and others showing vesicular nuclei, large nucleoli with scattered bizarre giant cells. High mean mitotic count of 7 mitoses/10 high power fields and extensive necrosis favored the diagnosis of malignancy. Immunohistochemical staining was positive for cytokeratin (AE1/AE3), epithelial membrane antigen, S-100 protein, glial fibrillary acidic protein, and vimentin. Conclusion. Considering the subcutaneous localization, myoepithelial immunophenotype and high-grade cytologic atypia the neoplasm was classified as a soft-tissue myoepithelial carcinoma.

scholarly journals Angiosarcoma of the lung

2016 ◽  
Vol 42 (1) ◽  
pp. 68-70 ◽  
Author(s):  
Mónica Grafino ◽  
Paula Alves ◽  
Margarida Mendes de Almeida ◽  
Patrícia Garrido ◽  
Direndra Hasmucrai ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Vascular Tumor ◽  
Pulmonary Involvement ◽  
Hematogenous Metastasis ◽  
Rare Neoplasm ◽  
Local Invasion

Angiosarcoma is a rare malignant vascular tumor. Pulmonary involvement is usually attributable to metastasis from other primary sites, primary pulmonary angiosarcoma therefore being quite uncommon. We report a case of angiosarcoma with pulmonary involvement, probably primary to the lung, which had gone untreated for more than two years. We describe this rare neoplasm and its growth, as well as the extensive local invasion and hematogenous metastasis at presentation. We also discuss its poor prognosis.

scholarly journals Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

Cancer Cell ◽  
2009 ◽  
Vol 15 (3) ◽  
pp. 220-231 ◽  
Author(s):  
Marta Pàez-Ribes ◽  
Elizabeth Allen ◽  
James Hudock ◽  
Takaaki Takeda ◽  
Hiroaki Okuyama ◽  
...  
Keyword(s):  
Distant Metastasis ◽  
Antiangiogenic Therapy ◽  
Malignant Progression ◽  
Local Invasion

Laryngeal salivary duct carcinoma

1981 ◽  
Vol 95 (7) ◽  
pp. 731-738 ◽  
Author(s):  
A. Ferlito ◽  
N. Gale ◽  
H. Hvala
Keyword(s):  
Light Microscopy ◽  
Myoepithelial Cells ◽  
Salivary Duct Carcinoma ◽  
Salivary Duct ◽  
Carcinoma Of The Breast ◽  
Duct Carcinoma

SummaryThe light microscopic and ultrastructural features of a laryngeal salivary duct carcinoma are presented. By light microscopy, the neoplasm bore a marked resemblance to the infiltrating duct carcinoma of the breast. Ultrastructurally, the tumour was characterized by the presence of two principal types of cells, i.e. epithelial and myoepithelial cells, arranged in duct-formation.

Ultrastructural observations on stumpy (stm,) a new chondrodystrophic mutant in the mouse

Development ◽  
1977 ◽  
Vol 39 (1) ◽  
pp. 279-284
Author(s):  
D. R. Johnson
Keyword(s):  
Electron Microscopy ◽  
Light Microscopy ◽  
Tight Junctions ◽  
Cell Membranes ◽  
Mitotic Rate ◽  
Close Approximation ◽  
Old Mice ◽  
Wide Zone

Stumpy (stm) is a new chondrodystrophic mutant in the mouse. Light microscopy of cartilage reveals a slightly increased mitotic rate, more chondrocytes than is usual per lacuna and a wide zone of hypertrophy. Electron microscopy shows that many chondrocytes are in close approximation with some tight junctions: in cartilage from 14-day-old mice there is much interdigitation and folding of the cell membranes of adjacent chondrocytes.

Fibrous histiocytoma of the larynx

1998 ◽  
Vol 112 (12) ◽  
pp. 1205-1207 ◽  
Author(s):  
M. Saleem ◽  
P. D. McArthur ◽  
B. Hainau ◽  
S. B. Velagapudi
Keyword(s):  
Distant Metastasis ◽  
Fibrous Histiocytoma ◽  
Malignant Tumour ◽  
Young Female ◽  
Growth Potential ◽  
Low Grade ◽  
Biological Behaviour ◽  
Rare Lesion

AbstractWe present a case of fibrous histiocytoma of the larynx in a young female who presented eight years ago and is still alive and well with no evidence of any regional invasion or distant metastasis. This rare lesion has been described in 30 cases previously of which 26 were malignant and four benign. Our case is unusual in a sense that histologically it has not been possible to determine its exact biological behaviour and growth potential. However, clinically it behaved as a low-grade malignant tumour.

scholarly journals METASTASIS AND LOCAL INVASION PATTERN OF BLADDER CANCER IN HASAN SADIKIN HOSPITAL

2018 ◽  
Vol 25 (2) ◽  
Author(s):  
Akhmad Mustafa ◽  
Ferry Safriadi
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Distant Metastasis ◽  
Transitional Cell ◽  
Nodal Metastasis ◽  
Common Site ◽  
Local Invasion ◽  
Distant Organ Metastasis ◽  
Organ Metastasis ◽  
Distant Organ

Objective: The aim of this study is to provide database about local invasion and metastasis pattern, as well as the disease characteristics of bladder cancer in Hasan Sadikin Hospital, Bandung. Material & Methods: Between January 2011 and December 2016 there were 321 cases of bladder cancer recorded in our hospital. Of all cases, 106 patients included in this study, with evident of local invasion or distant metastasis either radiologically (contrast abdominal pelvic CT scan) or pathologically. Results: The study group consist of 106 patients (86 men [81.7%], 20 women [28.3%]); with mean age of 56.78 ± 13.19 (4-76) years old. Histopathology findings of transitional cell carcinoma (TCC) consist of 82 (77.3%) patients and the atypical histology features group of 24 (22.7%) patients. Local invasion was found in 99 patients of 321 (30.8%), with the most common organ invasion to the prostate in male (n=38 [35.8%]). Lymph node metastasis were found in 47 patients (44.3%), with the most common nodal metastasis to obturator lymph nodes (n=21 [19.8%]). Distant metastasis was found in 24 patients (22.6%) with the most common site for distant metastasis was the liver (n=12 [11.3%]). In TCC group, 12 patients (63.1%) had a distant organ metastasis with nodal metastasis, whereas in atypical group, majority of the patients with distant organ metastasis (n=5 [83.3%]) had no lymph node involvement. Moreover, in transitional cell group, not all patient (n=17 [73.1%]) had local invasion of the tumor, while all patients with distant organ metastasis in atypical group (n=6 [100%]) had abdominal or pelvic wall invasion (cT4b). Conclusion: TCC is the most common pathology findings and with Prostate is the most common site for local tumor invasion. Obturator lymph nodes is the most common nodal metastasis and liver is the most common site for distant metastasis in bladder cancer. 

Primary Cutaneous Adenomyoepithelioma Ex Spiradenoma With Malignant Histologic Features, Epithelial-Myoepithelial Carcinoma Type: A First Case Report With Molecular Studies

2019 ◽  
Vol 28 (4) ◽  
pp. 427-435
Author(s):  
Tien Anh N. Tran ◽  
Julia A. Bridge ◽  
Sophie J. Deharvengt ◽  
Donald C. Green ◽  
Konstantinos Linos
Keyword(s):  
Subcutaneous Tissue ◽  
Myoepithelial Cells ◽  
Myoepithelial Carcinoma ◽  
Current Case ◽  
Ample Evidence ◽  
First Case ◽  
Molecular Studies ◽  
Genetic Aberration ◽  
Epithelial Myoepithelial Carcinoma ◽  
First Time

Adenomyoepithelioma is an extremely rare primary cutaneous neoplasm. Although there is ample evidence on the existence of malignant adenomyoepithelioma in the breast, a malignant counterpart in the skin has not been documented. We report a primary cutaneous adenomyoepithelioma (pcAME) with malignant features arising from a spiradenoma in a 39-year-old female patient. The tumor was solid-cystic in appearance and entirely located in the subcutaneous tissue. Histologically, the tumor displayed foci of adenomatous changes and adenomyoepitheliomatous hyperplasia adjacent to a minute spiradenoma. Gradual increase of architectural complexity, cytologic atypia, mitotic activity, and infiltrative growth were observed in a significant portion of the neoplasm, indicative of transformation to adenomyoepithelioma and subsequently low- to high-grade salivary-type epithelial-myoepithelial carcinoma (EMCA). The intimate dual populations of ductal and myoepithelial cells were highlighted by a panel of immunohistochemical stains in all different components of the tumor. Molecular studies revealed a PIKCA3 mutation, a genetic aberration that has been documented in EMCA, particularly of breast origin. The current case documents for the first time a pcAME with malignant features arising from a spiradenoma and suggests adenomyoepithelioma ex spiradenoma as a possible tumorigenesis pathway of this rare cutaneous tumor.

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