Langerhans Cell Histiocytosis: A Clinicopathologic Review and Molecular Pathogenetic Update
2015 ◽
Vol 139
(10)
◽
pp. 1211-1214
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Keyword(s):
Langerhans cell histiocytosis (LCH) comprises a wide spectrum of clinical disorders that have in common a proliferation of Langerhans-type cells with characteristic morphologic, immunophenotypic, and ultrastructural features. In part because of the diverse clinical manifestations of LCH, there has long been controversy over whether LCH is best considered a reactive process or a neoplasm. Herein, we discuss the clinical and pathologic features of LCH, including recent advances in the understanding of the molecular pathogenesis of this disease that support its categorization as a neoplasm. We also review the implications that these recently described molecular characteristics may have on risk stratification and treatment of LCH.
2017 ◽
Vol 26
(2)
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pp. 194-196
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2020 ◽
Vol 12
(3)
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pp. 79-86
Keyword(s):
2021 ◽