scholarly journals Pharmacokinetics of gallic acid following oral administration of Triphala formulation in rats

2021 ◽  
Vol 15 (8) ◽  
pp. 132-137
Author(s):  
Jumpa-ngern Piracha ◽  
Plengsuriyakarn Tullayakorn ◽  
Na-Bangchang Kesara
Keyword(s):  
Oral Administration ◽  
Gallic Acid

scholarly journals Development of a HPLC-MS/MS Method to Determine 11 Bioactive Compounds in Tongmai Yangxin Pill and Application to a Pharmacokinetic Study in Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Jiayuan Shen ◽  
Juan Wei ◽  
Li Li ◽  
Huizi Ouyang ◽  
Yanxu Chang ◽  
...  
Keyword(s):  
Oral Administration ◽  
Gallic Acid ◽  
Bioactive Compounds ◽  
Glycyrrhizic Acid ◽  
Multiple Reaction Monitoring ◽  
Rat Plasma ◽  
Plasma Samples ◽  
Mass System ◽  
Mobile Phases ◽  
Negative Ionization

A sensitive and reliable HPLC-MS/MS method has been developed and validated for simultaneous determination of eleven bioactive compounds (rhein, emodin, stilbene glycoside, liquiritin, ononin, verbascoside, gallic acid, schisandrin, liquiritigenin, glycyrrhizic acid, and isoliquiritigenin) in rat plasma after oral administration of Tongmai Yangxin Pill. The collected plasma samples were prepared by liquid-liquid extraction with ethyl acetate after acidification. Eleven compounds were separated on a CORTECS™ C18 column with mobile phases consisting of 0.1% formic acid in deionized water and acetonitrile. The flow rate was 0.3 mL/min. The detection was performed on a tandem mass system with an electrospray ionization (ESI) source in both positive and negative ionization using multiple-reaction monitoring (MRM) mode. The calibration curves were linear over the range of 8-2000 ng/mL for glycyrrhizic acid; 4-1000 ng/mL for liquiritin; 0.8-200 ng/mL for emodin, gallic acid, ononin, schisandrin, and stilbene glycoside; 0.4-100 ng/mL for isoliquiritigenin, liquiritigenin, rhein, and verbascoside, respectively. The intra- and interday precision of the analytes were less than 9.3% and 8.5%. The intra- and interday accuracy were in the range of -14.0% to 10.3% and -6.5% to 9.6%. Meanwhile, the extraction recovery of the analytes in plasma samples ranged from 85.2% to 109.1% and matrix effect from 89.2% to 113.4%. The developed method was successfully applied to the pharmacokinetics of eleven bioactive compounds in rat plasma after oral administration of Tongmai Yangxin Pill prescription.

Subchronic toxicity study of gallic acid by oral administration in F344 rats

2001 ◽  
Vol 39 (11) ◽  
pp. 1063-1070 ◽  
Author(s):  
N Niho ◽  
M Shibutani ◽  
T Tamura ◽  
K Toyoda ◽  
C Uneyama ◽  
...  
Keyword(s):  
Oral Administration ◽  
Gallic Acid ◽  
Toxicity Study ◽  
Subchronic Toxicity ◽  
F344 Rats

scholarly journals Oral Administration of Rosa gallica Prevents UVB−Induced Skin Aging through Targeting the c−Raf Signaling Axis

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1663
Author(s):  
Seongin Jo ◽  
Young-Sung Jung ◽  
Ye-Ryeong Cho ◽  
Ji-Won Seo ◽  
Won-Chul Lim ◽  
...  
Keyword(s):  
Oral Administration ◽  
Gallic Acid ◽  
Aging Effect ◽  
Mek Inhibitor ◽  
Skin Aging ◽  
Primary Component ◽  
Active Components ◽  
Rosa Gallica ◽  
Signaling Axis

Rosa gallica is a widely used Rosa species for medicinal and culinary purposes. Rosa gallica has been reported to display antioxidant, anti−inflammatory, and antibacterial activities. However, the effect of Rosa gallica against skin aging in vivo is unknown and its active components have not been fully understood. Oral administration of Rosa gallica prevented UVB−mediated skin wrinkle formation and loss of collagen/keratin fibers in the dorsal skin of mice. Examination of biomarkers at the molecular level showed that Rosa gallica downregulates UVB−induced COX−2 and MMP−1 expression in the skin. Through a direct comparison of major compounds identified using the UHPLC−MS/MS system, we discovered gallic acid as the primary component contributing to the anti-skin aging effect exhibited by Rosa gallica. Examination of the molecular mechanism revealed that gallic acid can potently and selectively target the c−Raf/MEK/ERK/c−Fos signaling axis. In addition, both gallic acid and MEK inhibitor blocked UVB−induced MMP−1 expression and restored collagen levels in a reconstructed 3D human skin model. Collectively, Rosa gallica could be used as a functional ingredient in the development of nutraceuticals against skin aging.

scholarly journals The Tissue Distribution and Urinary Excretion Study of Gallic Acid and Protocatechuic Acid after Oral Administration of Polygonum Capitatum Extract in Rats

Molecules ◽  
2016 ◽  
Vol 21 (4) ◽  
pp. 399 ◽  
Author(s):  
Feng-Wei Ma ◽  
Qing-Fang Deng ◽  
Xin Zhou ◽  
Xiao-Jian Gong ◽  
Yang Zhao ◽  
...  
Keyword(s):  
Oral Administration ◽  
Urinary Excretion ◽  
Tissue Distribution ◽  
Gallic Acid ◽  
Protocatechuic Acid ◽  
Excretion Study

scholarly journals Simultaneous Quantification of Gallic Acid, Bergenin, Epicatechin, Epicatechin Gallate, Isoquercitrin, and Quercetin-3-Rhamnoside in Rat Plasma by LC-MS/MS Method and Its Application to Pharmacokinetics after Oral Administration of Ardisia japonica Extract

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xie-an Yu ◽  
John Teye Azietaku ◽  
Jin Li ◽  
Hui Wang ◽  
Fang Zheng ◽  
...  
Keyword(s):  
Oral Administration ◽  
Gallic Acid ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Epicatechin Gallate ◽  
Chinese Medicinal Herb ◽  
Elution Time ◽  
Internal Standards ◽  
Negative Ionization Mode ◽  
Negative Ionization

Ardisia japonica is a well-known traditional Chinese medicinal herb used as a diuretic, for treating cough and for stopping uterine bleeding. A simple, sensitive, and reliable LC-MS/MS method was developed to determine six active compounds in rat plasma and this method was further applied to the pharmacokinetic study of these compounds after oral administration of Ardisia japonica extract. Acetonitrile was used to precipitate the protein in the plasma samples. Using acetonitrile and formic acid aqueous solution (0.05%) as the mobile phase, the separation of the six compounds and internal standards was achieved at a flow rate of 300 μL min−1 on an Eclipse plus C18 column at an elution time of 16 min. A tandem mass spectrometer having an electrospray ionization (ESI) source was used in the detection of the analytes and internal standards using multiple reactions monitoring (MRM) in the negative ionization mode. The LLOQ was 2, 2, 4, 2, 1, and 0.4 ng mL−1 for gallic acid, bergenin, epicatechin, epicatechin gallate, isoquercitrin, and quercetin-3-rhamnoside, respectively. The validated method was applied to the pharmacokinetic study of gallic acid, bergenin, and quercetin-3-rhamnoside in rat plasma after oral administration of A. japonica extract to rats.

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