Influence of the formulation on the maximum tolerated doses of brain targeted nanoparticles of gallic acid by oral administration in Wistar rats

2013 ◽  
Vol 65 (12) ◽  
pp. 1757-1764 ◽  
Author(s):  
Kalpana Nagpal ◽  
Shailendra Kumar Singh ◽  
Dinanath Mishra
Keyword(s):  
Oral Administration ◽  
Gallic Acid ◽  
Wistar Rats ◽  
Targeted Nanoparticles

3,4,5-Trihydroxybenzoic acid attenuates ligature-induced periodontal disease in Wistar rats.

2020 ◽  
Vol 19 ◽  
Author(s):  
Ozkan Karatas ◽  
Fikret Gevrek
Keyword(s):  
Bone Loss ◽  
Gallic Acid ◽  
Wistar Rats ◽  
Alveolar Bone ◽  
Alveolar Bone Loss ◽  
Collagenase Activity ◽  
Osteoblastic Activity ◽  
Cell Counts ◽  
Experimental Periodontitis ◽  
Anti Inflammatory

Background: 3,4,5-Trihydroxybenzoic acid, which is also known as gallic acid, is an anti-inflammatory agent who could provide beneficial effects in preventing periodontal inflammation. The present study aimed to evaluate the anti-inflammatory effects of gallic acid on experimental periodontitis in Wistar rats. Alveolar bone loss, osteoclastic activity, osteoblastic activity, and collagenase activity were also determined. Methods: 32 Wistar rats were used in the present study. Study groups were created as following: Healthy control (C,n=8) group; periodontitis (P,n=8) group; periodontitis and 30 mg/kg gallic acid administered group (G30,n=8); periodontitis and 60 mg/kg gallic acid administered group (G60,n=8). Experimental periodontitis was created by placing 4-0 silk sutures around the mandibular right first molar tooth. Morphological changes in alveolar bone were determined by stereomicroscopic evaluation. Mandibles were undergone histological evaluation. Matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1, bone morphogenetic protein (BMP)-2 expressions, tartrate-resistant acid phosphatase (TRAP) positive osteoclast cells, osteoblast, and inflammatory cell counts were determined. Results: Highest alveolar bone loss was observed in the periodontitis group. Both doses of gallic acid decreased alveolar bone loss compared to the P group. TRAP-positive osteoclast cell counts were higher in the P group, and gallic acid successfully lowered these counts. Osteoblast cells also increased in gallic acid administered groups. Inflammation in the P group was also higher than those of C, G30, and G60 groups supporting the role of gallic acid in preventing inflammation. 30 and 60 mg/kg doses of gallic acid decreased MMP-8 levels and increased TIMP-1 levels. BMP levels increased in gallic acid administered groups, similar to several osteoblasts. Conclusion: Present results revealed an anti-inflammatory effect of gallic acid, which was indicated by decreased alveolar bone loss and collagenase activity and increased osteoblastic activity.

Combination of donepezil and gallic acid improves antioxidant status and cholinesterases activity in aluminum chloride-induced neurotoxicity in Wistar rats

2021 ◽  
Author(s):  
Tajudeen O. Obafemi ◽  
Olutumise V. Owolabi ◽  
Benjamin O. Omiyale ◽  
Blessing A. Afolabi ◽  
Oluwafemi A. Ojo ◽  
...  
Keyword(s):  
Gallic Acid ◽  
Aluminum Chloride ◽  
Antioxidant Status ◽  
Wistar Rats

scholarly journals RESVERATROL INCLUSION COMPLEX WITH β-CYCLODEXTRIN (RCD): CHARACTERIZATION AND EVALUATION OF TOXICITY IN WISTAR RATS

2016 ◽  
Vol 9 (1) ◽  
pp. 27 ◽  
Author(s):  
V. S. K. Nishihira ◽  
N. J. Mezzomo ◽  
M. D. Baldissera ◽  
R. A. Vaucher ◽  
C. G. Pinto ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Oral Administration ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Metabolic Diseases ◽  
Hematological Parameters ◽  
Density Lipoprotein ◽  
Blood Parameters ◽  
Control Group ◽  
Scanning Calorimetry

<p class="RSCB01ARTAbstract"><strong>Objective</strong>:<strong> </strong>The aim of this study was to characterise the resveratrol inclusion complex with β-cyclodextrin (RCD) and evaluate their toxicity in wistar rats.</p><p class="RSCB01ARTAbstract"><strong>Methods: </strong>The RCD were prepared in ultra-turrax. For characterization of the RCD were used: Fourier transform infra-red Spectroscopy, Nuclear Magnetic Resonance (NMR), Differential Scanning Calorimetry (DSC) and X-ray powder diffraction. The RCD and others 4 treatments were performed by the chronic oral administration in 35 rats during 60 ds. After the treatments they were euthanized and the serum blood were collected to analyzed some hemogram and biochemical parameters including aspartyl aminotransferase (AST); alanine aminotransferase (AST); phosphatase alkaline (ALP); total bilirubin (TB); direct bilirubin (DB); total protein (TP); total cholesterol (TC), triacylglycerol (TAG), very low-density lipoprotein (VLDL), high-density lipoprotein (HDL), calcium, iron and phosphate using fully automated biochemistry analyzer.</p><p class="RSCB01ARTAbstract"><strong>Results: </strong>The characterization results indicated a successful formation of the RCD. All hematological parameters analysed were within the normal values in all the groups. Furthermore, the hemogram and biochemical parameters were significantly (P&gt;0.05) similar to the control group.</p><p class="RSCB01ARTAbstract"><strong>Conclusion: </strong>The daily oral administration during 60 d of RCD are not harmful on blood parameters of Wistar rats. Thus, RCD can be used safely for treatment of some metabolic diseases.</p>

scholarly journals Effect of the oral administration of monosodium glutamate during pregnancy and breast-feeding in the offspring of pregnant Wistar rats

2010 ◽  
Vol 25 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Vinicius von Diemen ◽  
Manoel Roberto Maciel Trindade
Keyword(s):  
Weight Gain ◽  
Oral Administration ◽  
Wistar Rats ◽  
Monosodium Glutamate ◽  
The Other ◽  
Control Group ◽  
Pregnant Rats ◽  
Dependent Relation ◽  
Dose Dependent

PURPOSE: Determine the effects of the MSG (monosodium glutamate) in the offspring of pregnant rats through the comparison of the weight, NAL (nasal-anal length) and IL (Index of Lee) at birth and with 21 days of life. METHODS: Pregnant Wistar rats and their offspring were divided into 3 groups: GC, G10 and G20. Each of the groups received 0%, 10% and 20% of MSG, respectively from coupling until the end of the weaning period. RESULTS: Neither weight nor NAL were different among the groups at birth. The group G20 at birth had an IL lower than the group GC (p<0,05) and with 21 days of life presented weight and NAL lower than the groups G10 and this lower than the GC (p<0,01). Otherwise the G20 at 21 days of life had the IL similar to the other two groups. The weight profit percentage from birth to the 21st day of life was lower in the G20 regarding the other two groups (p<0,01). The G20 had a NAL increase percentage from birth to the 21st day of life lower than the G10 and this lower than the GC (p<0,01). CONCLUSIONS: MSG presented a dose-dependent relation in the variables weight and NAL. It caused a decrease in the growth pattern as well as in the weight gain pattern until the 21st day of life. The IL of the group 20% had an increased in relation to the control group after 3 weeks of follow up.

scholarly journals Subchronic toxcity study of Khaya senegalensis aqueous extract in rats

2021 ◽  
Vol 41 (1) ◽  
pp. 235-243
Author(s):  
K. T. Biobaku ◽  
A. A. Yusuf ◽  
F. M. Mshelbwala ◽  
E. S. Ajibola ◽  
B. S Okediran ◽  
...  
Keyword(s):  
Blood Cell ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Haemoglobin Concentration ◽  
Glucose Levels ◽  
Khaya Senegalensis ◽  
High Doses ◽  
Group B

This study was carried out to investigate the sub chronic effects of oral administration of different doses: 100mg/kg, 400mg/kg, l600mg/kg, 6400mg/kg of aqueous extract of Khaya senegalensis in wistar rats. The rats were randomly separated to groups "A-G". The group "A" was considered as a non treated control. The other groups B, C, D and E respectively, were test groups and were treated with the extract. The biochemical and haematological parameters were assessed after 21 days of oral administration of the extract. The liver, kidney, pancreas, and heart of various experimental rats were harvested and preserved. The parenchymal tissues were fixed and using a microtome prepared to slides. Histopathological changes were observed using standard methods. There were no significant differences in white blood cell (WBC), Differential leucocytes count (DLC), haemoglobin concentration, packed cell volume (PCV) and Red Blood Cell count (RBC) respectively. There was however a significant (P<0.05) decrease in the serum Alanine amino transferase (ALT) in groups B, C and D and also a significant (p<0.05) decrease in AST levels in group B and E. The blood glucose levels also decreased significantly (P<0.05) in groups concentration in groups C, D, and E. Histopathological examination showed moderate degenerative changes and congestions in the livers and kidneys and pancreas in all treated groups. This gave an insiglht on the effects of oral administration of an aqueous extract of Khaya senegalensis on the haematological and biochemical parameters, with the related tissue pathology, in experimental wistar rats. Conclusion could be made that care should be taken in prolonged administration of high doses of aqueous extract of  Khaya senegalensis man and animals.

scholarly journals Evaluation of Efficacy of Cucumis melo in Gentamycin and CPD Induced Urolithiasis on Rats

2021 ◽  
Vol 11 (1-s) ◽  
pp. 113-116
Author(s):  
Dhaval M Patel ◽  
Advaita B Patel ◽  
Bhumi R Patel ◽  
Deepa R Patel ◽  
Nishith K Patel
Keyword(s):  
Oral Administration ◽  
Calcium Oxalate ◽  
Analysis Of Variance ◽  
Cucumis Melo ◽  
Wistar Rats ◽  
Renal Excretion ◽  
Methanolic Extract ◽  
Urinary Oxalate ◽  
Calcium Oxalate Urolithiasis ◽  
Oxalate Synthesis

Evaluation of the efficacy of methanolic extract of Cucumis melo in urolithiasis induced by gentamycin and calculi producing diet on Wistar rats. Gentamycin (40 mg/kg, subcutaneously) and calculi-producing diet (CPD) was fed to induce urolithiasis on Wistar rats. The effect of oral administration of methanolic extract of Cucumis melo seed on calcium oxalate urolithiasis has been studied and is compared with the effect of oral administration of Cystone as standard on Wistar rats. Gentamycin and CPD feeding resulted in hyperoxaluria and calcium oxalate deposition as well as increased renal excretion of calcium and oxalate. Supplementation with methanolic extract of Cucumis melo seed reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The results indicate that the seed of Cucumis melo is endowed with antiurolithiatic activity. Keywords: C. melo, Hyperoxaluria, calcium oxalate deposition, cystone, hyperoxaluria, analysis of variance

scholarly journals Free and liposome form of gallic acid improves calvarial bone wound healing in Wistar rats

2020 ◽  
Vol 10 (4) ◽  
pp. 156 ◽  
Author(s):  
Ahmet Altan ◽  
HaticeBalci Yuce ◽  
Őzkan Karataş ◽  
MehmetMurat Taşkan ◽  
Fikret Gevrek ◽  
...  
Keyword(s):  
Wound Healing ◽  
Gallic Acid ◽  
Wistar Rats ◽  
Calvarial Bone

Hormonal assays following oral administration of bonny light crude oil on male wistar rats

2013 ◽  
Vol 12 (2) ◽  
pp. 53
Author(s):  
VictorA Fischer ◽  
ChristieE Fischer ◽  
Mfon Akpaso ◽  
OladapoA Ashiru
Keyword(s):  
Oral Administration ◽  
Crude Oil ◽  
Wistar Rats ◽  
Light Crude Oil ◽  
Male Wistar Rats
Sign in / Sign up

Export Citation Format

Share Document