A Case Study - NeuBase Therapeutics, Inc.

2021 ◽  
Vol 26 (2) ◽  
Author(s):  
Dietrich A. Stephan
Keyword(s):  
Gene Function ◽  
Genetic Defects ◽  
New Class ◽  
Genetic Revolution

NeuBase is accelerating the genetic revolution by developing a new class of precision genetic medicines which can be designed to increase, decrease, or change gene function, as appropriate, to resolve genetic defects that drive disease.

Hierarchical multi-label classification with SVMs: A case study in gene function prediction

2014 ◽  
Vol 18 (4) ◽  
pp. 717-738 ◽  
Author(s):  
Peerapon Vateekul ◽  
Miroslav Kubat ◽  
Kanoksri Sarinnapakorn
Keyword(s):  
Gene Function ◽  
Function Prediction ◽  
Gene Function Prediction

Tudor Silver-Gilt Dress-hooks: A New Class of Treasure Find in England

2002 ◽  
Vol 82 ◽  
pp. 157-196 ◽  
Author(s):  
David Gaimster ◽  
Maria Hayward ◽  
David Mitchell ◽  
Karen Parker
Keyword(s):  
Sixteenth Century ◽  
Social Status ◽  
Historical Archaeology ◽  
Gender Bias ◽  
New Class ◽  
Documentary Sources

This paper combines a study of the typological, technological and constructional attributes of a sample of fifteen dress-hooks and cap-hooks, reported between 1998 and 2000 under the terms of the Treasure Act (1996), with a survey of contemporary pictorial sources, probate inventories and associated wills along with a trawl of ‘small wares’ in the records of the Goldsmiths' Company in order to assess the role of these accessories in vernacular dress of sixteenth-century England.Of particular interest are questions of manufacture and design, followed by the questions of how these objects functioned in relation to the closure and decoration of dress, their noteworthiness in contemporary accounts, their social status, their ranking in the output of contemporary goldsmiths and whether there was a gender bias in terms of their ownership. This cross-examination of excavated finds with contemporary iconographie and documentary sources represents an interdisciplinary case study in historical archaeology.

Reduction of Stress in Plastic Compliant Mechanisms by Introducing Metallic Reinforcement

2017 ◽  
Author(s):  
Joshua Crews ◽  
Ashok Midha ◽  
Lokeswarappa R. Dharani
Keyword(s):  
Stress Relaxation ◽  
Compliant Mechanisms ◽  
Experimental Testing ◽  
Testing Device ◽  
Bending Stress ◽  
New Class ◽  
Metallic Reinforcement ◽  
Creep And Stress Relaxation

A method is provided and validated for redesigning compliant segments to improve their fatigue, creep, and stress relaxation performance. The method reduces the bending stress in the polymer portion of the compliant segment without the need for overall mechanism redesign, by introducing metallic reinforcement and by matching the force-deflection response of the redesigned segment to that of the baseline segment. An example redesign case study is presented and validated with experimental testing using a unique deflection testing device designed for fixed-free compliant mechanisms. This vein of research is undertaken using metallic reinforcement (inserts) toward the development of a new class of compliant mechanisms with significantly greater performance, particularly insofar as the problems of fatigue and creep are concerned.

Pushing the Envelope of Residual Oil Measurement: A Field Case Study of a New Class of Inter-Well Chemical Tracers

2016 ◽  
Author(s):  
Modiu Sanni ◽  
Mohammed Al-Abbad ◽  
Sunil Kokal ◽  
Øyvind Dugstad ◽  
Sven Hartvig ◽  
...  
Keyword(s):  
Residual Oil ◽  
Field Case ◽  
Chemical Tracers ◽  
New Class

scholarly journals Transcriptional coregulators: emerging roles of SRC family of coactivators in disease pathology

2014 ◽  
Vol 53 (2) ◽  
pp. R47-R59 ◽  
Author(s):  
Subhamoy Dasgupta ◽  
Bert W O'Malley
Keyword(s):  
Gene Expression ◽  
Nuclear Receptors ◽  
Genetic Defects ◽  
Environmental Cues ◽  
Biological Functions ◽  
Regulate Gene Expression ◽  
New Class ◽  
Transcriptional Coregulators ◽  
Almost All ◽  
Regulate Gene

Transcriptional coactivators have evolved as an important new class of functional proteins that participate with virtually all transcription factors and nuclear receptors (NRs) to intricately regulate gene expression in response to a wide variety of environmental cues. Recent findings have highlighted that coactivators are important for almost all biological functions, and consequently, genetic defects can lead to severe pathologies. Drug discovery efforts targeting coactivators may prove valuable for treatment of a variety of diseases.

scholarly journals Enviromics in breeding: applications and perspectives on envirotypic-assisted selection

2019 ◽  
Author(s):  
Rafael T. Resende ◽  
Hans-Peter Piepho ◽  
Orzenil B. Silva-Junior ◽  
Fabyano F. e Silva ◽  
Marcos Deon V. de Resende ◽  
...  
Keyword(s):  
Genotype By Environment Interaction ◽  
Environment Interaction ◽  
New Class ◽  
Strategic Plans ◽  
Environmental Attributes ◽  
Current Perspective ◽  
Genetic Resources Management ◽  
Definition Of ◽  
Experimental Trials

AbstractGenotype by Environment interaction (G × E) studies have focused mainly on estimating genetic parameters over a limited number of experimental trials. However, recent Geographic Information System (GIS) techniques have opened new frontiers for understanding and dealing with G × E. These advances allow increasing selection accuracy across all sites of interest, including those where experimental trials have not yet been deployed. Here, we introduce the term Enviromics under an envirotypic-assisted breeding framework and propose the GIS-GE method, i.e. a geospatial tool to maximize genetic gains by predicting the phenotypic performance of unobserved genotypes using “enviromic markers”. In summary, a particular site represents a set of envirotypes, each one representing a set of environmental factors that interact with the genetic background of genotypes, thus resulting in informative re-rankings to make decisions over different environments. Based on a simulated case study, we show that GIS-GE allows accurate (i) matching of genotypes to their most appropriate sites; (ii) definition of breeding areas that have high genetic correlation to ensure selection gains across environments; and (iii) indication of the best sites to carry out experiments for further analysis based on environments that maximize heritability. Envirotyping techniques provide a new class of markers for genetic studies, which are inexpensive, increasingly available and transferable across species. We envision a promising future for the integration of the Enviromics approach into breeding when coupled with next-generation genotyping/phenotyping and powerful statistical modeling of genetic diversity. Environmental scenarios can also be improved using information from strategic plans for biodiversity and genetic resources management, especially in the current perspective of dynamic climate change.Key messageWe propose the application of Enviromics to breeding practice, by which the similarity among sites assessed on an “omics” scale of environmental attributes drives the prediction of unobserved genotypes.

scholarly journals Agricultural Model for Allocation of Crops Using Pollination Intelligence Method

2020 ◽  
Vol 2020 ◽  
pp. 1-6 ◽  
Author(s):  
C. N. Ejieji ◽  
A. E. Akinsunmade
Keyword(s):  
Decision Making ◽  
Iterative Scheme ◽  
Market Price ◽  
New Class ◽  
Intelligence Algorithm ◽  
Land Using

An agricultural model for allocation of crops is considered in this work using Pollination Intelligence Method. The model was constructed to solve farmer’s decision making in allocating crops to a piece of land using market price, known yield of crops, cost incurred during planting, and the total amount of land available. A new class of metaheuristic method called Flower Pollinated Algorithm is also presented in this work to solve the designed model. An improved version of the Flower Pollinated Algorithm called Pollination Intelligence Algorithm using an iterative scheme to override the switch parameter in Flower Pollinated Algorithm is also presented and used in solving the designed model. A case study of a farmer in Ife, Osun State, Nigeria, was used to implement the model, and the results obtained suggested that instead of allocating crops to land randomly based on farmer’s intuition, cost of planting, yield of crops, and market price were factors that must be considered by farmers for optimal profit before planting crops.

A Case Study: Treatment of Refractory Schizoaffective Disorder with Aripiprazole

2005 ◽  
Vol 21 (3) ◽  
pp. 150-153
Author(s):  
Joseph A De Soto ◽  
Aneela Kazi ◽  
Alejandro Rivera ◽  
AB Wilson Muhammad
Keyword(s):  
Schizoaffective Disorder ◽  
Mmse Score ◽  
Partial Agonist ◽  
Haloperidol Decanoate ◽  
New Class ◽  
Initial Injection ◽  
History Of ◽  
Novel Drug ◽  
State Examination

Objective: To report the use of aripiprazole in the treatment of refractory schizoaffective disorder. Case Summary: A 42-year-old African American male with a 10-year history of schizoaffective disorder decompensated while being treated with haloperidol decanoate 200 mg intramuscularly per month and valproic acid 500 mg twice daily. Upon admission, his Global Assessment of Function scale (GAF) score was 10 and his Mini-Mental State Examination (MMSE) score was 2. He was treated with an initial injection of haloperidol decanoate 100 mg and, thereafter, with haloperidol 5 mg orally twice a day. He remained refractory to haloperidol and, on day 14, chlorpromazine 150 mg/day was added. The patient continued to show no response. On day 20, oral aripiprazole 15 mg was substituted for haloperidol and chlorpromazine. Forty-eight hours later, the GAF score was 30 and the MMSE score was 18. Ninety-six hours after receiving aripiprazole, the GAF and MMSE scores were 40 and 26, respectively. Discussion: Aripiprazole has been approved for the treatment of schizophrenia and bipolar disorder; however, it has not been approved for treatment of schizoaffective disorder. Aripiprazole is a novel drug representing a new class of agents used for the treatment of psychosis. Aripiprazole is a partial agonist at the dopamine D2 and serotonin 5-HT1A receptors, but an antagonist at the serotonin 5-HT2A receptors. Conclusions: Aripiprazole may be useful in treatment of refractory schizoaffective disorder.

Pushing the envelope of residual oil measurement: A field case study of a new class of inter-well chemical tracers

2018 ◽  
Vol 163 ◽  
pp. 538-545 ◽  
Author(s):  
Modiu Sanni ◽  
Mohammed Al-Abbad ◽  
Sunil Kokal ◽  
Øyvind Dugstad ◽  
Sven Hartvig ◽  
...  
Keyword(s):  
Residual Oil ◽  
Field Case ◽  
Chemical Tracers ◽  
New Class

scholarly journals Mutations that affect the survival of selected amacrine cell subpopulations define a new class of genetic defects in the vertebrate retina

2005 ◽  
Vol 285 (1) ◽  
pp. 138-155 ◽  
Author(s):  
Andrei Avanesov ◽  
Ralf Dahm ◽  
William F. Sewell ◽  
Jarema J. Malicki
Keyword(s):  
Amacrine Cell ◽  
Genetic Defects ◽  
Vertebrate Retina ◽  
New Class ◽  
Cell Subpopulations
Sign in / Sign up

Export Citation Format

Share Document