scholarly journals Anti-fibrotic effects of rosmarinic acid on Tenon’s capsule fibroblasts stimulated with TGF-β: therapeutic potential in ocular surgery

2020 ◽  
Vol 83 (4) ◽  
Author(s):  
Carolina Maria Módulo ◽  
Larissa Domenegueti Ferreira ◽  
Lilian Eslaine Costa Mendes da Silva ◽  
Marco Andrey Cipriani Frade ◽  
Peter Sol Reinach ◽  
...  
Keyword(s):  
Rosmarinic Acid ◽  
Therapeutic Potential ◽  
Ocular Surgery ◽  
Tenon’S Capsule ◽  
Tenon's Capsule

scholarly journals Necrotizing Streptococcus pyogenes Infiltrating Conjunctiva and Tenon’s Capsule: A Case Report

2021 ◽  
pp. 146-149
Author(s):  
Dalton de Freitas Santoro ◽  
Murilo Ubukata Polizelli ◽  
Paulo Alberto Cervi Rosa ◽  
Denise de Freitas ◽  
Luciene Barbosa de Sousa ◽  
...  
Keyword(s):  
Case Report ◽  
Streptococcus Pyogenes ◽  
Purulent Discharge ◽  
Ocular Surgery ◽  
Topical Antibiotics ◽  
Tenon’S Capsule ◽  
Dense Membrane ◽  
Intravenous Antibiotics ◽  
Uncommon Condition ◽  
Tenon's Capsule

We report a case of a patient with necrotizing infection of the conjunctiva and Tenon’s capsule caused by <i>Streptococcus pyogenes</i>, a rare and atypical ophthalmologic condition. A 50-years-old male patient with acute red-eye, purulent discharge, and pain diagnosed with post-septal cellulitis presented with a yellowish and dense membrane covering the ocular surface with necrotic Tenon’s capsule. Patient was hospitalized, and intravenous antibiotics were initiated (ceftriaxone and clindamycin). Topical antibiotics and corticosteroids were also administered, and the infection was eradicated in 2 weeks. Ancillary exams excluded rheumatologic involvement. Conjunctival culture confirmed <i>Streptococcus pyogenes</i> growth. Tenon’s biopsy revealed unspecific acute inflammatory necrosis. This is an uncommon condition in daily ophthalmological clinic. Literature review reported 3 cases associated with previous ocular surgery.

Impact of age, sex and refractive error on conjunctival and Tenon’s capsule thickness dimensions by swept-source optical coherence tomography in a large population

2021 ◽  
Author(s):  
José Ignacio Fernández-Vigo ◽  
Hang Shi ◽  
Bárbara Burgos-Blasco ◽  
Lucía De-Pablo-Gómez-de-Liaño ◽  
Ignacio Almorín-Fernández-Vigo ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Refractive Error ◽  
Large Population ◽  
Optical Coherence ◽  
Swept Source ◽  
Tenon’S Capsule ◽  
Tenon's Capsule ◽  
Capsule Thickness

Comparison of Intravitreal versus Posterior Sub–Tenon’s Capsule Injection of Triamcinolone Acetonide for Diffuse Diabetic Macular Edema

Ophthalmology ◽  
2005 ◽  
Vol 112 (9) ◽  
pp. 1557-1563 ◽  
Author(s):  
José A. Cardillo ◽  
Luiz A.S. Melo ◽  
Rogério A. Costa ◽  
Mirian Skaf ◽  
Rubens Belfort ◽  
...  
Keyword(s):  
Macular Edema ◽  
Triamcinolone Acetonide ◽  
Diabetic Macular Edema ◽  
Tenon’S Capsule ◽  
Diffuse Diabetic Macular Edema ◽  
Tenon's Capsule

A sub-Tenon’s capsule injection of lidocaine induces extraocular muscle akinesia and mydriasis in dogs

2013 ◽  
Vol 196 (1) ◽  
pp. 103-108 ◽  
Author(s):  
J.S. Ahn ◽  
M.B. Jeong ◽  
Y.W. Park ◽  
Y.S.R. Lee ◽  
E.R. Lee ◽  
...  
Keyword(s):  
Extraocular Muscle ◽  
Tenon’S Capsule ◽  
Tenon's Capsule

Effects of varying 5-fluorouracil exposure duration on Tenon's capsule fibroblasts

2001 ◽  
Vol 29 (4) ◽  
pp. 248-252 ◽  
Author(s):  
Michael B Merriman ◽  
Justin S Mora ◽  
Brent W Beaumont ◽  
Mervyn J Merrilees
Keyword(s):  
Exposure Duration ◽  
Tenon’S Capsule ◽  
Tenon's Capsule

scholarly journals Effect of Lignocaine Concentration on Human Fibroblasts Growth in Eyes Undergoing Trabeculectomy: An in vitro Study

2018 ◽  
Vol 3 (3) ◽  
pp. 1-10 ◽  
Author(s):  
Madhuravasal Krishnan Janani ◽  
Venkatakrishnan Jaichandran ◽  
Hajib Narahari Rao Madhavan ◽  
Lingam Vijaya ◽  
Ronnie Jacob George ◽  
...  
Keyword(s):  
Culture Medium ◽  
In Vitro Model ◽  
Morphological Changes ◽  
Human Fibroblasts ◽  
Annexin V ◽  
In Vitro Study ◽  
Tenon’S Capsule ◽  
Tenon's Capsule ◽  
Vitro Model

Purpose: To evaluate the effect of lignocaine on growth and apoptosis indication of primary human Tenon’s capsule fibroblast (HTFs) in an in vitro model. Patients and Methods: Tenon’s capsule tissue obtained from patients undergoing trabeculectomy were grown in cell culture medium. The effect of different concentrations of lignocaine (0.5, 1.0, 1.5, and 2%) on the morphology and growth of the fibroblasts was studied using microscopy, cell viability, and proliferation assay, and apoptosis was detected using the FITC Annexin V Apoptosis Kit. Results: Morphological changes similar to those of apoptotic cells, including cytoplasmic vacuolation, shrinkage, and rounding were visualized in the cells treated with concentrations greater than 1.0% (i.e., 1.5, 2.0%). Though proliferation inhibition was found with all four concentrations (0.5–2.0%), the viability of cells decreased from 1.0% lignocaine. Conclusion: 0.5% lignocaine prevents proliferation of fibroblasts without causing apoptosis in vitro.

scholarly journals Biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulphated derivatives

2016 ◽  
Vol 62 (1) ◽  
pp. 22-30 ◽  
Author(s):  
A.M. Popov ◽  
O.N. Krivoshapko ◽  
A.A. Klimovich ◽  
A.A. Artyukov
Keyword(s):  
Type 2 Diabetes ◽  
Biological Activity ◽  
Lipid Metabolism ◽  
Phenolic Compounds ◽  
Rosmarinic Acid ◽  
Therapeutic Potential ◽  
Experimental Studies ◽  
Therapeutic Action ◽  
Carbohydrate And Lipid Metabolism

The review considers recent experimental studies of biological activity and mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives in diseases associated with disorders of carbohydrate and lipid metabolism. Particular attention is focused on the results of studies showing a high therapeutic potential of these phenolic compounds in their prophylactic and therapeutic use at experimental modeling of type 2 diabetes and hyperlipidemia. Based on the analysis of our results and the literature data putative mechanisms of therapeutic action of rosmarinic acid, luteolin and its sulfated derivatives have been proposed.

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