scholarly journals Protective effects of methanol extract of Plukenetia conophora seeds and 4H-Pyran-4-One 2,3-Dihydro-3,5-Dihydroxy-6-Methyl on the reproductive function of male Wistar rats treated with cadmium chloride

2018 ◽  
Author(s):  
Olugbemi Tope Olaniyan ◽  
Olufadekemi Tolulope Kunle-Alabi ◽  
Yinusa Raji
Keyword(s):  
Cadmium Chloride ◽  
Wistar Rats ◽  
Methanol Extract ◽  
Reproductive Function ◽  
Protective Effects ◽  
Male Wistar Rats

scholarly journals Ameliorative Effect of Aqueous Leaf Extract of Moringa oleifera on Reproductive Function Following Cadmium Chloride Induced Oxidative Stress in Male Wistar Rats

2019 ◽  
Vol 11 (4) ◽  
pp. 352-357 ◽  
Author(s):  
Avwerosuoghene ODODO ◽  
Sunday O. OJEKA ◽  
Victor D. DAPPER
Keyword(s):  
Oxidative Stress ◽  
Cadmium Chloride ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Reproductive Function ◽  
Testicular Tissue ◽  
Cellular Damage ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract

Cadmium disrupts the blood-testes barrier, interferes with various antioxidant levels thus enhancing lipid peroxidation and ultimately leading to apoptosis and necrosis of testicular tissue. Moringa oleifera is a medicinal plant and a rich source of essential phytochemicals possessing antioxidant properties. The effect of aqueous leaf extract of M. oleifera on reproductive function following cadmium chloride induced oxidative stress in male Wistar rats was investigated. Forty adult male Wistar rats were assigned into five groups of eight rats each. Treatment was administered orally daily as follows: Group 1 (control): animal feed and tap water ad libitum; Group 2: 5 mg kg-1 cadmium chloride for 21 days; Group 3: 500 mg kg-1 of M. oleifera and 5 mg kg-1 of cadmium chloride for 21 days; Group 4: 5 mg kg-1 cadmium chloride for 21 days followed by 500 mg kg-1 M. oleifera for the next 35 days; Group 5: 5 mg kg-1 cadmium chloride for 21 days followed by 750 mg kg-1 M. oleifera for the next 35 days. At the end of treatment, blood was obtained by direct cardiac puncture for fertility hormone assay and testicular tissue specimens were harvested for semen analysis and determination of antioxidant levels. Results obtained indicated that rats treated with the various extracts had significantly increased superoxide dismutase, malondialdehyde and catalase levels, increased serum concentrations of testosterone, follicle stimulating hormone and luteinizing hormone and increased percentage of viable and normal spermatozoa compared to control and only cadmium chloride treated rats (p < 0.05). The results obtained suggest that treatments with M. oleifera extract could ameliorate possible cellular damage caused by administration of cadmium chloride.

Graded doses of grape seed methanol extract attenuated ataxic movement, cerebellocortical toxicity, and impairment following chronic carbamazepine treatment in male Wistar rats

2020 ◽  
pp. 107484
Author(s):  
Opeyemi Samson Osuntokun ◽  
Adeniyi Jacob Ademinkanra ◽  
Tope Gafar Atere ◽  
Gbola Olayiwola ◽  
Kabiru Isola Adedokun ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Methanol Extract ◽  
Grape Seed ◽  
Male Wistar Rats

The psoralens adversely affect reproductive function in male wistar rats

2001 ◽  
Vol 15 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Moussa M. Diawaraa ◽  
Kathryn J. Chavez ◽  
Doug Simpleman ◽  
David E. Williams ◽  
Michael R. Franklin ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Function ◽  
Male Wistar Rats

Role of recombinant human erythropoietin against mitomycin C-induced cardiac, hepatic and renal dysfunction in Wistar rats

2014 ◽  
Vol 34 (5) ◽  
pp. 468-478 ◽  
Author(s):  
K Rjiba-Touati ◽  
I Ayed-Boussema ◽  
A Belarbia ◽  
M Mokni ◽  
A Achour ◽  
...  
Keyword(s):  
Body Weight ◽  
Renal Dysfunction ◽  
Mitomycin C ◽  
Recombinant Human Erythropoietin ◽  
Wistar Rats ◽  
Protective Effects ◽  
Normal Tissues ◽  
Human Erythropoietin ◽  
Male Wistar Rats ◽  
Glutamyl Transferase

Mitomycin C (MMC) is one of the most effective chemotherapeutic drugs. However, the dose of MMC is greatly limited by its toxicity in normal tissues. Recombinant human erythropoietin (rhEPO), an erythropoietic hormone, has also been shown to exert tissue protective effects. The purpose of this study was to explore the protective effect of rhEPO against MMC-induced heart, liver, and renal dysfunction. Adult male Wistar rats were divided into six groups (with six animals each), namely control, rhEPO alone group, MMC alone group, and rhEPO + MMC group (pre-, co-, and posttreatment conditions). The results showed that MMC induced a marked cardiac, renal, and liver failure characterized by a significant decrease in body weight, organs weight, and organs ratio and a significant increase in creatinine, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transferase, and conjugated and total bilirubin levels in serum. Histological examination showed that MMC caused liver alterations. rhEPO treatment restored body weight, organs weight, and organs ratio as well as serum biochemical parameters and histological damage caused by MMC exposure.

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