The psoralens adversely affect reproductive function in male wistar rats

2001 ◽  
Vol 15 (2) ◽  
pp. 137-144 ◽  
Author(s):  
Moussa M. Diawaraa ◽  
Kathryn J. Chavez ◽  
Doug Simpleman ◽  
David E. Williams ◽  
Michael R. Franklin ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Reproductive Function ◽  
Male Wistar Rats

scholarly journals Ameliorative Effect of Aqueous Leaf Extract of Moringa oleifera on Reproductive Function Following Cadmium Chloride Induced Oxidative Stress in Male Wistar Rats

2019 ◽  
Vol 11 (4) ◽  
pp. 352-357 ◽  
Author(s):  
Avwerosuoghene ODODO ◽  
Sunday O. OJEKA ◽  
Victor D. DAPPER
Keyword(s):  
Oxidative Stress ◽  
Cadmium Chloride ◽  
Wistar Rats ◽  
Leaf Extract ◽  
Moringa Oleifera ◽  
Reproductive Function ◽  
Testicular Tissue ◽  
Cellular Damage ◽  
Male Wistar Rats ◽  
Aqueous Leaf Extract

Cadmium disrupts the blood-testes barrier, interferes with various antioxidant levels thus enhancing lipid peroxidation and ultimately leading to apoptosis and necrosis of testicular tissue. Moringa oleifera is a medicinal plant and a rich source of essential phytochemicals possessing antioxidant properties. The effect of aqueous leaf extract of M. oleifera on reproductive function following cadmium chloride induced oxidative stress in male Wistar rats was investigated. Forty adult male Wistar rats were assigned into five groups of eight rats each. Treatment was administered orally daily as follows: Group 1 (control): animal feed and tap water ad libitum; Group 2: 5 mg kg-1 cadmium chloride for 21 days; Group 3: 500 mg kg-1 of M. oleifera and 5 mg kg-1 of cadmium chloride for 21 days; Group 4: 5 mg kg-1 cadmium chloride for 21 days followed by 500 mg kg-1 M. oleifera for the next 35 days; Group 5: 5 mg kg-1 cadmium chloride for 21 days followed by 750 mg kg-1 M. oleifera for the next 35 days. At the end of treatment, blood was obtained by direct cardiac puncture for fertility hormone assay and testicular tissue specimens were harvested for semen analysis and determination of antioxidant levels. Results obtained indicated that rats treated with the various extracts had significantly increased superoxide dismutase, malondialdehyde and catalase levels, increased serum concentrations of testosterone, follicle stimulating hormone and luteinizing hormone and increased percentage of viable and normal spermatozoa compared to control and only cadmium chloride treated rats (p < 0.05). The results obtained suggest that treatments with M. oleifera extract could ameliorate possible cellular damage caused by administration of cadmium chloride.

scholarly journals Effect of an Aqueous Extract of Alchornea Cordifolia (Euphorbiacea) Leaves on Sperm Parameters and Reproductive Function of Male Wistar Rats

2021 ◽  
Vol 17 (17) ◽  
Author(s):  
Kone Allassane ◽  
Gnahoue Goueh ◽  
Diabate Daouda ◽  
Kouakou Koffi
Keyword(s):  
Traditional Medicine ◽  
Reproductive System ◽  
Wistar Rats ◽  
Sperm Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Reproductive Function ◽  
Positive Effects ◽  
Male Wistar Rats ◽  
Reproductive Male

Alchornea cordifolia (euphorbiaceae) is a tree whose leaves are used in traditional medicine to cure several health problems. Little information, however, exist on the effects of this herb on the male reproductive system. In order to assess the effect of Alchornea cordifolia on reproductive male parameters and testosterone production, twenty-four male wistar rats divided into four groups of six rats were used. The aqualus extract of Alchornea cordifolia was administered at a dose of 100 mg/kg of bw, 200 mg/kg of bw, and 400 mg/kg of bw per day, orally for 60 days. A significant increase in androgen-dependent organs, testosterone quantity, mobility, and sperm concentration was observed at doses of 200 mg/kg of bw and 400 mg/kg of bw. Only the unwinger sperm count significantly increased at the 100 mg/kg of bw dose. These results revealed that the aqualius extract of the leaves of Alchornea cordifolia has the potential to improve sperm quality and have positive effects on the reproductive system.

scholarly journals MORPHOFUNCTIONAL CHARACTERISTICS OF TESTES IN WHITE RATS TREATED WITH BISPHENOL A AND TRICLOSAN

2018 ◽  
Vol 26 (4) ◽  
pp. 32-34
Author(s):  
S. V. Chigrinets ◽  
G. V. Bryuhin ◽  
S. N. Zavyalov
Keyword(s):  
Bisphenol A ◽  
Wistar Rats ◽  
Reproductive Function ◽  
Testicular Tissue ◽  
Seminiferous Tubules ◽  
White Rats ◽  
Comparison Groups ◽  
Negative Effect ◽  
Male Wistar Rats ◽  
Sexually Mature

We studied the effect of unstable ubiquitous endocrine disrupters bisphenol A (BPA) and triclosan (TCS) on the reproductive function of adult male Wistar rats. BPA and TCS concentrations were measured directly in testicular tissue by gas chromatography with mass spectrometry (GC-MS). Comparison groups were found to be statistically significantly different in the concentrations of bisphenol A and triclosan in testicular tissues. The study showed that bisphenol A and triclosan have a negative effect on the morphofunctional state of the male reproductive glands of sexually mature rats, causing a decrease in testicular mass, a decrease in parenchyma, the number and diameter of the seminiferous tubules, an increase in the number of convoluted seminiferous tubules with desquamated epithelium, and a decrease in sperm cells on the background of an increase in their atypical forms.

scholarly journals Effect of dietary supplementation with soybean on reproductive hormones of male Wistar rats

2021 ◽  
Vol 13 (2) ◽  
pp. 134-139
Author(s):  
Yahya Anisah ◽  
I.Y. Mohammed ◽  
M. El-Bashir Jibril
Keyword(s):  
Wistar Rats ◽  
Controlled Trial ◽  
Reproductive Function ◽  
Dietary Supplementation ◽  
Study Groups ◽  
Reproductive Hormones ◽  
Control Group ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Randomised Controlled

Dietary soybean has been shown to have variable effects on the reproductive system of male rodents, non-human primates and humans. These effects can affect subsequent fertility. Soybean intake in men has been advocated due to its protective effect in the prevention of prostate cancer, cardiovascular disease and osteo-arthritis. However, the protection it offers in the prevention of prostatic cancer by altering the levels of male reproductive hormones may lead to infertility. This study aimed at determining the effect of dietary supplementation with soybean on reproductive hormones of male Wistar rats. The study was a randomised controlled trial. Adult male Wistar rats were randomly assigned to a control group and two study groups. The rats in the control group were fed on soy-free diet while rats in Group 1 and Group 2 of the study were fed on 20% and 50% soybean supplemented diet for four weeks. Serum concentration of FSH, LH and Testosterone were estimated. Data obtained was analysed using statistical package for social sciences (SPSS) version 20.0.There was no statistically significant difference (p<0.05) in the level of FSH (p=0.783), LH (p=0.815)and Testosterone (p=0.330) between the study and control groups. Dietary supplementation with of soybean has no effect on the level of FSH, LH and Testosterone in male Wistar rats and therefore may not affect their reproductive function. 

Structural and functional renal alterations in five-sixth nephrectomized rats on unrestricted diet

1986 ◽  
Vol 44 ◽  
pp. 342-343
Author(s):  
I. Stachura ◽  
M. Pardo ◽  
J. Costello ◽  
D.M. Landwehr
Keyword(s):  
Wistar Rats ◽  
Renal Damage ◽  
Standard Diet ◽  
Experimental Conditions ◽  
Phosphate Intake ◽  
Dietary Restrictions ◽  
Severe Reduction ◽  
Male Wistar Rats ◽  
Unrestricted Diet ◽  
Progressive Renal Insufficiency

Under experimental conditions severe reduction of renal mass results in the hyperfiltration of the remaining nephrons leading to a progressive renal insufficiency. Similar changes are observed in patients with various renal disorders associated with a loss of the functioning nephrons. The progression of renal damage is accelerated by high protein and phosphate intake, and may be modified by the dietary restrictions.We studied 50 five-sixth nephrectarrized male Wistar rats on a standard diet (Rodent Laboratory Chow 5001 Ralston Purina Co., Richmond, Indiana; containing 23.4% protein) over a 20 week period.

Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats

2020 ◽  
pp. 1-6 ◽  
Author(s):  
Masoud Nasiri ◽  
Saja Ahmadizad ◽  
Mehdi Hedayati ◽  
Tayebe Zarekar ◽  
Mehdi Seydyousefi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Wistar Rats ◽  
Enzymatic Antioxidants ◽  
Acute Response ◽  
Total Antioxidant ◽  
Male Wistar Rats ◽  
Exercise Induced ◽  
And Control

Abstract. Physical exercise increases free radicals production; antioxidant supplementation may improve the muscle fiber’s ability to scavenge ROS and protect muscles against exercise-induced oxidative damage. This study was designed to examine the effects of all-trans resveratrol supplementation as an antioxidant to mediate anti-oxidation and lipid per-oxidation responses to exercise in male Wistar rats. Sixty-four male Wistar rats were randomly divided into four equal number (n = 16) including training + supplement (TS), training (T), supplement (S) and control (C) group. The rats in TS and S groups received a dose of 10 mg/kg resveratrol per day via gavage. The training groups ran on a rodent treadmill 5 times per week at the speed of 10 m/min for 10 min; the speed gradually increased to 30 m/min for 60 minutes at the end of 12th week. The acute phase of exercise protocol included a speed of 25 m/min set to an inclination of 10° to the exhaustion point. Superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activity, non-enzymatic antioxidants bilirubin, uric acid, lipid peroxidation levels (MDA) and the total antioxidant capacity (TAC) were measured after the exercise termination. The data were analyzed by using one-way ANOVA. The result showed that endurance training caused a significant increase in MDA level [4.5 ± 0.75 (C group) vs. 5.9 ± 0.41 nmol/l (T group)] whereas it decreased the total antioxidant capacity [8.5 ± 1.35 (C group) vs. 7.1 ± 0.55 mmol/l (T group)] (p = 0.001). In addition, GPx and CAT decreased but not significantly (p > 0.05). The training and t-resveratrol supplementation had no significant effect on the acute response of all variables except MDA [4.3 ± 1.4 (C group) vs. 4.0 ± 0.90 nmol/l (TS group)] (p = 0.001) and TAC [8.5 ± 0.90 (C group) vs. 6.6 ± 0.80 mmol/l (TS group)] (p = 0.004). It was concluded that resveratrol supplementation may prevent exercise-induced oxidative stress by preventing lipid peroxidation.

Augurin stimulates food intake in male Wistar rats

2013 ◽  
pp. 1-1
Author(s):  
Michael Patterson ◽  
John Tadross ◽  
Keisuke Suzuki ◽  
Kylie Beale ◽  
Charoltte Boughton ◽  
...  
Keyword(s):  
Food Intake ◽  
Wistar Rats ◽  
Male Wistar Rats

Pengaruh Profilaksis Ekstrak Ubi Jalar Ungu (Ipomoea batatas L.) terhadap Kadar Malondialdehida Hepar Tikus Putih (Rattus norvegicus) Jantan Galur Wistar yang Diinduksi Karagenan

2018 ◽  
Vol 15 (2) ◽  
pp. 146
Author(s):  
BRILIAN DINANTI ◽  
FITRI HANDAJANI
Keyword(s):  
Sweet Potato ◽  
Ipomoea Batatas ◽  
Wistar Rats ◽  
Group Method ◽  
Control Group ◽  
Intraplantar Injection ◽  
Significant Difference ◽  
Male Wistar Rats ◽  
Potato Extract ◽  
Purple Sweet Potato

<p>Liver is an organ with complex metabolism. When the liver is inflamed, cellular immunity will defend against inflammatory agents by stimulating immune cells to produce reactive oxygen species (ROS). Excessive ROS accumulation cause oxydative stress with increased  liver malondialdehyde (MDA) level. Some researches showed that purple sweet potato contain flavonoids (anthocyanins) that functioned as antioxydants. This study aimed to show the prophylactic effect of purple sweet potato extract to the liver MDA level of male Wistar rats induced by carrageenan.</p><p>This study used post-only control group method using 18 male Wistar rats divided into 3 groups: group of rats without treatment, group of rats induced by 0,1 ml of 1% carrageenan by intraplantar injection on day-8, and group of rats given with 872 mg/kgBW of purple sweet potato extract for 7 days and induced by 0,1 ml of 1% carrageenan. In the end of the study, the liver MDA levels were measured by Thio-Barbituric Acid method on each groups.</p><p>The results of One-Way ANOVA test showed there was no significant difference (p = 0,290) between group of rats without treatment (<em>x̅</em>= 207,50) and group of rats induced by carrageenan (<em>x̅</em>=233,17). Then, there is no significant difference (p = 0.978) between group of rats induced by carrageenan and group of rats given with prophylactic purple sweet potato extract and induced by carrageenan (<em>x̅</em>= 232,50).</p><p>The conclusion of this study is giving intraplantar injection of carrageenan can increase liver MDA level insignificantly and giving prophylactic purple sweet potato extract has an effect to decrease the liver MDA level of rats induced by carragenan insignificantly because it contains anthocyanins as antioxidants.</p><p> </p><strong>Keywords: </strong>Liver, <em>Ipomoea batatas</em> L., Malondialdehyde, Anthocyanins

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