Alkyl polyglucoside-based emulsions as vehicles for topical spironolactone: A textural analysis

Acne vulgaris is a chronic dermatological disease that affects the pilosebaceous unit; androgens play an important role in its pathogenesis. Acne therapy can be either systemic or topical, usual in the treatment of mild and moderate forms of acne. Spironolactone (SP) is an anti-androgen drug with potential to reduce the sebum secretion; in order to avoid systemic side effects, it could be used topically in acne treatment. Nowadays, more and more attention is being paid to the textural profile of dermopharmaceutical emulsions, which is normally influenced by their colloidal structure; texture analysis is performed in order to predict behavior of the emulsion systems in real-time conditions during manufacturing and application; the latter is closely related to ensuring patients' compliance and the positive outcome of the therapy. We formulated emulsions stabilized with different natural alkyl polyglucoside (APG) emulsifiers (Cetearyl glucoside and cetearyl alcohol and Arachidyl glucoside and arachidyl behenyl alcohol) as vehicles for 5% topical SP. Parameters obtained by texture analysis were firmness and cohesiveness. The study showed that SP affected the texture of APG-based emulsion; different APG-based emulsions showed satisfying textural characteristics per se after incorporation of 5% SP, which could imply their satisfying applicative characteristics on the skin with acne. APGs could be used as stabilizers of emulsion vehicles for topical SP. Dermoemulsion with Arachidyl glucoside and arachidyl behenyl alcohol, more lypophillic emulsifier, is a more acceptable carrier for 5% SP due to a better textural profile.

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Efficacy, Safety, and Patient Satisfaction with a Combined Acne Treatment Regimen for the Treatment of Acne Vulgaris in Adolescent Student Athletes

Journal of General Practice ◽

10.4172/2329-9126.1000228 ◽

2016 ◽

Vol 04 (01) ◽

Author(s):

Brian B ◽

York JP JP

Keyword(s):

Patient Satisfaction ◽

Treatment Regimen ◽

Student Athletes ◽

Acne Vulgaris ◽

Acne Treatment ◽

Adolescent Student

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The potential of bacteriocin AS-48 in the control of Propionibacterium acnes

10.7287/peerj.preprints.2107 ◽

2016 ◽

Cited By ~ 1

Author(s):

Rubén Cebrián ◽

Sergio Arévalo ◽

Samir Ananou ◽

Salvador Arias-Santiago ◽

Cristina Riazzo ◽

...

Keyword(s):

Antibacterial Activity ◽

Propionibacterium Acnes ◽

Acne Vulgaris ◽

Chemical Compounds ◽

Clinical Isolates ◽

Large Decrease ◽

Large Problem ◽

Specific Pcr ◽

Therapeutic Drugs ◽

Dermatological Disease

Background Global reports show that the antimicrobial-resistance of Propionibacterium acnes isolated from patients with acne vulgaris is becoming a large problem, making it necessary to find new therapeutic drugs. Methods In this study, 23 clinical isolates of P. acnes have been identified by MaldiToff and specific PCR. The susceptibility of theses strains to antibiotics (clindamicin, erytromycin and tetracicline) and to bacteriocin (AS-48) has been established, using the CECT 5684 strain as reference. Moreover, we have investigated the potential of several chemical compounds to bolster the activity of AS-48. Finally, the effectivity of four different formulations containing AS-48 and lysozyme have been evaluated on the surface of swine-ear skin previously inoculated with P. acnes CECT5684 strain. Results. The results presented in this work probe that AS-48 has a significant bactericidal activity against the 23 clinical isolates of P. acnes, including isolates resistant to one or more common antibiotics used in the treatment of acne. Antibacterial synergy of AS-48 with other chemical compounds has been demonstrated, as was the effect of lysozyme and to a lesser extent with palmitic acid. Likewise, the use of a combination therapy into a cream formulation, resulted in large decrease in the number of viable P. acnes counts in an experiemental model. Conclusion. Once more these studios support that compositions comprising bacteriocins displaying antibacterial activity, must be considered an approach for medical and pharmaceutical purposes. These applications are particularly promising in light of emerging antibiotic resistance across bacteria involved in treatment of dermatological disease as acne vulgaris.

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Effects of topical acne treatment on the ocular surface in patients with acne vulgaris

Contact Lens and Anterior Eye ◽

10.1016/j.clae.2016.06.009 ◽

2016 ◽

Vol 39 (6) ◽

pp. 431-434 ◽

Cited By ~ 7

Author(s):

Seray Aslan Bayhan ◽

Hasan Ali Bayhan ◽

Emine Çölgeçen ◽

Canan Gürdal

Keyword(s):

Ocular Surface ◽

Acne Vulgaris ◽

Acne Treatment

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Minocycline Topical Foam: A New Drug for the Treatment of Acne

Annals of Pharmacotherapy ◽

10.1177/1060028020939926 ◽

2020 ◽

Vol 55 (1) ◽

pp. 105-110

Author(s):

Erin St. Onge ◽

W. Cary Mobley

Keyword(s):

Bacterial Resistance ◽

Data Extraction ◽

Acne Vulgaris ◽

Phase 1 ◽

Systemic Exposure ◽

Preclinical Study ◽

Severe Acne ◽

Assessment Scores ◽

Acne Lesion ◽

Acne Therapy

Objective: To review the safety and efficacy of minocycline 4% topical foam for the treatment of moderate to severe acne vulgaris in adults and pediatric patients aged 9 years and older. Data Sources: A literature search through PubMed and EMBASE was conducted using the following keywords: FMX101, minocycline, foam, and acne. Study Selection and Data Extraction: Articles selected included those describing preclinical and clinical studies of pharmacokinetics, efficacy, or safety of topical minocycline foam. Data Synthesis: Minocycline 4% topical foam was shown in a preclinical study to effectively deliver minocycline to the pilosebaceous unit, with little penetration beyond the stratum corneum. This was consistent with a phase 1 pharmacokinetic study of the foam, which yielded a significantly reduced systemic exposure of minocycline compared with oral minocycline. In phase 2 and phase 3 clinical trials, the foam significantly reduced acne lesion counts and Investigator’s Global Assessment scores of acne severity compared with placebo. The foam has a good safety profile, with headache, mild erythema, hyperpigmentation, and mild dryness among the most common adverse effects. Relevance to Patient Care and Clinical Practice: Topical antibiotics have been a mainstay of acne therapy with the benefit of less systemic exposure compared with oral antibiotics. However, the development of bacterial resistance has reduced their use, thereby reducing options for many patients with acne. Minocycline 4% topical foam is a safe and effective alternative, which may help restore this important therapeutic approach for treating acne vulgaris.

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Evidence on acne therapy

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2013.1313616 ◽

2013 ◽

Vol 131 (3) ◽

pp. 193-197 ◽

Cited By ~ 1

Author(s):

Caroline Sousa Costa ◽

Edileia Bagatin

Keyword(s):

Bacterial Resistance ◽

Scientific Evidence ◽

Acne Vulgaris ◽

Optimum Dose ◽

Oral Antibiotics ◽

Duration Of Treatment ◽

Medical Databases ◽

Systemic Treatments ◽

Acne Therapy ◽

Oral Isotretinoin

Among the current treatments available for acne vulgaris, many widely practiced options lack support from studies at the best level of scientific evidence. The aim of this narrative review was to present the very latest information on topical and systemic treatments for acne vulgaris. Information from systematic reviews and well-designed clinical trials, obtained through a systematic search of the major medical databases, is emphasized. There are important issues regarding the clinical management of acne that still lack consistent grounding in scientific evidence. Among these are the optimum dose and duration of treatment with oral antibiotics that can be given without inducing bacterial resistance, and the safety of oral isotretinoin.

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CLINICAL RESULTS OF COMPLEX THERAPY ОF PATIENTS WITH ACNE - RESIDENTS OF IODINE DEFICIENCY REGION

Clinical & experimental pathology ◽

10.24061/1727-4338.xx.1.75.2021.12 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Yu.P. Karvatska ◽

O.I. Denysenko

Keyword(s):

Iodine Deficiency ◽

Conventional Treatment ◽

Acne Vulgaris ◽

Clinical Results ◽

Complex Treatment ◽

Immunological Parameters ◽

Severe Acne ◽

Complex Therapy ◽

Acne Therapy

The аim of research – the clinical results of complex therapy in patients with acne vulgaris- residents of the iodine deficiency region should be determined and analyzed consideringthe state of their pituitary-thyroid system, intestinal microbiota and immunologicalparameters.Material and methods. The study involved 109 patients with moderate to severe acnevulgaris, who are the residents of Chernivtsi region - a region with natural iodinedeficiency. Examination of the patients revealed changes in the pituitary-thyroid system,immunological parameters and intestinal biocenosis, which corresponded to the severityof dermatosis. During treatment, patients were divided into 3 groups: I comparative - 36people who received conventional acne therapies and medicines to normalize thyroidhomeostasis; group II comparative - 36 patients who were additionally prescribedprobiotics, and ІІІ (main) - 37 persons who received complex treatment with the additionaladministration of probiotics and immunotropic drug. The effectiveness of treatment ofpatients was evaluated by their earliest and long-term clinical results using statisticalanalysis methods.Results. It has been established that complex therapy of patients with moderate and severeacne vulgaris - residents of the iodine deficiency region with the administration alongsidewith the conventional acne therapy of medicines that normalize detected changes in thepituitary-thyroid system, immunotropic drug glucosaminylmuramyl dipeptide (licopid))and probiotic (lacium) reliably reduces (p <0.01) in comparison with conventional acnetherapy or conventional acne therapy with additional probiotics administration the termsof regress of acute inflammatory elements of acne with the achievement of the state ofclinical remission of dermatosis, (respectively: by 1,54 and 1,41 times). The frequency ofexacerbations acne process of patients with moderate and severe acne vulgaris duringthe year were also reduced (respectively: 1.59 and 1.26 times) relatively to patients in thecomparison groups.Conclusion. The complex therapy of patients with moderate to severe acne - residentsof the iodine deficiency region with administration of medicines to normalize thyroidhomeostasis, immunotropic drug glucosaminylmuramyl dipeptide (licopid) and probiotic(lacium) reliable improves the earliest and long-term clinical results of their treatment incomparison with conventional treatment or treatment using only the probiotic additionalprescription.

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A Novel Biocompatible Herbal Extract-Loaded Hydrogel for Acne Treatment and Repair

Oxidative Medicine and Cellular Longevity ◽

10.1155/2021/5598291 ◽

2021 ◽

Vol 2021 ◽

pp. 1-13

Author(s):

Ying-Yi Lin ◽

Shu-Hsu Lu ◽

Rong Gao ◽

Chia-Hung Kuo ◽

Wen-Hisn Chung ◽

...

Keyword(s):

Raw Materials ◽

Acne Vulgaris ◽

Morphological Characteristics ◽

Zingiber Officinale ◽

Herbal Extract ◽

Gravimetric Analysis ◽

Matrix Properties ◽

Acne Treatment ◽

Anti Inflammatory ◽

Clinical Trial Results

A novel herbal extract-loaded gel containing several biofunctional extracts, including green tea, Zingiber officinale Rosc, Phyllanthus emblica, and salicylic acid, was developed for acne vulgaris. These natural raw materials were blended with suitable dosages of gelatin and carboxymethyl cellulose (CMC) to produce a biocompatible herbal gel. The physical chemistry properties of the hydrogel were determined by Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), rheometry, and scanning electron microscopy (SEM), and the hydrogel showed good mechanical and morphological characteristics. The herbal extract-loaded hydrogel mimicked extracellular matrix properties and showed good antioxidant and anti-inflammatory properties and various advantages, serving as a potential wound dressing material because of its high moisture retention ability, wound exudate absorption behavior, and biocompatibility. It exhibited moderate-high antioxidative and anti-inflammatory qualities that were important for dermis wound closure. The clinical trial results showed that most patients experienced moderate to high healing rates, and four of twenty-four individuals (16.67%) had recovery area ratios greater than 80%. This herbal extract-loaded hydrogel has effective ingredients and excellent mechanical properties as a bioactive dressing agent for acne treatment.

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PREPARATION AND EVALUATION OF BB CONCEALER CREAM CONTAINING NEEM OIL FOR ACNE TREATMENT

INDIAN DRUGS ◽

10.53879/id.58.11.12450 ◽

2021 ◽

Vol 58 (11) ◽

pp. 66-69

Author(s):

Priyal Jangla ◽

Khushboo Merai ◽

Drishti Patel ◽

Kalyani Sheth ◽

Keyword(s):

Inflammatory Disease ◽

Acne Vulgaris ◽

In Vitro Release ◽

Antibacterial Properties ◽

Neem Oil ◽

Release Studies ◽

Acne Treatment ◽

Preparation And Evaluation ◽

Vitro Release

Acne vulgaris is a chronic dermatological inflammatory disease with symptoms like redness, comedones and blemishes appearing on face and neck. Propionobacterium acnes plays an important role in this disease. Neem oil, an ayurvedic, anti-bacterial medicine is non-comedogenic. Concealer is a type of cosmetic used to mask and camouflage blemishes and imperfections visible on skin and are available as liquid, balm, cream and stick. BB creams in cosmetics is termed as “beauty balm, blemish base, blemish balm” designed to serve as foundation, moisturizer and sunscreen all at once. The current study was to develop an aesthetic BB cream combining an anti-acne activity with concealing effect. Concentrations of upto 25 %w/w neem oil was prepared and evaluated for appearance, texture, pH, spreadability, antibacterial properties and in vitro release studies. All the formulations confirmed activity against P. acnes. Prolonged activity of neem oil observed at the end of 6 h as demonstrated in vitro

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Developing an Effective Formulation for an Acne Treatment Cream with Ocimum Basilicum using Invasome

10.20944/preprints201808.0499.v1 ◽

2018 ◽

Author(s):

Hyun Jee Han

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Antioxidant Activities ◽

Acne Vulgaris ◽

Ocimum Basilicum ◽

Common Disease ◽

Stability Performance ◽

Acneiform Eruption ◽

Acne Treatment

Cosmeceuticals formulations of Ocimum Basilicum are designed in an effective base for topical acne-causing inflammation medication using advanced drug delivery system. Acne vulgaris is a common disease found not only among the youth but also among adults. The present study suggests the use of Ocimum Basilicum as a cream for acne treatment. The anti-acne cream is formulated from herbal crude extracts for the antimicrobial and antioxidant activities of the formulation to prevent inflammation which causes acneiform eruption. The study proposes that, along with the formulation of micro-emulsion, the use of invasome will be an effective advanced drug delivery system which can promise a great efficacy and stability performance, while simultaneously ensuring the anti-acne effect by Ocimum Basilicum.

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