scholarly journals CLINICAL RESULTS OF COMPLEX THERAPY ОF PATIENTS WITH ACNE - RESIDENTS OF IODINE DEFICIENCY REGION

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yu.P. Karvatska ◽  
O.I. Denysenko
Keyword(s):  
Iodine Deficiency ◽  
Conventional Treatment ◽  
Acne Vulgaris ◽  
Clinical Results ◽  
Complex Treatment ◽  
Immunological Parameters ◽  
Severe Acne ◽  
Complex Therapy ◽  
Acne Therapy

The аim of research – the clinical results of complex therapy in patients with acne vulgaris- residents of the iodine deficiency region should be determined and analyzed consideringthe state of their pituitary-thyroid system, intestinal microbiota and immunologicalparameters.Material and methods. The study involved 109 patients with moderate to severe acnevulgaris, who are the residents of Chernivtsi region - a region with natural iodinedeficiency. Examination of the patients revealed changes in the pituitary-thyroid system,immunological parameters and intestinal biocenosis, which corresponded to the severityof dermatosis. During treatment, patients were divided into 3 groups: I comparative - 36people who received conventional acne therapies and medicines to normalize thyroidhomeostasis; group II comparative - 36 patients who were additionally prescribedprobiotics, and ІІІ (main) - 37 persons who received complex treatment with the additionaladministration of probiotics and immunotropic drug. The effectiveness of treatment ofpatients was evaluated by their earliest and long-term clinical results using statisticalanalysis methods.Results. It has been established that complex therapy of patients with moderate and severeacne vulgaris - residents of the iodine deficiency region with the administration alongsidewith the conventional acne therapy of medicines that normalize detected changes in thepituitary-thyroid system, immunotropic drug glucosaminylmuramyl dipeptide (licopid))and probiotic (lacium) reliably reduces (p <0.01) in comparison with conventional acnetherapy or conventional acne therapy with additional probiotics administration the termsof regress of acute inflammatory elements of acne with the achievement of the state ofclinical remission of dermatosis, (respectively: by 1,54 and 1,41 times). The frequency ofexacerbations acne process of patients with moderate and severe acne vulgaris duringthe year were also reduced (respectively: 1.59 and 1.26 times) relatively to patients in thecomparison groups.Conclusion. The complex therapy of patients with moderate to severe acne - residentsof the iodine deficiency region with administration of medicines to normalize thyroidhomeostasis, immunotropic drug glucosaminylmuramyl dipeptide (licopid) and probiotic(lacium) reliable improves the earliest and long-term clinical results of their treatment incomparison with conventional treatment or treatment using only the probiotic additionalprescription.

Minocycline Topical Foam: A New Drug for the Treatment of Acne

2020 ◽  
Vol 55 (1) ◽  
pp. 105-110
Author(s):  
Erin St. Onge ◽  
W. Cary Mobley
Keyword(s):  
Bacterial Resistance ◽  
Data Extraction ◽  
Acne Vulgaris ◽  
Phase 1 ◽  
Systemic Exposure ◽  
Preclinical Study ◽  
Severe Acne ◽  
Assessment Scores ◽  
Acne Lesion ◽  
Acne Therapy

Objective: To review the safety and efficacy of minocycline 4% topical foam for the treatment of moderate to severe acne vulgaris in adults and pediatric patients aged 9 years and older. Data Sources: A literature search through PubMed and EMBASE was conducted using the following keywords: FMX101, minocycline, foam, and acne. Study Selection and Data Extraction: Articles selected included those describing preclinical and clinical studies of pharmacokinetics, efficacy, or safety of topical minocycline foam. Data Synthesis: Minocycline 4% topical foam was shown in a preclinical study to effectively deliver minocycline to the pilosebaceous unit, with little penetration beyond the stratum corneum. This was consistent with a phase 1 pharmacokinetic study of the foam, which yielded a significantly reduced systemic exposure of minocycline compared with oral minocycline. In phase 2 and phase 3 clinical trials, the foam significantly reduced acne lesion counts and Investigator’s Global Assessment scores of acne severity compared with placebo. The foam has a good safety profile, with headache, mild erythema, hyperpigmentation, and mild dryness among the most common adverse effects. Relevance to Patient Care and Clinical Practice: Topical antibiotics have been a mainstay of acne therapy with the benefit of less systemic exposure compared with oral antibiotics. However, the development of bacterial resistance has reduced their use, thereby reducing options for many patients with acne. Minocycline 4% topical foam is a safe and effective alternative, which may help restore this important therapeutic approach for treating acne vulgaris.

scholarly journals IMMTJNOTROPIC THERAPY OF SEVERE ACNE IN MALE PATIENTS

2011 ◽  
Vol 8 (2) ◽  
pp. 96-99
Author(s):  
T Ya Pavlenko ◽  
L P Sizyakina ◽  
O A Sidorenko ◽  
T J Pavlenko ◽  
L P Siziakina ◽  
...  
Keyword(s):  
Immunological Methods ◽  
Control Group ◽  
Complex Treatment ◽  
High Efficacy ◽  
Standard Methods ◽  
Severe Acne ◽  
Complex Therapy ◽  
Male Patients ◽  
Experimental Group

Background.The aim of the study was to estimate the efficacy of systemic and topic immunotropic therapy in complex treatment of acne disease. Methods. 48 male patients with moderate to severe acne at the age from 16 to 34 years old were investigated. The patients of the control group were treated with standard methods and the patients of the experimental group were treated with complex of immunotropic medicines. All of them were examined with immunological methods, Cook scale and Vancouer scarring index. Results. High efficacy and fast positive dynamics were shown in patients who received complex therapy, consisting of standard drugs, systemic and topic immunotropic medicines. Conclusion. The results of this study show the efficiency of immunotropic treatment in complex therapy of moderate and severe acne disease.

scholarly journals ANALYSIS OF RESULTS 6 MONTHS AFTER COMPLEX TREATMENT IN INSULIN-DEPENDENT PATIENTS WITH GENERALIZED PАRODONTITIS

Globus ◽  
2021 ◽  
Vol 7 (1(58)) ◽  
pp. 17-19
Author(s):  
Ilona Vladislavovna Chaykovskaya ◽  
Viktoriya Konstantinovna Zabrodnyaya
Keyword(s):  
Diabetes Mellitus ◽  
Conventional Treatment ◽  
Insulin Dependent Diabetes Mellitus ◽  
Dependent Diabetes Mellitus ◽  
Comprehensive Treatment ◽  
Complex Treatment ◽  
Specialized Treatment ◽  
Complex Therapy ◽  
Analysis Of Results ◽  
Insulin Dependent

In this article, we will present the results of our research 6 months after comprehensive treatment of patients with generalized pаrodontitis (GP) against the background of insulin-dependent diabetes mellitus (IDD). According to the developed scheme of complex therapy, 60 GP patients with ISD were treated, which were divided into 2 randomized groups: I (A) subgroup (main), which is represented by 30 patients, and II (B) subgroup (control), which also included 30 patients. I (A) subgroup underwent specialized treatment according to the proposed author’s method, I (B) subgroup – traditional conventional treatment.

scholarly journals Study of the psychoemotional status of patients with medium and severe acne severity on the background of isotretinoin monotherapy (Sotret)

2020 ◽  
Vol 96 (6) ◽  
pp. 48-55
Author(s):  
Pavel E. Konnov ◽  
Antonina A. Arsenieva ◽  
Yuri A. Tokarev
Keyword(s):  
Quality Of Life ◽  
Social Impact ◽  
Clinical Effect ◽  
Acne Vulgaris ◽  
Life Assessment ◽  
Moderate Degree ◽  
Important Indicator ◽  
Severe Acne ◽  
Acne Therapy

Rationale. Acne vulgaris is a widespread chronic disease with no age, gender, or race restrictions. It does not pose a direct threat to the patient's life, but is reflected in his psycho-emotional status, which requires appropriate medical intervention. Purpose of the study. To study the psychoemotional status of patients aged 2224 years with moderate and severe acne and its changes during monotherapy with isotretinoin (Sotret). Methods. In an open, non-randomized study lasting 12 months, 310 students of the Samara State Medical University were included (52% healthy, 33% with mild acne, 13% with a moderate degree, 2% with a severe degree). All patients in the study before treatment and after 3, 6, 12 months were assessed the severity of the course using the dermatological index of acne (DIA); quality of life assessment using the Cardiff Acne Disability Index (CADI scale); assessment of the psychological and social impact of acne using the APSEA questionnaire. All patients received monotherapy using the drug Erase. The median and interquartile distance Me (Q3-Q1) were indicated as descriptive statistics. The Wilcoxon signed rank test was used to compare related groups. The comparison was carried out with 95% confidence. Results. An analysis of the assessment of the psychological and social status of patients with moderate and severe acne before treatment, 3, 6, 12 months after the start of treatment with isotretinoin (Erase) is presented. The study included 36 people (20 women and 16 men) aged 22 to 24 years with a disease duration from 1 to 10 years. The results of psychological testing at various intervals gave comparable data: all patients had a pronounced persistent level of social maladjustment. An important indicator of the effectiveness of acne therapy with isotretinoin is the frequency of cases of the formation of a persistent clinical effect from treatment, which is clearly expressed in the restoration of the psycho-emotional background of patients, improving the quality of life of patients. Conclusion. An important indicator of the effectiveness of acne therapy with Erase is the frequency of cases of the formation of a stable clinical effect of treatment, which is clearly expressed in the restoration of the psycho-emotional background of patients, improving the quality of life of patients. The treatment allowed us to change the psychoemotional background of our patients for the better, which increased their motivation to study, communication, and the desire for self-development.

Agonists of gonadotropin-releasing hormone: their role in the complex therapy of hyperplastic processes in reproductive organs

2014 ◽  
Vol 63 (2) ◽  
pp. 6-11
Author(s):  
Lyudmila Vladimirona Tkachenko ◽  
Nataliya Ivanovna Sviridova
Keyword(s):  
Gnrh Agonist ◽  
Postoperative Period ◽  
Endometrial Hyperplasia ◽  
Reproductive Organs ◽  
Gonadotropin Releasing Hormone ◽  
Complex Treatment ◽  
Laboratory Examination ◽  
Releasing Hormone ◽  
Complex Therapy

The aim of this study was to evaluate the efficacy of an agonist of gonadotropin-releasing hormone Buserilin in the treatment of patients with endometriosis in combination with endometrial hyperplasia. We conducted a clinical and laboratory examination and treatment of 108 patients aged 41 to 52 years old suffering from endometriosis varying degrees of prevalence in conjunction with endometrial hyperplasia. The results obtained suggest a scientifically sound complex treatment of patients with endometriosis on the background of endometrial hyperplasia with a GnRH agonist Buserilin-depo in the postoperative period, followed by the appointment of progestogens or combiened oral contraceptives as a long-term program management of patients to prevent relapse and re-operative treatment.

scholarly journals Combination of isotretinoin and Contractubex Anti-Red in acne therapy

2021 ◽  
Vol 24 (3) ◽  
pp. 285-296
Author(s):  
Olga A. Katkhanova ◽  
Svetlana A. Grigoryants ◽  
Irina I. Glazko
Keyword(s):  
Clinical Symptoms ◽  
Acne Vulgaris ◽  
Scientific Data ◽  
Ease Of Use ◽  
Complete Relief ◽  
Severe Acne ◽  
Medical Interventions ◽  
Acne Scars ◽  
Acne Therapy ◽  
Good Cosmetic

BACKGROUND: Acne vulgaris (acne vulgaris) is an urgent interdisciplinary problem. Analyzing modern scientific data on the development of acne vulgaris, it is necessary to focus on the role of inflammation that accompanies dermatosis at all its stages of development, sometimes preceding the formation of clinical symptoms. Prolonged chronic recurrent course, difficulties in choosing the correct therapy tactics, sometimes unreasonable medical interventions, exacerbation, improper skin care lead to the formation of a number of complications. AIMS: To optimize and improve the effectiveness of therapy in patients with moderate and severe degrees acne using isotretinoin and the combined innovative gel Contractubex Anti-Red. MATERIALS AND METHODS: The study included 60 patients aged 18 to 45 years with moderate to severe acne. Isotretinoin was prescribed in standard dosages. To study the effect of Сontraktubex Anti-Red on the dynamics of post-acne, patients with atrophic post-acne scars were divided into 3 subgroups, depending on the regimen of drug use. RESULTS: Almost complete relief of the inflammatory process, regression of elements was noted 12 months after the use of complex therapy, the value of the dermanologic index of acne (DIA) index was more than 70% noted in 62% of patients, significant improvement in 38%. The severity of post-acne scars on the SCAR-S scale changed significantly during treatment and in 53.3% this indicator was 1. The Cadi index decreased by 70% compared to the baseline. CONCLUSION: Good cosmetic effect, safety, absence of side effects, comfort and ease of use make it possible to recommend Contractubex Anti-Red together with basic acne therapy.

Klinische Langzeitergebnisse der perkutanen transluminalen Angioplastie bei Patienten mit peripherer arterieller Verschlusskrankheit

VASA ◽  
2002 ◽  
Vol 31 (1) ◽  
pp. 36-42 ◽  
Author(s):  
. Bucek ◽  
Hudak ◽  
Schnürer ◽  
Ahmadi ◽  
Wolfram ◽  
...  
Keyword(s):  
Success Rate ◽  
Clinical Stage ◽  
Ankle Brachial Index ◽  
Clinical Situation ◽  
Clinical Results ◽  
Transluminal Angioplasty ◽  
Term Outcome ◽  
Long Term Outcome

Background: We investigated the long-term clinical results of percutaneous transluminal angioplasty (PTA) in patients with peripheral arterial occlusive disease (PAOD) and the influence of different parameters on the primary success rate, the rate of complications and the long-term outcome. Patients and methods: We reviewed clinical and hemodynamic follow-up data of 166 consecutive patients treated with PTA in 1987 in our department. Results: PTA improved the clinical situation in 79.4% of patients with iliac lesions and in 88.3% of patients with femoro-popliteal lesions. The clinical stage and ankle brachial index (ABI) post-interventional could be improved significantly (each P < 0,001), the same results were observed at the end of follow-up (each P < 0,001). Major complications occurred in 11 patients (6.6%). The rate of primary clinical long-term success for suprainguinal lesions was 55% and 38% after 5 and 10 years (femoro-popliteal 44% and 33%), respectively, the corresponding data for secondary clinical long-term success were 63% and 56% (60% and 55%). Older age (P = 0,017) and lower ABI pre-interventional (P = 0,019) significantly deteriorated primary clinical long-term success for suprainguinal lesions, while no factor could be identified influencing the outcome of femoro-popliteal lesions significantly. Conclusion: Besides an acceptable success rate with a low rate of severe complications, our results demonstrate favourable long-term clinical results of PTA in patients with PAOD.

The rationale for the combined use of osteopathic methods of correction and reflexology in the complex treatment of patients with dorsopathy at the cervico-thoracic level

2020 ◽  
pp. 82-94 ◽  
Author(s):  
V. O. Belash ◽  
L. R. Urazgalieva ◽  
R. I. Fayzullina ◽  
L. G. Agasarov
Keyword(s):  
Drug Therapy ◽  
Drug Treatment ◽  
Pain Syndrome ◽  
Clinical Effectiveness ◽  
Complex Treatment ◽  
Standard Drug ◽  
Treatment Methods ◽  
Thoracic Level ◽  
Combined Use ◽  
Complex Therapy

Introduction. Degenerative-dystrophic changes in the spine are the most common chronic human diseases. Pronounced clinical manifestations of vertebrogenic diseases are observed during active labor activity and represent one of the most frequent causes of temporary disability. It is also known that any pain syndromes are accompanied by the development of psychovegetative disorders, which reduces the effectiveness of treatment. In recent years, there has been a reasonable increase in the interest of the medical community to the non-drug treatment methods. It is caused by the polypharmacotherapy side effects, an increased numbers of allergic reactions, problems with polypragmasia, and a low level of compliance. At the same time, the question of the possibility of various non-drug treatment methods combining is quite acute.The goal of research is to substantiate the clinical effectiveness of the combined application of osteopathic correction and reflexotherapy in the complex treatment of patients with dorsopathy at the cervical-thoracic level.Materials and methods. A prospective controlled randomized study was conducted on the basis of the medical clinics of LLC «Family Health» (Kazan) and ANO «Center for SEB assistance» (Kazan) from April 2018 to May 2019. The study involved 52 people with dorsopathy at the cervical-thoracic level, aged from 25 to 45 years. In accordance with the exclusion criteria, 7 people dropped out of the study. The remaining patients (45 people), depending on the used treatment method, were divided by a simple randomization method using a random number generator into three groups of 15 people. The first group (main group) received osteopathic correction and reflexotherapyon the background of standard drug therapy; the second and the third groups (control groups) received only osteopathic correction orreflexotherapy, respectively, on the background of standard drug therapy. The osteopathic examination was performed for all patients regardless of the group, before and after the course of therapy, with the formation of an osteopathic conclusion.Also there was the estimation of the degree of pain syndrome severity,the asthenia, and the degree of accumulated emotional and energy charge that does not get out in a person.Results. It was found in the course of the study that the inclusion of osteopathic correction and reflexotherapy in the complex therapy of patients with dorsopathy at the cervical-thoracic level is clinically more effective than the isolated use of these methods. Such complex therapy allows to achieve a more significant reduction in the severity of the pain syndrome by VAS (p<0,05), relief of internal emotional tension (p<0,05), and increase the effectiveness of correction of dominant somatic dysfunction. Based on the obtained data, it could be assumed that reflexotherapy potentiates the effects of osteopathic correction.Conclusion. Based on the study, it can be concluded that the combination of osteopathic correction and reflexotherapy in the treatment of patients with dorsopathy at the cervical-thoracic level increases the clinical effectiveness of the standard drug therapy. At the same time, it is worth noting the potentiating effect of the combined use of two non-medicinal methods. The question of combining of various non-drug treatment methods is quite acute today, so this study will be continued. 

Maintenance acne therapy: prophylactic efficacy of fixed combination of adapalene and benzoyl peroxide

2020 ◽  
pp. 57-62
Author(s):  
L. S. Kruglova ◽  
N. V. Gryazeva
Keyword(s):  
Maintenance Therapy ◽  
Fixed Combination ◽  
Psychological Impact ◽  
Supportive Therapy ◽  
Prophylactic Efficacy ◽  
Severe Acne ◽  
Topical Retinoids ◽  
Acne Therapy ◽  
Group 2 ◽  
Treatment Observation

Acne is a chronic disease and even reliable therapies do not completely ensure absence of relapses. Acne relapses have a negative psychological impact on patients, as they feel unable to control the disease and achieve complete and long-lasting recovery. Supportive therapy is necessary to prolong the remission of acne achieved with initial successful treatment and to minimize the risk of relapse. According to the literature sources, the most justified as a maintenance therapy is the use of topical retinoids, which have been shown to be effective in the prevention of exacerbations of acne. In the present study 54 patients were involved who after the active therapy used a fixed combination of adapalene 0.1% / BPO 2.5% as maintenance treatment. Only 1 patient (2.9%) with moderate acne and 2 patients (5.8%) with severe acne had a relapse within 6 months of maintenance therapy. The absence of adverse events during the course of treatment was recorded, as well as high adherence of patients to the treatment. During the period of post-treatment observation (6 months after maintenance therapy), among the patients without exacerbations during maintenance therapy, a relapse occurred in 2 (7.1%) patients of group 1 (n = 28) and 2 (8.7%) patients of group 2 (n = 23). The obtained data indicates that maintenance therapy with Effezel® gel can extend the achieved effectiveness of the treatment and prevent the development of relapses.

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