Association of the ATP-binding Cassette Transporter A1 Gene Polymorphism with Lipid Profile and Type 2 Diabetes Mellitus

2019 ◽  
Vol 12 (10) ◽  
pp. 4657
Author(s):  
Abbas Sabbar Dakhil
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Lipid Profile ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

Association of ATP binding cassette transporter 1 (ABCA 1) gene polymorphism with type 2 diabetes mellitus (T2DM) in Bangladeshi population

Gene ◽  
2019 ◽  
Vol 688 ◽  
pp. 151-154 ◽  
Author(s):  
Md. Mehedi Hasan ◽  
Md. Bayejid Hosen ◽  
Md. Mostafijur Rahman ◽  
M. Zakir Hossain Howlader ◽  
Yearul Kabir
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Gene Polymorphism ◽  
Atp Binding ◽  
Atp Binding Cassette Transporter ◽  
Bangladeshi Population ◽  
Atp Binding Cassette

scholarly journals Reduced Expression of ATP-Binding Cassette Transporter G1 Increases Cholesterol Accumulation in Macrophages of Patients With Type 2 Diabetes Mellitus

Circulation ◽  
2008 ◽  
Vol 117 (21) ◽  
pp. 2785-2792 ◽  
Author(s):  
Jeremy P. Mauldin ◽  
Melissa H. Nagelin ◽  
Allison J. Wojcik ◽  
Suseela Srinivasan ◽  
Marcus D. Skaflen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Atp Binding ◽  
Cholesterol Accumulation ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette

scholarly journals Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus among Malaysians

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Polin Haghvirdizadeh ◽  
Vasudevan Ramachandran ◽  
Ali Etemad ◽  
Farzad Heidari ◽  
Nooshin Ghodsian ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Genetic Risk ◽  
Gene Polymorphisms ◽  
Atp Binding ◽  
Abca1 Gene ◽  
Atp Binding Cassette Transporter ◽  
Significant Difference

Background. Type 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors. ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms are reported as the one of the genetic risk factors for T2DM in various populations with conflicting results. This study was conducted based on PCR-HRM to determine the frequency of ABCA1 gene by rs2230806 (R219K), rs1800977 (C69T), and rs9282541 (R230C) polymorphisms Malaysian subjects.Methods. A total of 164 T2DM and 165 controls were recruited and their genotypes for ABCA1 gene polymorphisms were determined based on the real time high resolution melting analysis.Results. There was a significant difference between the subjects in terms of age, BMI, FPG, HbA1c, HDL, LDL, and TGP<0.05. There was a significant association between HOM of R219KP=0.005, among Malaysian subjects; moreover, allele frequency revealed the significant difference in A allele of R219KP=0.003. But, there was no significant difference in genotypic and allelic frequencies of C69T and R230C polymorphism.Conclusion. R219K polymorphism of ABCA1 gene can be considered as a genetic risk factor for T2DM subjects among Malaysians.

The R230C variant of the ATP binding cassette protein A1 (ABCA1) gene is associated with a decreased response to glyburide therapy in patients with type 2 diabetes mellitus

Metabolism ◽  
2013 ◽  
Vol 62 (5) ◽  
pp. 638-641 ◽  
Author(s):  
Carlos A. Aguilar-Salinas ◽  
Linda Liliana Muñoz-Hernandez ◽  
Monica Cobos-Bonilla ◽  
Marcos Rafael Ramírez-Márquez ◽  
Maria Luisa Ordoñez-Sanchez ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Atp Binding ◽  
Abca1 Gene ◽  
Atp Binding Cassette

Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Hadi Bazyar ◽  
Seyed Ahmad Hosseini ◽  
Sirous Saradar ◽  
Delsa Mombaini ◽  
Mohammad Allivand ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Atherogenic Index ◽  
Control Group ◽  
Atherogenic Index Of Plasma ◽  
The Mean

Abstract Background In patients with type 2 diabetes mellitus (T2DM) the inflammatory and metabolic responses to epigallocatechin-3-gallate (EGCG) are unknown. Objectives Evaluate the impacts of EGCG on metabolic factors and some biomarkers of stress oxidative in patients with T2DM. Methods In this randomized, double-blind, placebo-controlled trial, 50 patients with T2DM consumed either 2 tablets (300 mg) EGCG (n=25) or wheat flour as placebo (n=25) for 2 months. The total antioxidant capacity (TAC), interleukin-6 (IL-6), lipid profile, mean arterial pressure (MAP), atherogenic index of plasma (AIP) were evaluated before and after the intervention. Results The finding of present study exhibited a significant increase in the serum levels of TAC after the EGCG supplementation (p=0.001). Also, in compare with control group, the mean changes of TAC were significantly higher in supplement group (p=0.01). In intervention group, a significant decrease was observed in the mean levels of triglyceride, total cholesterol, diastolic blood pressure (DBP), AIP, and MAP (p<0.05). Taking EGCG resulted in the mean changes of total cholesterol, MAP and DBP were significantly lower in compare with control group (p<0.05). Conclusions This study recommended that EGCG supplementation may be improved blood pressure, lipid profile, AIP, and oxidative status in patients with T2DM.

Correlation between TNF-α- serum level and TNF-α -308 gene polymorphism in Iraqi patients with type 2 diabetes mellitus

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101136
Author(s):  
Sarah Rahman Rasool ◽  
Othman Taha Qasim ◽  
Salaam Khudhur Muslem ◽  
Muataz Mohammed Al-Taee
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Level ◽  
Gene Polymorphism ◽  
Tnf Α
Sign in / Sign up

Export Citation Format

Share Document