scholarly journals Polymorphisms in vitamin D receptor, toll-like receptor 2 and Toll-Like receptor 4 genes links with Dengue susceptibility

2021 ◽  
Vol 17 (4) ◽  
pp. 506-513
Author(s):  
Arvind Kumar Singh ◽  
Keyword(s):  
Vitamin D ◽  
Virus Infection ◽  
Dengue Virus ◽  
Vitamin D Receptor ◽  
Gene Polymorphisms ◽  
P Value ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Dengue Virus Infection ◽  
Toll Like Receptor 2

Host genetic factors are known to determine disease susceptibility in dengue virus infection. Therefore, in this study association of gene polymorphisms of Vitamin D Receptor [rs731236 (Taq) and rs7975232(Apa1)], Toll-like receptor 2 [rs5743708(Arg735Gln) and rs5743704(Pro631His)] and Toll-like receptor 4 [rs4986790A/G(Asp299Gly13843) and rs4986791 C/T(Thr399Ile)] were studied in cases with dengue as compared to controls. Total 98 cases of confirmed dengue virus infection and 98 age, sex and geographically matched healthy controls were enrolled and their genetic polymorphisms for the above mentioned regions were studied by Sanger sequencing. Mutant genotypes CC of VDR rs731236(Taq1) [(OR 3.808, p value =0.02, CI 1.160-12.498)], GG of VDR rs7975232 (Apa1) [(OR 3.485, p value =0.02, CI 1.162-10.45)] and heterozygous genotypes of TLR4 rs4986790 A/G Asp299Gly [OR 2.40, p value= 0.02, CI 1.12-5.14], TLR4 rs4986791 C/T Thr399Ile [OR 2.09, p value=0.02, CI 1.12-5.14] were found to be significantly more in cases with dengue virus infection as compared to the controls. Also, at these positions mutant alleles were observed in significantly higher number of cases than controls. The values for C allele at VDR rs731236(Taq1) were OR 1.86, p value 0.009, CI 1.162-3.001; for allele G at rs7975232(Apa1) were OR 2.71, p value 0.006, CI 1.196-2.98 for allele G at TLR4s rs4986790 A/G Asp299Gly were OR 2.35, p value 0.009, CI 1.23-4.50 and for allele T at rs4986791 C/T Thr399Ile were OR 2.36, p value=0.006, CI 1.28-4.38. VDR and TLR4 but not TLR2 gene polymorphisms were found to be associated with dengue susceptibility in Indian population.

scholarly journals Polymorphisms in IL-1β, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis

2010 ◽  
Vol 11 (1) ◽  
Author(s):  
Alison A Motsinger-Reif ◽  
Paulo RZ Antas ◽  
Noffisat O Oki ◽  
Shawn Levy ◽  
Steven M Holland ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Extrapulmonary Tuberculosis ◽  
Toll Like Receptor ◽  
Toll Like Receptor 2

scholarly journals 25-Hydroxy Vitamin D, Vitamin D Receptor and Toll-like Receptor 2 Polymorphisms in Spinal Tuberculosis

Medicine ◽  
2016 ◽  
Vol 95 (17) ◽  
pp. e3418 ◽  
Author(s):  
Ajay Panwar ◽  
Ravindra Kumar Garg ◽  
Hardeep Singh Malhotra ◽  
Amita Jain ◽  
Arvind Kumar Singh ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Spinal Tuberculosis ◽  
Toll Like Receptor ◽  
25 Hydroxy Vitamin D ◽  
Toll Like Receptor 2

scholarly journals Non-HLA gene polymorphisms and their implications on dengue virus infection

2013 ◽  
Vol 14 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Harapan Harapan ◽  
Jonny K. Fajar ◽  
Nur Wahyuniati ◽  
Jay R. Anand ◽  
Lavanya Nambaru ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Gene Polymorphisms ◽  
Dengue Virus Infection

scholarly journals Detection of Proteinuria by Colorimetric Method and Correlation with Disease Severity in Patients Dengue

2021 ◽  
Vol 27 (3) ◽  
pp. 244
Author(s):  
Acivrida Mega Charisma ◽  
Elis Anita Farida ◽  
Farida Anwari
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Disease Severity ◽  
Dengue Infection ◽  
Urine Samples ◽  
P Value ◽  
Urine Protein ◽  
Dengue Virus Infection ◽  
Chi Square ◽  
Chi Square Test

Severe dengue virus infection often causes proteinuria through several mechanisms, such as leakage of plasma proteins caused by higher protein filtering in the kidneys. The condition of proteinuria in patients with dengue shock syndrome will affect the management, prognosis, and mortality of patients with dengue virus infection. The objectives of this study were to determine the presence of protein in urine samples in patients in which IgG/IgM dengue was detected, to determine the presence of protein in urine samples in patients without dengue infection, and to determine the relationship between proteinuria in dengue patients and the degree of disease severity. The study was conducted in March-June 2020 at the Clinical Laboratory and Inpatient Clinic of Vita Medika Kepung, Kediri Regency. The method used was the consecutive sampling technique. The minimum sample size was 100 respondents with criteria for suspected dengue infection, onset fever > 4 days, age > 2 years, and no indication of other infectious diseases (blood and urine), divided into two groups, group with positive dengue infection and non-dengue group. The results showed that proteinuria was detected in 26% of respondents, secondary dengue infection and positive serological test of IgG, IgM only IgG were detected in 24 (92.3%) respondents and positive IgG and IgM were found in 2 (7.7%) respondents, this was shown by the p-value = 0.000 in the Chi-Square test with a Prevalence Ratio (PR) value of 11,987. In addition, Chi-Square test results indicated that a higher urine protein/albumin led to more severe disease, with p-value = 0.012 and 0.025 (p <0.05) and PR values of 3.333 and 2.800. The results of this study concluded that there was a close relationship between high levels of protein/albumin in the urine with the degree of disease severity in patients with dengue infection. In addition, an increase in urine protein/albumin levels is always followed by a decrease in serum protein/albumin levels.

Polymorphisms in RNA sensing toll like receptor genes and its association with clinical outcomes of dengue virus infection

Immunobiology ◽  
2015 ◽  
Vol 220 (1) ◽  
pp. 164-168 ◽  
Author(s):  
K. Alagarasu ◽  
R.V. Bachal ◽  
R.S. Memane ◽  
P.S. Shah ◽  
D. Cecilia
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Clinical Outcomes ◽  
Toll Like Receptor ◽  
Dengue Virus Infection
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