TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets

Transient receptor potential (TRP) ion channels are essential for normal functions and health by acting as molecular sensors and transducing various stimuli into cellular and physiological responses. Growing evidence has revealed that TRP ion channels play important roles in a wide range of human diseases, including malignancies. In light of recent discoveries, it has been found that TRP melastatin-subfamily members, TRPM7 and TRPM8, are required for normal and cancerous development of exocrine pancreas. We are currently investigating the mechanisms which mediate the functional roles of TRPM7 and TRPM8 and attempting to develop these ion channels as clinical biomarkers and therapeutic targets for achieving the goal of personalized therapy in pancreatic cancer.

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Penile anesthesia in Post SSRI Sexual Dysfunction (PSSD) responds to low-power laser irradiation: A case study and hypothesis about the role of transient receptor potential (TRP) ion channels

European Journal of Pharmacology ◽

10.1016/j.ejphar.2014.11.031 ◽

2015 ◽

Vol 753 ◽

pp. 263-268 ◽

Cited By ~ 17

Author(s):

Marcel D. Waldinger ◽

Ruben S. van Coevorden ◽

Dave H. Schweitzer ◽

Janniko Georgiadis

Keyword(s):

Ion Channels ◽

Sexual Dysfunction ◽

Laser Irradiation ◽

Transient Receptor Potential ◽

Receptor Potential ◽

Power Laser ◽

Trp Ion Channels ◽

Transient Receptor

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Dysfunction of transient receptor potential ion channels as an important pathophysiological mechanism in asthma

Russian Open Medical Journal ◽

10.15275/rusomj.2020.0102 ◽

2020 ◽

Vol 9 (1) ◽

Author(s):

Oxana Yu. Kytikova ◽

Tatyana P. Novgorodtseva ◽

Yulia K. Denisenko ◽

Marina V. Antonyuk ◽

Tatyana A. Gvozdenko

Keyword(s):

Ion Channels ◽

Neurogenic Inflammation ◽

Transient Receptor Potential ◽

Trp Channels ◽

Receptor Potential ◽

Bronchial Hyperreactivity ◽

Pathophysiological Mechanism ◽

Lung Pathology ◽

Trp Ion Channels ◽

Transient Receptor

Asthma is a chronic heterogeneous disease characterized by chronic inflammation and bronchial hyperreactivity. Neurogenic inflammation is one of the important causes of hyperreactivity. Dysfunction of transient receptor potential (TRP) ion channels underlies the development of neurogenic inflammation, bronchial hyperreactivity and respiratory symptoms of asthma such as bronchospasm and cough. TRP channels are expressed in the respiratory tract. Their activation is mediated by endogenous and exogenous factors involved in the pathogenesis of asthma. The study of functioning and regulation of TRP channels is relevant, as they could be important therapeutic targets for asthma. The aim of the review is to summarize modern ideas about the mechanisms of functioning and regulation of members of the TRP channel superfamily, the role of which in lung pathology and physiology are the best studied.

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Ion Channels and Thermosensitivity: TRP, TREK, or Both?

International Journal of Molecular Sciences ◽

10.3390/ijms20102371 ◽

2019 ◽

Vol 20 (10) ◽

pp. 2371 ◽

Cited By ~ 12

Author(s):

J. Antonio Lamas ◽

Lola Rueda-Ruzafa ◽

Salvador Herrera-Pérez

Keyword(s):

Nervous System ◽

Ion Channels ◽

Body Temperature ◽

Molecular Mechanisms ◽

Transient Receptor Potential ◽

Receptor Potential ◽

Wide Range ◽

Cold Receptors ◽

Thermoregulatory System ◽

Transient Receptor

Controlling body temperature is a matter of life or death for most animals, and in mammals the complex thermoregulatory system is comprised of thermoreceptors, thermosensors, and effectors. The activity of thermoreceptors and thermoeffectors has been studied for many years, yet only recently have we begun to obtain a clear picture of the thermosensors and the molecular mechanisms involved in thermosensory reception. An important step in this direction was the discovery of the thermosensitive transient receptor potential (TRP) cationic channels, some of which are activated by increases in temperature and others by a drop in temperature, potentially converting the cells in which they are expressed into heat and cold receptors. More recently, the TWIK-related potassium (TREK) channels were seen to be strongly activated by increases in temperature. Hence, in this review we want to assess the hypothesis that both these groups of channels can collaborate, possibly along with other channels, to generate the wide range of thermal sensations that the nervous system is capable of handling.

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Structural mechanisms of transient receptor potential ion channels

The Journal of General Physiology ◽

10.1085/jgp.201811998 ◽

2020 ◽

Vol 152 (3) ◽

Cited By ~ 4

Author(s):

Erhu Cao

Keyword(s):

Ion Channels ◽

Transient Receptor Potential ◽

Trp Channels ◽

Receptor Potential ◽

Wide Range ◽

Human Disorders ◽

Transient Receptor ◽

Voltage Gated Ion Channels ◽

Structural Mechanisms ◽

Physical And Chemical

Transient receptor potential (TRP) ion channels are evolutionarily ancient sensory proteins that detect and integrate a wide range of physical and chemical stimuli. TRP channels are fundamental for numerous biological processes and are therefore associated with a multitude of inherited and acquired human disorders. In contrast to many other major ion channel families, high-resolution structures of TRP channels were not available before 2013. Remarkably, however, the subsequent “resolution revolution” in cryo-EM has led to an explosion of TRP structures in the last few years. These structures have confirmed that TRP channels assemble as tetramers and resemble voltage-gated ion channels in their overall architecture. But beyond the relatively conserved transmembrane core embedded within the lipid bilayer, each TRP subtype appears to be endowed with a unique set of soluble domains that may confer diverse regulatory mechanisms. Importantly, TRP channel TR structures have revealed sites and mechanisms of action of numerous synthetic and natural compounds, as well as those for endogenous ligands such as lipids, Ca2+, and calmodulin. Here, I discuss these recent findings with a particular focus on the conserved transmembrane region and how these structures may help to rationally target this important class of ion channels for the treatment of numerous human conditions.

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Transient Receptor Potential (TRP) Ion Channels Involved in Malignant Glioma Cell Death and Therapeutic Perspectives

Frontiers in Cell and Developmental Biology ◽

10.3389/fcell.2021.618961 ◽

2021 ◽

Vol 9 ◽

Author(s):

Florence Lefranc

Keyword(s):

Cell Death ◽

Ion Channels ◽

Malignant Glioma ◽

Cell Biology ◽

Glioma Cell ◽

Transient Receptor Potential ◽

Malignant Gliomas ◽

Receptor Potential ◽

Trp Ion Channels ◽

Transient Receptor

Among the most biologically, thus clinically, aggressive primary brain tumors are found malignant gliomas. Despite recent advances in adjuvant therapies, which include targeted and immunotherapies, after surgery and radio/chemotherapy, the tumor is recurrent and always lethal. Malignant gliomas also contain a pool of initiating stem cells that are highly invasive and resistant to conventional treatment. Ion channels and transporters are markedly involved in cancer cell biology, including glioma cell biology. Transient receptor potential (TRP) ion channels are calcium-permeable channels implicated in Ca2+ changes in multiple cellular compartments by modulating the driving force for Ca2+ entry. Recent scientific reports have shown that these channels contribute to the increase in glioblastoma aggressiveness, with glioblastoma representing the ultimate level of glioma malignancy. The current review focuses on each type of TRP ion channel potentially involved in malignant glioma cell death, with the ultimate goal of identifying new therapeutic targets to clinically combat malignant gliomas. It thus appears that cannabidiol targeting the TRPV2 type could be such a potential target.

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