scholarly journals The effect of antiviral substance 6-(2-morpholin-4-yl-ethyl)-6H-indolo [2,3-b]quinoxaline upon biomarkers of inflammation

2015 ◽  
Vol 31 (4) ◽  
pp. 264-271
Author(s):  
G. V. Antonovych ◽  
N. M. Zholobak ◽  
M. O. Shibinska ◽  
M. Ya. Spivak
Keyword(s):  
Antiviral Substance

Further Characterization of a Broad-Spectrum Antiviral Substance in Human Serum

1992 ◽  
Vol 5 (4) ◽  
pp. 293-303 ◽  
Author(s):  
I.P. SINGH ◽  
D.H. COPPENHAVER ◽  
A.K. CHOPRA ◽  
S. BARON
Keyword(s):  
Human Serum ◽  
Broad Spectrum ◽  
Antiviral Substance

Removal of Coliphages from Wastewater Effluent by Phototrophic Bacteria

1990 ◽  
Vol 22 (9) ◽  
pp. 59-63 ◽  
Author(s):  
H. Hirotani ◽  
Y. Agui ◽  
M. Kobayashi ◽  
E. Takahashi
Keyword(s):  
Field Test ◽  
Methanol Extract ◽  
Phototrophic Bacteria ◽  
Wastewater Effluent ◽  
Phototrophic Bacterium ◽  
Model Study ◽  
Antiviral Substance ◽  
Chloroform Methanol ◽  
Phage Inactivation

A wastewater purifying process using a phototrophic bacterium, Rhodopseudomonascapsulata, is presently operating in several countries. Removal of coliphage during the process was assessed by a field-test and a model study. It was found that 97.4% of coliphage was removed during the purification of wastewater from a pigpen. The model study was performed to ensure that the removal was due to biomass of the phototrophic bacterium, which produces an antiviral substance. Phage inactivation by chloroform-methanol extract from the bacterium with the presence of kaolinite as a contaminating particulate is also shown to describe the efficiency of the antiviral substance from the phototrophic bacterium to wastewater.

scholarly journals AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM

1953 ◽  
Vol 97 (5) ◽  
pp. 639-650 ◽  
Author(s):  
Richard E. Shope
Keyword(s):  
Chemical Nature ◽  
Water Bath ◽  
Boiling Water ◽  
Developmental Cycle ◽  
Penicillium Funiculosum ◽  
Boiling Water Bath ◽  
Freeze Dried ◽  
Antiviral Substance ◽  
Refrigerator Temperature ◽  
Frozen State

Helenine is moderately stable in solution at refrigerator temperature and can be kept for long periods of time without evident loss of activity if stored frozen at the temperature of solid CO2. It is filterable through a Seitz pad but not dialyzable. Crude SPS preparations of helenine do not lose activity when dried from the frozen state. Some conditions are described, however, which influence the preservation or inactivation of acetone-precipitated helenine when freeze-dried. Helenine is partially inactivated by exposure for 3 minutes to the temperature of a boiling water bath and is completely inactivated by autoclaving at 15 pounds' pressure for 15 minutes. The data presented suggest that helenine acts, either directly or by triggering some mechanism of the host itself, to destroy virus by a process which renders the latter non-antigenic. This effect may be exerted by action upon the virus itself or by interference with some stage in the developmental cycle of the virus. While the chemical nature of helenine is not known, the presence of a large proportion of polysaccharide in crude active preparations might suggest the possible importance of this class of substance in helenine activity. It is believed that helenine differs from the polysaccharide reported by Horsfall and McCarty and the penicillin impurity reported by Groupé and Rake to be active against certain viruses. It may be related, however, to the antiviral substance recently reported by Powell and his co-workers.

scholarly journals AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM

1953 ◽  
Vol 97 (5) ◽  
pp. 627-638 ◽  
Author(s):  
Richard E. Shope
Keyword(s):  
Therapeutic Effect ◽  
Semliki Forest Virus ◽  
Quantitative Difference ◽  
Qualitative Difference ◽  
Penicillium Funiculosum ◽  
Therapeutic Action ◽  
Virus Infections ◽  
Antiviral Substance

Helenine exerts a therapeutic effect against Semliki Forest virus infections of mice. Cures, that is to say the survival of treated animals, were more frequently observed in Semliki Forest virus infections than they were in SK virus infections. It is believed that this difference in end-result probably represented only a quantitative difference in the therapeutic effect of helenine against these two viruses and not a qualitative difference in its mechanism of therapeutic action. The findings reported in this paper with regard to the treatment of Semliki Forest virus infections with helenine parallel very closely those described in an accompanying paper which deals with the action of helenine on SK. virus infections.

scholarly journals Antiviral Substance from Silkworm Faeces: Purification and Its Chemical Characterization.

1997 ◽  
Vol 20 (5) ◽  
pp. 547-555 ◽  
Author(s):  
Akihiro HIRAKI ◽  
Masayuki YUKAWA ◽  
Jeman KIM ◽  
Shigeharu UEDA
Keyword(s):  
Chemical Characterization ◽  
Antiviral Substance

The mode of action of an antiviral substance from Penicillium cyaneo-fulvum

1968 ◽  
Vol 14 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Tam S. David-West ◽  
Patricia M. Cooke ◽  
J. W. Stevenson
Keyword(s):  
Influenza A ◽  
Antiviral Agents ◽  
Haemagglutination Inhibition ◽  
Influenza B Virus ◽  
Influenza B ◽  
Virus Particles ◽  
Virus Adsorption ◽  
B Virus ◽  
Antiviral Substance ◽  
Replicative Cycle

An antiviral substance elaborated in Czapek-Dox broth by a strain of Penicillium cyaneo-fulvum isolated in this laboratory, and active against influenza A virus (PR8), influenza B virus (Lee), and Newcastle disease virus (B1) in modified Maitland tissue cultures has been shown to act at an intracellular site in the viral replicative cycle. The substance neither blocks virus adsorption nor impedes the release of newly formed virus particles. It is not viricidal, does not interfere with the action of ths viral neuraminidase on red blood cells, and does not possess any haemagglutination or haemagglutination–inhibition activity. A comparison with other reported antiviral agents shows that the antiviral substance is different from those previously studied.

scholarly journals AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM FUNICULOSUM

1966 ◽  
Vol 123 (2) ◽  
pp. 213-227 ◽  
Author(s):  
Richard E. Shope
Keyword(s):  
Virus Infection ◽  
Semliki Forest Virus ◽  
Penicillium Funiculosum ◽  
Viral Immunity ◽  
Final Dose ◽  
Virus Inoculation ◽  
Antiviral Substance ◽  
Relationship Of ◽  
The Relationship ◽  
Protective Effectiveness

1. Helenine injected intraperitoneally 24 hr prior to a regularly fatal dose of Semliki Forest virus saves most of the mice to which it is administered. 2. Mice saved by helenine develop no viral immunity and regularly succumb when rechallenged 2 wk later with the same dose of virus from which they were originally saved. 3. The time during which helenine is optimally effective in protecting mice from death by Semliki Forest virus covers a period of approximately 36 hr beginning after about 12 hr and extending to 48 hr before virus infection. When periods of less than 12 hr, or more than 48 hr, elapse between the time of helenine administration and virus inoculation, its protective effectiveness diminishes progressively. 4. Repeated injections of helenine at 2- or 3-day intervals, if continued long enough, exhaust the capacity of a host to respond favorably to helenine administered 24 hr before virus inoculation. 5. Helenine injections at intervals of 4, 3, and 2 wk before its administration 24 hr prior to infection do not decrease the effectiveness of this final dose in protecting mice from fatal infection by the virus. The experimental results here reported indicate that, as suggested by the findings of earlier work, helenine does not act directly as an antiviral substance, but instead exerts its effect through some substance that it induces the host to elaborate. The nature of this induced antiviral substance is as yet unknown though, to judge from the failure of spared mice to acquire viral immunity, it appears to act at a stage in viral replication prior to that at which antigenic viral protein is produced. The findings with helenine and those thus far reported for interferon afford no factual basis for judging the relationship of the two, if any.

AN ANTIVIRAL SUBSTANCE FROM PENICILLIUM CYANEO-FULVUM BIOURGE: I. PRODUCTION AND PARTIAL PURIFICATION

1965 ◽  
Vol 11 (6) ◽  
pp. 913-919 ◽  
Author(s):  
Patricia M. Cooke ◽  
J. W. Stevenson
Keyword(s):  
Ammonium Sulfate ◽  
Ethyl Alcohol ◽  
Antiviral Agent ◽  
Partial Purification ◽  
Fractional Precipitation ◽  
Antiviral Substance

Penicillium cyaneo-fulvum Biourge, which produces a toxin-neutralizing substance, has been shown to produce a separate and distinct antiviral agent. The two products may be separated in a semipurified state by fractional precipitation with ammonium sulfate and ethyl alcohol.

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