scholarly journals Ophiopogonin B alleviates cisplatin resistance of lung cancer cells by inducing Caspase-1/GSDMD dependent pyroptosis

2022 ◽  
Vol 13 (2) ◽  
pp. 715-727
Author(s):  
Ziyu Cheng ◽  
Zhihui Li ◽  
Ling Gu ◽  
Liqiu Li ◽  
Qian Gao ◽  
...  
2018 ◽  
Vol 234 (6) ◽  
pp. 9077-9092 ◽  
Author(s):  
Maria Rita Milone ◽  
Rita Lombardi ◽  
Maria Serena Roca ◽  
Francesca Bruzzese ◽  
Laura Addi ◽  
...  

2012 ◽  
Vol 11 (3) ◽  
pp. 604-615 ◽  
Author(s):  
Medhi Wangpaichitr ◽  
Elizabeth J. Sullivan ◽  
George Theodoropoulos ◽  
Chunjing Wu ◽  
Min You ◽  
...  

2008 ◽  
Vol 38 (5) ◽  
pp. 559-565 ◽  
Author(s):  
Jin-Tang Chen ◽  
Chih-Yang Huang ◽  
Yung-Yen Chiang ◽  
Wen-Heng Chen ◽  
Shiow-Her Chiou ◽  
...  

2020 ◽  
Author(s):  
Ting-Ting Liu ◽  
Rui Li ◽  
Xiao Liu ◽  
Xi-Jia Zhou ◽  
Chen Huo ◽  
...  

Abstract Background: In recent years, LncRNA acts as a member of competing endogenous RNA (ceRNA), playing an important role in drug resistance of lung cancer. The aim of this study was to identify potential biomarkers about cisplatin resistant lung cancer cells using a comprehensive ceRNA network.Methods: GSE6410 (GPL-201) analyzed gene expression changes about cispaltin resistance in A549 NSCLC cells. GSE43249 (GPL-14613) included noncoding RNA expression profiling derived from the cisplatin resistant A549 lung cells. GEO2R, an online analysis tool, analyzed the differentially expressed mRNAs and miRNAs (DEmRNAs and DEmiRNAs). To explore the functional enrichment implication of differentially expressed mRNAs, we used the GO and KEGG pathway analysis. Through miRDB、Targetscan、Starbase、miRWalk, we found targeted miRNAs. The Kaplan-Meier curve method was used to show clinical survival analysis of targeted RNAs (P<0.05). The Starbase database predicted potential lncRNAs mediated targeted miRNAs. Eventually, the novel ceRNA network of lncRNAs, miRNAs, mRNA was constructed by cytoscape3.7.2.Results:118 differentially expressed mRNAs were the basis of the mediated ceRNA network. DAVID and Kaplan-Meier picked out BAX, an apoptosis regulator. Venn Diagram demonstrated 8 miRNAs commomly regulating Bax. Starbase predicted lncRNA XIST mediated miRNAs. Finally, lncRNA XIST maybe a useful biomarker regulating cisplatin resistance in lung cancer cells.Conclusions: LncRNA XIST competitively bound to miRNA 520 in the regulation of cisplatin resistance by BAX , participating apoptosis in the p53 signaling pathway.


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