scholarly journals Oncogenic and incidental HPV types associated with histologically confirmed cervical intraepithelial neoplasia in HIV-positive and HIV-negative South African women

2016 ◽  
Vol 106 (6) ◽  
pp. 617 ◽  
Author(s):  
Matthys Cornelis Van Aardt ◽  
Greta Dreyer ◽  
Leon Cornelius Snyman ◽  
Karin Louise Richter ◽  
Piet Becker ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
South African ◽  
Intraepithelial Neoplasia ◽  
African Women ◽  
Hiv Positive ◽  
Hpv Types ◽  
South African Women ◽  
Hiv Negative

scholarly journals Distribution of Human Papillomavirus (HPV) Genotypes in HIV-Negative and HIV-Positive Women with Cervical Intraepithelial Lesions in the Eastern Cape Province, South Africa

Viruses ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 280
Author(s):  
Ongeziwe Taku ◽  
Zizipho Z. A. Mbulawa ◽  
Keletso Phohlo ◽  
Mirta Garcia-Jardon ◽  
Charles B. Businge ◽  
...  
Keyword(s):  
South African ◽  
Hpv Infection ◽  
African Women ◽  
Hiv Positive ◽  
Eastern Cape ◽  
Hpv Prevalence ◽  
Hiv Positive Women ◽  
Hpv Types ◽  
South African Women ◽  
Hiv Negative

South African women have a high rate of cervical cancer cases, but there are limited data on human papillomavirus (HPV) genotypes in cervical intraepithelial neoplasia (CIN) in the Eastern Cape province, South Africa. A total of 193 cervical specimens with confirmed CIN from women aged 18 years or older, recruited from a referral hospital, were tested for HPV infection. The cervical specimens, smeared onto FTA cards, were screened for 36 HPV types using an HPV direct flow kit. HPV prevalence was 93.5% (43/46) in CIN2 and 96.6% (142/147) in CIN3. HIV-positive women had a significantly higher HPV prevalence than HIV-negative women (98.0% vs. 89.1%, p = 0.012). The prevalence of multiple types was significantly higher in HIV-positive than HIV-negative women (p = 0.034). The frequently detected genotypes were HPV35 (23.9%), HPV58 (23.9%), HPV45 (19.6%), and HPV16 (17.3%) in CIN2 cases, while in CIN3, HPV35 (22.5%), HPV16 (21.8%), HPV33 (15.6%), and HPV58 (14.3%) were the most common identified HPV types, independent of HIV status. The prevalence of HPV types targeted by the nonavalent HPV vaccine was 60.9% and 68.7% among women with CIN2 and CIN3, respectively, indicating that vaccination would have an impact both in HIV-negative and HIV-positive South African women, although it will not provide full protection in preventing HPV infection and cervical cancer lesions.

High prevalence of HPV 16 in South African women with cancer of the cervix and cervical intraepithelial neoplasia

2003 ◽  
Vol 71 (2) ◽  
pp. 265-273 ◽  
Author(s):  
Patti Kay ◽  
Robbert Soeters ◽  
James Nevin ◽  
Lynette Denny ◽  
Catherine M.C. Dehaeck ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
South African ◽  
Intraepithelial Neoplasia ◽  
African Women ◽  
Hpv 16 ◽  
High Prevalence ◽  
Cancer Of The Cervix ◽  
South African Women

scholarly journals Dietary intake and body composition in HIV-positive and -negative South African women

2013 ◽  
Vol 17 (7) ◽  
pp. 1603-1613 ◽  
Author(s):  
Stephanie V Wrottesley ◽  
Lisa K Micklesfield ◽  
Matthew M Hamill ◽  
Gail R Goldberg ◽  
Ann Prentice ◽  
...  
Keyword(s):  
Body Composition ◽  
Dietary Intake ◽  
South African ◽  
Overweight And Obesity ◽  
African Women ◽  
Hiv Positive ◽  
Cd4 Counts ◽  
South African Women ◽  
The Impact ◽  
Hiv Negative

AbstractObjectiveThe present paper examines dietary intake and body composition in antiretroviral (ARV)-naïve HIV-positive compared with HIV-negative South African women, as well as the impact of disease severity on these variables.DesignBaseline data from a longitudinal study assessing bone health in HIV-negative and HIV-positive premenopausal South African women over 18 years of age were used. Anthropometry and body composition, measured by dual energy X-ray absorptiometry, were analysed together with dietary intake data assessed using an interviewer-based quantitative FFQ.SettingSoweto, Johannesburg, South Africa.SubjectsBlack, urban South African women were divided into three groups: (i) HIV-negative (HIV−; n 98); (ii) HIV-positive with preserved CD4 counts (HIV+ non-ARV; n 74); and (iii) HIV-positive with low CD4 counts and due to start ARV treatment (HIV+ pre-ARV; n 75).ResultsThe prevalence of overweight and obesity was high in this population (59 %). The HIV+ pre-ARV group was lighter and had a lower BMI than the other two groups (all P < 0·001). HIV+ pre-ARV women also had lower fat and lean masses and percentage body fat than their HIV− and HIV+ non-ARV counterparts. After adjustment, there were no differences in macronutrient intakes across study groups; however, fat and sugar intakes were high and consumption of predominantly refined food items was common overall.ConclusionHIV-associated immunosuppression may be a key determinant of body composition in HIV-positive women. However, in populations with high obesity prevalence, these differences become evident only at advanced stages of infection.

Barriers to Recruitment and Retention of HIV-Negative Black South African Women into Behavioral HIV Prevention Programs

2011 ◽  
Vol 10 (3) ◽  
pp. 248-264 ◽  
Author(s):  
Dorina Onoya ◽  
Priscilla Reddy ◽  
Sibusiso Sifunda ◽  
Gina M. Wingood ◽  
Bart van den Borne ◽  
...  
Keyword(s):  
Hiv Prevention ◽  
South African ◽  
Prevention Programs ◽  
African Women ◽  
Recruitment And Retention ◽  
Black South African ◽  
South African Women ◽  
Hiv Negative

Cervical intraepithelial neoplasia recurrence after conization in HIV-positive and HIV-negative women

2008 ◽  
Vol 104 (2) ◽  
pp. 100-104 ◽  
Author(s):  
Maria Inês Lima ◽  
Alexandre Tafuri ◽  
Angela C Araújo ◽  
Luiza de Miranda Lima ◽  
Victor Hugo Melo
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Hiv Positive ◽  
Hiv Negative

scholarly journals The Impact of Structured Support Groups for Pregnant South African Women Recently Diagnosed HIV Positive

2011 ◽  
Vol 51 (6) ◽  
pp. 546-565 ◽  
Author(s):  
Jonathan P. Mundell ◽  
Maretha J. Visser ◽  
Jennifer D. Makin ◽  
Trace S. Kershaw ◽  
Brian W. C. Forsyth ◽  
...  
Keyword(s):  
South African ◽  
Support Groups ◽  
African Women ◽  
Hiv Positive ◽  
South African Women ◽  
The Impact

scholarly journals Patterns of prevalent HPV and STI co-infections and associated factors among HIV-negative young Western Cape, South African women: the EVRI trial

2017 ◽  
Vol 94 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Lynette J Menezes ◽  
Ubin Pokharel ◽  
Staci L Sudenga ◽  
Matthys H Botha ◽  
Michele Zeier ◽  
...  
Keyword(s):  
South African ◽  
Young Women ◽  
Hpv Vaccine ◽  
Associated Factors ◽  
African Women ◽  
Infection Prevalence ◽  
Western Cape ◽  
Link Type ◽  
South African Women ◽  
Hiv Negative

ObjectiveTo estimate the prevalence and describe the patterns of concurrent human papillomavirus (HPV) and STIs and associated factors among HIV-negative young Western Cape, South African women participating in the Efficacy of HPV Vaccine to Reduce HIV Infection (EVRI) trial.MethodsHIV-negative women aged 16–24 years old were enrolled in the EVRI trial (NCT01489527) and randomised to receive the licensed four-valent HPV vaccine or placebo. At study entry, participants were clinically evaluated for five STIs: herpes simplex virus type 2 (HSV-2), chlamydia, gonorrhoea, syphilis and disease-causing HPV genotypes (6/11/16/18/31/33/35/39/45/51/52/56/58/59/68). Demographic and sexual history characteristics were compared among women with STI co-infections, single infection and no infection using Pearson χ2 and Mann-Whitney tests. ORs were calculated to evaluate factors associated with STI co-infection prevalence.ResultsAmong 388 young women, STI co-infection prevalence was high: 47% had ≥2 concurrent STIs, 36% had a single STI and 17% had none of the five evaluated STIs. HPV/HSV-2 (26%) was the most prevalent co-infection detected followed by HPV/HSV-2/Chlamydia trachomatis (CT) (17%) and HPV/CT (15%). Co-infection prevalence was independently associated with alcohol use (adjusted OR=2.01, 95% CI 1.00 to 4.06) and having a sexual partner with an STI (adjusted OR=6.96, 95% CI 1.53 to 30.08).ConclusionsAmong high-risk young women from underserved communities such as in Southern Africa, a multicomponent prevention strategy that integrates medical and behavioural interventions targeting both men and women is essential to prevent acquisition of concurrent STI infections and consequent disease.Trial registration numberNCT01489527; Post-results.

Performance of cytology and colposcopy in diagnosis of cervical intraepithelial neoplasia (CIN) in HIV-positive and HIV-negative women

Cytopathology ◽  
2001 ◽  
Vol 12 (2) ◽  
pp. 84-93 ◽  
Author(s):  
M. Branca ◽  
E. Rossi ◽  
M. Alderisio ◽  
G. Migliore ◽  
P. L. Morosini ◽  
...  
Keyword(s):  
Cervical Intraepithelial Neoplasia ◽  
Intraepithelial Neoplasia ◽  
Hiv Positive ◽  
Hiv Negative
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