The use of a hydrocolloid dressing in the facial wound healing process of a horse - case report

Hydrocolloid dressing is a bioactive product used to improve the healing process of large open wounds. InMarch 2011, a horse was evaluated at the Veterinary Medical Teaching Hospital- UNICENTRO, Guarapuava,Brazil. The animal presented with epistaxis and inspiratory dyspnoea associated with fracture of the orbitalpart of the frontal bone with a comminuted fracture of the zygomatic process and bone loss of the articulartubercle of the temporal bone reaching the zygomatic process, tooth fracture and a partial laceration of theleft cheek with avulsion of the eyeball. After the reconstructive facial surgery and enucleation we used thehydrocolloid dressing during the repair phase. It helped re-establish the epithelial layer, avoided excessivegranulation tissue formation and decreased the healing time. Seven days after surgery and the use ofbiological membrane we verified the production of intense and controlled granulation tissue, beyond thatthe membrane was a viable and low cost alternative.

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Bee Pollen as a Promising Agent in the Burn Wounds Treatment

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2016/8473937 ◽

2016 ◽

Vol 2016 ◽

pp. 1-12 ◽

Cited By ~ 4

Author(s):

Paweł Olczyk ◽

Robert Koprowski ◽

Justyna Kaźmierczak ◽

Lukasz Mencner ◽

Robert Wojtyczka ◽

...

Keyword(s):

Quantitative Research ◽

Healing Process ◽

Physiological Saline ◽

Healing Time ◽

Wound Healing Process ◽

Burn Treatment ◽

Bee Pollen ◽

Domestic Pigs ◽

Burn Wounds ◽

Number Of Microorganisms

The aim of the present study was to visualize the benefits and advantages derived from preparations based on extracts of bee pollen as compared to pharmaceuticals commonly used in the treatment of burns. The bee pollen ointment was applied for the first time in topical burn treatment. Experimental burn wounds were inflicted on two white, domestic pigs. Clinical, histopathological, and microbiological assessment of specimens from burn wounds, inflicted on polish domestic pigs, treated with silver sulfadiazine or bee pollen ointment, was done. The comparative material was constituted by either tissues obtained from wounds treated with physiological saline or tissues obtained from wounds which were untreated. Clinical and histopathological evaluation showed that applied apitherapeutic agent reduces the healing time of burn wounds and positively affects the general condition of the animals. Moreover the used natural preparation proved to be highly effective antimicrobial agent, which was reflected in a reduction of the number of microorganisms in quantitative research and bactericidal activity of isolated strains. On the basis of the obtained bacteriological analysis, it may be concluded that the applied bee pollen ointment may affect the wound healing process of burn wounds, preventing infection of the newly formed tissue.

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Evaluation of Indonesian and two types of Japanese honey on the acceleration of cutaneous wound healing: an experimental study in mice

Journal of Health Technology Assessment in Midwifery ◽

10.31101/jhtam.912 ◽

2019 ◽

Vol 2 (2) ◽

pp. 80-88

Author(s):

Haryanto Haryanto ◽

Kanae Mukai ◽

Nakajima Yukari ◽

Mayumi Okuwa ◽

Cau Kim Jiu ◽

...

Keyword(s):

Wound Healing ◽

Healing Process ◽

Control Group ◽

Wound Healing Process ◽

Wound Area ◽

Hydrocolloid Dressing ◽

Thickness Skin ◽

Microscopic Evaluation ◽

Acacia Honey ◽

Macroscopic Findings

The purpose of this study is to evaluate and clarify the effect of Indonesian honey, two types of Japanese honey and hydrocolloid dressing on wound healing process. Four groups of male mice were treated to produce two circular full-thickness skin wounds on the dorsum. They were then randomly allocated to receive daily Indonesian honey, Japanese honey (Buckwheat and Acacia honey) or hydrocolloid dressing as a control for treatment application. Macroscopic findings were observed from day 0 to 14 after wounding. Microscopic evaluation was assessed using qualitative analysis. The ratios of wound areas for honey groups on day 3 and 7 were smaller than those of the control group. Wound areas of honey groups gradually decreased to almost the same wound area as the control group on day 14, while the wound area of the control group peaked on day 5 and rapidly decreased until day 14. Microscopic finding that Indonesian honey was different with Japanese honey especially Buckwheat honey.

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Wound-healing activity of immobilized postbiotics from Bacillus subtilis exometabolites

BIO Web of Conferences ◽

10.1051/bioconf/20214001002 ◽

2021 ◽

Vol 40 ◽

pp. 01002

Author(s):

Dina Shokatayeva ◽

Irina Savitskaya ◽

Aida Kistaubayeva

Keyword(s):

Wound Healing ◽

Bacillus Subtilis ◽

Healing Process ◽

Antagonistic Activity ◽

Healing Time ◽

Wound Dressings ◽

Laboratory Animals ◽

Wound Healing Process ◽

Antimicrobial Substances ◽

Treatment Of Wounds

The biological activity of postbiotic from Bacillus subtilis exometabolites was determined due to protein content - 0.541±13.4 mg/ml, the level of proteases - 7.8±0.3 U/ml and the presence of antimicrobial substances. A biocomposite material was developed by co-aggregation of bacterial cellulose, chitosan and Bacillus exometabolites. Modified BC gel film possesses high antagonistic activity against causative agents of wound infections: Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis. The use of the obtained material in treatment of wounds on laboratory animals reduces healing time by an average of 20%. The developed bioactive wound dressings is intended for local application in order to optimize the wound healing process.

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Sirtuins in wound healing

Trends in Immunotherapy ◽

10.24294/ti.v3.i2.122 ◽

2019 ◽

Vol 3 (2) ◽

pp. 89

Author(s):

Akihiro Aioi

Keyword(s):

Wound Healing ◽

Cell Differentiation ◽

Histone Deacetylase ◽

Calorie Restriction ◽

Human Life ◽

Healing Process ◽

Wound Healing Process ◽

Tissue Formation ◽

Anti Inflammation ◽

Human Life Span

Sirtuins (SIRTs) are initially recognized as NAD+-dependent histone deacetylase. SIRTs attract attention for their role as calorie restriction-induced “longevity proteins” to be expected to extend human life span and to promote health. As advancing studies, SIRTs have been recognized as cell signaling regulators which contribute to anti-inflammation, cell differentiation and so on. Therefore, SIRTs are supposed to affect wound healing which is comprised highly orchestrated complex four phases: hemostasis, inflammation, tissue formation and tissue remodeling. This review highlights the roles of SIRTs in wound healing process and provides a foundation and impetus for future basic and clinical research.

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Sirtuins in wound healing

Trends in Immunotherapy ◽

10.24294/ti.v1.i3.122 ◽

2017 ◽

Vol 1 (3) ◽

Author(s):

Akihiro Aioi

Keyword(s):

Wound Healing ◽

Cell Differentiation ◽

Histone Deacetylase ◽

Calorie Restriction ◽

Human Life ◽

Healing Process ◽

Wound Healing Process ◽

Tissue Formation ◽

Anti Inflammation ◽

Human Life Span

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Neodermis Formation in Full Thickness Wounds Using an Esterified Hyaluronic Acid Matrix

Journal of Burn Care & Research ◽

10.1093/jbcr/irz057 ◽

2019 ◽

Vol 40 (5) ◽

pp. 585-589 ◽

Cited By ~ 1

Author(s):

Ariel Aballay ◽

Michel H E Hermans

Keyword(s):

Wound Healing ◽

Hyaluronic Acid ◽

Normal Skin ◽

Healing Process ◽

Healing Time ◽

Wound Healing Process ◽

Dermal Matrix ◽

Impaired Wound Healing ◽

Normal Wound Healing ◽

The Many

AbstractThe role of the dermis is essential for the proper orchestration of all phases of the normal wound healing process. Wounds with seriously damaged or even absent dermis consistently show seriously impaired wound healing and/or long-term complications such as hypertrophic scarring. Replacing a damaged dermis requires a dermal matrix that is compatible with, or even stimulates, the process of wound healing. Hyaluronic acid (HA), in an esterified form, is among the many matrices that are available. HA has been used in a number of indications, such as ulcers (ie, diabetic foot ulcers and venous leg ulcers), trauma, including burns, and for the repair of contractures and hypertrophic scars. The shorter healing time and the decrease of recurring hypertrophy demonstrate the efficiency of HA-derived matrices. Biopsies, taken up to 12 months post-reconstruction show a neodermis that histologically is largely comparable to normal skin, which probably is a function of HA playing such a pivotal role in normal, unwounded skin, as well as in the process of healing.

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Role of oxygen in wound healing

Journal of Wound Care ◽

10.12968/jowc.2020.29.sup5b.s4 ◽

2020 ◽

Vol 29 (Sup5b) ◽

pp. S4-S10 ◽

Cited By ~ 1

Author(s):

Ibby Younis

Keyword(s):

Wound Healing ◽

Host Resistance ◽

Essential Role ◽

Oxygen Supply ◽

Healing Process ◽

Wound Healing Process ◽

Tissue Formation ◽

Granulation Tissue Formation ◽

Resistance To Infection

Not only does oxygen play an essential role in each stage of the wound healing process. It also helps to increases host resistance to infection. Any impairment to the oxygen supply can therefore delay healing. This article explores the affects of oxygen on the wound cells and tissue, and explains how an adequate supply is required for granulation tissue formation and epithelialisation to occur

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Marine Polysaccharides for Wound Dressings Application: An Overview

Pharmaceutics ◽

10.3390/pharmaceutics13101666 ◽

2021 ◽

Vol 13 (10) ◽

pp. 1666

Author(s):

Shenghai Shen ◽

Xiaowen Chen ◽

Zhewen Shen ◽

Hao Chen

Keyword(s):

Wound Healing ◽

Low Cost ◽

Healing Process ◽

Wound Dressings ◽

Wound Management ◽

Wound Healing Process ◽

Comprehensive Understanding ◽

Wound Therapy ◽

Accelerate Wound Healing ◽

Active Substances

Wound dressings have become a crucial treatment for wound healing due to their convenience, low cost, and prolonged wound management. As cutting-edge biomaterials, marine polysaccharides are divided from most marine organisms. It possesses various bioactivities, which allowing them to be processed into various forms of wound dressings. Therefore, a comprehensive understanding of the application of marine polysaccharides in wound dressings is particularly important for the studies of wound therapy. In this review, we first introduce the wound healing process and describe the characteristics of modern commonly used dressings. Then, the properties of various marine polysaccharides and their application in wound dressing development are outlined. Finally, strategies for developing and enhancing marine polysaccharide wound dressings are described, and an outlook of these dressings is given. The diverse bioactivities of marine polysaccharides including antibacterial, anti-inflammatory, haemostatic properties, etc., providing excellent wound management and accelerate wound healing. Meanwhile, these biomaterials have higher biocompatibility and biodegradability compared to synthetic ones. On the other hand, marine polysaccharides can be combined with copolymers and active substances to prepare various forms of dressings. Among them, emerging types of dressings such as nanofibers, smart hydrogels and injectable hydrogels are at the research frontier of their development. Therefore, marine polysaccharides are essential materials in wound dressings fabrication and have a promising future.

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Growth Factors and Ocular Scarring

European Ophthalmic Review ◽

10.17925/eor.2009.03.02.58 ◽

2009 ◽

Vol 03 (02) ◽

pp. 58 ◽

Cited By ~ 4

Author(s):

James S Ellis ◽

Daniel J Paull ◽

Sumit Dhingra ◽

Ashkan Khalili ◽

Maria Notara ◽

...

Keyword(s):

Growth Factors ◽

Transforming Growth Factor ◽

Healing Process ◽

Control Cell ◽

Scar Tissue ◽

Scar Formation ◽

Wound Healing Process ◽

Tissue Formation ◽

Matrix Deposition ◽

Scar Tissue Formation

Growth factors play a part in every stage of the wound healing process that leads to scar tissue formation. Ocular scarring can cause decreased vision or blindness by virtue of the opaque nature of the new matrix that is deposited as scar tissue (as in the lens or cornea). In addition, the contractile nature of the ocular scar tissue is the most common cause of failed retinal attachment. Scar formation after glaucoma surgery can lead to surgery failure. Growth factors, particularly the transforming growth factor (TGF-βs), play a major role in scar tissue formation in the eye and induce the synthesis of growth factors that control cell migration, proliferation, enzyme production and matrix deposition. Neurotrophins are also neuroprotective and can delay ganglion cell death, thus delaying scar formation in the retina if retinal attachment is restored promptly. Growth factors can be seen as a major target for preventing ocular scarring in the future.

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