Influence of Scar Tissue Formation on the Early Wound Healing Process of Palate Bones in Rats

2005 ◽  
Vol 47 (3) ◽  
pp. 294-304
Author(s):  
Hitoshi Kawanabe ◽  
Shouichi Kinoshita ◽  
Yuichiro Hata ◽  
Hiroyuki Ishikawa ◽  
Kazuhiko Okamura ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Scar Tissue ◽  
Wound Healing Process ◽  
Tissue Formation ◽  
Early Wound ◽  
Scar Tissue Formation

Growth Factors and Ocular Scarring

2009 ◽  
Vol 03 (02) ◽  
pp. 58 ◽  
Author(s):  
James S Ellis ◽  
Daniel J Paull ◽  
Sumit Dhingra ◽  
Ashkan Khalili ◽  
Maria Notara ◽  
...  
Keyword(s):  
Growth Factors ◽  
Transforming Growth Factor ◽  
Healing Process ◽  
Control Cell ◽  
Scar Tissue ◽  
Scar Formation ◽  
Wound Healing Process ◽  
Tissue Formation ◽  
Matrix Deposition ◽  
Scar Tissue Formation

Growth factors play a part in every stage of the wound healing process that leads to scar tissue formation. Ocular scarring can cause decreased vision or blindness by virtue of the opaque nature of the new matrix that is deposited as scar tissue (as in the lens or cornea). In addition, the contractile nature of the ocular scar tissue is the most common cause of failed retinal attachment. Scar formation after glaucoma surgery can lead to surgery failure. Growth factors, particularly the transforming growth factor (TGF-βs), play a major role in scar tissue formation in the eye and induce the synthesis of growth factors that control cell migration, proliferation, enzyme production and matrix deposition. Neurotrophins are also neuroprotective and can delay ganglion cell death, thus delaying scar formation in the retina if retinal attachment is restored promptly. Growth factors can be seen as a major target for preventing ocular scarring in the future.

Identifying wound infections for veterinary nurses

2020 ◽  
Vol 11 (10) ◽  
pp. 447-451
Author(s):  
Amanda Curtis
Keyword(s):  
Healing Process ◽  
Scar Tissue ◽  
Care Practice ◽  
Wound Infections ◽  
Tissue Formation ◽  
Deep Tissue ◽  
The Difference ◽  
Bite Wounds ◽  
Major Factors ◽  
Scar Tissue Formation

Heavily contaminated wounds are a common occurrence in both referral and primary care practice, with traumatic and bite wounds being among the most typical aetiologies seen. Each type of wound can be affected by numerous factors that can inhibit the healing process, one of these major factors is infection. Wound infections and the formation of biofilms can present veterinary nurses with a variety of challenges, which is why it is important that we understand the difference between normal inflammatory signs and the signs of infection. The early identification of infection and biofilms within a wound can influence healing times, scar tissue formation and length of healing. This article aims to highlight the difference between inflammation and infection, the different levels of contamination within a wound, and ways to decipher between superficial and deep tissue infections.

scholarly journals Hydrogels for management of chronic wound healing

2021 ◽  
Vol 5 (3) ◽  
pp. 095-104
Author(s):  
IM Cardoso-Daodu ◽  
CP Azubuike ◽  
MO Ilomuanya
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Healing Process ◽  
Three Dimensional ◽  
Scar Tissue ◽  
The Body ◽  
Polymer Chains ◽  
Wound Healing Process ◽  
Dimensional Network ◽  
Healing Wound

Chronic wounds occur when one wound healing process or a sequence of wound healing events are affected resulting in slow healing of the wound thereby placing the patient in deep pain. Various diseases and conditions can delay the process of wound healing. Wound healing can be classified into four main stages: hemostasis, inflammation, remodeling, and scar tissue formation with each phase overlapping one another. The skin is the largest organ in the body. It protects the entire external surface of the human body and is the primary site of interaction with the outside environment. There is therefore a need to fabricate an ideal dressing through scientific research and investigations. Hydrogels are a three-dimensional network of hydrophilic polymers that can swell in water and absorb copious amounts of water while maintaining their structure because of their chemical or physical crosslinking of individual polymer chains. A hydrogel must be composed of at least 10% water. Hydrogels possess the flexibility and water percentage which is remarkably like tissues. They are biocompatible and biodegradable which makes them ideal for dermal wound healing.

scholarly journals Fibroblast migration and collagen deposition during dermal wound healing: mathematical modelling and clinical implications

2006 ◽  
Vol 364 (1843) ◽  
pp. 1385-1405 ◽  
Author(s):  
Steven McDougall ◽  
John Dallon ◽  
Jonathan Sherratt ◽  
Philip Maini
Keyword(s):  
Wound Healing ◽  
Diffusion Coefficient ◽  
Scar Tissue ◽  
Tissue Formation ◽  
Collagen Deposition ◽  
Dermal Wound Healing ◽  
Fibroblast Migration ◽  
Collagen Alignment ◽  
Dermal Wound ◽  
Scar Tissue Formation

The extent to which collagen alignment occurs during dermal wound healing determines the severity of scar tissue formation. We have modelled this using a multiscale approach, in which extracellular materials, for example collagen and fibrin, are modelled as continua, while fibroblasts are considered as discrete units. Within this model framework, we have explored the effects that different parameters have on the alignment process, and we have used the model to investigate how manipulation of transforming growth factor-β levels can reduce scar tissue formation. We briefly review this body of work, then extend the modelling framework to investigate the role played by leucocyte signalling in wound repair. To this end, fibroblast migration and collagen deposition within both the wound region and healthy peripheral tissue are considered. Trajectories of individual fibroblasts are determined as they migrate towards the wound region under the combined influence of collagen/fibrin alignment and gradients in a paracrine chemoattractant produced by leucocytes. The effects of a number of different physiological and cellular parameters upon the collagen alignment and repair integrity are assessed. These parameters include fibroblast concentration, cellular speed, fibroblast sensitivity to chemoattractant concentration and chemoattractant diffusion coefficient. Our results show that chemoattractant gradients lead to increased collagen alignment at the interface between the wound and the healthy tissue. Results show that there is a trade-off between wound integrity and the degree of scarring. The former is found to be optimized under conditions of a large chemoattractant diffusion coefficient, while the latter can be minimized when repair takes place in the presence of a competitive inhibitor to chemoattractants.

scholarly journals Application of ADSCs and their Exosomes in Scar Prevention

2021 ◽  
Author(s):  
Cong Li ◽  
Shuqiang Wei ◽  
Quanchen Xu ◽  
Yu Sun ◽  
Xuchao Ning ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Adipose Tissue ◽  
Tissue Injury ◽  
Healing Process ◽  
Treatment Method ◽  
Scar Tissue ◽  
Wound Healing Process ◽  
Target Cells ◽  
Cellular Components

AbstractScar is a common way of healing after tissue injury. The poor scar healing will not only cause dysfunction of tissues and organs but also affect the appearance of the patients’ body surface, which causes the pressure of life and spirit to the patients. However, the formation of scar tissue is an extremely complex process and its mechanism is not fully understood. At present, there is no treatment method to eliminate scars completely. Fibroblasts are the most abundant cells in the dermis, which have the ability to synthesize and remodel extracellular matrix (ECM). Myofibroblasts actively participate in the wound healing process and influence the outcome. Therefore, both of them play important roles in wound healing and scar formation. Adipose tissue-derived stem cells (ADSCs) are pluripotent stem cells that can act on target cells by paracrine. Adipose tissue stem cell-derived exosomes (ADSC-Exos) are important secretory substances of ADSCs. They are nanomembrane vesicles that can transport a variety of cellular components and fuse with target cells. In this review, we will discuss the effects of ADSCs and ADSC-Exos on the behavior of fibroblasts and myofibroblasts during wound healing and scarring stage in combination with recent studies. Graphical Abstract

scholarly journals Sirtuins in wound healing

2019 ◽  
Vol 3 (2) ◽  
pp. 89
Author(s):  
Akihiro Aioi
Keyword(s):  
Wound Healing ◽  
Cell Differentiation ◽  
Histone Deacetylase ◽  
Calorie Restriction ◽  
Human Life ◽  
Healing Process ◽  
Wound Healing Process ◽  
Tissue Formation ◽  
Anti Inflammation ◽  
Human Life Span

Sirtuins (SIRTs) are initially recognized as NAD+-dependent histone deacetylase. SIRTs attract attention for their role as calorie restriction-induced “longevity proteins” to be expected to extend human life span and to promote health. As advancing studies, SIRTs have been recognized as cell signaling regulators which contribute to anti-inflammation, cell differentiation and so on. Therefore, SIRTs are supposed to affect wound healing which is comprised highly orchestrated complex four phases: hemostasis, inflammation, tissue formation and tissue remodeling. This review highlights the roles of SIRTs in wound healing process and provides a foundation and impetus for future basic and clinical research.

scholarly journals Sirtuins in wound healing

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Akihiro Aioi
Keyword(s):  
Wound Healing ◽  
Cell Differentiation ◽  
Histone Deacetylase ◽  
Calorie Restriction ◽  
Human Life ◽  
Healing Process ◽  
Wound Healing Process ◽  
Tissue Formation ◽  
Anti Inflammation ◽  
Human Life Span

Sirtuins (SIRTs) are initially recognized as NAD+-dependent histone deacetylase. SIRTs attract attention for their role as calorie restriction-induced “longevity proteins” to be expected to extend human life span and to promote health. As advancing studies, SIRTs have been recognized as cell signaling regulators which contribute to anti-inflammation, cell differentiation and so on. Therefore, SIRTs are supposed to affect wound healing which is comprised highly orchestrated complex four phases: hemostasis, inflammation, tissue formation and tissue remodeling. This review highlights the roles of SIRTs in wound healing process and provides a foundation and impetus for future basic and clinical research.

scholarly journals A review on Vranagranthi (Keloid) in Ayurvedic and Modern Aspect

2019 ◽  
Vol 7 (06) ◽  
Author(s):  
Abhijeet Suresh Shinde
Keyword(s):  
Wound Healing ◽  
Scar Tissue ◽  
Review Article ◽  
Tissue Formation ◽  
Pathological Study ◽  
Modern Aspect ◽  
Surgical Scar ◽  
Severe Acne ◽  
Scar Tissue Formation ◽  
Regressive Phase

Hypertrophic appearing scar tissue formation is known as Keloids. The growth of keloid is as compare to other raised scars is more rapid and progressive. If the keloid is formed then it grow much larger than the wound that caused the scar. Keloid is hypertrophic appearing scar that continue to evolve over the time without quiescent or regressive phase in the process of wound healing [1,2]    The certain communities e.g. Africans having Keloid-prone skin. The cut, burn, pin prick or severe acne are the some examples that causes Keloid. A keloid can also form as chickenpox clear. Sometimes, a surgical scar becomes a keloid. In very rare cases, keloids form when people do not injure their skin. These are called “spontaneous keloids.” A keloid usually takes time to appear. After an injury, months can pass before this scar appears. A keloid can also form more quickly. Once it begins, a keloid can enlarge slowly for months or years. Ayurveda Vagbhatacharya described it is as Vrunagranthi. This review article is a comparative pathological study of Vrunagranthi with special references to keloid is found that having direct and much more identical Causes, features, pathology and prognostic between these.

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