Peer Review #1 of "Comparison of routine hematological indicators of liver and kidney function, blood count and lipid profile in healthy people and stroke patients (v0.1)"

Background and methods Stroke has become a major public health problem worldwide. In this article, we carried out statistical analysis, correlation analysis and principal component analysis (PCA) to evaluate the clinical value of routine hematological indicators in early diagnosis of ischemic stroke using R language. Results For the full blood count comparisons, stroke patients had obvious differences in the distribution width of red blood cells (RDW-CV), average distribution width of red blood cells (RDW-SD), mean hemoglobin concentrations, platelet large cell ratio, mean platelet volume and lymphocytes. Patients with ischemic stroke also exhibited different degrees of abnormalities in liver function test. With respect to renal function, stroke patients had obvious changes in uric acid and urea levels. Finally, when comparing the lipid profile, triglyceride concentrations were increased and high-density lipoprotein cholesterol concentrations were reduced in stroke patients. In addition, correlation analysis among these clinical indicators indicated that there were both common characteristics and differences between patients and health controls. Furthermore, the results of PCA indicated that these clinical indicators could distinguish patients from the healthy controls. Conclusion Conventional hematological clinical indicators, such as liver function, renal function, full blood count and lipid concentration profiles highly correlated with the occurrence of ischemic stroke. Therefore, the detection and analyzation of these clinical indicators are of great significance for the prediction of ischemic stroke.

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Hypotensive and Antihypertensive Properties and Safety for Use of Annona muricata and Persea americana and Their Combination Products

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/8833828 ◽

2020 ◽

Vol 2020 ◽

pp. 1-13

Author(s):

Authentia Sokpe ◽

Merlin L. K. Mensah ◽

George A. Koffuor ◽

Kwesi P. Thomford ◽

Richmond Arthur ◽

...

Keyword(s):

Blood Pressure ◽

Kidney Function ◽

Blood Count ◽

Persea Americana ◽

Full Blood Count ◽

Annona Muricata ◽

Leaf Extracts ◽

Induced Hypertension ◽

Liver And Kidney ◽

Antihypertensive Properties

Introduction. In the management of hypertension (a cardiovascular disease and the leading metabolic risk factor in noncommunicable diseases) with herbal medicines, efficacy and safety are of uttermost concern. This study sought to establish hypotensive, antihypertensive, drug interaction, and safety for use of the aqueous leaf extracts of Annona muricata (AME), Persea americana (PAE), or their combination products (CAPE). Methodology. Systolic and diastolic blood pressure (SBP and DBP), mean arterial blood pressure (MAP), and heart rate (HR) were measured in normotensive Sprague-Dawley rats treated with 50–150 mg/kg of AME, PAE, or CAPE to establish a hypotensive effect. “Combination index” was calculated to establish interaction between AME and PAE. The antihypertensive effect of CAPE was established by measuring SBP, DBP, MAP, and HR in ethanol-sucrose- and epinephrine-induced hypertension. Full blood count, liver and kidney function tests, and urinalysis were determined in ethanol/sucrose-induced hypertension to establish safety for use. Results. AME, PAE, and CAPE significantly ( p ≤ 0.001 ) decreased BP in both normotensive and hypertensive animals. Effects of CAPE 1, CAPE 2, and CAPE 3 were synergistic (combination indices of 0.65 ± 0.07, 0.76 ± 0.09, and 0.87 ± 0.07, respectively). There was a significant decrease ( p ≤ 0.01 − 0.001 ) in SBP and MAP with 100 mg/kg CAPE 1 and 75 mg/kg CAPE 2 treatment in hypertension as well as with nifedipine ( p ≤ 0.001 ) treatment. Epinephrine-induced hypertension in anesthetized cats was significantly and dose-dependently inhibited ( p < 0.05 − 0.001 ) by 25–100 mg/ml CAPE 1 and 37.5–75 mg/ml CAPE 2. CAPE administration had no deleterious effect ( p > 0.05 ) on full blood count, liver and kidney function, and urine composition in hypertensive rats. Conclusion. The aqueous leaf extracts of Annona muricata, Persea americana, and their combination products possess antihypertensive properties, with combination products showing synergism and safety with use.

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Safety of co-administration of herbal and conventional medicines on liver and kidney function in stroke patients: A single-center retrospective study

Phytomedicine ◽

10.1016/j.phymed.2020.153435 ◽

2021 ◽

Vol 81 ◽

pp. 153435

Author(s):

Sang-Hwa Lee ◽

Seo-Young Kim ◽

Seung-Bo Yang ◽

Chul Jin ◽

Seungwon Kwon ◽

...

Keyword(s):

Retrospective Study ◽

Kidney Function ◽

Single Center ◽

Stroke Patients ◽

Liver And Kidney

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In vivo and in vitro antidiabetic properties of alkaloids extract from Salvia chudaei

Acta periodica technologica ◽

10.2298/apt2152045t ◽

2021 ◽

pp. 45-53

Author(s):

Mohammed Tlili ◽

Roukia Hammoudi ◽

Mahfoud Hadj-Mahammed

Keyword(s):

Blood Glucose ◽

Lipid Profile ◽

Kidney Function ◽

Inhibitory Effect ◽

Diabetic Rats ◽

Albino Rats ◽

Liver And Kidney ◽

Mean Blood Glucose

The aim of this study was to evaluate, for the first time, the antidiabetic effect of the alkaloids extract of Salvia chudaei Batt. & Trab. (Lamiaceae) on alloxan-induced diabetic rats. The alkaloids extract was prepared, and the in vitro inhibitory effect of key digesting enzymes related to postprandial hyperglycemia were determined. After acute toxicity test, the Swiss albino rats were induced with alloxan to get experimental diabetes animals. The fasting mean blood glucose, lipid profile, different liver and kidney function biomarkers and antioxidant biomarkers levels, after treatment for 30 days, diabetic untreated and diabetic rats treated with alkaloids extract were estimated. The alkaloids displayed remarkable in inhibiting ?-glucosidase (IC50 = 248.25?2.61 ?g/ml) than ?-amylase (IC50 = 262.96?9.64 ?g/ml) activities. In vivo, the results proved that alkaloids extract at dose of 500 mg/kg bw decreased significantly the blood glucose, lipid profile levels and improved the liver and kidney function biomarkers and increased the activities of antioxidant enzymes (superoxide dismutase and gluthatione reductase). This study demonstrates, that alkaloids are effective in inhibiting hyperglycemia and oxidative stress caused by diabetes.

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Effects of Bifidobacterium longum BB536 on lipid profile and histopathological changes in hypercholesterolaemic rats

Beneficial Microbes ◽

10.3920/bm2014.0032 ◽

2015 ◽

Vol 6 (5) ◽

pp. 661-668 ◽

Cited By ~ 4

Author(s):

S.H. Al-Sheraji ◽

I. Amin ◽

A. Azlan ◽

M.Y. Manap ◽

F.A. Hassan

Keyword(s):

Lipid Profile ◽

Total Cholesterol ◽

Kidney Function ◽

Liver Lipid ◽

Bifidobacterium Longum ◽

Control Group ◽

Lipid Deposition ◽

Adipocyte Size ◽

Liver And Kidney ◽

Glutamyl Transferase

The present study investigated the effects of Bifidobacterium longum BB536 on lipid profile, liver and kidney function, and body fat in hypercholesterolaemic rats. 40 Sprague-Dawley rats were randomly divided into five groups. The negative control group received a standard diet. The positive control group received a cholesterol-enriched diet, whereas the intervention groups received a cholesterol-enriched diet supplemented with B. longum BB536 alone or in combination with inulin or Mangifera pajang fibrous polysaccharides. After 8 weeks, plasma lipids, and liver and kidney function were tested. Intake of the cholesterol-enriched diet increased total cholesterol, alanine aminotransferase, gamma-glutamyl transferase, creatinine, urea, liver weight, adipose tissue weight, liver lipid deposition and adipocyte size. B. longum BB536 supplementation significantly reduced total cholesterol, liver lipid deposition and adipocyte size, and positively affected liver and kidney function. These effects were significantly increased in the presence of inulin and M. pajang fibrous polysaccharides.

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