scholarly journals Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study

2012 ◽  
Vol 13 (12) ◽  
pp. 6295-6298 ◽  
Author(s):  
Rakesh Kumar Gupta ◽  
Amit Kumar Patel ◽  
Rajni Kumari ◽  
Seema Chugh ◽  
Chitrangada Shrivastav ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Lipid Profile ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals The association of depression with metabolic syndrome parameters and malondialdehyde (MDA) in obese women: A case-control study

2021 ◽  
Vol 11 (4) ◽  
pp. 492-497
Author(s):  
Elnaz Vaghef-Mehrabani ◽  
Azimeh Izadi ◽  
Mehrangiz Ebrahimi-Mameghani
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Depressive Symptoms ◽  
Lipid Profile ◽  
Case Control Study ◽  
Case Control ◽  
Obese Women ◽  
Anthropometric Parameters ◽  
Control Study

Background: There is evidence for a bidirectional association between obesity and depression, and obesity is the main risk factor for metabolic syndrome (MetS). This study aimed to compare oxidative stress and MetS features between depressed and non-depressed obese women and study the association of depressive symptoms, oxidative stress, and components of MetS. Methods: In this case-control study conducted in Tabriz (East Azarbaijan, Iran), obese women (body mass index [BMI]: 30-40 kg/m2 ) with a primary diagnosis of major depressive disorder (MDD; based on diagnostic interview with a psychiatrist; n=75) and their age-matched non-depressed controls (n=150) were enrolled. Beck Depression Inventory-version II (BDI-II) was used to assess depressive symptoms in both groups. Anthropometric parameters, blood pressure, fasting blood sugar (FBS), lipid profile and malondialdehyde (MDA) were measured. Results: No significant differences in anthropometric parameters and blood pressure were observed between the two groups. However, FBS of the MDD group was significantly higher than the control (P<0.05). FBS was significantly correlated with BDI-II scores (r=0.158, P=0.017). No significant difference in lipid profile was observed between the groups. Serum MDA level was significantly lower in the MDD group and was inversely associated with BDI-II scores (r=-0.328, P<0.001). Overall, MDD was not significantly associated with MetS in our study (OR=0.848, 95% CI: 0.484, 1.487; P=0.566). Conclusion: Although we found a correlation between higher depressive symptoms and some adverse metabolic outcomes, our findings do not support a significant association between MDD and MetS.

scholarly journals A case-control study of the lipid profile of women with breast cancer

2020 ◽  
Vol 10 (2) ◽  
pp. 41
Author(s):  
Katarzyna Piasecka ◽  
Andrzej Stanisławek ◽  
Elżbieta Stasiak ◽  
Anna Irzmańska-Hudziak ◽  
Katarzyna Kociuba-Adamczuk
Keyword(s):  
Breast Cancer ◽  
Lipid Profile ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Altered Levels of Salivary 8-oxo-7-hydrodeoxyguanosine in Breast Cancer

2016 ◽  
Vol 1 (2) ◽  
pp. 171-177 ◽  
Author(s):  
M. Gornitsky ◽  
A.M. Velly ◽  
S. Mohit ◽  
M. Almajed ◽  
H. Su ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Case Control Study ◽  
Redox Homeostasis ◽  
Growth Factor Receptor ◽  
Case Control ◽  
Enzyme Linked Immunosorbent Assay ◽  
Current Case ◽  
Modified Dna ◽  
Control Study

Oxidative stress has been implicated in the pathogenesis of breast cancer (BC). To determine whether BC is associated with altered salivary redox homeostasis, we performed a case-control study assessing the relationship between BC and 8-oxo-7-hydrodeoxyguanosine (8-oxodG), a marker for oxidative damage to DNA. Enzyme-linked immunosorbent assay for 8-oxodG was used on whole, unstimulated saliva of 134 BC patients and 226 healthy controls. Associations of the redox data were assessed by analysis of variance and logistic regression analysis. Our results revealed that there were 1) significantly lower mean levels of salivary 8-oxodG in BC patients versus controls ( P = 0.0005), 2) significantly lower levels among participants who did not receive radiotherapy and/or chemotherapy as compared with controls ( P < 0.0001), 3) significantly lower levels among BC patients who did not receive these treatments than among those who did ( P < 0.02), 4) and no significant differences in mean 8-oxodG levels among BC patients positive or negative for estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 ( P ≥ 0.08). Our results suggest that BC is associated with decreased levels of oxidatively modified DNA in saliva. Knowledge Transfer Statement: The results of our current case-control study indicate that the molecular biomarker of oxidative stress 8-oxo-7-hydrodeoxyguanosine, measured from saliva, is associated with breast cancer. Our findings may provide the basis for future studies on molecular biomarkers of oxidative stress and breast cancer using saliva as an accessible and noninvasive tissue.

scholarly journals Association of CYBA gene (-930 A/G and 242 C/T) polymorphisms with oxidative stress in breast cancer: a case-control study

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5509 ◽  
Author(s):  
Mohini A. Tupurani ◽  
Chiranjeevi Padala ◽  
Kaushik Puranam ◽  
Rajesh K. Galimudi ◽  
Keerthi Kupsal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Case Control Study ◽  
Case Control ◽  
Breast Cancer Patients ◽  
Functional Polymorphisms ◽  
Increased Risk ◽  
Cancer Initiation ◽  
Control Study ◽  
Cyba Gene

Background Oxidative stress (OS) is a key characteristic feature in cancer initiation and progression. Among multiple cancers, NADPH oxidase (NOX) dependent free radical production is implicated in oxidative stress. P22phox, a subunit of NADPH oxidase encoded by the CYBA gene has functional polymorphisms associated with various complex diseases. The present study was aimed to examine the importance and association of the functional polymorphisms of CYBA gene (-930 A/G and 242 C/T) with the oxidative stress in breast cancer (BC) development and progression. Materials and Methods We have performed a case-control study on 300 breast cancer patients and 300 healthy individuals as controls to examine the role of CYBA gene -930 A/G and 242 C/T single nucleotide polymorphisms (SNPs) using As-PCR and PCR-RFLP assays and its association with OS as measured by plasma MDA levels. Linkage disequilibrium (LD) plots were generated using Haploviewtool and Multifactor dimensionality reduction (MDR) analysis was applied to assess high-order interactions between the SNPs. The Insilco analysis has been performed to predict the effect of SNPs on the gene regulation using online tools. Results We have found that genotype frequencies of CYBA gene -930 A/G and 242C/T polymorphism were significantly different between controls and BC patients (p < 0.05). The haplotype combination -930G/242C and -930G/242T were associated with 1.44 & 1.56 folds increased risk for breast cancer respectively. Further, the MDA levels were higher in the patients carrying -930G/242C and -930G/242T haplotype (p < 0.001). Our results have been substantiated by Insilco analysis. Conclusion Results of the present study suggest that GG genotype of -930 A/G polymorphism, -930G/242C and -930G/242T haplotypes of CYBA gene polymorphisms have shown association with higher MDA levels in breast cancer patients, signify that elevated oxidative stress might aid in increased risk for breast cancer initiation and progression.

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