scholarly journals The association of depression with metabolic syndrome parameters and malondialdehyde (MDA) in obese women: A case-control study

2021 ◽  
Vol 11 (4) ◽  
pp. 492-497
Author(s):  
Elnaz Vaghef-Mehrabani ◽  
Azimeh Izadi ◽  
Mehrangiz Ebrahimi-Mameghani
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Depressive Symptoms ◽  
Lipid Profile ◽  
Case Control Study ◽  
Case Control ◽  
Obese Women ◽  
Anthropometric Parameters ◽  
Control Study

Background: There is evidence for a bidirectional association between obesity and depression, and obesity is the main risk factor for metabolic syndrome (MetS). This study aimed to compare oxidative stress and MetS features between depressed and non-depressed obese women and study the association of depressive symptoms, oxidative stress, and components of MetS. Methods: In this case-control study conducted in Tabriz (East Azarbaijan, Iran), obese women (body mass index [BMI]: 30-40 kg/m2 ) with a primary diagnosis of major depressive disorder (MDD; based on diagnostic interview with a psychiatrist; n=75) and their age-matched non-depressed controls (n=150) were enrolled. Beck Depression Inventory-version II (BDI-II) was used to assess depressive symptoms in both groups. Anthropometric parameters, blood pressure, fasting blood sugar (FBS), lipid profile and malondialdehyde (MDA) were measured. Results: No significant differences in anthropometric parameters and blood pressure were observed between the two groups. However, FBS of the MDD group was significantly higher than the control (P<0.05). FBS was significantly correlated with BDI-II scores (r=0.158, P=0.017). No significant difference in lipid profile was observed between the groups. Serum MDA level was significantly lower in the MDD group and was inversely associated with BDI-II scores (r=-0.328, P<0.001). Overall, MDD was not significantly associated with MetS in our study (OR=0.848, 95% CI: 0.484, 1.487; P=0.566). Conclusion: Although we found a correlation between higher depressive symptoms and some adverse metabolic outcomes, our findings do not support a significant association between MDD and MetS.

scholarly journals Analysis of metabolic syndrome factors to determine contributions to pathogenesis of mammary gland disease in Japanese women– Case-control study based on health screening results

2020 ◽  
Author(s):  
Tadayuki Iida ◽  
Sakika Sumida ◽  
Yoshikawa Masao ◽  
Nagaoka Kaoru
Keyword(s):  
Breast Cancer ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Mammary Gland ◽  
Waist Circumference ◽  
Odds Ratio ◽  
Case Control Study ◽  
Hdl Cholesterol ◽  
Case Control ◽  
Control Study

Abstract Background: Recently, the relationship between obesity and breast cancer has been clarified, and findings obtained in a study that used body mass index (BMI) suggested that its presence might increase the risk for development of that disease. However, the association between metabolic syndrome caused by obesity and development of mammary gland disease has not been elucidated in a longitudinal manner. In the present case-control study, that association was examined.Methods: Two hundred sixty-five women who underwent breast cancer screening with mammography and measurements of metabolic syndrome factors, including waist circumference, blood glucose, and triglycerides, HDL-cholesterol levels, and systolic and diastolic blood pressure, twice within a 2-year period at the Disease Prevention Promotion and Research Center of the Dai-ikai Medical Corporation were enrolled. To determine the presence of mammary gland disease, 2 expert physicians interpreted radiogram findings, with category 3 or higher shown by mammography considered to indicate an abnormality.Results and Discussion: Waist circumference at the initial measurement was shown to be significantly associated (odds ratio=1.036, p=0.045) as a risk factor for onset of mammary gland disease. During the 2-year examination period, changes in systolic blood pressure (odds ratio=1.020, p=0.085) and diastolic pressure (odds ratio=1.040, p=0.065) showed a marginally significant association. As for protective factors, HDL-cholesterol level (odds ratio=0.982, p=0.064) at the initial examination was confirmed to have a marginally significant relationship. We concluded that waist circumference and 2-year changes in systolic and diastolic blood pressure are risk factors for mammary gland disease, while HDL-cholesterol level is a protective factor.

scholarly journals A case-control study to find out the prevalence of metabolic syndrome in patients with psoriasis as compared to age and sex matched controls

2021 ◽  
Author(s):  
Shilpa Patwekar ◽  
Nitin Chaudhari ◽  
Chandrakant B. Poulkar ◽  
Swapna S. Khatu ◽  
Abhishek S. Patokar ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Severity Index ◽  
Case Control ◽  
Fasting Blood Sugar ◽  
Control Study

<p><strong>Background: </strong>Psoriasis is an immune mediated chronic inflammatory dermatosis and it is associated with high risk of cardiovascular events. Aim of the study was to estimate the prevalence of metabolic syndrome and its association with disease severity in patients with psoriasis.</p><p><strong>Methods:</strong> This was a case control study which included 150 cases of chronic plaque psoriasis and 150 healthy controls. All subjects underwent detailed history and clinical examination including measurement of blood pressure and waist circumference and psoriasis area and severity index (PASI) score. Fasting blood sugar, triglyceride, cholesterol, and high-density lipoprotein cholesterol levels were tested following overnight fasting. Various parameters of metabolic syndrome were compared in two groups using chi square test and fisher’s exact test. Statistical analysis of the data was done using epi-info <sup>TM</sup> software.</p><p><strong>Results:</strong> Prevalence of metabolic syndrome was more common in patients of psoriasis than in control (56.67% vs. 17.33%; p&lt;0.0001). Psoriatic patients had higher prevalence of abdominal obesity (57.33% vs. 27.33%; p=0.0037), elevated blood pressure (32% vs. 12%; p=0.0001), elevated fasting blood sugar level (62% vs. 22%; p&lt;0.0001), hypertriglyceridemia (44.66% vs. 32%; p=0.0326), low level of HDL cholesterol (64% vs. 21.33%; p&lt;0.0001 and alcohol abuse (22.22% vs. 14.66%; p=0.0154).</p><p><strong>Conclusions:</strong> The findings in our study demonstrated a robust association between psoriasis and metabolic syndrome and its components, irrespective of psoriasis severity.</p>

scholarly journals Association of serum uric acid and serum lipid profile in pre- eclampsia- A hospital based case-control study

2020 ◽  
Vol 4 (3) ◽  
pp. 831-834
Author(s):  
Shikha Rizal ◽  
Bishal Raj Joshi ◽  
Amita Dhakal ◽  
Reshu Agrawal Sagtani
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Pregnant Women ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Serum Uric Acid ◽  
Case Control Study ◽  
Density Lipoprotein ◽  
Case Control ◽  
Control Study

Introduction: Pre-eclampsia, one of the most common medical complication in pregnancy results in considerable maternal and fetal morbidity and mortality. Endothelial dysfunction is a central feature of pre-eclampsia. Elevated serum uric acid level may serve as a marker for early diagnosis of the disease as well as a surrogate for clinical severity of the condition. High serum values of triglycerides, total cholesterol, low- density lipoprotein and and low levels of high density lipoprotein are all significantly related to risk developing preeclampsia.  Objective: To find out the association between serum uric acid levels and lipid profile in pre-eclamptic women and compare it with the normal pregnant women.  Methodology: A case control study was conducted among 180 pregnant women (90 cases of pre-eclamptic women and 90 cases of age matched normal pregnant women) between 21-35 years who were admitted in the Gynaecology and Obstetrics ward of Nobel Medical College and Teaching Hospital, Biratnagar. Blood pressure was measured. Serum from all the patients were analyzed for the following biochemical parameters: serum uric acid, triglyceride, total cholesterol, LDL-C and HDL- C. The data were collected and entered in MS-Excel and analyzed using Statistical Package for Social Sciences (SPSS) ver. 16 software. Results: Mean serum uric acid of pre-eclamptic women was higher than those of normal pregnant women  which was found to be statistically significant with p value <0.001. Among the lipid parameters, serum triglyceride and total cholesterol was significantly higher in pre-eclamptic women whereas high density lipoprotein was significantly lower in pre-eclamptic. Also there was a positive co-relation between triglyceride and blood pressure and a negative co-relation between HDL-C in preeclamptic women. Conclusion: Development of simple and inexpensive methods to predict and prevent pre-eclampsia in early stage is very important. Thus, our study concludes the utility of measurement of serum uric acid and lipid profile for screening patients at risk of developing pre-eclampsia.

scholarly journals Correlation of Osteopontin, Oxidative Stress and Total Antioxidant Capacity in Hypothyroidism Subjects

2021 ◽  
pp. 255-262
Author(s):  
Sumesh Prasad Sah ◽  
Jyoti Batra ◽  
Aarushi Batra ◽  
Manisha Arora ◽  
Sonu Sah ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Case Control Study ◽  
Clinical Chemistry ◽  
Case Control ◽  
Anthropometric Parameters ◽  
Medical College ◽  
Total Antioxidant ◽  
Control Study

Aims: To find out the correlation between Osteopontin (OPN), oxidative stress and total antioxidant capacity (TAC) in female hypothyroidism subjects. Study Design: Case Control study Place and Duration of Study: The present case control study was conducted with the collaboration of the Department of Biochemistry, Santosh Medical college, Ghaziabad and Muzaffarnagar Medical College, Muzaffarnagar from September 2018 to September 2020. Methodology: The study includes 120 female hypothyroidism subjects and 120 age and sex matched normal healthy individuals as controls.  Serum OPN was estimated by commercially available ELISA kit, MDA by method described by Satoh et al. method, TAC by FRAP method and Ceruloplasmin was estimated on Access 2 Beckman Coulter clinical chemistry analyser. Results: The anthropometric parameters, Body mass index (BMI), waist circumference (WC), hip circumference (HC) and waist hip ratio (WHR) were increased significantly in all the female hypothyroidism subjects as compared to controls. Study showed increased levels of TSH and MDA and decreased levels of serum Osteopontin, T3, T4, TAC and Ceruloplasmin (Cp) in hypothyroid subjects as compared to controls. A Significant positive correlation was found between OPN vs T3, OPN vs T4, OPN vs TAC and OPN vs Cp whereas significant negative correlation was found between OPN vs TSH, and OPN vs MDA. Conclusion:  In the present study, we found decreased levels of Osteopontin in hypothyroidism subject. Pearson’s correlation analysis predicts, OPN negatively correlated with MDA and positively correlated with total antioxidant capacity and ceruloplasmin. Hence, Osteopontin, malondialdehyde, total antioxidant capacity and ceruloplasmin should all be considered while assessing the hypothyroidism.

scholarly journals Interactions between Oxidative Stress, Lipid Profile and Antioxidants in Breast Cancer: A Case Control Study

2012 ◽  
Vol 13 (12) ◽  
pp. 6295-6298 ◽  
Author(s):  
Rakesh Kumar Gupta ◽  
Amit Kumar Patel ◽  
Rajni Kumari ◽  
Seema Chugh ◽  
Chitrangada Shrivastav ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Lipid Profile ◽  
Case Control Study ◽  
Case Control ◽  
Control Study
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