scholarly journals Acute and Subacute Toxicity Profile of Asparagus racemosus root extract, Isoprinosine and Shatvari Syrup in Swiss Albino Mice

2017 ◽  
Keyword(s):  
Root Extract ◽  
Asparagus Racemosus ◽  
Toxicity Profile ◽  
Swiss Albino Mice ◽  
Subacute Toxicity ◽  
Albino Mice

scholarly journals TOXICITY PROFILE OF CELASTRUS PANICULATUS SEEDS: A PRECLINICAL STUDY

2020 ◽  
pp. 115-118
Author(s):  
BHARAT MISHRA ◽  
ELEZABETH JOHN ◽  
KRUPAMOL JOY ◽  
BADMANABAN R ◽  
ALEESHA R
Keyword(s):  
Seed Oil ◽  
Preclinical Study ◽  
Tween 20 ◽  
Toxicity Profile ◽  
Swiss Albino Mice ◽  
Subacute Toxicity ◽  
Toxicity Studies ◽  
Group I ◽  
Celastrus Paniculatus ◽  
Albino Mice

Objective: The objective of the study was to evaluate the toxicity profile of Celastrus paniculatus (CP) by performing a preclinical study on Swiss albino mice and demonstrate a safety description through monitoring their autonomic, neurological, behavioral, physical, and biochemistry profiles. Methods: The toxicity profiles (acute and subacute) of CP were evaluated using Swiss albino mice in which they were divided into four groups: Group I received 1% Tween 20 and dimethyl sulfoxide. Group II, III, and IV received CP seed oil orally, at doses of 300, 2000, and 5000 mg/kg body weight for both acute and subacute toxicity studies in accordance with Organization for Economic Cooperation and Development guidelines No. 423. Special attention was given during the first 4 h and daily thereafter for a total of 14 days. Behavioral profile, physical state changes, and other parameters such as tremors, convulsion, lethargy were noted. Clinical signs were observed daily during the 28 days of the treatment period. Body weights were measured once a week. On the 29th day, the animals were kept to overnight and blood samples were collected through retro-orbital puncture for biochemical analysis. Results: In both acute and subacute toxicity studies, the treatment with CP did not affect the normal health status of animals. It is suggestive that CP is considered practically non-toxic. Conclusion: The toxicity profile of CP seed oil was evaluated and found to be safe until 2000 mg/kg dose.

scholarly journals Protective Efficacy of Asparagus racemosus root extract and Isoprinosine against Ionizing Radiation - induced Clastogenicity and Toxicity in Swiss Albino Mice

2018 ◽  
Vol 11 (1) ◽  
pp. 40-45
Author(s):  
Sharmila Kameyanda Poonacha ◽  
Satheesh Kumar Bhandary Bavabeedu ◽  
Ronald Fernandes ◽  
Suchetha Kumari Nalilu ◽  
Vadisha Srinivas Bhat ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Protective Efficacy ◽  
Root Extract ◽  
Asparagus Racemosus ◽  
Swiss Albino Mice ◽  
Radiation Induced ◽  
Albino Mice

scholarly journals Asparagus racemosus Root Extract and Isoprinosine Exhibits Radio-mitigating Activity against Ionizing Radiation-induced Detrimental Effects in Swiss Albino Mice

2020 ◽  
Vol 12 (3) ◽  
pp. 226-230
Author(s):  
Sharmila Kameyanda Poonacha ◽  
Satheesh Kumar Bhandary Bavabeedu ◽  
Suchetha Kumari Nalilu ◽  
Pooja Pooja S ◽  
Vadisha Srinivas Bhat ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Root Extract ◽  
Asparagus Racemosus ◽  
Swiss Albino Mice ◽  
Radiation Induced ◽  
Albino Mice

scholarly journals Analgesic Activity of Dichloromethanolic Root Extract of Clutia abyssinica in Swiss Albino Mice

2017 ◽  
Vol 05 (02) ◽  
Author(s):  
Koech SC ◽  
Ouko RO ◽  
Michael NM ◽  
Ireri MM ◽  
Ngugi MP ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Root Extract ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Evaluation of the Effect of Hydroethanolic Root Extract and Solvent Fractions of Cyphostemma adenocaule (Steud. ex A. Rich) Descoings ex Wild & Drummond on Cell-Mediated Immune Response and Blood Cell Count in Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Dehnnet Abebe ◽  
Gomathi Periasamy ◽  
Aman Karim ◽  
Helen Bitew
Keyword(s):  
Blood Cell ◽  
Cell Count ◽  
Test Method ◽  
Delayed Type Hypersensitivity ◽  
Cell Mediated Immunity ◽  
Root Extract ◽  
Blood Cell Count ◽  
Swiss Albino Mice ◽  
Organ Index ◽  
Albino Mice

Introduction. Cyphostemma adenocaule (Steud. ex A. Rich) Descoings ex wild & Drummond (Vitaceae) has been used in traditional medicine for the management of various immunological and hematological disorders in different areas of Ethiopia and the rest of the world. In Ethiopia, the plant is used for the management of enlarged spleen, rabies virus, helminthic infection, snake bite, and various types of tumors. Objective. To evaluate the effect of hydroethanolic root extract and solvent fractions of Cyphostemma adenocaule on cell-mediated immunity (delayed-type hypersensitivity), organ index (spleen and liver), and blood cell count in Swiss albino mice. Materials and Methods. Acute oral toxicity test was conducted using nulliparous and nonpregnant Swiss albino mice following OECD 425 limit test method. Delayed-type hypersensitivity model was used to evaluate the effect on cell-mediated immunity. The experimental animals were divided into twelve groups which were sensitized and challenged with sheep red blood cells on day 0 and day 7, respectively. Levamisole 50 mg/kg was used as stimulant control, whereas cyclophosphamide 30 mg/kg was used as suppressant control. Hydroethanolic root extract (100 mg/kg, 200 mg/kg, and 400 mg/kg), aqueous fraction (100 mg/kg, 200 mg/kg, and 400 mg/kg), and n-butanol fraction (100 mg/kg, 200 mg/kg, and 400 mg/kg) were administered for seven days. The paw volume was measured using a digital plethysmometer before challenge and 24 hours after challenge. Blood was collected, and organs (spleen and liver) were isolated from each challenged mouse to determine blood cell count and organ index, respectively. Results. No mortality and noticeable behavioral changes were observed among all mice receiving hydroethanolic root extract and solvent fractions at a dose of 2000 mg/kg. Hydroethanolic root extract and solvent fractions of Cyphostemma adenocaule showed enhancement of delayed-type hypersensitivity, organ index, and blood cell count. Hydroethanolic root extract at a dose of 400 mg/kg showed the highest and statistically significant stimulation of delayed-type hypersensitivity (0.123 ± 0.010) and blood cell count compared to the vehicle. Conclusion. Hydroethanolic root extract and solvent fractions of Cyphostemma adenocaule showed a stimulatory effect on cell-mediated immunity and hematopoiesis.

Evaluation of acute and sub-acute oral toxicity of ethanolic root extract of Tetracera akara (Burm. f.) Merr., an ethnomedicinal plant used by the Kani tribe of Kerala

2018 ◽  
Vol 5 (2) ◽  
Author(s):  
Ragesh R Nair
Keyword(s):  
Acute Toxicity ◽  
Wistar Rats ◽  
Body Weight Gain ◽  
Root Extract ◽  
Oral Toxicity ◽  
Swiss Albino Mice ◽  
Toxicity Studies ◽  
Biochemical Profiles ◽  
Albino Mice ◽  
Group Sex

The aim of the study was to evaluate the acute oral and sub-acute toxicity of ethanolic root extract of Tetracera akara in Swiss albino mice and Wistar rats. Tetracera akara (Burm. f.) Merr. has been used as traditional medicine by the Kani tribe of Kerala to cure liver diseases. In acute toxicity studies, four groups of mice (n = 5/group/sex) were orally treated with doses of 0.625 g, 1.25 g, 2.5 g and 5.0 g/kg and mortality were recorded. In the sub-acute toxicity study, animals received T. akara extract at the doses of 0.1 g, 0.5 g and 2.5 g/kg/day (n = 5/group/sex) for 28 days, biochemical, hematological, morphological and histopathological parameters were determined. T. akara did not produce any mortality in the acute toxicity studies, showing LD50 higher than 5 g/kg. Sub-acute treatment with T. akara didn’t cause any changes in body weight gain, hematological, biochemical profiles when compared to normal control. In addition, no changes in morphological and histopathological aspect of organs were observed in the animals. Taking all factors into consideration, administration of Tetracera akara does not produce acute toxicity in Swiss albino mice or sub-acute toxicity in Wistar rats, suggesting it’s safe use by humans.

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