Correlation between Glycated hemoglobin and Lipid profile in Type 2 Diabetic population of district Meerut, U.P.

The high risk of lipid abnormalities in type 2 diabetic (T2D) patients with uncontrolled hyperglycemia may be associated with an increased risk of cardiovascular complications. The aim of the current study was to investigate the association between glycated hemoglobin )HbA1c( and lipid profile levels in T2D patients. This cross-sectional study was conducted on 802 T2D patients, aged≥ 40 years, visiting the Abu Reyhan Clinic of Shahid Mohammadi Hospital in Bandar Abbas, Iran. Serum lipid profiles were measured by the enzymatic method. Diabetes was defined based on the criteria of the American Diabetes Association. The association of HbA1c and estimated glomeruli filtration rate (eGFR) with lipid profile indices was assessed using the Spearman correlation coefficient test and linear regression model. The mean±SD age of participants (27.7% of men) was 53.55±5.56 years. The mean±SD of HbA1c and eGFR for all subjects were 8.97±2.14 and 86.30±17.48, respectively. In this study,a positive association was observed between HbA1c and fasting blood glucose (r=0.619, β=0.635), total cholesterol (r=0.165, β=0.188), triglycerides (r=0.103, β=0.095), and low-density lipoprotein cholesterol (r=0.162, β=0.173), (P<0.01). Also, an inverse association has been observed between eGFR level and TGs (r=-0.08, β=-0.096) and FBS (r=- 0.123, β=-0.172), (P<0.05). Our findings suggested that HbA1c is not only an applicable predictor of longterm glycaemic control but also can be considered as a potential biomarker for predicting lipid abnormalities in T2D patients.

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A correlative study of HbA1C and lipid profile parameters among type 2 diabetic population in a rural hospital in puducherry.

IOSR Journal of Dental and Medical Sciences ◽

10.9790/0853-1509125963 ◽

2016 ◽

Vol 15 (09) ◽

pp. 59-63 ◽

Cited By ~ 1

Author(s):

P. Muraliswaran ◽

T. Elamathi ◽

P. Kanagavalli ◽

G. Radhika

Keyword(s):

Lipid Profile ◽

Rural Hospital ◽

Correlative Study ◽

Diabetic Population ◽

Type 2 Diabetic

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Study of Correlation Between Glycated Hemoglobin (Hba1c) and Serum Lipid Profile in Type 2 Diabetic Patients

Journal of Nepalgunj Medical College ◽

10.3126/jngmc.v18i1.35200 ◽

2020 ◽

Vol 18 (1) ◽

pp. 67-69

Author(s):

Anil Shrestha

Keyword(s):

Lipid Profile ◽

Serum Lipid ◽

Glycated Hemoglobin ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Diabetic Patients ◽

Low Density ◽

Type 2 Diabetic Patients ◽

Type 2 Diabetic

Introduction: Diabetic mellitus is a chronic metabolic disease characterized by hyperglycemia. Type 2 diabetes mellitus accounts for more than 90% of cases worldwide. Elevated HbA1c and dyslipidemia proportionately increases the risk of development of cardiovascular disease (CVD) which is the major cause of morbidity and mortality worldwide. Aims: To Study the correlation between glycated hemoglobin (HbA1c) and serum lipid profile in type 2 diabetic patients. Methods: This is a hospital based cross sectional study conducted at Nepalgunj medical college teaching hospital, which included 104 type 2 diabetic patients (54 males and 50 females).Venous blood samples were collected from all patients and serum was used for analyzing HbA1c, lipid profile panel and fasting blood glucose (FBG). DM was defined as per American diabetic association (ADA) criteria. Dyslipidemia was defined as per the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III Guidelines. The data were analyzed using standard statistical methods, including SPSS 21. Results : Abnormal lipid parameters were demonstrated with increased Total Chloseterol (TC), Triglyceride (TG), Low density lipoprotein (LDL),Very low density lipoprotein (VLDL) and low High density lipoprotein (HDL) suggestive of dyslipidemia.HbA1c showed direct and significant correlation with TC,LDL,TG and VLDL. Patients with HbA1c > 7.0% had a significantly higher value of TC, LDL, TG and VLDL as compared to patients with HbA1c ≤7.0%.However, the significant difference in value of HDL-C was not found between two groups. Conclusion: Due to the strong correlation with lipid profile, HbA1c could be the ideal marker for predicting dyslipidemia in type 2 DM . Patients with higher HbA1c value and dyslipidemia should be considered as a very high risk group for CVD.

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Antihyperglycemic and Lipid Profile Effects of Salvia amarissima Ortega on Streptozocin-Induced Type 2 Diabetic Mice

Molecules ◽

10.3390/molecules26040947 ◽

2021 ◽

Vol 26 (4) ◽

pp. 947 ◽

Cited By ~ 1

Author(s):

Jesus Ivan Solares-Pascasio ◽

Guillermo Ceballos ◽

Fernando Calzada ◽

Elizabeth Barbosa ◽

Claudia Velazquez

Keyword(s):

Lipid Profile ◽

Oral Tolerance ◽

Glycated Hemoglobin ◽

Petroleum Ether Extract ◽

Density Lipoprotein ◽

Inhibitory Effect ◽

Control Group ◽

Aerial Parts ◽

Type 2 Diabetic

Salvia amarissima Ortega was evaluated to determinate its antihyperglycemic and lipid profile properties. Petroleum ether extract of fresh aerial parts of S. amarissima (PEfAPSa) and a secondary fraction (F6Sa) were evaluated to determine their antihyperglycemic activity in streptozo-cin-induced diabetic (STID) mice, in oral tolerance tests of sucrose, starch, and glucose (OSTT, OStTT, and OGTT, respectively), in terms of glycated hemoglobin (HbA1c), triglycerides (TG), and high-density lipoprotein (HDL). In acute assays at doses of 50 mg/kg body weight (b.w.), PEfAPSa and F6Sa showed a reduction in hyperglycemia in STID mice, at the first and fifth hour after of treatment, respectively, and were comparable with acarbose. In the sub-chronic test, PEfAPSa and F6Sa showed a reduction of glycemia since the first week, and the effect was greater than that of the acarbose control group. In relation to HbA1c, the treatments prevented the increase in HbA1c. In the case of TG and HDL, PEfAPSa and F6Sa showed a reduction in TG and an HDL increase from the second week. OSTT and OStTT showed that PEfAPSa and F6Sa significantly lowered the postprandial peak at 1 h after loading but only in sucrose or starch such as acarbose. The results suggest that S. amarissima activity may be mediated by the inhibition of disaccharide hydrolysis, which may be associated with an α-glucosidase inhibitory effect.

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