scholarly journals The Association of Glycated Hemoglobin With Lipid Profile Indices in Type 2 Diabetic Patients

2020 ◽  
Author(s):  
Hamidreza Samimagham ◽  
Mariana Bargak ◽  
Mehran Ghasemzadeh ◽  
Mitra Kazemi Jahromi
Keyword(s):  
Lipid Profile ◽  
Glycated Hemoglobin ◽  
Diabetic Patients ◽  
Inverse Association ◽  
Potential Biomarker ◽  
Increased Risk ◽  
The Mean ◽  
Lipid Abnormalities ◽  
Type 2 Diabetic

The high risk of lipid abnormalities in type 2 diabetic (T2D) patients with uncontrolled hyperglycemia may be associated with an increased risk of cardiovascular complications. The aim of the current study was to investigate the association between glycated hemoglobin )HbA1c( and lipid profile levels in T2D patients. This cross-sectional study was conducted on 802 T2D patients, aged≥ 40 years, visiting the Abu Reyhan Clinic of Shahid Mohammadi Hospital in Bandar Abbas, Iran. Serum lipid profiles were measured by the enzymatic method. Diabetes was defined based on the criteria of the American Diabetes Association. The association of HbA1c and estimated glomeruli filtration rate (eGFR) with lipid profile indices was assessed using the Spearman correlation coefficient test and linear regression model. The mean±SD age of participants (27.7% of men) was 53.55±5.56 years. The mean±SD of HbA1c and eGFR for all subjects were 8.97±2.14 and 86.30±17.48, respectively. In this study,a positive association was observed between HbA1c and fasting blood glucose (r=0.619, β=0.635), total cholesterol (r=0.165, β=0.188), triglycerides (r=0.103, β=0.095), and low-density lipoprotein cholesterol (r=0.162, β=0.173), (P<0.01). Also, an inverse association has been observed between eGFR level and TGs (r=-0.08, β=-0.096) and FBS (r=- 0.123, β=-0.172), (P<0.05). Our findings suggested that HbA1c is not only an applicable predictor of longterm glycaemic control but also can be considered as a potential biomarker for predicting lipid abnormalities in T2D patients.

scholarly journals Comparison of Lipid Profile in Type-2 Obese Diabetics and Obese Non-diabetic Individuals. A hospital Based Study from Western Nepal

2013 ◽  
Vol 10 (3) ◽  
pp. 44-47 ◽  
Author(s):  
Naval Kishor Yadav ◽  
C Thanpari ◽  
MK Shrewastwa ◽  
RK Mittal
Keyword(s):  
Lipid Profile ◽  
Venous Blood ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Serum Triglycerides ◽  
Control Subjects ◽  
Significant Difference ◽  
The Mean ◽  
Type 2 Diabetic

Background Type-2 diabetes mellitus is an independent risk factor for coronary artery disease and risk of coronary disease is three to four fold increased in patients with diabetes compared with non-diabetic population and 60-80% 0f type-2 diabetics are obese. Methods This study was conducted in Nepalgunj Teaching Hospital, Kohalpur, Banke, Nepal, between 1st March, 2011 and 28th February, 2012. A total of 150 samples were taken to assess the lipid profile in type-2 diabetic patients associated with obesity and 25 obese controls for their lipid profile. Venous blood samples were taken from all the subjects in the morning after fasting overnight. Exclusion criteria included pregnancy, chronic infectious disease, heart failure; renal failure and drug allergy were confirmed from the subject’s personal physician report and a detailed history. The data was analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results The mean ± SD age of diabetic patients with obesity was 53.76 ± 6.23 while the mean ± SD age of control was 49.61 ± 4.8. Out of 150 patients 105 (70%) were males and 45 (30%) were females. Among control subjects 16 (64%) were males and 9 (36%) were females. Obese type-2 diabetic patients when compared to obese control subjects showed statistically significant increase in the levels of serum total cholesterol (p ? 0.001), serum triglycerides (p ? 0.001), serum LDL-cholesterol (p ? 0.001) while serum HDL-cholesterol levels did not show statistically significant difference in the two group (p ? 0.05). Conclusion This study showed obese diabetic individuals have dyslipidemia and more prone to develop cardiovascular diseases. Kathmandu University Medical Journal | VOL.10 | NO. 3 | ISSUE 39 | JUL- SEP 2012 | Page 44-47 DOI: http://dx.doi.org/10.3126/kumj.v10i3.8017

scholarly journals A study on evaluating lipid profile of patients with diabetes mellitus

2019 ◽  
Vol 6 (5) ◽  
pp. 1869
Author(s):  
M. Abdul Majid ◽  
M. Abdul Bashet ◽  
M. Estiar Rahman ◽  
M. Sabrina Moonajilin ◽  
M. Ruhul Furkan Siddique
Keyword(s):  
Diabetes Mellitus ◽  
Lipid Profile ◽  
Venous Blood ◽  
Density Lipoprotein ◽  
High Serum ◽  
Diabetic Patients ◽  
Serum Triglycerides ◽  
Increased Risk ◽  
Lipid Abnormalities

Background: The diabetic patients are at increased risk to develop lipid abnormalities (hyperlipidemia). Diabetic patients who have lipid abnormalities are more prone to develop cardiovascular diseases. The aim of the current study was to estimate lipid profiles of patients with type-2 diabetes mellitus at Savar area, Dhaka, Bangladesh.Methods: This was a multidisciplinary study conducted between January to April, 2017. A total of 105 known cases of type-2 diabetic patients were investigated. Demographic characteristics and clinical data situation of the patients were taken by interview questionnaire. About 5 ml of fasting venous blood sample was collected from each subject for biochemical analysis. Data obtained were analyzed using Statistical Package of Social Sciences (SPSS-IBM) version 22.Results: Out of 105 patients, 64.8% patients were male and 35.2% were female. The mean±SD for age of patients was 47.67±5.9. The pattern of lipid abnormalities estimated was high serum triglycerides (TGs) in 58.1% patients, high serum total cholesterol (TC) in 61.9%, low high-density lipoprotein cholesterol (HDL-C) in 44.8%, high low-density lipoprotein (LDL-C) in 53.3%. Among all the variables only HDL levels was found significantly associated with age group (p=0.043). Study also revealed that, among all the variables only LDL-C level was found significantly associated with education (p=0.028) and TC level was associated with gender (p=0.003).Conclusions: Hyperlipidemia is a common complication of diabetes mellitus. Therefore maintaining good lipid profile can prevent development and progression of related complications among patient with diabetes mellitus.

scholarly journals Analysis of serum leptin levels as a biomarker in metabolic syndrome in type 2 diabetic patients in Okhla industrial area

2019 ◽  
Vol 7 (11) ◽  
pp. 4340
Author(s):  
Juhi Aggarwal ◽  
Niharika Singh ◽  
Mayur Kumar
Keyword(s):  
Metabolic Syndrome ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Increased Risk ◽  
Study Results ◽  
Type 2 Diabetic

Background: Metabolic syndrome is a progressive disorder which includes a wide array of disorders i.e. central obesity, hypertension, dyslipidemia, hyperglycemia, and insulin resistance. In patients with metabolic syndrome there is an increased risk of mortality due to coronary heart disease, stroke, vascular dysfunction etc. Obesity is one of the most crucial epidemics of modern times and hormone leptin plays an important role in regulation of body weight and energy balance.Methods: A total of 355 individuals were selected from the OPD, Department of general medicine at ESIC hospital, Okhla and it comprised of 196 males and 159 females suffering from type 2 diabetes mellitus with metabolic syndrome. The data was collected over a year i.e. June 2018 to July 2019. After baseline clinical and anthropometric evaluation, Fasting Blood Sugar (FBS), Post Prandial Blood Sugar (PPBS), lipid profile, Insulin (fasting), and leptin levels of the patients were analyzed.Results: Blood sugar fasting, blood sugar post prandial, lipid profile, leptin and insulin levels were increased significantly in female patients as compared to male patients with type 2 diabetic patients and metabolic syndrome.Conclusions: Based on the study results, it was found that leptin correlate significantly with metabolic syndrome and could be used as a biomarker for the early detection of the disease.

scholarly journals Serum Homocysteine and its Association with Lipid Profile in Type 2 Diabetic Patients

2018 ◽  
Vol 10 (1) ◽  
pp. 42-46
Author(s):  
Moitreyee Majumder ◽  
Forhadul Hoque Mollah ◽  
Md Fariduddin ◽  
Sharif Mohammad Ehsan ◽  
Shamim Ara Ferdous
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Inverse Association ◽  
Type 2 Diabetic Patients ◽  
Study Population ◽  
Medical University ◽  
Type 2 Diabetic

Background: Diabetes accounts for almost 6% of total global mortality, with 50% of diabetesassociated deaths being attributed to cardiovascular disease (CVD). Prevalence of type 2 diabetes in rural Bangladeshi and in urban Bangladeshi is found to be 7.2% and 10.5% respectively. People of developing countries suffer from the disease at earlier age than that of developed countries. Among the diabetic patients, vascular complications represent a major cause of morbidity and mortality. Diabetes is commonly accompanied by other cardiovascular risk factors: dyslipidemia, hypertension, and increased prothrombotic factors. Total plasma homocysteine (tHcy) is an emerging CVD risk factor. Insulin resistance and hyperinsulinemia in diabetes mellitus along with increased homocysteine is thought to cause endothelial dysfunction. Endothelial dysfunction together with other factors such as dyslipidemia, microalbuminemia etc. causes cardiovascular disease.Objectives: Objective of the study was to evaluate serum total homocysteine level and to correlate it with fasting lipid profile in type 2 diabetic patients.Methodology: This cross sectional study was conducted during the period of July 2011- June 2013 on 95 patients of type 2 diabetes mellitus, attending the Endocrine OPD of Bangabandhu Sheikh Mujib Medical University (BSMMU). The study was carried out in the Department of Biochemistry, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka. Study subjects were selected by purposive and convenient sampling technique.Result: Study subjects were categorized according to the presence or absence of hyperhomocysteinemia. Among the total study population hyperhomocysteinemia was found in 21.05 %. Among them number of male was greater. The study population had mean serum total cholesterol 198.34±39.62(mg/dl), triacylglycerol 198.91±116.71(mg/dl), LDL 126.75±35.38(mg/ dl), HDL 34.35±8.31(mg/dl), TC:HDL=15.67±6.07:1,and LDL:HDL=9.94±3.88:1 Independant sample t test showed that there was significant inverse association of hyperhomocysteinemia with HDL. Other parameters of lipid profile and lipid ratios did not show any significant association.Conclusions: Around one fifth of the type 2 diabetic patients had hyperhomocysteinemia. Significant inverse association was present between hyperhomocysteinemia and HDL. Other parameters of lipid profile and lipid ratios did not show any significant association.J Shaheed Suhrawardy Med Coll, June 2018, Vol.10(1); 42-46

scholarly journals The effects of anethum graveolens (dill) powder supplementation on glycemic control, lipid profile, some antioxidants and inflammatory markers, and gastrointestinal symptoms in type 2 diabetic patients: a double-blind, placebo-controlled trial

2019 ◽  
Author(s):  
Fatemeh Haidari ◽  
Mehrnoosh Zakerkish ◽  
Fatemeh Borazjani ◽  
Kambiz Ahmadi Angali ◽  
Golnaz Amoochi
Keyword(s):  
Lipid Profile ◽  
Intervention Group ◽  
Gastrointestinal Symptoms ◽  
Control Group ◽  
Diabetic Patients ◽  
Anethum Graveolens ◽  
Type 2 Diabetic Patients ◽  
The Mean ◽  
Type 2 Diabetic

Abstract Background: The objective of this study was to investigate the effects of anethum graveolens (dill) powder supplementation on glycemic control, lipid profile, some antioxidants and inflammatory markers, and gastrointestinal symptoms in type 2 diabetic patients. Material and methods: In this study, 42 type 2 diabetic patients were randomly allocated to intervention and control groups and received either 3 gr dill powder or placebo (3 capsules 1 gr) three per day. Fasting blood sugar (FBS), insulin, homeostatic model assessment of insulin resistance (HOMA- IR), lipid profile, hs-C-reactive protein (hs-CRP), total antioxidant capacity (TAC), malondialdehyde (MDA) and gastrointestinal symptoms were measured in all subjects at baseline and post-intervention. Results: The dill powder supplementation significantly decreased the mean serum levels of insulin, HOMA-IR, LDL-C and MDA in the intervention group in compare with baseline (p < 0.05). Also, the mean serum levels of HDL and TAC was significantly increased in the intervention group in compare with baseline (p < 0.05). Colonic motility disorders was the only gastrointestinal symptom that its frequency was significantly reduced by supplementation (P = 0.01). The mean changes of insulin, LDL-c and MDA were significantly lower in intervention group in compare with control group (p < 0.05). In addition, the mean changes of HDL was significantly higher in intervention group in compare with control group (p < 0.05). Conclusion: It is recommended that dill powder supplementation may be effective in control of the glycemic, lipid, stress oxidative and gastrointestinal symptoms in type 2 diabetic patients.

scholarly journals Influence of Ramadan Fasting on Hemoglobin A1C, Lipid Profile, and Body Mass Index among Type 2 Diabetic Patients in Najran City, Saudi Arabia

2021 ◽  
Vol 9 (B) ◽  
pp. 318-325
Author(s):  
Hatem Mohamed ◽  
Anass M. Abbas ◽  
Mohammed Ayed Huneif ◽  
Seham M. Alqahtani ◽  
Awad Mohamed Ahmed ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Ramadan Fasting ◽  
The Mean ◽  
The Impact ◽  
Type 2 Diabetic

BACKGROUND: Saudi Arabia is known to have one of the highest prevalence of diabetes in the world. The impact of Ramadan fasting on the health of type 2 diabetic patients is an important issue that has not been adequately investigated. AIM: The current study was aimed at assessing the impact of Ramadan fasting on hemoglobin A1C (HbA1c), lipid profile, blood pressure, and body mass index (BMI) in adult Saudis with Type 2 diabetes residing in Najran city. METHODS: This is a descriptive cross-sectional study which enrolled 289 patients who chose to fast during the month of Ramadan and were attending the outpatient clinics of Najran University Hospital. Fasting blood samples were taken 1 month before and 1 month after Ramadan to determine glycated hemoglobin and fasting lipid profile (low-density lipoprotein [LDL], high-density lipoprotein [HDL], triglyceride [TG], and total cholesterol [TC]) and BMI was also calculated. Information regarding demographics and physical activity was obtained through a questionnaire. RESULTS: As many as 176 (60.9%) of the participants reported to be physically inactive during Ramadan. There was a statistically significant (p < 0.05) decrease in the mean percentage of HbA1c when comparing before Ramadan (9.85 ± 2.37%) with after Ramadan (7.65 ± 1.70%). Furthermore, statistically significant difference (p < 0.05) was detected in the mean concentrations of LDL before (3.39 ± 1.06 mmol/L) and after (2.40 ± 0.83 mmol/L) Ramadan. The mean concentration of TC (before = 5.98 ± 2.00 mmol/L; after = 4.05 ± 1.18 mmol/L) and TG (before = 2.97 ± 1.95 mmol/L; after = 2.65 ± 1.65 mmol/L) also reduced after Ramadan. The mean concentrations of HDL (before = 1.78 ± 0.74 mmol/L; after= 2.23 ± 0.23 mmol/L) increased after Ramadan. The mean BMI of the study participants (before = 28.30 ± 6.27; after = 27.43 ± 5.92) decreased slightly after Ramadan. The systolic blood pressure (SBP) (before= 128.10 ± 6.32; after, 123.09 ± 5.71) and diastolic blood pressure (DBP) (before = 81.21 ± 8.51; after = 79.83 ± 7.21) showed a slight reduction after Ramadan. CONCLUSIONS: Type 2 diabetic patients who performed Ramadan fasting displayed a lowering of HbA1c, LDL, TC, and TG, and increased HDL, but had small positive effects on body weight, BMI, as well as SBP and DBP. More studies are needed with a larger population in the future to assess the potential of Ramadan fasting as a therapeutic strategy for managing Type 2 diabetes.

scholarly journals Study of Correlation Between Glycated Hemoglobin (Hba1c) and Serum Lipid Profile in Type 2 Diabetic Patients

2020 ◽  
Vol 18 (1) ◽  
pp. 67-69
Author(s):  
Anil Shrestha
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Glycated Hemoglobin ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Diabetic Patients ◽  
Low Density ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Introduction: Diabetic mellitus is a chronic metabolic disease characterized by hyperglycemia. Type 2 diabetes mellitus accounts for more than 90% of cases worldwide. Elevated HbA1c and dyslipidemia proportionately increases the risk of development of cardiovascular disease (CVD) which is the major cause of morbidity and mortality worldwide. Aims: To Study the correlation between glycated hemoglobin (HbA1c) and serum lipid profile in type 2 diabetic patients. Methods: This is a hospital based cross sectional study conducted at Nepalgunj medical college teaching hospital, which included 104 type 2 diabetic patients (54 males and 50 females).Venous blood samples were collected from all patients and serum was used for analyzing HbA1c, lipid profile panel and fasting blood glucose (FBG). DM was defined as per American diabetic association (ADA) criteria. Dyslipidemia was defined as per the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III Guidelines. The data were analyzed using standard statistical methods, including SPSS 21. Results : Abnormal lipid parameters were demonstrated with increased Total Chloseterol (TC), Triglyceride (TG), Low density lipoprotein (LDL),Very low density lipoprotein (VLDL) and low High density lipoprotein (HDL)  suggestive of dyslipidemia.HbA1c showed direct and significant correlation with TC,LDL,TG and VLDL. Patients with HbA1c  > 7.0% had a significantly higher value of TC, LDL, TG and VLDL as compared to patients with HbA1c ≤7.0%.However, the significant difference in value of HDL-C was not found between two groups. Conclusion: Due to the strong correlation with lipid profile, HbA1c could be the ideal marker for predicting dyslipidemia in type 2 DM . Patients with higher HbA1c value and dyslipidemia should be considered as a very high risk group for CVD.

scholarly journals Pattern of serum lipid profile of type 2 diabetes patients in a tertiary hospital in Nigeria

2021 ◽  
Vol 9 (7) ◽  
pp. 1854
Author(s):  
Rifkatu S. Reng ◽  
Gerald A. Onwuegbuzie ◽  
Felicia Anumah
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Tertiary Hospital ◽  
Diabetic Patients ◽  
Chronic Hyperglycemia ◽  
Increased Risk ◽  
Low Hdl ◽  
Lipid Abnormalities

Background: Diabetes mellitus is a metabolic disorder characterised by chronic hyperglycemia and disturbances of carbohydrate, lipid and protein metabolism. Diabetic patients have an increased risk of developing dyslipidemia with various lipid abnormalities which makes them prone to develop cardiovascular disease. The aim of the study is to determine the patterns of lipid profile in patients with Type 2 diabetes mellitus.Methods: Lipid profile data for a total of 104 known type 2 DM patients from the medical outpatient clinic were collected. The profile of the study sample was analysed for dyslipidemia using the ATP III classification. Data obtained were analysed using Analyse-it v3.0 statistical software for Microsoft Excel.Results: This study showed that there were more females 53.8% than males 46.2% with type 2 diabetes mellitus with the mean age of 52.5±11.9 years. The pattern of dyslipidaemia revealed elevated LDL 51.9%, TG 37.5%, TC 36.5% and low HDL 27.9%. We had more patients who were overweight 33.7% than obese 32.7%.Conclusions: It was observed from the study that a significant number of diabetic patients have dyslipidaemia and most common lipid abnormalities are elevated LDL, triglyceride and low HDL.

scholarly journals High Glucagon-to-C-peptide Ratio and Inadequate Glucose Control in Type 2 Diabetic Patients

2020 ◽  
Author(s):  
Chunfeng Lu ◽  
Jianbin Su ◽  
Xueqin Wang ◽  
Xiaoqin Ge ◽  
Wangshu Liu ◽  
...  
Keyword(s):  
Glucose Control ◽  
Mean Difference ◽  
Oral Glucose ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
C Peptide ◽  
Increased Risk ◽  
The Mean ◽  
Type 2 Diabetic

Abstract Objective: Unbalanced glucagon and insulin secretion may contribute to glucose fluctuations and inadequate glucose control in type 2 diabetic patients. This study aimed to investigate the relationship between the glucagon-to-C-peptide ratio and glycemic control. Methods: From January 2017 to December 2018, a total of 1128 type 2 diabetic patients were recruited. The fasting and postprandial glucagon-to-C-peptide ratios were calculated following a 75-g oral glucose tolerance test (OGTT). Subjects were divided into quartiles based on their fasting and postprandial glucagon-to-C-peptide ratios. Statistical analysis was then carried out. Results: HbA1c levels were significantly and positively correlated with fasting (r = 0.333, p < 0.001) and postprandial glucagon-C-peptide-ratio (r = 0.373, p < 0.001). The proportion of patients with uncontrolled hyperglucose significantly increased from 76.2% to 83.0%, 89.4% and 94.7% from the first to second, third and fourth quartiles of the fasting glucagon-C-peptide ratio and increased from 73.4% to 80.9%, 93.3% and 95.7% from the first to second, third and fourth quartiles of the postprandial glucagon-C-peptide ratio, respectively. After adjusting for potential influences, the mean difference (95% CI) in HbA1c between the patients in the lowest and highest quartiles of the fasting glucagon-C-peptide ratio was 1.925 (1.512, 2.338) %, and the mean difference in HbA1c between the patients in the lowest andhighest quartiles of the prandial glucagon-C-peptide ratio was 2.401 (1.981, 2.820) %. After adjusting for possible metabolic risks by multiple logistic regression analysis, the corresponding odds ratios (ORs) for uncontrolled hyperglucose of the second, third and fourth quartiles versus the first quartile of fasting glucagon-C-peptide-ratiowere 1.331 (95% CI 0.829–2.136), 2.818 (1.647–4.823) and 7.268 (3.573–14.784), respectively. When compared with the first quartile of the postprandial glucagon-C-peptide ratio, the corresponding ORs for uncontrolled hyperglucose of the second, third and fourth quartiles were 1.752 (95% CI 1.100–2.793), 6.304 (3.348–11.560) and 15.998 (7.353–34.805), respectively. Conclusions: For type 2 diabetic patients, an increased glucagon-to-C-peptide ratio is associated with an increased risk of uncontrolled hyperglucose.

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