Aquatic systems are becoming increasingly susceptible to invasive species whereby local species are reduced in abundance and richness leading to changes in many food webs. Dispersal of species from surrounding lakes may provide a natural mechanism to increase local resistance by providing a diversity of locally adapted species to colonize affected communities. This study examined how zooplankton dispersal could potentially reduce the effects of the invasive zebra mussel, Dreissena polymorpha, on zooplankton community total abundance, species richness and diversity. Field experiments were conducted in 20 large tanks, with five replicates, to observe zooplankton community response to (1) the presence and absence of zebra mussels, and (2) the presence and absence of regional disperser zooplankton. Live regional zooplankton, from six surrounding lakes, were added fortnightly to dispersal treatments, while heat-killed zooplankton were added to no-dispersal treatments. All tanks were sampled for chlorophyll and zooplankton community samples prior to dispersal additions. Zooplankton were counted and identified as cladocerans and copepods (macrozooplankton), and rotifers (microzooplankton) to species. In the presence of mussels, chlorophyll was significantly depleted, reducing nutrient availability. All zooplankton richness and abundance decreased suggesting strong resource competition and direct predation by mussels. Dispersal did not affect macrozooplankton community structure, however, dispersal influenced the effect of zebra mussels on rotifers, further decreasing richness. This suggests species from the surrounding lakes may be highly competitive among local species, further proposing that regional species may influence zooplankton community structure and responses to zebra mussel invasion, but the effect is species dependent.