Schwannoma of the Sural Nerve: A Case Report

2020 ◽  
Vol 110 (3) ◽  
Author(s):  
Anusha Pundu ◽  
Bruce Lehnert
Keyword(s):  
Case Report ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Sural Nerve ◽  
Neurogenic Tumor ◽  
Clinical Implications ◽  
Foot Pain ◽  
Rare Finding ◽  
Nerve Sheath ◽  
Slow Growing

A schwannoma is a slow-growing, neurogenic tumor composed of Schwann cells arising from a peripheral nerve sheath. The authors present a rare finding of a schwannoma of the sural nerve that was overlooked in a 51-year-old female with radiating foot pain. This case highlights the clinical implications and important teaching points in recognizing a schwannoma of the foot.

scholarly journals Neurofibroma of lumbosacral region: a case report

2019 ◽  
Vol 7 (5) ◽  
pp. 1948
Author(s):  
Elfiah . ◽  
Syaifullah Asmiragani
Keyword(s):  
Case Report ◽  
Peripheral Nerve ◽  
Vertebral Body ◽  
Cervical Cord ◽  
Benign Tumors ◽  
Lumbosacral Region ◽  
Sacral Region ◽  
Nerve Sheath ◽  
Sensory Changes ◽  
Slow Growing

Neurofibromas are benign tumors of the peripheral nerve sheath. Spinal neurofibroma often asymptomatic. Symptoms may present include sensory changes. Neurofibroma mostly encountered cervical cord, difficult to distinguish from schwannomas. This slow growing tumor remodel the bone resulting pedicle thinning and posterior vertebral body scalloping. MRI shows hyperintense rim. Although this highly suggestive neurofibroma, occasionally also seen in schwannoma and malignant PNST. Treatment choice for symptomatic lesions is surgery. We are reporting a case of neurofibroma in the 5th lumbar and 1st sacral region.

Palatal Schwannoma: A Rare Case Report

2016 ◽  
Vol 8 (1) ◽  
pp. 29-31
Author(s):  
Nikhil Arora ◽  
PS Shahul Hameed
Keyword(s):  
Case Report ◽  
Oral Cavity ◽  
Schwann Cells ◽  
Rare Case ◽  
Benign Tumor ◽  
Neck Region ◽  
Head And Neck Region ◽  
Nerve Sheath ◽  
Rare Case Report ◽  
Slow Growing

ABSTRACT Schwannoma is a benign tumor that originates from perineural Schwann cells of nerve sheath. They are solitary, wellencapsulated, slow-growing adjacent to the parental nerve but extrinsic to the nerve fascicles. Approximately 25 to 45% of all schwannomas are seen in the head and neck region and are found rarely in the oral cavity. Most of the intraoral schwannomas are located in the tongue. Palatal schwannoma is very rare as till date and only 16 cases have been reported; one such rare case we came across is reported here. How to cite this article Hameed PSS, Arora N, Malhotra V. Palatal Schwannoma: A Rare Case Report. Int J Otorhinolaryngol Clin 2016;8(1):29-31.

scholarly journals Case Report of Schwannomas: Benign Tumour of the Peripheral Nerve Sheath

EMJ Neurology ◽  
2020 ◽  
pp. 103-107
Author(s):  
Ansilata Marlyn Ansilata Marlyn ◽  
Faisal Ameer ◽  
Hillol Kanti Pal
Keyword(s):  
Case Report ◽  
Postoperative Complications ◽  
Peripheral Nerve ◽  
Peripheral Nerves ◽  
Sural Nerve ◽  
Tibial Nerve ◽  
The Other ◽  
Surgical Microscope ◽  
Nerve Sheath ◽  
Benign Tumours

Schwannomas, also known as neurilemmomas, are benign peripheral nerve sheath tumours arising from the Schwann cells surrounding the nerve. Incidence of peripheral nerve sheath benign tumours occurring in the lower extremities is rare (1–10%). The authors present two cases with solitary schwannomas from the peripheral nerves. In one case, the schwannoma arose from the sural nerve and in the other, from the tibial nerve. They were successfully surgically removed with the aid of a surgical microscope, with no intraoperative or postoperative complications.

scholarly journals Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1584
Author(s):  
Germán L. Vélez-Reyes ◽  
Nicholas Koes ◽  
Ji Hae Ryu ◽  
Gabriel Kaufmann ◽  
Mariah Berner ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Schwann Cell ◽  
Peripheral Nerve ◽  
Cell Line ◽  
Schwann Cells ◽  
Tumor Suppressor Genes ◽  
Tumor Formation ◽  
Loss Of Function ◽  
Suppressor Genes ◽  
Nerve Sheath

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive, genomically complex, have soft tissue sarcomas, and are derived from the Schwann cell lineage. Patients with neurofibromatosis type 1 syndrome (NF1), an autosomal dominant tumor predisposition syndrome, are at a high risk for MPNSTs, which usually develop from pre-existing benign Schwann cell tumors called plexiform neurofibromas. NF1 is characterized by loss-of-function mutations in the NF1 gene, which encode neurofibromin, a Ras GTPase activating protein (GAP) and negative regulator of RasGTP-dependent signaling. In addition to bi-allelic loss of NF1, other known tumor suppressor genes include TP53, CDKN2A, SUZ12, and EED, all of which are often inactivated in the process of MPNST growth. A sleeping beauty (SB) transposon-based genetic screen for high-grade Schwann cell tumors in mice, and comparative genomics, implicated Wnt/β-catenin, PI3K-AKT-mTOR, and other pathways in MPNST development and progression. We endeavored to more systematically test genes and pathways implicated by our SB screen in mice, i.e., in a human immortalized Schwann cell-based model and a human MPNST cell line, using CRISPR/Cas9 technology. We individually induced loss-of-function mutations in 103 tumor suppressor genes (TSG) and oncogene candidates. We assessed anchorage-independent growth, transwell migration, and for a subset of genes, tumor formation in vivo. When tested in a loss-of-function fashion, about 60% of all TSG candidates resulted in the transformation of immortalized human Schwann cells, whereas 30% of oncogene candidates resulted in growth arrest in a MPNST cell line. Individual loss-of-function mutations in the TAOK1, GDI2, NF1, and APC genes resulted in transformation of immortalized human Schwann cells and tumor formation in a xenograft model. Moreover, the loss of all four of these genes resulted in activation of Hippo/Yes Activated Protein (YAP) signaling. By combining SB transposon mutagenesis and CRISPR/Cas9 screening, we established a useful pipeline for the validation of MPNST pathways and genes. Our results suggest that the functional genetic landscape of human MPNST is complex and implicate the Hippo/YAP pathway in the transformation of neurofibromas. It is thus imperative to functionally validate individual cancer genes and pathways using human cell-based models, to determinate their role in different stages of MPNST development, growth, and/or metastasis.

Metastatic malignant peripheral nerve sheath tumour presenting as a spontaneous extradural haematoma – A case report

2016 ◽  
Vol 31 (3) ◽  
pp. 382-384
Author(s):  
A. S. Ramesh ◽  
Pushkar Singh ◽  
Sajini Elizabeth Jacob ◽  
Venkatesh S. Madhugiri
Keyword(s):  
Case Report ◽  
Peripheral Nerve ◽  
Extradural Haematoma ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Peripheral Nerve Sheath Tumour

scholarly journals Malignant Intraosseous Peripheral Nerve Sheath Tumour of the Proximal Femur: A Case Report

2006 ◽  
Vol 14 (1) ◽  
pp. 84-89 ◽  
Author(s):  
A Lesic ◽  
M Bumbasirevic ◽  
HDE Atkinson ◽  
R Maksimovic ◽  
J Sopta ◽  
...  
Keyword(s):  
Case Report ◽  
Peripheral Nerve ◽  
Proximal Femur ◽  
Nerve Sheath Tumour ◽  
Nerve Sheath ◽  
Peripheral Nerve Sheath Tumour

scholarly journals Immunohistochemical study of a canine neurofibroma

2012 ◽  
Vol 83 (1) ◽  
Author(s):  
Hamidreza Fattahian ◽  
Pejman Mortazavi ◽  
Hamidreza Moosavian ◽  
Hamid Mohyeddin ◽  
Roozbeh Moridpour
Keyword(s):  
Case Report ◽  
Diagnostic Imaging ◽  
Peripheral Nerve ◽  
Schwann Cells ◽  
Immunohistochemical Study ◽  
Collagen Fibres ◽  
Spindle Cells ◽  
Left Mandible ◽  
S 100 ◽  
Diagnostic Approaches

Accurate diagnostic approaches to differentiate peripheral nerve sheet tumours from others have not been firmly established. The aim of this case report was to diagnose neurofibroma using a combination of diagnostic imaging, histopathology and immunohistochemistry, which were applied to a canine neurofibroma arising in the left mandible. The tumour was surgically excised and examined histologically. Round or spindle cells, with elongated, dense and homogenous chromatin and pale cytoplasm typical of Schwann cells in an abundant fibromyxomatous stroma, with ruby collagen fibres were seen. Immunohistochemistry demonstrated that S-100 and vimentin were more than 70% positive. Neurofibroma may therefore be recognisable using markers such as S-100 and vimentin.

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