scholarly journals Epidemiological and ecological determinants of Zika virus transmission in an urban setting

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
José Lourenço ◽  
Maricelia Maia de Lima ◽  
Nuno Rodrigues Faria ◽  
Andrew Walker ◽  
Moritz UG Kraemer ◽  
...  
Keyword(s):  
Public Health ◽  
Zika Virus ◽  
Herd Immunity ◽  
Virus Transmission ◽  
Health Impact ◽  
Urban Setting ◽  
Health Concern ◽  
Transmission Model ◽  
Global Public Health ◽  
Transmission Potential

The Zika virus has emerged as a global public health concern. Its rapid geographic expansion is attributed to the success of Aedes mosquito vectors, but local epidemiological drivers are still poorly understood. Feira de Santana played a pivotal role in the Chikungunya epidemic in Brazil and was one of the first urban centres to report Zika infections. Using a climate-driven transmission model and notified Zika case data, we show that a low observation rate and high vectorial capacity translated into a significant attack rate during the 2015 outbreak, with a subsequent decline in 2016 and fade-out in 2017 due to herd-immunity. We find a potential Zika-related, low risk for microcephaly per pregnancy, but with significant public health impact given high attack rates. The balance between the loss of herd-immunity and viral re-importation will dictate future transmission potential of Zika in this urban setting.

scholarly journals Epidemiological and ecological determinants of Zika virus transmission in an urban setting

2017 ◽  
Author(s):  
J Lourenço ◽  
M Maia de Lima ◽  
NR Faria ◽  
A Walker ◽  
MUG Kraemer ◽  
...  
Keyword(s):  
Herd Immunity ◽  
Virus Transmission ◽  
Urban Setting ◽  
Health Concern ◽  
Transmission Model ◽  
Surveillance Systems ◽  
Global Public Health ◽  
Transmission Potential ◽  
Near Future ◽  
The City

AbstractZika has emerged as a global public health concern. Although its rapid geographic expansion can be attributed to the success of its Aedes mosquito vectors, local epidemiological drivers are still poorly understood. The city of Feira de Santana played a pivotal role in the early phases of the Chikungunya and Zika epidemics in Brazil. Here, using a climate-driven transmission model, we show that low Zika observation rates and a high vectorial capacity in this region were responsible for a high attack rate during the 2015 outbreak and the subsequent decline in cases in 2016, when the epidemic was peaking in the rest of the country. Our projections indicate that the balance between the loss of herd-immunity and the frequency of viral re-importation will dictate the transmission potential of Zika in this region in the near future. Sporadic outbreaks are expected but unlikely to be detected under current surveillance systems.

scholarly journals Measuring mosquito-borne viral suitability in Myanmar and implications for local Zika virus transmission

2017 ◽  
Author(s):  
PN Perez ◽  
U Obolski ◽  
LCJ Alcantara ◽  
M Maia de Lima ◽  
EA Ashley ◽  
...  
Keyword(s):  
Zika Virus ◽  
Spatial Scales ◽  
Virus Transmission ◽  
Geographical Location ◽  
Health Impact ◽  
Natural Oscillations ◽  
Transmission Potential ◽  
Mosquito Abundance ◽  
Country Level ◽  
Suitability Index

AbstractINTRODUCTION: In South East Asia, mosquito-borne viruses (MBVs) have long been a cause of high disease burden and significant economic costs. While in some SEA countries the epidemiology of MBVs is spatio-temporally well characterised and understood, in others such as Myanmar our understanding is largely incomplete. MATERIALS AND METHODS: Here, we use a simple mathematical approach to estimate a climate-driven suitability index aiming to better characterise the intrinsic, spatio-temporal potential of MBVs in Myanmar. RESULTS: Results show that the timing and amplitude of the natural oscillations of our suitability index are highly informative for the temporal patterns of DENV case counts at the country level, and a mosquito-abundance measure at a city level. When projected at fine spatial scales, the suitability index suggests that the time period of highest MBV transmission potential is between June and October independently of geographical location. Higher potential is nonetheless found along the middle axis of the country and in particular in the southern corridor of international borders with Thailand. DISCUSSION: This research complements and expands our current understanding of MBV transmission potential in Myanmar, by identifying key spatial heterogeneities and temporal windows of importance for surveillance and control. We discuss our findings in the context of Zika virus given its recent worldwide emergence, public health impact, and current lack of information on its epidemiology and transmission potential in Myanmar. The proposed suitability index here demonstrated is applicable to other regions of the world for which surveillance data is missing, either due to lack of resources or absence of an MBV of interest.

scholarly journals South-east Asian Zika virus strain linked to cluster of cases in Singapore, August 2016

2016 ◽  
Vol 21 (38) ◽  
Author(s):  
Sebastian Maurer-Stroh ◽  
Tze-Minn Mak ◽  
Yi-Kai Ng ◽  
Shiau-Pheng Phuah ◽  
Roland G Huber ◽  
...  
Keyword(s):  
Public Health ◽  
Phylogenetic Analysis ◽  
Virus Strain ◽  
Zika Virus ◽  
East Asian ◽  
Public Health Emergency ◽  
Global Public Health ◽  
Genome Sequences ◽  
First Case ◽  
Large Outbreak

Zika virus (ZIKV) is an ongoing global public health emergency with 70 countries and territories reporting evidence of ZIKV transmission since 2015. On 27 August 2016, Singapore reported its first case of local ZIKV transmission and identified an ongoing cluster. Here, we report the genome sequences of ZIKV strains from two cases and find through phylogenetic analysis that these strains form an earlier branch distinct from the recent large outbreak in the Americas.

scholarly journals Author response: Epidemiological and ecological determinants of Zika virus transmission in an urban setting

2017 ◽  
Author(s):  
José Lourenço ◽  
Maricelia Maia de Lima ◽  
Nuno Rodrigues Faria ◽  
Andrew Walker ◽  
Moritz UG Kraemer ◽  
...  
Keyword(s):  
Zika Virus ◽  
Virus Transmission ◽  
Urban Setting ◽  
Author Response

scholarly journals Normalisation and Stigmatisation of Obesity in UK Newspapers: a Visual Content Analysis

2013 ◽  
Vol 5 (1) ◽  
pp. 82-91 ◽  
Author(s):  
Mr. Chris Patterson ◽  
Dr. Shona Hilton
Keyword(s):  
Public Health ◽  
Content Analysis ◽  
Media Coverage ◽  
The Body ◽  
Health Concern ◽  
Global Public Health ◽  
Obese Adults ◽  
Manifest Content ◽  
Body Sizes ◽  
The Uk

Obesity represents a major and growing global public health concern. The mass media play an important role in shaping public understandings of health, and obesity attracts much media coverage. This study offers the first content analysis of photographs illustrating UK newspaper articles about obesity. The researchers studied 119 articles and images from five major national newspapers. Researchers coded the manifest content of each image and article and used a graphical scale to estimate the body size of each image subject. Data were analysed with regard to the concepts of the normalisation and stigmatisation of obesity. Articles’ descriptions of subjects’ body sizes were often found to differ from coders’ estimates, and subjects described as obese tended to represent the higher values of the obese BMI range, differing from the distribution of BMI values of obese adults in the UK. Researchers identified a tendency for image subjects described as overweight or obese to be depicted in stereotypical ways that could reinforce stigma. These findings are interpreted as illustrations of how newspaper portrayals of obesity may contribute to societal normalisation and the stigmatisation of obesity, two forces that threaten to harm obese individuals and undermine public health efforts to reverse trends in obesity.

scholarly journals Global Governance of Anti-microbial Resistance: A Legal and Regulatory Toolkit

2020 ◽  
pp. 401-420
Author(s):  
Calvin W. L. Ho ◽  
Tsung-Ling Lee
Keyword(s):  
Public Health ◽  
System Approach ◽  
Action Plan ◽  
World Health ◽  
Health Concern ◽  
Global Public Health ◽  
Agricultural Industry ◽  
Treatment And Prevention ◽  
Global Action ◽  
Health Organization

Abstract Recognizing that antimicrobial resistance (AMR) poses a serious threat to global public health, the World Health Organization (WHO) has adopted a Global Action Plan (GAP) at the May 2015 World Health Assembly. Underscoring that systematic misuse and overuse of drugs in human medicine and food production is a global public health concern, the GAP-AMR urges concerted efforts across governments and private sectors, including pharmaceutical industry, medical professionals, agricultural industry, among others. The GAP has a threefold aim: (1) to ensure a continuous use of effective and safe medicines for treatment and prevention of infectious diseases; (2) to encourage a responsible use of medicines; and (3) to engage countries to develop their national actions on AMR in keeping with the recommendations. While the GAP is a necessary step to enable multilateral actions, it must be supported by effective governance in order to realize the proposed aims. This chapter has a threefold purpose: (1) To identify regulatory principles embedded in key WHO documents relating to AMR and the GAP-AMR; (2) To consider the legal and regulatory actions or interventions that countries could use to strengthen their regulatory lever for AMR containment; and (3) To highlight the crucial role of the regulatory lever in enabling other levers under a whole-of-system approach. Effective AMR containment requires a clearer understanding of how the regulatory lever could be implemented or enabled within health systems, as well as how it underscores and interacts with other levers within a whole-of-system approach.

scholarly journals Gambling Harm as a Global Public Health Concern: A Mixed Method Investigation of Trends in Wales

2020 ◽  
Vol 8 ◽  
Author(s):  
Bev John ◽  
Katy Holloway ◽  
Nyle Davies ◽  
Tom May ◽  
Marian Buhociu ◽  
...  
Keyword(s):  
Public Health ◽  
Mixed Method ◽  
Health Concern ◽  
Global Public Health ◽  
Public Health Concern ◽  
Gambling Harm

scholarly journals Autophagy in Zika Virus Infection: A Possible Therapeutic Target to Counteract Viral Replication

2019 ◽  
Vol 20 (5) ◽  
pp. 1048 ◽  
Author(s):  
Rossella Gratton ◽  
Almerinda Agrelli ◽  
Paola Tricarico ◽  
Lucas Brandão ◽  
Sergio Crovella
Keyword(s):  
Public Health ◽  
Viral Replication ◽  
Zika Virus ◽  
Health Concern ◽  
Mtor Signaling Pathway ◽  
Catabolic Pathway ◽  
Public Health Concern ◽  
Zikv Infection ◽  
Fundamental Process

Zika virus (ZIKV) still constitutes a public health concern, however, no vaccines or therapies are currently approved for treatment. A fundamental process involved in ZIKV infection is autophagy, a cellular catabolic pathway delivering cytoplasmic cargo to the lysosome for degradation—considered as a primordial form of innate immunity against invading microorganisms. ZIKV is thought to inhibit the Akt-mTOR signaling pathway, which causes aberrant activation of autophagy promoting viral replication and propagation. It is therefore appealing to study the role of autophagic molecular effectors during viral infection to identify potential targets for anti-ZIKV therapeutic intervention.

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