Valinomycin-Modified Graphene Field-Effect Transistors for Potassium Ion Sensors

Direct and sensitive short-wavelength ultraviolet (UVC) dosimeters could enable safer disinfection environment against virus. We develop direct, quantitative, specific and highly sensitive UVC dosimeters based on DNA nanostructure-modified graphene field-effect...

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Ion-Selective Carbon Nanotube Field-Effect Transistors for Monitoring Drug Effects on Nicotinic Acetylcholine Receptor Activation in Live Cells

Sensors ◽

10.3390/s20133680 ◽

2020 ◽

Vol 20 (13) ◽

pp. 3680

Author(s):

Youngtak Cho ◽

Viet Anh Pham Ba ◽

Jin-Young Jeong ◽

Yoonji Choi ◽

Seunghun Hong

Keyword(s):

Carbon Nanotube ◽

Nicotinic Acetylcholine Receptors ◽

Field Effect ◽

Field Effect Transistors ◽

Drug Effects ◽

Receptor Activation ◽

Potassium Ion ◽

Live Cells ◽

Ion Release ◽

Nicotinic Acetylcholine

We developed ion-selective field-effect transistor (FET) sensors with floating electrodes for the monitoring of the potassium ion release by the stimulation of nicotinic acetylcholine receptors (nAChRs) on PC12 cells. Here, ion-selective valinomycin-polyvinyl chloride (PVC) membranes were coated on the floating electrode-based carbon nanotube (CNT) FETs to build the sensors. The sensors could selectively measure potassium ions with a minimum detection limit of 1 nM. We utilized the sensor for the real-time monitoring of the potassium ion released from a live cell stimulated by nicotine. Notably, this method also allowed us to quantitatively monitor the cell responses by agonists and antagonists of nAChRs. These results suggest that our ion-selective CNT-FET sensor has potential uses in biological and medical researches such as the monitoring of ion-channel activity and the screening of drugs.

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Sensitivity enhancement of potassium ion (K+) detection based on graphene field-effect transistors with surface plasma pretreatment

Sensors and Actuators B Chemical ◽

10.1016/j.snb.2019.01.058 ◽

2019 ◽

Vol 285 ◽

pp. 333-340 ◽

Cited By ~ 15

Author(s):

Qilong Yuan ◽

Sudong Wu ◽

Chen Ye ◽

Xiangqi Liu ◽

Jingyao Gao ◽

...

Keyword(s):

Field Effect ◽

Field Effect Transistors ◽

Sensitivity Enhancement ◽

Potassium Ion ◽

Surface Plasma ◽

Plasma Pretreatment

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Label-Free Biosensors Based on Aptamer-Modified Graphene Field-Effect Transistors

Journal of the American Chemical Society ◽

10.1021/ja108127r ◽

2010 ◽

Vol 132 (51) ◽

pp. 18012-18013 ◽

Cited By ~ 359

Author(s):

Yasuhide Ohno ◽

Kenzo Maehashi ◽

Kazuhiko Matsumoto

Keyword(s):

Field Effect ◽

Field Effect Transistors ◽

Label Free ◽

Modified Graphene

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Influence of ssDNA Immobilization on the Conductance of Solution Gated Graphene Transistors

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.830.302 ◽

2013 ◽

Vol 830 ◽

pp. 302-305 ◽

Cited By ~ 1

Author(s):

Meng Song ◽

Cheng Ju ◽

Yun Fang Jia

Keyword(s):

Phosphate Buffer ◽

Field Effect ◽

Field Effect Transistors ◽

Phosphate Buffer Solution ◽

Single Strand ◽

Buffer Solution ◽

Reduced Graphene ◽

Modified Graphene ◽

Carboxyl Modification ◽

Reduced State

Carboxyl-modified graphene materials in both oxide and reduced state were explored in parallel for the preparation of field-effect transistors (FET). They were solution gated by phosphate buffer solution (PBS) (pH 7.2). Their conductance were examined and compared with unmodified graphene transistors, firstly. Then, after single strand DNA molecules were immobilized on reduced and oxide graphene transistors, their conductance and compared. Here ssDNA molecules were amino-tagged at the terminal five. It was found that ambipolar characteristic was exhibited by reduced graphene transistors, even they were undergone carboxyl modification. And it was also discovered that there were opposite conductance variation with the increasing of ssDNA concentrations and bigger changes were obtained by reduced carboxyl-modified graphene transistors.

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Comparison of Potassium ISFETs with the Radiometer KNA1 and the Corning 902 Ion Selective Electrode Analysers for Whole Blood Potassium Ion Estimation

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456328902600313 ◽

1989 ◽

Vol 26 (3) ◽

pp. 274-280 ◽

Cited By ~ 4

Author(s):

John M Thompson ◽

Christopher Emmett ◽

Stephen C H Smith ◽

Robert Cramb ◽

Peter Hutton

Keyword(s):

Whole Blood ◽

Mass Production ◽

Field Effect ◽

Field Effect Transistors ◽

Potassium Ion ◽

Selective Electrode ◽

Stage Of Development ◽

Small Constant ◽

Clinical Chemical ◽

Blood Potassium

Evaluation of the performance of potassium ion sensitive field effect transistors (K+ ISFETs), developed by Thorn EMI in a form suitable for mass production and for incorporation in ‘near the patient’ analysers, showed only very small constant and proportional biases against the Radiometer KNA1 and the Corning 902 for whole blood potassium ion estimation. Between batch imprecision tests with whole blood showed the K+ ISFET was comparable in performance to the Corning 902 but inferior to the Radiometer KNA1. The evaluation demonstrated that ISFET manufacturing technology has now reached a stage of development at which ISFETs should be considered seriously for use in clinical chemical analysers.

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