scholarly journals CANINE DISTEMPER VIRUS–ASSOCIATED ENCEPHALITIS IN FREE-LIVING LYNX (LYNX CANADENSIS) AND BOBCATS (LYNX RUFUS) OF EASTERN CANADA

2009 ◽  
Vol 45 (3) ◽  
pp. 611-624 ◽  
Author(s):  
Pierre-Yves Daoust ◽  
Scott R. McBurney ◽  
Dale L. Godson ◽  
Marco W. G. van de Bildt ◽  
Albert D. M. E. Osterhaus
1970 ◽  
Vol 48 (6) ◽  
pp. 1287-1293 ◽  
Author(s):  
Carl C. Bursey ◽  
Michael D. B. Burt

Examination of 129 bobcats (Lynx rufus) from New Brunswick, Nova Scotia, and Maine and 14 lynx (Lynx canadensis) from Newfoundland revealed the presence of adult Taenia macrocystis (Diesing 1850) in 86% of the bobcats and in all the lynx. Concurrent examination of snowshoe hares (Lepus americanus) showed that a high proportion of adult hares were infected with cestode larvae of the strobilocercus type. Scolices of these larvae were identical with scolices of T. macrocystis adults recovered from wild cats.Experimental infection of domestic cats with fresh larvae from hares yielded adult taeniids, within 42 days, which were identical with the adult T. macrocystis found in wild cats.Experimental infection of laboratory-reared snowshoe hares with eggs of these cestodes produced fully developed, infective strobilocercus larvae within 14 weeks, thus establishing that Lepus americanus acts as an intermediate host in the life cycle of T. macrocystis in northeastern North America.


2001 ◽  
Vol 87 (5) ◽  
pp. 1194 ◽  
Author(s):  
P. Labelle ◽  
J. P. Dubey ◽  
I. Mikaelian ◽  
N. Blanchette ◽  
R. Lafond ◽  
...  

2018 ◽  
Vol 96 (12) ◽  
pp. 1299-1308 ◽  
Author(s):  
T. Gooliaff ◽  
K.E. Hodges

Species across the planet are shifting their ranges in response to climate change and habitat loss. However, range shifts may vary, with populations moving in some areas but remaining stable in others; the conditions that encourage range stability rather than range shifts are poorly known. Bobcats (Lynx rufus (Schreber, 1777)) and Canada lynx (Lynx canadensis Kerr, 1792) are congeneric mesocarnivores with wide ranges across North America and range overlap in southern boreal and montane forests (the southern edge for lynx and the northern edge for bobcat). The ranges of both species are shifting in some parts of North America, in most cases resulting in a northward expansion for bobcats and a northward contraction for lynx. However, their range dynamics in the Pacific Northwest, which contains the northwestern range margin for bobcats and the southwestern range margin for lynx, have not been thoroughly documented. Here, we examine whether the range of each species has shifted in British Columbia (BC), Canada, provincially during 1983–2013 or in central BC during 1935–2013. Trapping records indicated that ranges have remained stable, and surveys from trappers supported these findings. Our findings are consistent with previous work showing that many wide-ranging species do not shift their range uniformly across their entire range edge. For bobcats and lynx, their range stability in BC contrasts with their range dynamics in other parts of North America.


PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0194243 ◽  
Author(s):  
Laura E. Farrell ◽  
Daniel M. Levy ◽  
Therese Donovan ◽  
Ruth Mickey ◽  
Alan Howard ◽  
...  

FACETS ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 503-522 ◽  
Author(s):  
Robby R. Marrotte ◽  
Jeff Bowman ◽  
Samantha J. Morin

Harvest records suggest that the abundance of bobcats ( Lynx rufus) has increased and the leading edge of their distribution has spread northward, while the trailing edge of the Canada lynx ( Lynx canadensis) range has contracted in Ontario, Canada. There has been a debate about whether these closely related felids might compete in areas of sympatry, but there is little research on sympatric populations of bobcat and lynx. Both species are found on the north shore of Lake Huron in Ontario, Canada, which provided an opportunity to investigate their spatial patterns and habitat use. We surveyed snowmobile routes for snow tracks over three winters and estimated probability of occupancy for the two felid species while accounting for detectability. Bobcat and lynx tracks were never found on the same survey route. Bobcat occupancy increased with habitat heterogeneity, whereas lynx occupancy increased with homogeneity. Our results fit with the common assumption of the generalist and specialist natures of bobcat and lynx, respectively. Our findings suggest that bobcats invaded former lynx territory after these areas became vacant. The story of the bobcat and the lynx is one of the loss of a unique, boreal specialist due to anthropogenic change, and eventual replacement by an adaptable generalist.


2015 ◽  
Vol 93 (7) ◽  
pp. 521-530 ◽  
Author(s):  
E.L. Koen ◽  
J. Bowman ◽  
P.J. Wilson

Landscape barriers to gene flow, such as rivers, can affect animal populations by limiting the potential for rescue of these isolated populations. We tested the riverine barrier hypothesis, predicting that the St. Lawrence River in eastern Canada would cause genetic divergence of Canada lynx (Lynx canadensis Kerr, 1792) populations by restricting dispersal and gene flow. We sampled 558 lynx from eastern Canada and genotyped these at 14 microsatellite loci. We found three genetic clusters, defined by the St. Lawrence River and the Strait of Belle Isle, a waterway separating Newfoundland from mainland Canada. However, these waterways were not absolute barriers, as we found 24 individuals that appeared to have crossed them. Peripheral populations of lynx are threatened in parts of Canada and the USA, and it is thought that these populations are maintained by immigration from the core. Our findings suggest that in eastern North America, rescue might be less likely because the St. Lawrence River restricts dispersal. We found that ice cover was often sufficient to allow lynx to walk across the ice in winter. If lynx used ice bridges in winter, then climate warming could cause a reduction in the extent and longevity of river and sea ice, further isolating these peripheral lynx populations.


2001 ◽  
Vol 87 (5) ◽  
pp. 1194-1196 ◽  
Author(s):  
P. Labelle ◽  
J. P. Dubey ◽  
I. Mikaelian ◽  
N. Blanchette ◽  
R. Lafond ◽  
...  
Keyword(s):  

2021 ◽  
Vol 22 (7) ◽  
pp. 3578
Author(s):  
Federico Armando ◽  
Adnan Fayyad ◽  
Stefanie Arms ◽  
Yvonne Barthel ◽  
Dirk Schaudien ◽  
...  

Histiocytic sarcomas refer to highly aggressive tumors with a poor prognosis that respond poorly to conventional treatment approaches. Oncolytic viruses, which have gained significant traction as a cancer therapy in recent decades, represent a promising option for treating histiocytic sarcomas through their replication and/or by modulating the tumor microenvironment. The live attenuated canine distemper virus (CDV) vaccine strain Onderstepoort represents an attractive candidate for oncolytic viral therapy. In the present study, oncolytic virotherapy with CDV was used to investigate the impact of this virus infection on tumor cell growth through direct oncolytic effects or by virus-mediated modulation of the tumor microenvironment with special emphasis on angiogenesis, expression of selected MMPs and TIMP-1 and tumor-associated macrophages in a murine xenograft model of canine histiocytic sarcoma. Treatment of mice with xenotransplanted canine histiocytic sarcomas using CDV induced overt retardation in tumor progression accompanied by necrosis of neoplastic cells, increased numbers of intratumoral macrophages, reduced angiogenesis and modulation of the expression of MMPs and TIMP-1. The present data suggest that CDV inhibits tumor growth in a multifactorial way, including direct cell lysis and reduction of angiogenesis and modulation of MMPs and their inhibitor TIMP-1, providing further support for the concept of its role in oncolytic therapies.


2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Rocío Almuna ◽  
Andrés M. López‐Pérez ◽  
Rosa E. Sarmiento ◽  
Gerardo Suzán

Viruses ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 128
Author(s):  
Neeta Shrestha ◽  
Flavio M. Gall ◽  
Jonathan Vesin ◽  
Marc Chambon ◽  
Gerardo Turcatti ◽  
...  

Canine distemper virus (CDV), a close relative of the human pathogen measles virus (MeV), is an enveloped, negative sense RNA virus that belongs to the genus Morbillivirus and causes severe diseases in dogs and other carnivores. Although the vaccination is available as a preventive measure against the disease, the occasional vaccination failure highlights the importance of therapeutic alternatives such as antivirals against CDV. The morbilliviral cell entry system relies on two interacting envelope glycoproteins: the attachment (H) and fusion (F) proteins. Here, to potentially discover novel entry inhibitors targeting CDV H, F and/or the cognate receptor: signaling lymphocyte activation molecule (SLAM) proteins, we designed a quantitative cell-based fusion assay that matched high-throughput screening (HTS) settings. By screening two libraries of small molecule compounds, we successfully identified two membrane fusion inhibitors (F2736-3056 and F2261-0043). Although both inhibitors exhibited similarities in structure and potency with the small molecule compound 3G (an AS-48 class morbilliviral F-protein inhibitor), F2736-3056 displayed improved efficacy in blocking fusion activity when a 3G-escape variant was employed. Altogether, we present a cell-based fusion assay that can be utilized not only to discover antiviral agents against CDV but also to dissect the mechanism of morbilliviral-mediated cell-binding and cell-to-cell fusion activity.


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