Ricekojireduced body weight gain, fat accumulation, and blood glucose level in high-fat diet-induced obese mice

Abstract Objectives Cinnamon is one of the oldest spices widely used in traditional medicine and also currently used by people all around the world. Cinnamon has been known for modulating metabolic disorders by regulating insulin sensitivity. The aim of this study was to investigate the anti-obese effects of cinnamon extracts in high-fat-diet induced obese mice model. Methods After a week of adaptation period, the 6-week-old male C57BL/6J mice were randomly divided into 4 groups (n = 11 for each group) of the normal diet group (ND), the high-fat-diet group (HF), the normal diet with 1% cinnamon extracts (NC), and the high-fat diet with 1% cinnamon extracts (HC). All groups were treated for 14 weeks. Results In final body weight and body weight gain, NC group was significantly lower than ND group and HC group was significantly lower than HF group (P = 0.000). In serum TG (Triglyceride) levels and TC (Total cholesterol) levels, NC group showed significantly decreased level compared to that of ND group and HC group represented significantly decreased level compared to that of HF group (P = 0.000). Conclusions The present data showed NC group and HC group showed lower final body weight and body weight gain than ND group and HF group. Also, NC group and HC group showed the decreased level of TG (Triglyceride) and TC (Total cholesterol) compared to ND group and HF group. The further indicators of insulin-related factors are in progress. Funding Sources This study received no external funding.

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Gut Dysbiosis Clinical Indicators Associate with Body Weight Gain and Cognitive Dysfunction in High-Fat Diet-Induced Pre-obese Mice

Journal of Diseases and Medicinal Plants ◽

10.11648/j.jdmp.20160203.12 ◽

2016 ◽

Vol 2 (3) ◽

pp. 26

Author(s):

Paul F. Seke Etet

Keyword(s):

Body Weight ◽

Weight Gain ◽

Cognitive Dysfunction ◽

High Fat Diet ◽

Body Weight Gain ◽

Obese Mice ◽

High Fat ◽

Clinical Indicators ◽

Gut Dysbiosis

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Suppression by Licorice Flavonoids of Abdominal Fat Accumulation and Body Weight Gain in High-Fat Diet-Induced Obese C57BL/6J Mice

Bioscience Biotechnology and Biochemistry ◽

10.1271/bbb.60463 ◽

2007 ◽

Vol 71 (1) ◽

pp. 206-214 ◽

Cited By ~ 79

Author(s):

Fumiki AOKI ◽

Shinichi HONDA ◽

Hideyuki KISHIDA ◽

Mitsuaki KITANO ◽

Naoki ARAI ◽

...

Keyword(s):

Body Weight ◽

Weight Gain ◽

High Fat Diet ◽

Body Weight Gain ◽

Abdominal Fat ◽

High Fat ◽

Fat Accumulation

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Microencapsulated feruloyl esterase-producing lactobacilli ameliorate lipid profile and glycaemia in high fat diet-induced obese mice

Beneficial Microbes ◽

10.3920/bm2018.0025 ◽

2019 ◽

Vol 10 (2) ◽

pp. 189-198

Author(s):

M. Russo ◽

A. Marquez ◽

M.C. Abeijón-Mukdsi ◽

A. Santacruz ◽

A. López-Malo ◽

...

Keyword(s):

Body Weight ◽

Weight Gain ◽

High Fat Diet ◽

Body Weight Gain ◽

Atherogenic Index ◽

Feruloyl Esterase ◽

Obese Mice ◽

High Fat ◽

Adiposity Index ◽

Plasma Leptin

The effect of oral administration of spray-dried microcapsules of feruloyl esterase (FE) producing Lactobacillus fermentum CRL1446 (Lf) and Lactobacillus johnsonii CRL1231 (Lj) on high fat diet-induced obese mice was investigated to evaluate whether these strains could be used as a biotherapeutic for obesity. Swiss albino mice were divided into a normal diet fed group receiving empty microcapsules (control), a high fat diet plus empty microcapsules (HFD group), HFD plus microcapsules with Lf (HFD-Lf group) and HDF plus microcapsules with Lj (HFD-Lj group). Microcapsules containing Lf or Lj at a dose of ~107 cells/day/mouse were given orally for 7 weeks. Body weight gain, adiposity index, plasma leptin, lipid profiles, glycaemia, insulinemia, oral glucose tolerance, intestinal FE, glutathione peroxidase and glutathione reductase (GR) activities were determined. Administration of lactobacilli (HFD-Lf and HFD-Lj groups) improved metabolic parameters (triglyceride, total cholesterol, low-density lipoprotein cholesterol levels) and cardiovascular risk indicators (37-46% decrease of atherogenic index), and reduced body weight gain (29-38%), adiposity index (42-62%), plasma leptin levels, liver weight and fat deposition in liver. Intestinal FE activities significantly increased in HFD-Lf (62%) and HFD-Lj group (48%), thus improving hepatic GR activity (42% increment) compared to HFD group. Moreover, L. johnsonii increased HDL-cholesterol and L. fermentum reduced blood glucose to levels similar to the control. These FE-producing lactobacilli have the potential to improve biomarkers involved in obesity by increasing intestinal FE activity.

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