scholarly journals Gastrointestinal Stromal Tumor - Experience From A Tertiary Care Center

2018 ◽  
Vol 39 (2) ◽  
Author(s):  
Kalidas Biswas
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Care Center ◽  
Tertiary Care ◽  
Stromal Tumor ◽  
Tertiary Care Center

scholarly journals Avapritinib in advanced gastrointestinal stromal tumor: case series and review of the literature from a tertiary care center in India

2021 ◽  
pp. FSO676
Author(s):  
Saurav Verma ◽  
Rohit Reddy ◽  
Sheragaru Hanumanthappa Chandrashekhara ◽  
Shamim Ahmed Shamim ◽  
Sarthak Tripathy ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Clinical Benefit ◽  
Care Center ◽  
Tertiary Care ◽  
Case Series ◽  
Progression Free Survival ◽  
Response Assessment ◽  
Stromal Tumor ◽  
Significant Difference ◽  
Us Fda

The therapeutic landscape in advanced gastrointestinal stromal tumor has evolved. Avapritinib and ripretinib have now been approved by the US FDA for platelet-derived growth factor alpha D842V-mutant and refractory gastrointestinal stromal tumor patients, respectively. Here we report five patients who have been on avapritinib under an expanded access program. Response assessment was available for four patients – a partial response in two patients and stable disease in one, while one patient had progressive disease. Though preliminary results of the VOYAGER trial have shown less activity of avapritinib and no significant difference in progression-free survival when compared with regorafenib, avapritinib may show some clinical benefit in a subset of patients refractory to approved therapies. We share our experience of five cases, with clinical benefit in three. We believe avapritinib should be further evaluated in clinical trials.

scholarly journals Carney’s triad in an adult male from a tertiary care center in India: a case report

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Ghazal Tansir ◽  
Nihar Ranjan Dash ◽  
Saurabh Galodha ◽  
Prasenjit Das ◽  
Shamim Ahmed Shamim ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Succinate Dehydrogenase ◽  
Adrenal Adenoma ◽  
Care Center ◽  
Tertiary Care ◽  
Stromal Tumor ◽  
Wild Type ◽  
Common Component ◽  
Carney’S Triad ◽  
Pulmonary Chondroma

Abstract Background Carney’s triad is a rare syndrome comprising gastrointestinal stromal tumor, extra-adrenal paraganglioma, and pulmonary chondroma along with newer additions of adrenal adenoma and esophageal leiomyoma. The triad is completely manifest in only 25–30% cases, with most patients presenting with two out of three parts of the syndrome. Wild-type succinate-dehydrogenase-deficient gastric gastrointestinal stromal tumor forms the most common component of Carney’s triad and is usually multicentric and multifocal. It usually demonstrates indolent behavior and resistance to imatinib; hence, the management remains predominantly surgical. Pulmonary chondromas are commonly unilateral and multiple with slow-growing nature, which allows for conservative management. Adrenocortical adenomas are found in 20% of patients and are usually detected as incidentalomas. Case presentation A 49-year-old Asian male presented with upper gastrointestinal bleed and was diagnosed with multiple gastric succinate-dehydrogenase-deficient gastrointestinal stromal tumors. On evaluation, he was found to have left pulmonary chondroma and non-secretory adrenal adenoma, thus completing the Carney’s triad. He underwent surgery with sleeve gastrectomy and excision of the antral tumor nodule, while the adrenal and pulmonary tumors have been under close follow-up. Conclusion Literature regarding Carney’s triad is scarce, especially from the Indian setting. Our report aims to highlight the various manifestations of this syndrome with emphasis on management of wild-type succinate-dehydrogenase-deficient gastrointestinal stromal tumor. Radical gastric surgeries do not offer a survival advantage in this condition; hence, more conservative modalities of resection can be adopted.

Study of risk factors of eclampsia in a tertiary care center

2019 ◽  
Vol 12 (2) ◽  
pp. 31-35
Author(s):  
Padma Chandavathu ◽  
◽  
Akurathi Krishna Rao ◽  
Keyword(s):  
Risk Factors ◽  
Care Center ◽  
Tertiary Care ◽  
Tertiary Care Center
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