scholarly journals STANDARDIZATION STUDY OF POLYHERBAL FORMULATION: ARTHRUM OINTMENT

2020 ◽  
Vol 11 (12) ◽  
pp. 26-30
Author(s):  
Amit Patel ◽  
Komal Hirani ◽  
Hiral Gohil

To access the quality of drug the standardization is very critical. As per WHO guidelines, 80% of the peoples have relied on traditional medicine in a rising nation. Most of the conventional system is valuable but a lack of standardization. The parameters studied are physicochemical parameters, heavy metal analysis, aflatoxin content, pesticide residue and microbial analysis. These values will help to obtain the batch-to-batch variation in Arthrum ointment. This is used to treat different types of pain. We calculated and discussed physicochemical parameters, heavy metal analysis, aflatoxin content, pesticide residue and microbial analysis. The scientific method for its quality and safety evaluation is not yet to be documented. Hence in the current work, an attempt has been made to evaluate the quality parameters to be used for its preparation and processing.

2017 ◽  
Vol 10 (1) ◽  
pp. 29
Author(s):  
Mohammad Rehan ◽  
Dhirendra Kumar Bharati ◽  
Sushmita Banerjee ◽  
Ravindra Kumar Gautam ◽  
Mahesh Chandra Chattopadhyaya

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Christopher Larbie ◽  
Christabel Owusu Nyarkoh ◽  
Clement Owusu Adjei

Tecoma stans (yellow bell) is a popular ornamental plant mostly found in the tropical regions. It is reported to have significant pharmacological activity and has gained attention by natives of various cultures. This study focused on the phytoconstituents screening, antioxidant activity, and heavy metal analysis as well as the acute and subchronic toxicity of the hydroethanolic leaf extract (TSE) using standard methods. The presence of flavonoids, alkaloids, cardiac glycosides, saponins, coumarins, and terpenoids in the raw leaf of the plant was observed while the hydroethanolic extract contained coumarins, saponins, cardiac glycosides, and flavonoids. The DPPH percentage scavenging activity of the crude extract was 64.32% while the fractions, ethyl acetate (55.26%), methanol (60.72%), and hydro (36.97%.), gave varying activities. The UV-Vis and FT-IR indicated the presence of alcohols, phenols, alkanes, alkenes, carbonyls (general), aliphatic amines, aromatics, ketones, ethers, esters, carboxylic acids, alkyl halides, saturated aliphatic acids, 1° and 2° amines, amides, and α,β-unsaturated aldehydes. The heavy metal analysis showed a high level of iron (Fe) and zinc (Zn) in the raw leaf. The median acute toxicity (LD50) of the extract was determined to be <5000mg/kg body weight in mice. Subchronic use for 28 days resulted in significant weight gain, reduction in platelet levels, decrease in WBCs, and increase in blood glucose compared to the normal. TSE caused no adverse effects on vital organs. No mortality was recorded. The hydroethanolic extract of T. stans could therefore be considered safe in moderate doses.


2020 ◽  
Vol 8 (1) ◽  
pp. 58-62
Author(s):  
Sidra Yasmeen ◽  
Rafia Usman ◽  
Sultan Ayaz ◽  
Fatima Qamar ◽  
Syeda Zainab ◽  
...  

The current study was conducted with the aim to evaluate Ivy leaf extract to authenticate the quality of extract. Evaluation was conducted on different physicochemical factors of extract that include physical appearance, organoleptic properties and solubility. Loss on drying, microbial analysis and heavy metal analysis was also carried out to execute the safety of extract. High performance liquid chromatography was executed to evaluate the presence of Hederacoside C in Ivy leaf extract employing phosphoric acid 85 %, acetonitrile, water (2:140:860 v/v/v) as a mobile phase. Extract exhibited greenish brown color, distinctive odor and sweet taste. An Ivy extract was found in agreement of the allowable microbial limit as well as with the heavy metal contents limit. The presence of Hederacoside C in Ivy leaf extract was confirmed by HPLC. The current evaluation reveals conformity with all the analytical procedures. Hence Ivy leaf extract is well standardized formulation at the base line consideration.


INDIAN DRUGS ◽  
2014 ◽  
Vol 51 (01) ◽  
pp. 55-58
Author(s):  
S Parida ◽  
◽  
K. K. Rout ◽  
S. K. Mishra

Present study aims to standardize ‘Vamsalochana’, which is a siliceous concrete material found in the hollow internodes of Bambusa arundinacea (Retz.). It is attributed with varieties of medicinal properties and highly valued in the Indian System of Medicine. Various physicochemical parameters like alcohol soluble extractive, water soluble extractive, total ash, acid insoluble ash were determined according to Ayurvedic Pharmacopoeia of India (API). Microscopic examination revealed the presence of rosette crystals of calcium oxalate. Characteristic colours were obtained when the powder drug treated with different chemical reagents and solvents. Heavy metal analysis indicates the presence of silica as major component (85.78 %). Toxic metals like arsenic, cadmium, mercury and lead were absent.


2018 ◽  
Vol 136 ◽  
pp. 332-340
Author(s):  
Inayat ur Rehman ◽  
Muhammad Zahoor ◽  
Muhammad Tariq Bashir ◽  
Imran Ud Din ◽  
Jehangir Shah ◽  
...  

2020 ◽  
Vol 71 (8) ◽  
pp. 240-248
Author(s):  
Kafeel Ahmad ◽  
Yongjun Yang ◽  
Zafar Iqbal Khan ◽  
Nimra Arshad ◽  
Tasneem Ahmad ◽  
...  

The article is focused on estimation of Zinc in the roadside forages, and blood of buffaloes feeding on these forages. This study was carried out in Sargodha during December 2015 to January 2016 (winter) and May 2016 to June 2016 (summer). Five road sites (Mateela, Faisalabad roadside, Shaheenabad roadside, Bhalwal roadside and 50 chak) were selected from sampling of forages, soil and buffalo blood sample. Heavy metal analysis of all digested samples was done with atomic absorption spectrophotometer. Analysis of variance and correlation was done with two way ANOVA. This study regarding the accumulation of zinc in forages, soil and the buffalo blood would help the authorities to exactly determine the agents which are responsible for increasing pollution in the environment.


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