scholarly journals Study to Evaluate Association of Torch Infection with Bad Obstetric History in Pregnant Women at Sms Medical College and Attached Group of Hospitals, Jaipur

2021 ◽  
pp. 97-108
Author(s):  
Bhanu Priya Panwar ◽  
Rameshwari Bithu ◽  
Manju Yadav ◽  
Rakesh Kumar Maheshwari ◽  
Bharti Malhotra
Keyword(s):  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Herpes Virus ◽  
In Utero ◽  
P Value ◽  
Medical College ◽  
Obstetric History ◽  
Herpès Virus ◽  
Torch Infection ◽  
Simplex Virus

Background: Congenital infections are transmissible in utero and it can lead to serious foetal outcomes. These infections can be early detected in pregnant women with bad obstetric history for better foetal outcomes. Aim of the Study was to evaluate the association of TORCH infection with bad obstetric history among pregnant women. Study Design: Observational and comparative study Place and Duration of Study: Central laboratory, Department of Microbiology, SMS Medical College, Jaipur between April 2020 and September 2021. Methodology: 260 blood samples of pregnant women (130 with bad obstetric history and 130 pregnant women without bad obstetric history) were collected. and tested for the presence of IgM and IgG antibodies against Toxoplasma gondii, Rubella virus, Cytomegalovirus by Chemiluminescence and Herpes simplex virus using ELISA kits. Results: Overall TORCH IgM seropositivity in high-risk pregnant women was 17.19%. In pregnant women with bad obstetric history, IgM Seropositivity for Toxoplasma gondii was 3.84% (P value .02), rubella 2.34% (P value .30), Cytomegalovirus 5.47% (P value .08), and 6.25% (P value .56) for Herpes-1 and 2 infections and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 16.41% (P value .001), 93.75% (P value .11), 98.44% (P value .55), 48.44% (P value .53) respectively. In pregnant women without bad obstetric history, IgM and IgG seropositivity for toxoplasma, rubella, cytomegalovirus and herpes virus was 0/0.77%, 0.76/97.69%, 1.53/99.23% and 4.61/44.62% respectively. The average age of the study population was 27.13 years. Conclusion: As TORCH infections are transmissible in-utero in all the stages of pregnancy and contributes in neonatal and infant deaths, so early diagnosis and appropriate interventions necessary which help in proper management of the pregnant women.

Réactivations à herpès virus (HSV, CMV) en réanimation : qui et quand traiter ?

2019 ◽  
Vol 28 (3) ◽  
pp. 232-238
Author(s):  
C.-E. Luyt ◽  
G. Hékimian ◽  
N. Bréchot
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Herpes Virus ◽  
Herpès Virus ◽  
Simplex Virus ◽  
Charge Virale

Les réactivations à herpès simplex virus (HSV) et à cytomégalovirus (CMV) sont fréquentes chez le patient non immunodéprimé de réanimation. La réactivation HSV est localisée aux voies aériennes ; elle débute au niveau oropharyngé, progresse de façon descendante avec la contamination des voies aériennes distales et peut aboutir, chez certains malades, à une véritable bronchopneumonie herpétique. Elle est en outre associée à un pronostic défavorable. Le traitement prophylactique et préemptif des réactivations HSV ne peut pas être préconisé à l’heure actuelle. Le traitement curatif repose sur un avis d’experts, chez des malades présentant soit une charge virale élevée dans les voies aériennes distales, soit des signes cytologiques d’atteinte parenchymateuse pulmonaire sur les cellules recueillies lors du lavage bronchoalvéolaire. La réactivation CMV sanguine est fréquente et peut être isolée ou associée à une réactivation/atteinte pulmonaire et est aussi associée à un pronostic défavorable. Le traitement prophylactique de la réactivation CMV ne peut pas être préconisé, et le traitement préemptif est en cours d’évaluation. À l’heure actuelle, le traitement curatif des maladies pulmonaires à CMV repose soit sur des signes histologiques d’atteinte pulmonaire, soit sur un faisceau d’arguments clinicobiologiques évoquant une possible maladie à CMV.

scholarly journals Epidemiology of Human Herpes Virus 8 in Pregnant Women and their Newborns - A cross-sectional delivery survey in Central Gabon

2015 ◽  
Vol 39 ◽  
pp. 16-19 ◽  
Author(s):  
Mesküre Capan-Melser ◽  
Ghyslain Mombo-Ngoma ◽  
Daisy Akerey-Diop ◽  
Arti Basra ◽  
Rella Manego-Zoleko ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Herpes Virus ◽  
Human Herpes ◽  
Cross Sectional ◽  
Human Herpes Virus 8 ◽  
Human Herpes Virus ◽  
Herpès Virus

scholarly journals The effect of herpes viruses on antenatal programming of children's health

2019 ◽  
Vol 18 (3) ◽  
pp. 37-41
Author(s):  
L. A. Lityaevа ◽  
O. V. Kovaleva
Keyword(s):  
Pregnant Women ◽  
Herpes Virus ◽  
Cholesterol Metabolism ◽  
Risk Group ◽  
Bacterial Load ◽  
Gas Chromatography Mass Spectrometry ◽  
Herpes Viruses ◽  
Laboratory Observation ◽  
Quantitative Content ◽  
Herpès Virus

Objective: to assess the effect of viruses of herpes family in pregnant women on the health of children in the first half of their lives.A clinical and laboratory observation of 33 mother-child pairs was conducted. Of these, 25 women were from the risk group for intrauterine infection and 8 women were with a physiological course of pregnancy. The quantitative content of herpes virus markers was studied by their effect on cholesterol metabolism and symbiotic microbiota was studied by the quantitative content of long chain fatty acids and fatty aldehydes, phospholipids by gas chromatography-mass spectrometry in all women at 34-37 weeks of gestation and their infants.It was revealed that pregnant women of “risk group” increased the quantitative content of herpes virus markers with the prevalence of herpes simplex virus (HSV) 1,2 types and its associations with cytomegalovirus (CMV) and Epstein-Barr virus (EBV).A correlation was found between the degree of increase in markers of HSV, EBV, and CMV with that of the bacterial load of the intestine by conditionally pathogenic representatives and the deficiency of priority genera of the intestinal microbiota in mothers and the same indicators in their children.An increase in the quantitative content of herpes viruses, exceeding the norm by more than 2 times, is interconnected with the pathological course of pregnancy and the violation of the microecological status of pregnant women, which predicts the realization of somatic and infectious pathology in children in the first half of life.

scholarly journals Pathological processes of immunological decontamination of herpes simplex virus type 1 from the cornea

2020 ◽  
pp. 4-11
Author(s):  
Т.З. Керимов ◽  
В.П. Соболев ◽  
М.А. Соболева ◽  
Н.А. Гаврилова ◽  
С.А. Борзенок
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Herpes Virus ◽  
Toll Like Receptors ◽  
Herpès Virus ◽  
Simplex Virus ◽  
Hsv 1

В обзоре представлено описание патофизиологических механизмов герпесвирусной инфекции. Согласно данным медицинской статистики, вирусом простого герпеса 1 типа инфицировано большинство населения планеты. В развивающихся странах данный вирус является ведущей инфекционной причиной поражения роговицы. Также вирусу простого герпеса 1 типа отводится роль одного из факторов, приводящих к отторжению трансплантата роговицы. Вышеописанные патологические явления сопряжены с перестройкой клеточных систем в ответ на вирусное воздействие. Недавние открытия в данной области обнаружили значительный вклад трансмембранных и эндосомальных Toll-подобных рецепторов во врожденный противовирусный клеточный ответ. Показано, что эндосомальные Toll-подобные рецепторы 3 типа экспрессируются в кератоцитах только после их фенотипического перехода в фибробласты. Данная трансформация обычно происходит в результате механических и патогенных воздействий на роговицу. Изменение рецепторного состава клеток в ответ на герпесвирусную инвазию вызывает выработку интерферонов 1 типа - интерферона-альфа, интерферона-бета, и синтезу провоспалительных цитокинов, что приводит к вирусной деконтаминации. This review describes pathophysiological mechanisms of herpes virus infection in cornea cells. It has been previously reported that herpes simplex virus type 1 (HSV-1) infects most of the world’s population. In developing countries, HSV-1 is the leading infectious cause of corneal damage. Also, herpes simplex virus type 1 was assigned the role of one of the factors leading to rejection of the corneal transplant. These pathological phenomena are associated with restructuring of cellular systems in response to viral exposure. Recent discoveries have revealed a significant contribution of transmembrane and endosomal Toll-like receptors to the innate antiviral cell response. It is well known that endosomal Toll-like receptors-3 are expressed in keratocytes only after their phenotypic transformation to fibroblasts. This transformation usually occurs as a result of mechanical or infectious impact on the cornea. Changes in the receptor composition of cells as a response to herpes virus invasion is the main cause of type 1 interferons (interferon-alpha and interferon-beta) production and expression of proinflammatory cytokines, which leads to viral decontamination.

scholarly journals Kaposi's Sarcoma Associated-Herpes Virus (KSHV) Seroprevalence in Pregnant Women in South Africa

2010 ◽  
Vol 5 (1) ◽  
pp. 14 ◽  
Author(s):  
Babatyi I Malope-Kgokong ◽  
Patrick MacPhail ◽  
Georgina Mbisa ◽  
Edith Ratshikhopa ◽  
Mhairi Maskew ◽  
...  
Keyword(s):  
South Africa ◽  
Pregnant Women ◽  
Kaposi's Sarcoma ◽  
Herpes Virus ◽  
Kaposi’S Sarcoma ◽  
Herpès Virus

scholarly journals Alpha herpes virus type and viral load in intraocular fluids in patients with acute retinal necrosis

2019 ◽  
Vol 4 (1) ◽  
pp. e000247 ◽  
Author(s):  
Joanna von Hofsten ◽  
Tomas Bergström ◽  
Madeleine Zetterberg
Keyword(s):  
Herpes Simplex Virus ◽  
Viral Load ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Virus ◽  
Visual Outcome ◽  
High Viral Load ◽  
Acute Retinal Necrosis ◽  
Herpès Virus ◽  
Simplex Virus

ObjectivesTo identify all patients tested positive for herpes viruses in intraocular samples between 2007 and 2016 in South-Western Sweden and evaluate which of these met the criteria of acute retinal necrosis (ARN). To compare viral load in intraocular samples and virus type with clinical outcome.Method and analysisRetrospective case series. Intraocular samples and serum were analysed with quantitative real-time PCR (qPCR) and presence of antibodies (IgG and IgM) were detected by ELISA in serum.ResultsBetween 2007 and 2016, 13 patients met the clinical criteria of ARN and were PCR-positive in aqueous or vitreous for herpes simplex virus 1 (HSV1; n=4), herpes simplex virus 2 (HSV2; n=3) and varicella zoster virus (VZV; n=6). None of the patients tested positive for cytomegalovirus (n=13) or Epstein Barr virus (n=2) met the criteria of ARN. All ARN patients had specific serum IgG and three patients exhibited virus DNA in serum. There was no correlation between high viral load and worse visual outcome. However, higher viral loads were seen in samples taken earlier in the disease process. Median age was higher (p=0.049) in VZV-ARN than for HSV-ARN patients (60.5 and 45.4 years, respectively) with a tendency of worse best corrected visual acuity at presentation (1.62 and 0.79 log MAR, respectively; p=0.079).ConclusionARN is a reactivation of alpha herpes virus and presence of herpes DNA in serum may occur. VZV-ARN are older than HSV-ARN patients. High viral load does not appear to be a predictor of worse visual outcome, but rather indicates earlier sampling.

Human herpes virus type 8 seroprevalence in pregnant women in Geneva, Switzerland

2010 ◽  
Vol 24 (1) ◽  
pp. 183-185 ◽  
Author(s):  
B. Martinez de Tejada ◽  
Ingrid Steffen ◽  
Pablo Cantero ◽  
Klara M. Posfay-Barbe ◽  
Olivier Irion ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Virus Type ◽  
Herpes Virus ◽  
Human Herpes ◽  
Human Herpes Virus ◽  
Herpès Virus ◽  
Human Herpes Virus Type
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